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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Pantoprazole Manufacturer/High quality/Best price/In stock

Cas:102625-70-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Pantoprazole powder 102625-70-7

Cas:102625-70-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Pantoprazole manufacturer with low price

Cas:102625-70-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Pantoprazole (base and/or unspecified salts)

Cas:102625-70-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Pantoprazole CAS NO:102625-70-7 Grade:Medical scientific research and export Molecular formula:C16H15F2N3O4S Molecular weight:383.3698 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabilit

Pantoprazole/ CAS:102625-70-7/ raw material/ high-quality

Cas:102625-70-7

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Pantoprazole

Cas:102625-70-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

HPLC 98% CAS 102625-70-7 with best quality

Cas:102625-70-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Pantoprazole/ LIDE PHARMA- Factory supply / Best price

Cas:102625-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Benzimidazole,6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]- 102625-70-7

Cas:102625-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Pantoprazole Digestive system medication

Cas:102625-70-7

Min.Order:1 Kilogram

FOB Price: $45.0 / 55.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Pantoprazole CAS:102625-70-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

Pantoprazole CAS:102625-70-7

Cas:102625-70-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pantoprazol

Cas:102625-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Benzimidazole,6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-

Cas:102625-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

Pantoprazole

Cas:102625-70-7

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

pantoprazole

Cas:102625-70-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Pantoprazole

Cas:102625-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Pantoprazole

Cas:102625-70-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Pantoprazole CAS NO.102625-70-7Appearance:white powder Package:according to customers' requirements Application:For chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to your dem

Pantoprazole CAS NO.102625-70-7

Cas:102625-70-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Pantoprazole

Cas:102625-70-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Pantoprazole CAS No.:102625-70-7 Molecule Formula:C16H15F2N3O4S Molecule Weight:383.37 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Pantoprazole in stock

Cas:102625-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity Pantoprazole

Cas:102625-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Pantoprazole

Cas:102625-70-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Pantoprazole Manufacturer/High quality/Best price/In stock 102625-70-7

Cas:102625-70-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Pantoprazole

Cas:102625-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Pantoprazole

Cas:102625-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Pantoprazole

Cas:102625-70-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Pantoprazole

Cas:102625-70-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Pantoprazole Manufacturer/High quality/Best price/In stock 102625-70-7

Cas:102625-70-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

pantoprazole sulfide
102625-64-9

pantoprazole sulfide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide; N-chlorophthalimide In DMF (N,N-dimethyl-formamide); water; acetonitrile at -10 - 20℃; for 1.75h;98%
With peracetic acid; LACTIC ACID In methanol; dichloromethane at -25 - -20℃; for 1h; Reagent/catalyst;95%
Stage #1: pantoprazole sulfide With triethylamine In acetonitrile at 0℃; for 0.166667h; pH=8-9;
Stage #2: With dihydrogen peroxide In acetonitrile for 10h; Solvent; Temperature; Reagent/catalyst;
94.3%
5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
409098-86-8

5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

sodium methylate
124-41-4

sodium methylate

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
In methanol for 50h; Product distribution / selectivity; Heating / reflux;78%
In tetrahydrofuran; methanol for 3 - 4h; Product distribution / selectivity; Heating / reflux;75%
In methanol; acetonitrile for 3 - 4h; Product distribution / selectivity; Heating / reflux;75%
Product distribution / selectivity;51%
pantoprazole sulfide
102625-64-9

pantoprazole sulfide

A

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

B

Pantoprazole sulfone

Pantoprazole sulfone

Conditions
ConditionsYield
With sodium hydroxide; sodium hypochlorite In water; ethyl acetate at -10 - 20℃; for 1.83333 - 3.25h;A 71%
B n/a
5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole
953787-51-4

5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With trisodium Edetate; ruthenium trichloride In tetrahydrofuran; 1,4-dioxane; water at 80℃; for 1h;
With edetate trisodium; ruthenium trichloride In tetrahydrofuran; 1,4-dioxane; water at 80℃; for 1h; Heating / reflux;
3-methoxy-2-methyl-4-nitropyridine 1-oxide
15931-25-6

