99071-31-5

Basic information

• Product Name: N-(4-iodophenyl)methacrylamide
• Synonyms: N-(4-iodophenyl)methacrylamide
• CAS NO: 99071-31-5
• Molecular Weight: 287.1
• Mol File: 99071-31-5.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: N-(4-iodophenyl)methacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-iodophenyl)methacrylamide(99071-31-5)
• EPA Substance Registry System: N-(4-iodophenyl)methacrylamide(99071-31-5)

Safety Data

• Hazardous Substances Data: 99071-31-5(Hazardous Substances Data)

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 1588429-77-9 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one 
• 1287759-64-1 N-(4-iodophenyl)-N-methylmethacrylamide 

Relevant articles and documents

Bromo Radical-Mediated Photoredox Aldehyde Decarbonylation towards Transition-Metal-Free Hydroalkylation of Acrylamides at Room Temperature

Herein, we report a visible-light-mediated hydroalkylation reaction of alkenes using easily available aldehydes as alkyl sources via bromo radical-promoted photoredox decarbonylation. This protocol provides an alternative entry to C(sp3)?C(sp3) bond formation and features considerable advantages including mild and clean reaction conditions, obviation for transition-metal catalyst, and good functional group compatibility.

Catalyst-free and selective trifluoromethylative cyclization of acryloanilides using PhICF3Cl

Trifluoromethylation-triggered cyclization of alkenes provides a useful route to CF3-containing cyclic compounds. Current approaches to generate CF3-based initiators from a CF3 source require a catalyst or an activator. This work describes a catalyst-free protocol to innately produce electrophilic CF3 species from PhICF3Cl for trifluoromethylative cyclization of acryloanilides. A new domino biscyclization of dienes has been developed leading to trifluoroethylated tetrahydroindenoquinolinones with chemo- and stereo-selectivity.

Synthesis of oxindoles via Cu-mediated reactions between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate

A novel way of synthesizing alkylated oxindoles via Cu-mediated atom transfer radical addition reaction between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate has been described. It was found that the use of N,N,N′,N′-1,1,2,2,-tetramethylethylenediamine as ligand was important for achieving good yields. Additionally, the use of DMSO as solvent and running the reaction at 130 °C were also crucial. In some cases, the product can be further brominated when the reaction temperature was raised to 150 °C.