99643-38-6 Usage
General Description
1,13,3,5,56,6-Octamethyl-2,2-spiro(2,3-dihydro-1H-benzimidazole), also known as HSP90 inhibitor, is a chemical compound with potential therapeutic applications. It is a spiropiperidine derivative that has been studied for its ability to target heat shock protein 90 (HSP90), a molecular chaperone that plays a crucial role in the regulation of cell growth and survival. By inhibiting HSP90, this compound has shown promise in the treatment of cancer and other diseases. Its unique structure and mechanism of action make it a subject of interest in the field of medicinal chemistry, with potential for further development as a targeted therapy for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 99643-38-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,6,4 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 99643-38:
(7*9)+(6*9)+(5*6)+(4*4)+(3*3)+(2*3)+(1*8)=186
186 % 10 = 6
So 99643-38-6 is a valid CAS Registry Number.
99643-38-6Relevant articles and documents
Electronic Structure of Heterospirenes-PE Spectroscopic Investigations
Gleiter, Rolf,Uschmann, Joachim
, p. 370 - 380 (2007/10/02)
The synthesis of the heterospirenes 1-9 is described and their He I photoelectron (PE) spectra are recorded.The assignment of the first PE bands is based on a comparison with fragment molecules and on molecular orbital calculations using semiempirical methods (PPP, MINDO/3). in the case of 1, 2, 4, and 5 strong spirointeraction has been elucidated.For 3 the analysis of the spectrum is hampered due to the strong overlap of the bands while for 6 the nonplanarity brings about a reduction of spirointeractions.For 7-9 the interaction between both fragments could not be detected.