3-methoxy-2-methyl-4-nitropyridine 1-oxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 88 percent / NaOMe / 16 h / 40 °C
2: 2 h / 90 °C
3: 2 N aq. NaOH / 2 h / 80 °C
4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
5: 2 N aq. NaOH / ethanol / 2 h / 50 °C
6: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
2-methyl-3-methoxy-4(1H)-pyridinone
76015-11-7

2-methyl-3-methoxy-4(1H)-pyridinone

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 96 percent / POCl3 / 18 h / 90 °C
2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
3: 91 percent / NaOMe / 18 h
4: 2 h / 90 °C
5: 2 N aq. NaOH / 2 h / 80 °C
6: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
7: 2 N aq. NaOH / ethanol / 2 h / 50 °C
8: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
3-methoxy-2-methylpyridine 1-oxide
35392-65-5

3-methoxy-2-methylpyridine 1-oxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C
2: 88 percent / NaOMe / 16 h / 40 °C
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
6: 2 N aq. NaOH / ethanol / 2 h / 50 °C
7: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
4-Chloro-3-methoxy-2-methyl-pyridine
107512-34-5

4-Chloro-3-methoxy-2-methyl-pyridine

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
2: 91 percent / NaOMe / 18 h
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
6: 2 N aq. NaOH / ethanol / 2 h / 50 °C
7: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
4-chloro-3-methoxy-2-methylpyridine N-oxide
122307-41-9

4-chloro-3-methoxy-2-methylpyridine N-oxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 91 percent / NaOMe / 18 h
2: 2 h / 90 °C
3: 2 N aq. NaOH / 2 h / 80 °C
4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
5: 2 N aq. NaOH / ethanol / 2 h / 50 °C
6: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
2-hydroxymethyl-3,4-dimethoxypyridine
72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
2: 2 N aq. NaOH / ethanol / 2 h / 50 °C
3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
3,4-dimethoxy-2-methylpyridine N-oxide
72830-07-0

3,4-dimethoxy-2-methylpyridine N-oxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 90 °C
2: 2 N aq. NaOH / 2 h / 80 °C
3: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
4: 2 N aq. NaOH / ethanol / 2 h / 50 °C
5: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
2-acetoxymethyl-3,4-dimethoxypyridine
102625-99-0

2-acetoxymethyl-3,4-dimethoxypyridine

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2 N aq. NaOH / 2 h / 80 °C
2: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
3: 2 N aq. NaOH / ethanol / 2 h / 50 °C
4: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2 N aq. NaOH / ethanol / 2 h / 50 °C
2: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C
View Scheme
pantoprazole sodium

pantoprazole sodium

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With ethanol
Stage #2: With water
concentrated acetic acid

concentrated acetic acid

Diethyl tartrate
408332-88-7

Diethyl tartrate

pantoprazole sulfide
102625-64-9

pantoprazole sulfide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With isopropylbenzene hydroperoxide; titanium(IV) isopropylate In dichloromethane; water; acetonitrile
concentrated acetic acid

concentrated acetic acid

diethyl (2S,3S)-tartrate
13811-71-7

diethyl (2S,3S)-tartrate

pantoprazole sulfide
102625-64-9

pantoprazole sulfide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In dichloromethane; water; acetonitrile
magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With water; acetic acid In ethanol at 20 - 25℃; pH=7.5 - 8; Product distribution / selectivity;
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol / 8 h / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol; water
2: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water; methanol / 3.5 h / 40 - 55 °C
2: LACTIC ACID; peracetic acid / methanol; dichloromethane / 1 h / -25 - -20 °C
View Scheme
3,4-dinitophenol
577-71-9

3,4-dinitophenol

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: caesium carbonate / N,N-dimethyl-formamide / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C
3: sodium carbonate / water / 12 h / 20 - 70 °C
4: sodium hydroxide / methanol; water
5: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C
View Scheme
4-(difluoromethoxy)-1,2-dinitrobenzene

4-(difluoromethoxy)-1,2-dinitrobenzene

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C
2: sodium carbonate / water / 12 h / 20 - 70 °C
3: sodium hydroxide / methanol; water
4: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C
View Scheme
4-(difluoromethoxy)benzene-1,2-diamine
172282-50-7

