As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryName:Pantoprazole CAS NO:102625-70-7 Grade:Medical scientific research and export Molecular formula:C16H15F2N3O4S Molecular weight:383.3698 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabilit
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryPantoprazole CAS:102625-70-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: Pantoprazole CAS No.:102625-70-7 Molecule Formula:C16H15F2N3O4S Molecule Weight:383.37 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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inquirypantoprazole sulfide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; N-chlorophthalimide In DMF (N,N-dimethyl-formamide); water; acetonitrile at -10 - 20℃; for 1.75h; | 98% |
With peracetic acid; LACTIC ACID In methanol; dichloromethane at -25 - -20℃; for 1h; Reagent/catalyst; | 95% |
Stage #1: pantoprazole sulfide With triethylamine In acetonitrile at 0℃; for 0.166667h; pH=8-9; Stage #2: With dihydrogen peroxide In acetonitrile for 10h; Solvent; Temperature; Reagent/catalyst; | 94.3% |
5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
sodium methylate
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
In methanol for 50h; Product distribution / selectivity; Heating / reflux; | 78% |
In tetrahydrofuran; methanol for 3 - 4h; Product distribution / selectivity; Heating / reflux; | 75% |
In methanol; acetonitrile for 3 - 4h; Product distribution / selectivity; Heating / reflux; | 75% |
Product distribution / selectivity; | 51% |
pantoprazole sulfide
A
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hypochlorite In water; ethyl acetate at -10 - 20℃; for 1.83333 - 3.25h; | A 71% B n/a |
5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With trisodium Edetate; ruthenium trichloride In tetrahydrofuran; 1,4-dioxane; water at 80℃; for 1h; | |
With edetate trisodium; ruthenium trichloride In tetrahydrofuran; 1,4-dioxane; water at 80℃; for 1h; Heating / reflux; |
3-methoxy-2-methyl-4-nitropyridine 1-oxide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 88 percent / NaOMe / 16 h / 40 °C 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 5: 2 N aq. NaOH / ethanol / 2 h / 50 °C 6: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
2-methyl-3-methoxy-4(1H)-pyridinone
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 3: 91 percent / NaOMe / 18 h 4: 2 h / 90 °C 5: 2 N aq. NaOH / 2 h / 80 °C 6: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 7: 2 N aq. NaOH / ethanol / 2 h / 50 °C 8: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
3-methoxy-2-methylpyridine 1-oxide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C 2: 88 percent / NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C 5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 6: 2 N aq. NaOH / ethanol / 2 h / 50 °C 7: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
4-Chloro-3-methoxy-2-methyl-pyridine
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 2: 91 percent / NaOMe / 18 h 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C 5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 6: 2 N aq. NaOH / ethanol / 2 h / 50 °C 7: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
4-chloro-3-methoxy-2-methylpyridine N-oxide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 5: 2 N aq. NaOH / ethanol / 2 h / 50 °C 6: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
2-hydroxymethyl-3,4-dimethoxypyridine
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
3,4-dimethoxy-2-methylpyridine N-oxide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 90 °C 2: 2 N aq. NaOH / 2 h / 80 °C 3: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 4: 2 N aq. NaOH / ethanol / 2 h / 50 °C 5: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
2-acetoxymethyl-3,4-dimethoxypyridine
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2 N aq. NaOH / 2 h / 80 °C 2: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 3: 2 N aq. NaOH / ethanol / 2 h / 50 °C 4: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2 N aq. NaOH / ethanol / 2 h / 50 °C 2: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Stage #1: pantoprazole sodium With ethanol Stage #2: With water |
Diethyl tartrate
pantoprazole sulfide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With isopropylbenzene hydroperoxide; titanium(IV) isopropylate In dichloromethane; water; acetonitrile |
diethyl (2S,3S)-tartrate
pantoprazole sulfide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In dichloromethane; water; acetonitrile |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With water; acetic acid In ethanol at 20 - 25℃; pH=7.5 - 8; Product distribution / selectivity; |
