99972-45-9

Basic information

• Product Name: methyl 5-phenylthiazole-4-carboxylate
• Synonyms: methyl 5-phenylthiazole-4-carboxylate
• CAS NO: 99972-45-9
• Molecular Weight: 219.264
• Mol File: 99972-45-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 5-phenylthiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-phenylthiazole-4-carboxylate(99972-45-9)
• EPA Substance Registry System: methyl 5-phenylthiazole-4-carboxylate(99972-45-9)

Safety Data

• Hazardous Substances Data: 99972-45-9(Hazardous Substances Data)

Upstream product

• 80625-18-9 methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate 
• 98-91-9 thiobenzoic acid 
• 59418-09-6 4-thiazolecarboxylate methyl ester 
• 108-90-7 chlorobenzene 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 32803-73-9 methyl 3-phenyl-3-chloro-2-ketopropionate 
• 64765-90-8 (Z)-2-Formylamino-3-phenyl-acrylic acid methyl ester 
• 1265278-17-8 (Z)-methyl β-bromo-α-formylaminocinnamate 
• 100-52-7 benzaldehyde 
• 533886-71-4 Methyl (E)/(Z)-3-Bromo-2-isocyanocinnamate 
• 115174-41-9 5-Phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 

Downstream Products

• 103264-40-0 5-phenyl-thiazole-4-carboxylic acid hydrazide 
• 13743-14-1 5-phenyl-1,3-thiazole-4-carboxylic acid 

Relevant articles and documents

One-pot four-component synthesis of polysubstituted thiazoles via cascade Ugi/Wittig cyclization starting from odorless Isocyano(triphenylphosphoranylidene)-acetates

A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1, aldehydes 2, amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5-disubstituted thiazoles 6 in good yields as well.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives

A series of thiazole-4-carboxylic acid thiazol-2-ylamide (TCAT, 4) derivatives were designed and synthesized according to simple bioisosteric replacement from previously reported pyridine-2-carboxylic acid thiazol-2-ylamide (PCAT) MetAP inhibitors. The preliminary SAR studies demonstrated that these TCAT series of compounds showed different activity and selectivity compared with those of the corresponding PCAT compounds. These findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs.