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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry99.5% 113775-47-6 DexmedetomidineHclC13H16N2.HclAppearance:white powder Storage:sealed preservation at room temperature Package:according to customers' requirements Application:API Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FO
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transp
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryTIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price Application:TIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory price
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryTIANFUCHEM--113775-47-6--High purity DexmedetomidineHclC13H16N2.Hcl factory priceAppearance:White Powder Storage:Room temperature Package:25KGS/Drum Application:API,Pharmaceutical intermediates Transportation:By express (Door to door) such as FEDEX,
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inquirymedetomidine
dexmedetomidine
Conditions | Yield |
---|---|
Stage #1: medetomidine With L-Lysine ethyl ester In ethanol at 75℃; for 3h; Stage #2: With sodium hydroxide In water at 100℃; Temperature; enantioselective reaction; | 94.2% |
Stage #1: medetomidine With sodium carbonate In dichloromethane at 20 - 25℃; for 0.25h; Stage #2: With L-Tartaric acid In ethanol; water at 10℃; for 1.5h; Reflux; Stage #3: With ammonium hydroxide In ethanol; water at 30 - 40℃; for 1h; | 45.3% |
Multi-step reaction with 2 steps 1: water; acetone / 0.5 h / 45 - 55 °C 2: water; ethanol; isopropyl alcohol / 0.2 h / 30 - 70 °C View Scheme |
4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole
dexmedetomidine
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid In dichloromethane at -10 - 20℃; | 89% |
With formic acid; palladium 10% on activated carbon; ammonium formate at 120℃; for 10h; | 82.8% |
With triethylsilane; hydrogen; trifluoroacetic acid; palladium on activated charcoal 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With iron(III) chloride at 75℃; for 0.5h; Reagent/catalyst; Temperature; | 84.8% |
dexmedetomidine
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 80 - 84℃; for 4h; | 78.6% |
dexmedetomidine
Conditions | Yield |
---|---|
In ethanol; water; isopropyl alcohol at 30 - 70℃; for 0.2h; | 65% |
2,3-dimethylbromobenzene
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) magnesium, iodine / 1.) THF, reflux, 1 h, 2.) r.t., THF, 1.5 h 2: 90 percent / MnO2 / dioxane / 5 h / Heating 3: 95 percent / tetrahydrofuran / 2 h / Ambient temperature 4: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O View Scheme | |
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran / 1 h / 65 - 70 °C 1.2: 1 h / 0 - 40 °C 2.1: methylmagnesium bromide / tetrahydrofuran; 2-methyltetrahydrofuran / 2 h / 0 - 20 °C 3.1: formic acid; ammonium formate; palladium 10% on activated carbon / 10 h / 120 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: ethylene dibromide; magnesium / tetrahydrofuran / 1 h / 40 - 65 °C 1.2: 2 h / -5 - 0 °C 1.3: 3 h / 30 °C 2.1: tetrahydrofuran / 2 h / 0.4 - 65 °C 3.1: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark 4.1: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr View Scheme |
4-<(2,3-dimethylphenyl)carbonyl>-1-(triphenylmethyl)imidazole
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / tetrahydrofuran / 2 h / Ambient temperature 2: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O View Scheme |
4-<(2,3-dimethylphenyl)hydroxymethyl>-1-(triphenylmethyl)imidazole
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / MnO2 / dioxane / 5 h / Heating 2: 95 percent / tetrahydrofuran / 2 h / Ambient temperature 3: 1.) trifluoroacetic acid, triethylsilane, 2.) H2 / Pd/C / 1.) r.t., CH2Cl2, 2.) r.t., 1 bar, 2 h, H2O View Scheme |
(S)-dexmedetomidine-L-(+)-tartrate
dexmedetomidine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate | 12.16 g |
dexmedetomidine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane pH=> 12; | 65 g |
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: titanium tetrachloride; triethylamine / dichloromethane / 5 h / -3 - 20 °C 2.1: sodium carbonate / dichloromethane / 0.25 h / 20 - 25 °C 2.2: 1.5 h / 10 °C / Reflux 2.3: 1 h / 30 - 40 °C View Scheme |
1-(2,3-dimethyl-phenyl)-ethanone
