98968-68-4

Basic information

• Product Name: 2-amino-4-chloro-3-methylbenzoic acid
• Synonyms: 2-amino-4-chloro-3-methylbenzoic acid
• CAS NO: 98968-68-4
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.60762
• Product Categories: Miscellaneous Reagents
• Mol File: 98968-68-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 210-212 °C
• Boiling Point: 352.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.401±0.06 g/cm3(Predicted)
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 2-amino-4-chloro-3-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-chloro-3-methylbenzoic acid(98968-68-4)
• EPA Substance Registry System: 2-amino-4-chloro-3-methylbenzoic acid(98968-68-4)

Safety Data

• Hazardous Substances Data: 98968-68-4(Hazardous Substances Data)

Usage

Description

2-amino-4-chloro-3-methylbenzoic acid is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by the presence of an amino group, a chlorine atom, and a methyl group attached to a benzene ring, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
2-amino-4-chloro-3-methylbenzoic acid is used as a synthetic intermediate for the development of glycine B antagonists, which are important in the treatment of neurological disorders such as schizophrenia and Huntington's disease. Its structural features allow for the formation of specific interactions with the glycine B receptor, modulating its activity and offering therapeutic benefits.
Additionally, 2-amino-4-chloro-3-methylbenzoic acid is used as a building block in the synthesis of PARP inhibitors. These inhibitors are valuable in the treatment of various types of cancer by targeting the enzyme poly(ADP-ribose) polymerase, which plays a crucial role in DNA repair. By inhibiting PARP, these compounds can lead to the accumulation of DNA damage in cancer cells, ultimately resulting in cell death.
Furthermore, 2-amino-4-chloro-3-methylbenzoic acid is utilized in the preparation of potential anti-tumor agents. Its chemical structure can be modified to create compounds with anti-tumor properties, which can be further optimized for improved efficacy and selectivity in targeting cancer cells. This makes it a valuable component in the development of novel cancer therapies.

Upstream product

• 6374-90-9 6-Chloro-7-methyl-1H-indole-2,3-dione 
• 87-60-5 3-chloro-2-methylbenzenamine 

Downstream Products

• 18730-22-8 7-chloro-8-methyl-2-phenyl-benzo[d][1,3]oxazin-4-one 
• 129833-34-7 4-Chloro-2-iodo-3-methyl-benzoic acid 
• 129833-22-3 6-chloro-5-methyl-9-oxo-9H-xanthene-4-acetic acid 
• 129833-43-8 2-(2-Carboxymethyl-phenoxy)-4-chloro-3-methyl-benzoic acid 
• 1415596-05-2 (2-amino-4-chloro-3-methylphenyl)-methanol 
• 1415596-07-4 2-amino-4-chloro-3-methyl-benzaldehyde 
• 1415596-09-6 2-amino-4,5-dichloro-3-methylbenzaldehyde 

Relevant articles and documents

HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (1): has excellent pesticidal activity.