Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryProduct Name: (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Synonyms: (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester;tert-butyl (2s,4r)-4-hydroxy-2-methylpyrrolidine-1-carboxylate;(2S,4R)-t
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryShanghai Sikuo Chemical Technology Co., Ltd. was established in 2012 and is a chemical supplier that integrates research and development, production, and sales. Dedicated to providing basic chemical, fine chemical, pesticide, and pharmaceutical inter
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
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inquiryStrong R&D strength and team We have a R&D team with around 30 R&D personnel.All of our employees have chemical backgrounds and have worked in the chemical industry for many years.Our laboratory can synthesize target products with wei
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inquiryIt is composed of professionals with senior industry background and rich market experience. More than 90% of the personnel have chemistry, chemical, pharmaceutical or related professional knowledge. They are all rigorously trained and evaluated, and
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inquiryHigh quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS
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inquiryReply quotation within 2 hours.Guarantee the time of delivery. Update the progress of customization Weekly.High purity& High product customization success rate.Inquiries for other compounds are acceptable. Storage:refrigeration Package:1g,5g,10g,100g
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inquiryWe promise quality; We deliver goods timely; We test product purity before delivery;We quote price reasonabl;We guarantee after sale service.Appearance:White or off-white crystalline powder Storage:cool and dry area,avoiding light Package:1g/5g/10g/2
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inquirytert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-methylpyrrolidine-1-carboxylate
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; | 99% |
With tetrabutyl ammonium fluoride In tetrahydrofuran for 2.5h; Yield given; | |
With tetrabutyl ammonium fluoride In tetrahydrofuran |
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
dimethyl sulfate
A
(2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate
B
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tetrahydrofuran 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C; Yield given. Yields of byproduct given; |
di-tert-butyl dicarbonate
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / triethylamine / CH2Cl2 / 12 h 2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 4: 94 percent / triethylamine / CH2Cl2 / 15 h 5: lithium triethylborohydride / tetrahydrofuran / 2 h 6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 2: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 3: 94 percent / triethylamine / CH2Cl2 / 15 h 4: lithium triethylborohydride / tetrahydrofuran / 2 h 5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / triethylamine / CH2Cl2 / 12 h 2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature 3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h 4: 94 percent / triethylamine / CH2Cl2 / 15 h 5: lithium triethylborohydride / tetrahydrofuran / 2 h 6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme |
(2R,4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / triethylamine / CH2Cl2 / 15 h 2: lithium triethylborohydride / tetrahydrofuran / 2 h 3: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 °C 2: sodium triethylborohydride / tetrahydrofuran / 2 h / 5 - 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 10 - 41℃; for 0.416667h; Stage #2: 1-(2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one In tetrahydrofuran; mineral oil at 40℃; Temperature; | 99% |
toluene-4-sulfonic acid
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 62℃; | 93% |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
methyl iodide
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; | 92% |
5-bromo-2-fluoropyridine
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 90℃; for 2h; | 86% |
formic acid
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
(2S,4S)-4-Formyloxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu esterification; | 83% |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 50℃; for 4.5h; | 47% |
ethyl 2-chloroimidazo[1,2-a]pyrimidine-3-carboxylate
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 90℃; for 12h; | 40% |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With methanesulfonato(2-di-t-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-tri-i-propylbiphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II); caesium carbonate In toluene at 75℃; for 72h; | 24% |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 45℃; for 5h; | 22% |
7-chloroimidazo[1,2-c]pyrimidine
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 15h; Inert atmosphere; | 21% |
methanesulfonyl chloride
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
(2S,4R)-4-Methanesulfonyloxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 14h; | 16.1 g |
With triethylamine |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
C24H31F3O6S
C33H49NO6
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl acetamide at 0℃; |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
tert-Butyl (2S,4S)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
(2S,4R)-4-Acetylsulfanyl-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C 3: 66 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
C28H41NO3S
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2.1: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C 3.1: 66 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 4.1: NaOMe / dimethylformamide / 0 °C 4.2: 47 percent / dimethylformamide / 20 °C 5.1: 81 percent / TFA / CH2Cl2 / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2.1: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C 3.1: 66 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 4.1: NaOMe / dimethylformamide / 0 °C 4.2: 47 percent / dimethylformamide / 20 °C 5.1: 81 percent / TFA / CH2Cl2 / 20 °C 6.1: 21 percent / K2CO3; KI / acetonitrile / 20 °C 7.1: 52 percent / Pd(PPh3)4; morpholine / tetrahydrofuran / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
C35H47NO3S
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2.1: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C 3.1: 66 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 4.1: NaOMe / dimethylformamide / 0 °C 4.2: 47 percent / dimethylformamide / 20 °C 5.1: 81 percent / TFA / CH2Cl2 / 20 °C 6.1: 21 percent / K2CO3; KI / acetonitrile / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate
C33H49NO5S
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 83 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2.1: 90 percent / aq. NaOH / tetrahydrofuran / 20 °C 3.1: 66 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 4.1: NaOMe / dimethylformamide / 0 °C 4.2: 47 percent / dimethylformamide / 20 °C View Scheme |
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