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrabutyl-ammonium chloride; lanthanum(III) chloride; SeCl3 / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere 1.2: 3 h / 0 - 20 °C 2.1: triethylsilane; trifluoroacetic acid / dichloromethane / -10 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: medetomidine With L-lysine In ethanol at 75℃; for 12h; Stage #2: With sodium hydroxide In water at 100℃; Overall yield = 61.7 %; Overall yield = 13.3 g; enantioselective reaction; | A n/a B n/a |
With Chiralcel OJ-3R In acetonitrile at 25℃; pH=8; Reagent/catalyst; Resolution of racemate; |
1H-imidazole
A
dexmedetomidine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 90℃; for 0.5h; Temperature; Reagent/catalyst; Inert atmosphere; Overall yield = 81.1 %; Overall yield = 16.9 g; | A n/a B n/a |
With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; potassium carbonate; zinc In N,N-dimethyl-formamide at 70℃; for 5h; Reagent/catalyst; Temperature; Inert atmosphere; Overall yield = 89.5 %; Overall yield = 17.9 g; Optical yield = 90.61 %ee; |
dexmedetomidine
Conditions | Yield |
---|---|
With phosphoric acid at 23℃; for 48h; pH=6.5; Enzymatic reaction; | 18.2 g |
1H-imidazole
A
dexmedetomidine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; N-butylpyridinium tetrafluoroborate at 70℃; for 0.5h; Temperature; Reagent/catalyst; Inert atmosphere; Overall yield = 84.7 %; Overall yield = 17.6 g; Optical yield = 79.89 %ee; |
1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / chloroform / 2 h / 20 - 26 °C / Inert atmosphere 2: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene / dichloromethane / 24 h / 25 °C / 6000.6 Torr 3: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / chloroform / 2 h / 20 - 26 °C / Inert atmosphere 2: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / dichloromethane / 3 h / 25 °C / 6000.6 Torr 3: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C View Scheme |
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-[bis[4-(trifluoromethyl)phenyl]phosphino]ferrocene / dichloromethane / 24 h / 25 °C / 6000.6 Torr 2: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C View Scheme | |
Multi-step reaction with 2 steps 1: bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / dichloromethane / 3 h / 25 °C / 6000.6 Torr 2: hydrogenchloride / toluene; water / 4 h / 80 - 84 °C View Scheme |
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 2 h / 0.4 - 65 °C 2: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark 3: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr View Scheme |
dexmedetomidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 2 h / 0.11 °C / Dean-Stark 2: (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / methanol / 5 h / 40 - 45 °C / 2250.23 - 7500.75 Torr View Scheme |
1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene
A
dexmedetomidine
Conditions | Yield |
---|---|
With bis(norbornadiene)rhodium(l)tetrafluoroborate; (R)-1-[(SP)-2-(diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; hydrogen In methanol at 40 - 45℃; under 2250.23 - 7500.75 Torr; for 5h; Optical yield = 79.3 percent ee; |
dexmedetomidine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; ethyl acetate at 20℃; for 1h; | 92.5% |
With hydrogenchloride In ethanol; water; isopropyl alcohol at 35 - 50℃; | 90% |
Conditions | Yield |
---|---|
In ethanol; isopropyl alcohol at 20℃; Reflux; | 77.1% |
dexmedetomidine
Rezatomidine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; phenylcarbonochloridothioate In tetrahydrofuran; water at 20℃; for 4h; | 53% |
With sodium hydrogencarbonate; phenylcarbonochloridothioate In tetrahydrofuran; water at 20℃; for 4h; | 53% |
Conditions | Yield |
---|---|
In ethanol at 65℃; for 2h; Temperature; | 47.3% |
dexmedetomidine
p-toluenesulfonyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 2.5h; Ambient temperature; | 31.1% |
dexmedetomidine
(S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide Dean-Stark; |
dexmedetomidine
Conditions | Yield |
---|---|
With hydrogen iodide Dean-Stark; |
oxalic acid
dexmedetomidine
Conditions | Yield |
---|---|
In ethanol |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0 - 50℃; for 4h; Temperature; Solvent; Reagent/catalyst; | A 200 mg B 400 mg |
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