99970-01-1Relevant articles and documents
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil
Andreani,Cavalli,Granaiola,Guardigli,Leoni,Locatelli,Morigi,Rambaldi,Recanatini,Roda
, p. 4011 - 4014 (2007/10/03)
The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (ACHE) inhibitors related to donepezil are reported. A molecular dynamics simulation of the complex between AChE and one representative compound of the series showed a possible inhibitor binding mode in which favorable interactions are formed between the benzylpiperidinone moiety and some active-site residues. The biochemical evaluation of this newly synthesized series was performed using a chemiluminescent method suitable for high-throughput screening.
