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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality DexmedetomidineHcl supplier in China

Cas:113775-47-6

Min.Order:1 Metric Ton

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Dexmedetomidine CAS:113775-47-6

Cas:113775-47-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% DexmedetomidineHclC13H16N2.Hcl 113775-47-6 GMP Manufacturer

Cas:113775-47-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 113775-47-6 DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:1 Kilogram

FOB Price: $1000.0

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 113775-47-6 with competitive price

Cas:113775-47-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]- 113775-47-6

Cas:113775-47-6

Min.Order:1 Kilogram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

Cas:113775-47-6

Min.Order:1 Kilogram

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

DexmedetomidineHclC13H16N2.Hcl CAS:113775-47-6

Cas:113775-47-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

Cas:113775-47-6

Min.Order:0

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Shaanxi New nine Material Technology Co., Ltd.

Our Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali

DexmedetomidineHcl

Cas:113775-47-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality DexmedetomidineHcl

Cas:113775-47-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

99.5% 113775-47-6 DexmedetomidineHclC13H16N2.HclAppearance:white powder Storage:sealed preservation at room temperature Package:according to customers' requirements Application:API Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FO

99.5% 113775-47-6 DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transp

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:1 Gram

Negotiable

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

DexmedetomidineHcl

Cas:113775-47-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Cas:113775-47-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Cas:113775-47-6

Min.Order:1 Gram

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Cas:113775-47-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Cas:113775-47-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

DexmedetomidineHclC13H16N2.HclCAS NO.: 113775-47-6

Cas:113775-47-6

Min.Order:0

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Type:Other

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-IMidazole,5-[(1S)-1-(2,3-diMethylphenyl)ethyl]-

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

(S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price Application:TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

DexmedetomidineHclC13H16N2.Hcl

Cas:113775-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hunan Longxianng Runhui Trading Co.,Ltd

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory priceAppearance:White Powder Storage:Room temperature Package:25KGS/Drum Application:API,Pharmaceutical intermediates Transportation:By express (Door to door) such as FEDEX,

TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price

Cas:113775-47-6

Min.Order:0

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Synthetic route

medetomidine
86347-14-0

medetomidine

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Stage #1: medetomidine With L-Lysine ethyl ester In ethanol at 75℃; for 3h;
Stage #2: With sodium hydroxide In water at 100℃; Temperature; enantioselective reaction;
94.2%
Stage #1: medetomidine With sodium carbonate In dichloromethane at 20 - 25℃; for 0.25h;
Stage #2: With L-Tartaric acid In ethanol; water at 10℃; for 1.5h; Reflux;
Stage #3: With ammonium hydroxide In ethanol; water at 30 - 40℃; for 1h;
45.3%
Multi-step reaction with 2 steps
1: water; acetone / 0.5 h / 45 - 55 °C
2: water; ethanol; isopropyl alcohol / 0.2 h / 30 - 70 °C
View Scheme
4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole
176721-03-2

4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid In dichloromethane at -10 - 20℃;89%
With formic acid; palladium 10% on activated carbon; ammonium formate at 120℃; for 10h;82.8%
With triethylsilane; hydrogen; trifluoroacetic acid; palladium on activated charcoal 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O; Yield given. Multistep reaction;
1H-imidazole
288-32-4

1H-imidazole

1-(1-chloroethyl)-2,3-dimethylbenzene

1-(1-chloroethyl)-2,3-dimethylbenzene

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With iron(III) chloride at 75℃; for 0.5h; Reagent/catalyst; Temperature;84.8%
(S)-4-(1-(2,3-dimethylphenyl)ethyl)-1-trityl-1H-imidazole

(S)-4-(1-(2,3-dimethylphenyl)ethyl)-1-trityl-1H-imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 80 - 84℃; for 4h;78.6%
C13H16N2*C6H10O4

C13H16N2*C6H10O4

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
In ethanol; water; isopropyl alcohol at 30 - 70℃; for 0.2h;65%
2,3-dimethylbromobenzene
576-23-8

