99055-45-5 Usage
Description
1-(3-nitro-benzenesulfonyl)-aziridine is a chemical compound that belongs to the category of sulfonyl aziridines. It is characterized by the presence of a nitro group and a benzene ring attached to the aziridine functional group. 1-(3-nitro-benzenesulfonyl)-aziridine is known for its reactivity and potential use in the synthesis of complex organic compounds, particularly in the pharmaceutical and agrochemical industries.
Uses
Used in Pharmaceutical Industry:
1-(3-nitro-benzenesulfonyl)-aziridine is used as a building block for the development of pharmaceuticals. The presence of the nitro and sulfonyl groups in the molecule contributes to its reactivity, making it a valuable component in the synthesis of various medicinal compounds. The aziridine moiety in this chemical can undergo ring-opening reactions, leading to the formation of diverse chemical derivatives with potential therapeutic applications.
Used in Agrochemical Industry:
1-(3-nitro-benzenesulfonyl)-aziridine is also used as a building block in the synthesis of agrochemicals. Its reactivity and the presence of functional groups make it suitable for the development of compounds with pesticidal, herbicidal, or fungicidal properties. The aziridine ring's ability to undergo ring-opening reactions allows for the creation of a wide range of agrochemical derivatives with different modes of action and target pest spectra.
Organic Synthesis:
1-(3-nitro-benzenesulfonyl)-aziridine is used as a key intermediate in organic synthesis. Its unique structure and reactivity enable the formation of various complex organic compounds with diverse properties and applications. The nitro and sulfonyl groups present in the molecule can be further modified or functionalized to create new compounds with specific characteristics, making it a versatile building block in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 99055-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,5 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 99055-45:
(7*9)+(6*9)+(5*0)+(4*5)+(3*5)+(2*4)+(1*5)=165
165 % 10 = 5
So 99055-45-5 is a valid CAS Registry Number.
99055-45-5Relevant articles and documents
Development of hypoxia-sensitive Gd3+-based MRI contrast agents
Iwaki, Shimpei,Hanaoka, Kenjiro,Piao, Wen,Komatsu, Toru,Ueno, Tasuku,Terai, Takuya,Nagano, Tetsuo
, p. 2798 - 2802 (2012/06/01)
Hypoxia occurs in various diseases, including cancer, ischemia, and acute and chronic vascular diseases. Here we describe the design and synthesis of the first hypoxia-sensitive MRI contrast agents, SAGds. SAGds showed a pH-dependent r1 relaxivity change associated with intramolecular chelation of the nitrogen atom of the sulfonamide moiety to the Gd3+ center. There was a correlation between the pKa of the r1 relaxivity change and the sum of the Hammett σ constants of substituents on the aromatic ring. Among the synthesized compounds, 4NO22MeOSAGd was selectively reduced to the amine by rat liver microsomes under hypoxic conditions, resulting in a 1.8-fold increment of the r1 relaxivity owing to the change in pKa of the arylsulfonamide moiety. This enhancement of the r 1 relaxivity could be clearly detected in T1-weighted MR images. Thus, 4NO22MeOSAGd is a 'smart' MRI contrast agent for the detection of hypoxia under physiological conditions.
