99056-81-2

Basic information

• Product Name: {4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol
• Synonyms: {4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol
• CAS NO: 99056-81-2
• Molecular Weight: 217.23
• Mol File: 99056-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol(99056-81-2)
• EPA Substance Registry System: {4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol(99056-81-2)

Safety Data

• Hazardous Substances Data: 99056-81-2(Hazardous Substances Data)

Upstream product

• 623-50-7 ethyl 2-hydroxyacetate 
• 102-02-3 1-phenylbiguanide 
• 62-53-3 aniline 
• 104-94-9 4-methoxy-aniline 
• 43191-41-9 1-carbamimidamido-N-(4-methoxyphenyl)methanimidamide 

Downstream Products

• 1002789-86-7 (4-amino-6-(phenylamino)[1,3,5]triazin-2-yl)methyl 4-nitrobenzoate 
• 537-17-7 W 1191-2 
• 101080-83-5 4-amino-6-(phenylamino)-1,3,5-triazine-2-carboxylic acid 

Relevant articles and documents

Optimised synthesis of diamino-triazinylmethyl benzoates as inhibitors of Rad6B ubiquitin conjugating enzyme

Recently, we have identified the first inhibitors of Rad6B, an E2 enzyme essential for post-replication DNA repair and a potential new drug target for the treatment of breast cancer. We report two newly optimised synthetic routes to our [4-amino-6-(phenylamino)-1,3,5-triazin-2-yl]methyl 4-nitrobenzoate target compounds TZ8 and TZ9 with general applicability for further structure-activity relationship studies around this pharmacophore. The key step involved the condensation/cyclisation between phenylbiguanide and either ethyl bromoacetate or dimethyloxalate in good yield.