99291-20-0 Usage
Description
V-9-M Cholecystokinin nonapeptide, also known as a GLP-1 receptor agonist, is a peptide hormone that functions as an analog of human glucagon-like peptide-1 (GLP-1). It is secreted by intestinal L cells and plays a crucial role in glucose homeostasis.
Used in Pharmaceutical Industry:
V-9-M cholecystokinin nonapeptide is used as a hypoglycemic drug for the treatment of type 2 diabetes. It works by increasing insulin secretion in a glucose-dependent manner, inhibiting glucagon secretion, promoting gastric emptying, centrally suppressing appetite, reducing food intake, and ultimately lowering blood sugar levels. This makes it a valuable therapeutic agent for managing blood glucose levels in diabetic patients.
Mechanism of action
V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.
Check Digit Verification of cas no
The CAS Registry Mumber 99291-20-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,2,9 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 99291-20:
(7*9)+(6*9)+(5*2)+(4*9)+(3*1)+(2*2)+(1*0)=170
170 % 10 = 0
So 99291-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C42H69N9O14S/c1-20(2)31(43)41(63)51-17-10-12-28(51)37(59)49-33(22(5)6)38(60)45-24(13-14-29(52)53)35(57)44-23(7)34(56)48-32(21(3)4)39(61)47-26(19-30(54)55)40(62)50-16-9-11-27(50)36(58)46-25(42(64)65)15-18-66-8/h20-28,31-33H,9-19,43H2,1-8H3,(H,44,57)(H,45,60)(H,46,58)(H,47,61)(H,48,56)(H,49,59)(H,52,53)(H,54,55)(H,64,65)/t23-,24-,25-,26-,27-,28?,31-,32-,33-/m0/s1
