99530-17-3

Basic information

• Product Name: C₂₇H₂₈BrNO₁₀*ClH
• CAS NO: 99530-17-3
• Molecular Weight: 642.885
• Mol File: 99530-17-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₈BrNO₁₀*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₈BrNO₁₀*ClH(99530-17-3)
• EPA Substance Registry System: C₂₇H₂₈BrNO₁₀*ClH(99530-17-3)

Safety Data

• Hazardous Substances Data: 99530-17-3(Hazardous Substances Data)

Upstream product

• 56390-08-0 chlorhydrate de 3,4-diepidaunorubicine 

Relevant articles and documents

EPIMERIZATION OF 4'-C BOND AND MODIFICATION OF 14-CH3-(CO)-FRAGMENT IN ANTHRACYCLIN ANTIBIOTICS

A method of synthesizing Rl, R2-substituted-4' (ax. or eq.)-OH anthracyclines and their corresponding salts of Formula (1) from daunorubicin or N-Trifluoroacetyl-4- Rl - derivatives of daunorubicin, wherein Rl is defined as H, OH, and 4'-HO is defined as ax[ial]. The method includes producing N-Trifluoroacetyl daunorubicin and treating the N- Trifluoroacetyldaunorubicin or N-Trifluoroacetyl-4-R1 -derivatives of daunorubicin, wherein R1 is defined as H, OH, with dimethylsulfoxide activated by different acylating agents. The attained intermediate product is then treated with a strong base (ex. tertiary amines) resulting in the 4 -keto-N-Trifluoroacetyl-4-R1 daunorubicin wherein Ri is defined as H, OH, OMe. The 4-keto-N-Trifluoroacetyl-4-R1 -daunorubicin is reacted with a reducing agent, a derivative of a borohydride of an alkaline metal MHBL3 ,to produce N- Trifluoroacetyl-4'-epi-4-R1 -daunorubicin. The N-Trifluoroacetyl-4'-epi-4-R1 -daunorubicin undergoes hydrolysis in a basic solution to produce a derivate of an anthoacyclin which is halogenized [by complex halogenidesjto form a 14-Hal-derivative. This result is then hydrolyzed by well-known methods in the presence of a formate of an alkaline metal to form the desired final compound.