99454-75-8

Basic information

• Product Name: 2-(2-methoxy-4-methylthiophenyl)-1H-imidazo<4,5-b>pyrazine
• Synonyms: 2-(2-methoxy-4-methylthiophenyl)-1H-imidazo<4,5-b>pyrazine
• CAS NO: 99454-75-8
• Molecular Weight: 272.33
• Mol File: 99454-75-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-methoxy-4-methylthiophenyl)-1H-imidazo<4,5-b>pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxy-4-methylthiophenyl)-1H-imidazo<4,5-b>pyrazine(99454-75-8)
• EPA Substance Registry System: 2-(2-methoxy-4-methylthiophenyl)-1H-imidazo<4,5-b>pyrazine(99454-75-8)

Safety Data

• Hazardous Substances Data: 99454-75-8(Hazardous Substances Data)

Upstream product

• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 13134-31-1 pyrazine-2,3-diamine 
• 72856-73-6 2-methoxy-4-(methylsulfanyl)benzoic acid 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 

Downstream Products

• 120236-85-3 2-(2-methoxy-4-methylsulphinylphenyl)-1H-imidazo<4,5-b>pyrazine 

Relevant articles and documents

Inotropic activity of heterocyclic analogues of isomazole

Aryl-substituted benzimidazole, imidazopyridine, imidazopyrazine, imidazopyridazine, oxazolopyridine, purine, pyrollopyridine and thiazolopyridine derivatives have been prepared and evaluated as inotropic agents.Purine 8 and the 1H-imidazo- and pyridazines 9 and 10 proved to be of most interest, having similar in vivo inotropic potencies to sulmazole.The pKa's, protonation sites and lipophilicities for most heterocycles were determined experimentally and some of their electronic properties calculated.For a subset of active heterocycles a correlation was observed between in vitro inotropism and the charge density of the imidazo nitrogen adjacent to the electrostatic potential minimum.Structure-activity relationships are discussed in some detail.