99134-25-5

Basic information

• Product Name: (E)-ethyl 3-(2-bromophenyl)acrylate
• Synonyms: (E)-ethyl 3-(2-bromophenyl)acrylate;Ethyl 3-(2-bromophenyl)acrylate
• CAS NO: 99134-25-5
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.10784
• Mol File: 99134-25-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-ethyl 3-(2-bromophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(2-bromophenyl)acrylate(99134-25-5)
• EPA Substance Registry System: (E)-ethyl 3-(2-bromophenyl)acrylate(99134-25-5)

Safety Data

• Hazardous Substances Data: 99134-25-5(Hazardous Substances Data)

Usage

Description

(E)-ethyl 3-(2-bromophenyl)acrylate, with the molecular formula C11H11BrO2, is a chemical compound that serves as a versatile reagent in organic synthesis. This clear, colorless to pale yellow liquid is characterized by its fruity odor and is widely recognized for its applications across various industries.

Uses

Used in Pharmaceutical Industry:
(E)-ethyl 3-(2-bromophenyl)acrylate is used as an intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of a range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, (E)-ethyl 3-(2-bromophenyl)acrylate is utilized as a key component in the production of various agrochemicals. Its role in this industry is crucial for the development of effective pesticides, herbicides, and other agricultural products.
Used in Fine Chemicals Production:
(E)-ethyl 3-(2-bromophenyl)acrylate is also employed as an intermediate in the manufacture of other fine chemicals. Its versatility in organic synthesis makes it a valuable asset in the production of specialty chemicals for various applications.
Used in Fragrance and Flavor Industry:
This chemical compound is used as a component in the production of fragrances and flavors, capitalizing on its distinctive fruity odor to enhance the sensory qualities of various products in this industry.
Safety Precautions:
Given that (E)-ethyl 3-(2-bromophenyl)acrylate is a flammable liquid, it is essential to handle and store it with proper safety measures. This includes adhering to specific guidelines and protocols to minimize the risk of accidents and ensure the safe use of this compound in various applications.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 583-55-1 1-Bromo-2-iodobenzene 
• 140-88-5 ethyl acrylate 
• 64-17-5 ethanol 
• 119411-68-6 C₉H₆BrClO 
• 7345-79-1 2-bromocinnamic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 3132-99-8 m-bromobenzoic aldehyde 
• 141-78-6 ethyl acetate 

Downstream Products

• 124854-94-0 (E)-3-(2-bromophenyl)-2-propen-1-ol 
• 938164-56-8 4-(2-bromo-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 938164-27-3 3-(2-bromo-phenyl)-1-methyl-1H-pyrrole 
• 938164-26-2 4-(2-bromo-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 76304-46-6 3-(2-bromo-phenyl)-1H-pyrrole 
• 347392-10-3 (E)-{[3-(2-bromophenyl)allyl]oxy}(tert-butyl)dimethylsilane 
• 347392-12-5 (E)-tert-butyldiphenyl[3-(2-bromophenyl)allyloxy]silane 
• 5209-07-4 1-(2-Brom-phenyl)-1,2,3,10b-tetrahydro-fluoranthen 
• 668-30-4 Dibenzofluoranthen 
• 5209-08-5 1-(2-Brom-phenyl)-1,2,3,10b-tetrahydro-fluoranthen-3-on 
• 5209-09-6 2-(2-Brom-phenyl)-2-(9-fluorenyl)-propionsaeure 
• 1171825-28-7 ethyl 3-(2-bromophenyl)-4-nitrobutanoate 
• 90725-35-2 1-bromo-2-(3-chloro-propenyl)benzene 
• 56984-71-5 (E:Z)-3-(2-bromophenyl)prop-2-en-1-ol 

Relevant articles and documents

Improved preparation method of indole-2-formic acid as starting material of perindopril

The invention discloses an improved preparation method of indole-2-formic acid by using perindopril as a starting raw material, which comprises the following steps: S1, taking 2-bromobenzaldehyde and ethyl acetate as raw materials, under the action of sodium ethoxide, carrying out Claisen-Schmidt condensation reaction to synthesize ethyl 2-bromocinnamate; s2, carrying out cyclization reaction on the ethyl 2-bromocinnamate in an amide solvent by using cuprous halide as a coupling catalyst and sodium azide as a nitrogen source to synthesize the indole-2-formic acid in one pot. According to the invention, 2-bromobenzaldehyde is used as a raw material for preparation, ethyl 2-bromocinnamate is firstly prepared, then cuprous halide is used as a coupling catalyst, sodium azide is used as a nitrogen source, cyclization reaction is carried out in an amide solvent, indole-2-formic acid is synthesized in one pot, and the HPLC content is 99% or above.

Structure?Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents

Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model.

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.