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 8 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol; water 2: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 3.5 h / 40 - 55 °C 2: LACTIC ACID; peracetic acid / methanol; dichloromethane / 1 h / -25 - -20 °C View Scheme |
3,4-dinitophenol
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: caesium carbonate / N,N-dimethyl-formamide / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C 3: sodium carbonate / water / 12 h / 20 - 70 °C 4: sodium hydroxide / methanol; water 5: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C View Scheme |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C 2: sodium carbonate / water / 12 h / 20 - 70 °C 3: sodium hydroxide / methanol; water 4: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C View Scheme |
4-(difluoromethoxy)benzene-1,2-diamine
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium carbonate / water / 12 h / 20 - 70 °C 2: sodium hydroxide / methanol; water 3: dihydrogen peroxide; sodium tungstate (VI) dihydrate; sodium hydroxide / methanol; water / 20 °C View Scheme |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
pantoprazole sodium
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetonitrile at 20℃; | 95% |
With sodium hydroxide In ethanol for 5h; Reflux; | 95% |
With sodium hydroxide In water; ethyl acetate at 20℃; for 5.5h; | 92% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; water In isopropyl alcohol at 20℃; for 1h; | 95% |
With sodium hydroxide In ethanol; water at 25 - 32℃; for 2.25h; | 88.68% |
With sodium hydroxide; water at 0 - 35℃; Product distribution / selectivity; | 82.3% |
magnesium ethylate
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
In methanol for 0.166667 - 1h; Product distribution / selectivity; Heating / reflux; | 88% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; butanone In water at 40 - 75℃; Purification / work up; | 84.9% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water
Conditions | Yield |
---|---|
With sodium hydroxide; acetone In water at 15 - 45℃; for 1h; Heating / reflux; | 80.4% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
acetone
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt, complex with one molecule of acetone and two molecules of water
Conditions | Yield |
---|---|
With sodium hydroxide; water at 15 - 45℃; for 1h; Heating / reflux; | 80.4% |
Stage #1: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; acetone at 28℃; Stage #2: With sodium hydroxide; water at 2 - 37℃; for 2.25h; |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; pentan-3-one In water at 25 - 50℃; for 1h; Purification / work up; | 74.9% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide; 4-methyl-2-pentanone In water at 25 - 50℃; for 1h; Purification / work up; | 69.6% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
5‐(difluoromethoxy)‐2‐[(3,4‐dimethoxy‐2‐pyridyl)methylsulfinyl]‐1H‐benzimidazole
Conditions | Yield |
---|---|
Stage #1: 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In ethyl acetate at 40 - 45℃; Stage #2: With (S)-Mandelic acid In ethyl acetate at 40 - 45℃; for 2h; Stage #3: With sodium hydrogencarbonate In water; ethyl acetate for 0.5h; | 55% |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
A
9-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
B
10-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
Conditions | Yield |
---|---|
With hexafluorophosphoric acid In methanol at 0 - 5℃; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
2,4-Dinitrofluorobenzene
dimethyl sulfoxide
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
Kinetics; |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With magnesium methanolate In isopropyl alcohol at 60 - 70℃; |
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With lithium hydroxide In acetone at 50℃; for 1.83333h; |
2-[(chlorocarbonyl)(methyl)amino]ethyl ethyl carbonate
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With triethylamine; dmap In tetrahydrofuran at 60℃; for 17.5h; | |
With dmap; triethylamine In tetrahydrofuran at 60℃; for 17.5h; Overall yield = 0.09 g; |
Pyridine-3-sulfonyl chloride
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
A
1-(pyridine-3-sulfonyl)-5-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole
B
1-(pyridine-3-sulfonyl)-6-(difluoromethoxy)-2-[[(3,4-dimethoxy-pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With triethylamine; sodium chloride In dichloromethane |
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