99651-28-2

Basic information

• Product Name: CHEMPACIFIC 38147
• Synonyms: CHEMPACIFIC 38147;2-CHLOROMETHYL-4-METHOXY-PYRIDINE;2-(chloromethyl)-4-methoxypyridine(SALTDATA: 1.02HCl 0.19H2O);Pyridine, 2-(chloroMethyl)-4-Methoxy-;2-(chloromethyl)-4-methoxypyridine 1-oxide
• CAS NO: 99651-28-2
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Mol File: 99651-28-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 239.463°C at 760 mmHg
• Flash Point: 98.624°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.02±0.20(Predicted)
• CAS DataBase Reference: CHEMPACIFIC 38147(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMPACIFIC 38147(99651-28-2)
• EPA Substance Registry System: CHEMPACIFIC 38147(99651-28-2)

Safety Data

• Hazardous Substances Data: 99651-28-2(Hazardous Substances Data)

Usage

General Description

CHEMPACIFIC 38147 is a chemical compound primarily composed of 2,4,6-tri-tert-butylphenol, which is commonly used as an antioxidant in various industrial applications. It is a white, crystalline substance with a molecular formula of C19H30O. This chemical is known for its ability to inhibit the oxidation of organic materials, making it an important ingredient in products such as lubricants, plastics, and rubber. It also has potential applications in the production of fuel additives and other chemical processes. CHEMPACIFIC 38147 is handled and stored according to standard safety protocols due to its potential hazards, including skin and eye irritation, as well as toxicity to aquatic organisms.

InChI:InChI=1/C7H8ClNO/c1-10-7-2-3-9-6(4-7)5-8/h2-4H,5H2,1H3

Upstream product

• 16665-38-6 4-methoxy-2-(hydroxymethyl)pyridine 
• 931-19-1 2-methylpyridine N-oxide 
• 6890-60-4 4-methoxy-2-methylpyridine 1-oxide 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 16665-37-5 (4-methoxypyridin-2-yl)methyl acetate 
• 98-98-6 2-Picolinic acid 
• 29681-43-4 methyl 4-methoxypicolinate 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 

Downstream Products

• 122307-84-0 2-(4-Methoxy-pyridin-2-ylmethylsulfanyl)-6-phenyl-3H-thieno[3,4-d]imidazole 
• 122307-87-3 6-(4-Methoxy-phenyl)-2-(4-methoxy-pyridin-2-ylmethylsulfanyl)-3H-thieno[3,4-d]imidazole 
• 122320-37-0 2-(4-Methoxy-pyridin-2-ylmethanesulfinyl)-6-phenyl-3H-thieno[3,4-d]imidazole 
• 122307-95-3 6-(4-Methoxy-phenyl)-2-(4-methoxy-pyridin-2-ylmethanesulfinyl)-3H-thieno[3,4-d]imidazole 

Relevant articles and documents

Tautomerism-Induced Cis-Trans Isomerization of Pyridylethenyl N-Confused Porphyrin

Pyridylethenyl-substituted N-confused porphyrins (NCPs) were synthesized, and their cis-trans isomerization was studied. Among four possible isomers, trans-3H and cis-2H types of structures, of which aromaticity and absorption/emission properties differ largely, were isolated. The cis-isomer was largely stabilized by the intramolecular hydrogen bonding between the pyrrolic-NH and the pyridinic-N in the vicinity. The thermal cis-trans isomerization proceeded even at 30 °C, which was significantly accelerated by the pyridine added to the system. The kinetic studies revealed that the isomerization reaction was second-order and the activation energy of the thermal isomerization from cis to trans isomer was ΔG0?cis→trans = 35.7 kcal/mol at 298 K, which is significantly smaller than that of Ni complex (42.3 kcal/mol). An intermolecular proton transfer induced cis-trans isomerization mechanism was proposed.

Design of coordination interaction of Zn(II) complex with oligo-aspartate peptide to afford a high-affinity tag-probe pair

A complementary recognition pair consisting of a genetically encodable peptide tag and a small molecular probe isa powerful tool to specifically label and manipulate a protein ofinterest under biological conditions. In this study, we report the redesign of a tag-probe pair comprising an oligo-aspartate peptide tag (such as DDDD) and a binuclear zinc complex. Isothermal-titration calorimetry screening of binding between the series of peptides and zinc complexes revealed that the binding affinity was largely influenced by subtle changes of the ligand structure of the probe. However, the binding was tolerant to differences of the tag peptide sequence. Of those tested, a pair containing a peptide tag (DDAADD) and a binuclear zinc complex possessing 4-chloropyridines (3-2Zn(II)) showed the strongest binding affinity (Ka = 3.88 × 105 M-1), which was about 10-fold larger than the conventional pair of D4-peptide tag (DDDD) and 1-2Zn(II) containing nonsubstituted pyridines (Ka = 3.73 × 104 M-1). The strong binding of this new complementary recognition pair enabled the rapid covalent labeling of a tag-fused maltose binding protein with a fluorescent zinc complex, demonstrating its potential utility in protein analysis.

Superoxide dismutase activity of iron(II)TPEN complex and its derivatives

Superoxide is involved in the pathogenesis of various diseases, such as inflammation, ischemia-reperfusion injury and carcinogenesis. Superoxide dismutases (SODs) catalyze the disproportionation reaction of superoxide to produce oxygen and hydrogen peroxide, and can protect living cells against the toxicity of free radicals derived from oxygen. Thus, SODs and their functional mimics have potential value as pharmaceuticals. We have previously reported that Fe(II)tetrakis-N,N,N',N'-(2-pyridylmethyl)ethylenediamine (Fe(II)TPEN) has an excellent SOD activity (IC50=0.5 μM) among many iron complexes examined (J. Biol. Chem., 264, 9243-9249 (1989)). Fe(II)TPEN can act like native SOD in living cells, and protect Escherichia coli cells from free radical toxicity caused by paraquat. In order to develop more effective SOD functional mimics, we synthesized Fe(II)TPEN derivatives with electron-donating or electron-withdrawing groups at the 4-position of all pyridines of TPEN, and measured the SOD activities and the redox potentials of these complexes. Fe(II) tetrakis-N,N,N',N'-(4-methoxy-2-pyridylmethyl)ethylenediamine (Fe(II)(4MeO)4TPEN) had the highest SOD activity (IC50=0.1 μM) among these iron-based SOD mimics. In addition, a good correlation was found between the redox potential and the SOD activity of 15 Fe(II) complexes, including iron-based SOD mimics reported in the previous paper (J. Organometal. Chem., in press). Iron-based SOD mimics may be clinically applicable, because these complexes are generally tissue-permeable and show low toxicity. Therefore our findings should be significant for the development of clinically useful SOD mimics.