98796-09-9

Basic information

• Product Name: 3(2H)-Pyridazinone, 4-chloro-2-methyl-5-(methylamino)-
• Synonyms: 3(2H)-Pyridazinone, 4-chloro-2-methyl-5-(methylamino)-;4-CHLORO-2-METHYL-5-(METHYLAMINO)PYRIDAZIN-3(2H)-ONE
• CAS NO: 98796-09-9
• Molecular Formula: C6H8ClN3O
• Molecular Weight: 173.6
• Mol File: 98796-09-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-Pyridazinone, 4-chloro-2-methyl-5-(methylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 4-chloro-2-methyl-5-(methylamino)-(98796-09-9)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 4-chloro-2-methyl-5-(methylamino)-(98796-09-9)

Safety Data

• Hazardous Substances Data: 98796-09-9(Hazardous Substances Data)

Upstream product

• 933-76-6 4,5-dichloro-2-methyl-3(2H)-pyridazinone 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 212622-32-7 4-chloro-5-(methylamino)-3(2H)-pyridazone 
• 74-88-4 methyl iodide 

Relevant articles and documents

Discovery of a potent, cell penetrant, and selective p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain chemical probe

P300/CREB binding protein associated factor (PCAF/KAT2B) and general control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retroviral infection, inflammation pathways, and cancer development. However, outside of viral replication, little is known about the dependence of these effects on the C-terminal bromodomain. Herein, we report GSK4027 as a chemical probe for the PCAF/GCN5 bromodomain, together with GSK4028 as an enantiomeric negative control. The probe was optimized from a weakly potent, nonselective pyridazinone hit to deliver high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and ≥18000-fold selectivity over the BET family, together with ≥70-fold selectivity over the wider bromodomain families.

A Novel Synthesis of 2-Arylaminothiazolopyridazinones

The reaction of 5(4)-amino-4(5)-chloropyridazin-3(2H)-ones 1 (9) with methyl dithiocarbamates 2 gave 2-arylaminothiazolopyridazinones 3 (10).Treatment of 5(4)-alkylamino-4(5)-chloropyridazin-3(2H)-ones 5 (12) with 2 afforded the corresponding 2-aryliminothiazolopyridazinones 6 (13).Cyclization of 1a with phenylisothiocyanate produced 2-amino- and 2-iminothiazolopyridazinones 3a and 16.