4-(difluoromethoxy)benzene-1,2-diamine

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium carbonate / water / 12 h / 20 - 70 °C
2: sodium hydroxide / methanol; water
3: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C
View Scheme
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
With sodium hydroxide In water; acetonitrile at 20℃;95%
With sodium hydroxide In ethanol for 5h; Reflux;95%
With sodium hydroxide In water; ethyl acetate at 20℃; for 5.5h;92%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sodium sesquihydrate

pantoprazole sodium sesquihydrate

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 20℃; for 1h;95%
With sodium hydroxide In ethanol; water at 25 - 32℃; for 2.25h;88.68%
With sodium hydroxide; water at 0 - 35℃; Product distribution / selectivity;82.3%
magnesium ethylate
2414-98-4

magnesium ethylate

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

Conditions
ConditionsYield
In methanol for 0.166667 - 1h; Product distribution / selectivity; Heating / reflux;88%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with methyl ethyl ketone

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with methyl ethyl ketone

Conditions
ConditionsYield
With sodium hydroxide; butanone In water at 40 - 75℃; Purification / work up;84.9%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water
797789-89-0

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water

Conditions
ConditionsYield
With sodium hydroxide; acetone In water at 15 - 45℃; for 1h; Heating / reflux;80.4%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

acetone
67-64-1

acetone

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water
797789-89-0

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water

Conditions
ConditionsYield
With sodium hydroxide; water at 15 - 45℃; for 1h; Heating / reflux;80.4%
Stage #1: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; acetone at 28℃;
Stage #2: With sodium hydroxide; water at 2 - 37℃; for 2.25h;
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with diethyl ketone

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with diethyl ketone

Conditions
ConditionsYield
With sodium hydroxide; pentan-3-one In water at 25 - 50℃; for 1h; Purification / work up;74.9%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with methyl isobutyl ketone

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate monosolvate with methyl isobutyl ketone

Conditions
ConditionsYield
With sodium hydroxide; 4-methyl-2-pentanone In water at 25 - 50℃; for 1h; Purification / work up;69.6%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

5‐(difluoromethoxy)‐2‐[(3,4‐dimethoxy‐2‐pyridyl)methylsulfinyl]‐1H‐benzimidazole
142678-35-1

5‐(difluoromethoxy)‐2‐[(3,4‐dimethoxy‐2‐pyridyl)methylsulfinyl]‐1H‐benzimidazole

Conditions
ConditionsYield
Stage #1: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In ethyl acetate at 40 - 45℃;
Stage #2: With (S)-Mandelic acid In ethyl acetate at 40 - 45℃; for 2h;
Stage #3: With sodium hydrogencarbonate In water; ethyl acetate for 0.5h;
55%
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

A

9-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
138786-75-1

9-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate

B

10-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
138786-76-2

10-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate

Conditions
ConditionsYield
With hexafluorophosphoric acid In methanol at 0 - 5℃; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Meisenheimer complex

Meisenheimer complex

Conditions
ConditionsYield
Kinetics;
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

Conditions
ConditionsYield
With magnesium methanolate In isopropyl alcohol at 60 - 70℃;
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

lithium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

lithium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

Conditions
ConditionsYield
With lithium hydroxide In acetone at 50℃; for 1.83333h;
2-[(chlorocarbonyl)(methyl)amino]ethyl ethyl carbonate
635751-00-7

2-[(chlorocarbonyl)(methyl)amino]ethyl ethyl carbonate

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

A

2-[[[5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl](methyl)amino]ethyl ethyl carbonate

2-[[[5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1-yl]carbonyl](methyl)amino]ethyl ethyl carbonate

B

2-[[[6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimi-dazol-1-yl]carbonyl]methylamino] ethyl ethyl carbonate

2-[[[6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimi-dazol-1-yl]carbonyl]methylamino] ethyl ethyl carbonate

Conditions
ConditionsYield
With triethylamine; dmap In tetrahydrofuran at 60℃; for 17.5h;
With dmap; triethylamine In tetrahydrofuran at 60℃; for 17.5h; Overall yield = 0.09 g;
Pyridine-3-sulfonyl chloride
16133-25-8

Pyridine-3-sulfonyl chloride

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

A

1-(pyridine-3-sulfonyl)-5-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole
259182-91-7

1-(pyridine-3-sulfonyl)-5-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

B

1-(pyridine-3-sulfonyl)-6-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole
259182-92-8

1-(pyridine-3-sulfonyl)-6-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With triethylamine; sodium chloride In dichloromethane

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