99615-74-4Relevant articles and documents
Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues
Anindya, Roy,Jena, Tapan Kumar,Karamathulla, Shaik,Khadake, Shivaji Narayan,Khan, Faiz Ahmed,Monisha, Mohan,Tuti, Nikhil Kumar
, (2021/03/15)
Marine sponges of the genus Suberea produce variety of brominated tyrosine alkaloids which display diverse range of biological activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biologicall
Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation
Ohe, Tomoyuki,Umezawa, Ryutaro,Kitagawara, Yumina,Yasuda, Daisuke,Takahashi, Kyoko,Nakamura, Shigeo,Abe, Akiko,Sekine, Shuichi,Ito, Kousei,Okunushi, Kentaro,Morio, Hanae,Furihata, Tomomi,Anzai, Naohiko,Mashino, Tadahiko
supporting information, p. 3708 - 3711 (2018/11/02)
We synthesized six novel BBR derivatives that were designed to avoid metabolic activation via ipso-substitution and evaluated for their degree of toxicity and hURAT1 inhibition. It was found that all of the derivatives demonstrate lower cytotoxicity in mouse hepatocytes and lower levels of metabolic activation than BBR, while maintaining their inhibitory activity toward the uric acid transporter. We propose that these derivatives could serve as effective uricosuric agents that have much better safety profiles than BBR.
Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni
Ramirez Osuna, Moises,Aguirre, Gerardo,Somanathan, Ratnasamy,Molins, Elias
, p. 2261 - 2266 (2007/10/03)
Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.