2,3-dimethylbromobenzene

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) magnesium, iodine / 1.) THF, reflux, 1 h, 2.) r.t., THF, 1.5 h
2: 90 percent / MnO2 / dioxane / 5 h / Heating
3: 95 percent / tetrahydrofuran / 2 h / Ambient temperature
4: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 1 h / 65 - 70 °C
1.2: 1 h / 0 - 40 °C
2.1: methylmagnesium bromide / tetrahydrofuran; 2-methyltetrahydrofuran / 2 h / 0 - 20 °C
3.1: formic acid; ammonium formate; palladium 10% on activated carbon / 10 h / 120 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ethylene dibromide; magnesium / tetrahydrofuran / 1 h / 40 - 65 °C
1.2: 2 h / -5 - 0 °C
1.3: 3 h / 30 °C
2.1: tetrahydrofuran / 2 h / 0.4 - 65 °C
3.1: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark
4.1: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr
View Scheme
4-<(2,3-dimethylphenyl)carbonyl>-1-(triphenylmethyl)imidazole
176721-02-1

4-<(2,3-dimethylphenyl)carbonyl>-1-(triphenylmethyl)imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / tetrahydrofuran / 2 h / Ambient temperature
2: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O
View Scheme
4-<(2,3-dimethylphenyl)hydroxymethyl>-1-(triphenylmethyl)imidazole
176721-01-0

4-<(2,3-dimethylphenyl)hydroxymethyl>-1-(triphenylmethyl)imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / MnO2 / dioxane / 5 h / Heating
2: 95 percent / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O
View Scheme
(S)-dexmedetomidine-L-(+)-tartrate
176721-04-3

(S)-dexmedetomidine-L-(+)-tartrate

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With sodium hydrogencarbonate12.16 g
C4H6O5*C13H16N2

C4H6O5*C13H16N2

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane pH=> 12;65 g
1-(1-chloroethyl)-2,3-dimethylbenzene

1-(1-chloroethyl)-2,3-dimethylbenzene

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: titanium tetrachloride; triethylamine / dichloromethane / 5 h / -3 - 20 °C
2.1: sodium carbonate / dichloromethane / 0.25 h / 20 - 25 °C
2.2: 1.5 h / 10 °C / Reflux
2.3: 1 h / 30 - 40 °C
View Scheme
1-(2,3-dimethyl-phenyl)-ethanone
2142-71-4

1-(2,3-dimethyl-phenyl)-ethanone

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrabutyl-ammonium chloride; lanthanum(III) chloride; SeCl3 / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere
1.2: 3 h / 0 - 20 °C
2.1: triethylsilane; trifluoroacetic acid / dichloromethane / -10 - 20 °C
View Scheme
medetomidine
86347-14-0

medetomidine

A

dexmedetomidine
113775-47-6

dexmedetomidine

B

levomedetomidine

levomedetomidine

Conditions
ConditionsYield
Stage #1: medetomidine With L-lysine In ethanol at 75℃; for 12h;
Stage #2: With sodium hydroxide In water at 100℃; Overall yield = 61.7 %; Overall yield = 13.3 g; enantioselective reaction;
A n/a
B n/a
With Chiralcel OJ-3R In acetonitrile at 25℃; pH=8; Reagent/catalyst; Resolution of racemate;
1H-imidazole
288-32-4

1H-imidazole

1-(1-chloroethyl)-2,3-dimethylbenzene

1-(1-chloroethyl)-2,3-dimethylbenzene

A

dexmedetomidine
113775-47-6

dexmedetomidine

B

levomedetomidine

levomedetomidine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 90℃; for 0.5h; Temperature; Reagent/catalyst; Inert atmosphere; Overall yield = 81.1 %; Overall yield = 16.9 g;A n/a
B n/a
With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; potassium carbonate; zinc In N,N-dimethyl-formamide at 70℃; for 5h; Reagent/catalyst; Temperature; Inert atmosphere; Overall yield = 89.5 %; Overall yield = 17.9 g; Optical yield = 90.61 %ee;
C20H19ClN2O

C20H19ClN2O

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
With phosphoric acid at 23℃; for 48h; pH=6.5; Enzymatic reaction;18.2 g
1H-imidazole
288-32-4

1H-imidazole

1-(2,3-dimethylphenyl)ethyl trifluoromethanesulfonate

1-(2,3-dimethylphenyl)ethyl trifluoromethanesulfonate

A

dexmedetomidine
113775-47-6

dexmedetomidine

B

levomedetomidine

levomedetomidine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; N-butylpyridinium tetrafluoroborate at 70℃; for 0.5h; Temperature; Reagent/catalyst; Inert atmosphere; Overall yield = 84.7 %; Overall yield = 17.6 g; Optical yield = 79.89 %ee;
1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene
1021949-47-2

