99658-03-4
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Basic information
- Product Name: ALPHA-HELICAL CRF (9-41)
- Synonyms: CORTICOTROPIN RELEASING FACTOR ANTAGONIST;H-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-ALA-GLU-GLN-ALA-LEU-ASN-ARG-LEU-LEU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR;α-helical corticotropin releasing factor fragment (9-41);alpha-Helical corticotropin releasing factor fragment;ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41)
- CAS NO:99658-03-4
- Molecular Formula: C22H25IN2O6
- Molecular Weight: 540.34817
- EINECS: N/A
- Product Categories: CRF receptor and related
- Mol File: 99658-03-4.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white/powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: ALPHA-HELICAL CRF (9-41)(CAS DataBase Reference)
- NIST Chemistry Reference: ALPHA-HELICAL CRF (9-41)(99658-03-4)
- EPA Substance Registry System: ALPHA-HELICAL CRF (9-41)(99658-03-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 99658-03-4(Hazardous Substances Data)
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99658-03-4 Usage
Biochem/physiol Actions
The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.Check Digit Verification of cas no
The CAS Registry Mumber 99658-03-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,6,5 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 99658-03:
(7*9)+(6*9)+(5*6)+(4*5)+(3*8)+(2*0)+(1*3)=194
194 % 10 = 4
So 99658-03-4 is a valid CAS Registry Number.
99658-03-4Upstream product
99658-03-4Downstream Products
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ALPHA-HELICAL CRF (9-41)
