Oxymetazoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 - 30 °C / Inert atmosphere 4: hydrogen; palladium 10% on activated carbon / methanol View Scheme |
Oxymetazoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 - 30 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With ammonium hydroxide at 25 - 30℃; |
Oxymetazoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C View Scheme |
Oxymetazoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonium hydroxide / 25 - 30 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3.1: sodium hydride / tetrahydrofuran / 0 - 5 °C 3.2: 2 h / 0 - 5 °C View Scheme |
Oxymetazoline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ammonium hydroxide / 25 - 30 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3.1: sodium hydride / tetrahydrofuran / 0 - 5 °C 3.2: 2 h / 0 - 5 °C 4.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 25 - 30 °C View Scheme |
IUPAC Name: 6-Tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol hydrochloride
Molecular Formula: C16H25ClN2O
Formula Weight: 296.84g/mol
EINECS: 219-015-0
Flash Point: 215 °C
Enthalpy of Vaporization: 71.41 kJ/mol
Boiling Point: 431.9 °C at 760 mmHg
Vapour Pressure: 4.59E-08 mmHg at 25°C
Form: solid
Color: white
H bond acceptors: 3
Freely Rotating Bonds: 4
Synonyms of Afrin hydrochloride (2315-02-8): 2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride ; 2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori ; 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride ; 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride ; Afrazine ; Duration ; Iliadinhydrochloride
Product Categories of Afrin hydrochloride (2315-02-8): Adrenoceptor
Structure of Afrin hydrochloride (2315-02-8):
It is used in local vasoconstriction drugs.
It is also used as allergic conjunctivitis, allergic rhinitis, acute and chronic
rhinitis and so on.
1. | ipr-rat TDLo:1800 µg/kg (1-3D preg):REP | IJMRAQ Indian Journal of Medical Research. 67 (1978),478. | ||
2. | orl-rat LD50:680 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),1760. | ||
3. | scu-rat LD50:1630 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
4. | ivn-rat LD50:1070 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
5. | orl-mus LD50:4700 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 1 (1967),74. | ||
6. | ipr-mus LD50:48 mg/kg | FRPPAO Farmaco, Edizione Pratica. 21 (1966),204. | ||
7. | scu-mus LD50:34 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
8. | ivn-mus LD50:2700 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 1 (1967),74. |
Hazard Codes: T+
Risk Statements: 28
R28: Very toxic if swallowed.
Safety Statements: 22-28-36/37/39-45
S22: Do not breathe dust.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
Hazard Class: 6.1(a)
It will be kept in ventilated, cold ,dry place,and separately from
raw materials and food.
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