99742-07-1Relevant articles and documents
Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
Kim, Darrick S. H. L.,Kim, Jin Yung
, p. 1287 - 1289 (2004)
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from βA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against βA insult was demonstrated using 3-[4,5- dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from βA insult by these shogaols was shown to improve as the length of the side chain increase.