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99216-67-8

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99216-67-8 Usage

General Description

Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1- is an organic compound with the molecular formula C5H11NO4. It is a carbamic acid derivative with a 1,1 configuration, meaning that the hydroxy and hydroxymethyl groups are positioned in a specific arrangement on the carbon atoms. Carbamic acid, [(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, 1,1- is commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of carbamate pesticides and in the synthesis of carbamic acid esters. Additionally, it has potential applications in the fields of medicine and biotechnology due to its unique chemical structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 99216-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,2,1 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 99216-67:
(7*9)+(6*9)+(5*2)+(4*1)+(3*6)+(2*6)+(1*7)=168
168 % 10 = 8
So 99216-67-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H19NO4/c1-6(12)7(5-11)10-8(13)14-9(2,3)4/h6-7,11-12H,5H2,1-4H3,(H,10,13)/t6-,7-/m1/s1

99216-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl ((2R,3R)-1,3-dihydroxybutan-2-yl)carbamate

1.2 Other means of identification

Product number -
Other names N-BOC-L-THREONOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:99216-67-8 SDS

99216-67-8Downstream Products

99216-67-8Relevant articles and documents

Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2′s-hydroxy-3′s-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors

Kandalkar, Sachin R.,Ramaiah, Parimi Atchuta,Joshi, Manoj,Wavhal, Atul,Waman, Yogesh,Raje, Amol A.,Tambe, Ashwini,Ansari, Shariq,De, Siddhartha,Palle, Venkata P.,Mookhtiar, Kasim A.,Deshpande, Anil M.,Barawkar, Dinesh A.

, p. 5799 - 5819 (2017/09/28)

A series of terminal nonyl chain and nucleobase modified analogues of (+)-EHNA (III) were synthesized and evaluated for their ability to inhibit adenosine deaminase (ADA). The constrained carbon analogues of (+)-EHNA, 7a-7h, 10a-c, 12, 13, 14 and 17a-c appeared very potent with Ki values in the low nanomolar range. Thio-analogues of (+)-EHNA 24a-e wherein 5′C of nonyl chain replaced by sulfur atom found to be less potent compared to (+)-EHNA. Docking of the representative compounds into the active site of ADA was performed to understand structure-activity relationships. Compounds 7a (Ki: 1.1 nM) 7b (Ki: 5.2 nM) and 26a (Ki: 5.9 nM) showed suitable balance of potency, microsomal stability and demonstrated better pharmacokinetic properties as compared to (+)-EHNA and therefore may have therapeutic potential for various inflammatory diseases, hypertension and cancer.

IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS

-

Paragraph 0275; 0288; 0289, (2016/03/13)

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which is useful in the treatment of a tumor through its ROS1 kinase enzyme activity inhibitory effect and NTRK kinase enzyme inhibitory effect. The present invention provides a compound having an imidazo[1,2-b]pyridazine structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, G, T, Y1, Y2, Y3, and Y4 are as defined herein.

Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464

Osman, Sami,Albert, Brian J.,Wang, Yanping,Li, Miaosheng,Czaicki, Nancy L.,Koide, Kazunori

supporting information; experimental part, p. 895 - 904 (2011/03/20)

FR901464, a natural product isolated from a bacterium source, activates a reporter gene, inhibits pre-mRNA splicing, and shows antitumor activity. We previously reported the development of a more potent analogue, meayamycin, through the total synthesis of

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