1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / chloroform / 2 h / 20 - 26 °C / Inert atmosphere
2: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene / dichloromethane / 24 h / 25 °C / 6000.6 Torr
3: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / chloroform / 2 h / 20 - 26 °C / Inert atmosphere
2: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / dichloromethane / 3 h / 25 °C / 6000.6 Torr
3: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C
View Scheme
4-(1-(2,3-dimethylphenyl)vinyl)-1-trityl-1H-imidazole

4-(1-(2,3-dimethylphenyl)vinyl)-1-trityl-1H-imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene / dichloromethane / 24 h / 25 °C / 6000.6 Torr
2: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C
View Scheme
Multi-step reaction with 2 steps
1: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / dichloromethane / 3 h / 25 °C / 6000.6 Torr
2: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C
View Scheme
4-(2,3-dimethylbenzoyl)-1H-imidazole

4-(2,3-dimethylbenzoyl)-1H-imidazole

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 2 h / 0.4 - 65 °C
2: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark
3: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr
View Scheme
1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-yl)ethanol

1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-yl)ethanol

dexmedetomidine
113775-47-6

dexmedetomidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark
2: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr
View Scheme
1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene
1021949-47-2

1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene

A

dexmedetomidine
113775-47-6

dexmedetomidine

B

levomedetomidine

levomedetomidine

Conditions
ConditionsYield
With bis(norbornadiene)rhodium(l)tetrafluoroborate; (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; hydrogen In methanol at 40 - 45℃; under 2250.23 - 7500.75 Torr; for 5h; Optical yield = 79.3 percent ee;
dexmedetomidine
113775-47-6

dexmedetomidine

dexmedetomidine hydrochloride

dexmedetomidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; ethyl acetate at 20℃; for 1h;92.5%
With hydrogenchloride In ethanol; water; isopropyl alcohol at 35 - 50℃;90%
L-Tartaric acid
87-69-4

L-Tartaric acid

dexmedetomidine
113775-47-6

dexmedetomidine

(S)-dexmedetomidine-L-(+)-tartaric acid salt

(S)-dexmedetomidine-L-(+)-tartaric acid salt

Conditions
ConditionsYield
In ethanol; isopropyl alcohol at 20℃; Reflux;77.1%
dexmedetomidine
113775-47-6

dexmedetomidine

Rezatomidine
847829-38-3

Rezatomidine

Conditions
ConditionsYield
With sodium hydrogencarbonate; phenylcarbonochloridothioate In tetrahydrofuran; water at 20℃; for 4h;53%
With sodium hydrogencarbonate; phenylcarbonochloridothioate In tetrahydrofuran; water at 20℃; for 4h;53%
L-Tartaric acid
87-69-4

L-Tartaric acid

dexmedetomidine
113775-47-6

dexmedetomidine

(S)-dexmedetomidine-L-(+)-tartrate
176721-04-3

(S)-dexmedetomidine-L-(+)-tartrate

Conditions
ConditionsYield
In ethanol at 65℃; for 2h; Temperature;47.3%
dexmedetomidine
113775-47-6

dexmedetomidine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(+)-(S)-4-<1-(2,3-dimethylphenyl)ethyl>-1-tosyl-1H-imidazole

(+)-(S)-4-<1-(2,3-dimethylphenyl)ethyl>-1-tosyl-1H-imidazole

Conditions
ConditionsYield
With triethylamine In dichloromethane for 2.5h; Ambient temperature;31.1%
dexmedetomidine
113775-47-6

dexmedetomidine

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole hydrobromide
1391972-96-5

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole hydrobromide

Conditions
ConditionsYield
With hydrogen bromide Dean-Stark;
dexmedetomidine
113775-47-6

dexmedetomidine

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole hydroiodide

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole hydroiodide

Conditions
ConditionsYield
With hydrogen iodide Dean-Stark;
oxalic acid
144-62-7

oxalic acid

dexmedetomidine
113775-47-6

dexmedetomidine

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole oxalate

(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole oxalate

Conditions
ConditionsYield
In ethanol
ethyl iodide
75-03-6

ethyl iodide

dexmedetomidine
113775-47-6

dexmedetomidine

A

C15H20N2

C15H20N2

B

C15H20N2

C15H20N2

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 50℃; for 4h; Temperature; Solvent; Reagent/catalyst;A 200 mg
B 400 mg

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