98948-82-4Relevant articles and documents
A synthesis method for 4,6-dihydroxy quinoline-5,8-diquinone-2-formic acid medicine intermediate
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Paragraph 0014-0025, (2018/09/08)
The invention discloses a synthesis method for 4,6-dihydroxy quinoline-5,8-diquinone-2-formic acid medicine intermediate including the following steps: adding 4,6-dihydroxy-5,8-dimethoxy-quinoline-2-formic acid and an octane solution into a reaction container, raising the temperature, adding potassium persulfate in batches, controlling the stirring speed, adding an aqueous solution, and continuingthe reaction; adding cadmium nitrate powder, rising the solution temperature, adding potassium sulfate solution, continuing the reaction, reducing the temperature, standing, allowing layering of thesolution, adding a sodium chloride solution to wash multiple times and adding a methyl ether solution to wash multiple times, recrystallizing in an o-chlorotoluene solution, performing dehydration with a dehydrating agent, and obtaining the finished product of the 4,6-dihydroxy quinoline-5,8-diquinone-2-formic acid.