99293-85-3

Basic information

• Product Name: N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
• CAS NO: 99293-85-3
• Molecular Weight: 265.355
• Mol File: 99293-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine(99293-85-3)
• EPA Substance Registry System: N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine(99293-85-3)

Safety Data

• Hazardous Substances Data: 99293-85-3(Hazardous Substances Data)

Upstream product

• 99-94-5 p-Toluic acid 
• 3349-64-2 1-tetralone oxime 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 1701-57-1 2,3,4,5-tetrahydro-1Hbenzo[b]azepine 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 99293-99-9 5-hydroxy-N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

Microbiological Transformations, Part 6. Microbiological Transformations of Acyl Derivatives of Indoline, 1,2,3,4-Tetrahydroquinoline, 1,2,3,4-Tetrahydroisoquinoline and 2,3,4,5-Tetrahydro-1H-1-benzazepine with the Fungus Cunninghamella elegans

Incubation of N-benzoyl and N-(p-toluoyl)indoline with Cunninghamella elegans resulted in reductive cleavage with the formation of indoline and the corresponding benzyl alcohol.N-Acetylindoline underwent normal benzylic hydroxylation ond open chain analogues of N-(p-toluoyl)indolines were hydroxylated at the aryl methyl group by C. elegans.The fungus effected benzylic oxidation at the 4-position on N-benzoyl-1,2,3-tetrahydroquinoline and in N-benzoyl-1,2,3,4-tetrahydroisoquinoline derivatives.N-(p-Toluoyl)-1,2,3,4-tetrahydroquinoline and N-(p-ethylbenzoyl)-1,2,3,4-tetrahydroisoquinoline were, however, hydroxylated at the alternative 4'-benzylic position.Incubation of N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine with C. elegans gave 5-hydroxy-N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine