99059-14-0Relevant articles and documents
Towards novel biolabels: Synthesis of a tagged highly fluorescent Schiff-base aluminium complex
Briggs, Mark S.J,Fossey, John S,Richards, Christopher J,Scott, Brian,Whateley, John
, p. 5169 - 5171 (2002)
Starting from 3-(4-hydroxyphenyl)propanoic acid, formylation ortho to the phenol and condensation with ortho-aminophenol gave a novel functionalised Schiff-base ligand. Formation of the N-hydroxysuccinimidyl ester and non-aqueous complexation with AlEt2Cl gave a novel fluorescent biolabel displaying a Stokes shift of 100 nm. The efficacy of the new system was demonstrated by its attachment to rabbit IgG.
COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF
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Page/Page column 148, (2019/01/21)
Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.
Inhibitors of protein kinase for the treatment of disease
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, (2008/06/13)
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.