99519-16-1

Basic information

• Product Name: 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester
• Synonyms: 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester
• CAS NO: 99519-16-1
• Molecular Weight: 1189.61
• Mol File: 99519-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester(99519-16-1)
• EPA Substance Registry System: 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester(99519-16-1)

Safety Data

• Hazardous Substances Data: 99519-16-1(Hazardous Substances Data)

Upstream product

• 539-47-9 3-(fur-2-yl)crotonic acid 
• 99272-58-9 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester 
• 99272-53-4 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester 
• 99272-57-8 1,5-dicarbomethoxy-3-methoxy-2-pentene 
• 27024-77-7 3,3-dimethoxy-1,5-dicarbomethoxypentane 
• 22634-92-0 4-oxo-heptanedioic acid dimethyl ester 
• 98-01-1 furfural 
• 24324-17-2 9-Fluorenylmethanol 
• 99272-63-6 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester; compound with triethyl-amine 

Downstream Products

• 99272-74-9 4-{(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester 

Relevant articles and documents

Chemical synthesis of a pentaribonucleoside tetraphosphate constituting the 3'-acceptor stem sequence of E. coli tRNAIle using 2'-O-(3-methoxy-1,5-dicarbomethoxypentan-3-yl)-ribonucleoside building blocks. Application of a new achiral and acid-labile 2'-hydroxyl protecting group in tRNA synthesis.

A synthesis of a pentaribonucleotide fragment constituting the residues 59-63 of 3'-terminus of E. coli tRNAIle, 5'-ApGpUpCpC-3', has been carried out using a new, easily accessible and achiral 2'-ketal protecting group. The new 2'-ketal group has an additional advantage in that it is easily functionalized to the diamide with aqueous ammonia in the penultimate step of deblocking of fully protected oligoribonucleotides. Such a functionalization of the 2'-ketal group at the penultimate step of deblocking of the fully protected tRNA molecule enhances its relative rate of removal under an acidic condition with a minimum of damage of the target tRNA molecule.