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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

DIETHYL ((2-CHLOROETHOXY)METHYL)PHOSPHONATE

Cas:116384-56-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl [(2-Chloroethoxy)Methyl]Phosphonate(A2) supplier in China

Cas:116384-56-6

Min.Order:1 Metric Ton

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl [(2-Chloroethoxy)Methyl]Phosphonate(A2)

Cas:116384-56-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Diethyl [(2-chloroethoxy)methyl]phosphonate 116384-56-6 Producer

Cas:116384-56-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New productCAS 116384-56-6 with competitive price

Cas:116384-56-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-[(2-chloroethoxy)methyl]-, diethyl ester 116384-56-6

Cas:116384-56-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Diethyl [(2-chloroethoxy)methyl]phosphonate CAS:116384-56-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in h

Diethyl [(2-chloroethoxy)methyl]phosphonate CAS:116384-56-6

Cas:116384-56-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-[(2-chloroethoxy)methyl]-, diethyl ester

Cas:116384-56-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:116384-56-6

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl [(2-Chloroethoxy)Methyl]Phosphonate(A2)

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Phosphonic acid,P-[(2-chloroethoxy)methyl]-, diethyl ester

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Diethyl [(2-Chloroethoxy)Methyl]Phosphonate(A2)

Cas:116384-56-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Diethyl[(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Diethyl ((2-chloroethoxy)methyl)phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Manufacturers

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU CHEM Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Colorless to light brown liquid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2-Chloro-ethoxymethyl)-phosphonic acid diethyl ester cas no. 116384-56-6 90%+%

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

Diethyl [(2-chloroethoxy)methyl]phosphonateAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Manufacturers

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Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Diethyl [(2-Chloroethoxy)Methyl]Phosphonate(A2)

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Diethyl [(2-chloroethoxy)methyl]phosphonate

Cas:116384-56-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-chloroethyl chloromethyl ether
1462-33-5

2-chloroethyl chloromethyl ether

triethyl phosphite
122-52-1

triethyl phosphite

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

Conditions
ConditionsYield
at 125 - 140℃; for 4h; Arbuzov Reaction;100%
at 125℃; Arbuzov reaction;82%
at 110℃; for 7h;
at 80℃; for 3h; Neat (no solvent);
diethyl 2-hydroxyethoxymethanephosphonate
116384-55-5

diethyl 2-hydroxyethoxymethanephosphonate

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

Conditions
ConditionsYield
With tetrachloromethane; triphenylphosphine for 4h; Heating;50%
2-chloroethyl chloromethyl ether
1462-33-5

2-chloroethyl chloromethyl ether

triethyl phosphite
122-52-1

triethyl phosphite

A

methylene chloride
74-87-3

methylene chloride

B

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

Conditions
ConditionsYield
1) 90 min at 90 deg C 2) 4 h at 125 deg C; Yield given;
2-((diethoxyphosphoryl)methoxy)ethyl acetate
100708-15-4

2-((diethoxyphosphoryl)methoxy)ethyl acetate

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / Dowex 50X8 (H(+)-form) / ethanol / 30 h / Heating
2: 50 percent / CCl4, triphenylphosphine / 4 h / Heating
View Scheme
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

4-chloro-2-oxabutanyl-1-phosphonic acid
1391871-33-2

4-chloro-2-oxabutanyl-1-phosphonic acid

Conditions
ConditionsYield
With trimethylsilyl bromide In acetonitrile at 20℃; Inert atmosphere;100%
ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate
123237-03-6, 5395-36-8

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

C21H31N2O7P
1442461-39-3

C21H31N2O7P

Conditions
ConditionsYield
Stage #1: ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
92%
With potassium carbonate In acetonitrile at 20 - 85℃;
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

nifetepimine
123371-44-8

nifetepimine

C21H30N3O9P
1442461-32-6

C21H30N3O9P

Conditions
ConditionsYield
Stage #1: nifetepimine With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
92%
With potassium carbonate In acetonitrile at 20 - 85℃;
5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione
123043-88-9, 33458-26-3

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

C21H31N2O6PS

C21H31N2O6PS

Conditions
ConditionsYield
Stage #1: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
90%
ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
123629-41-4

ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

ethyl 3-(2-((diethoxyphosphoryl)methoxy)ethyl)-4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
1442461-41-7

ethyl 3-(2-((diethoxyphosphoryl)methoxy)ethyl)-4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
85%
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile at 20 - 85℃; for 20h;
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

5-ethoxycarbonyl-6-methyl-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-thione

5-ethoxycarbonyl-6-methyl-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-thione

C21H31N2O7PS

C21H31N2O7PS

Conditions
ConditionsYield
Stage #1: 5-ethoxycarbonyl-6-methyl-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-thione With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
85%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

6-methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

6-methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

C21H30N3O8PS

C21H30N3O8PS

Conditions
ConditionsYield
Stage #1: 6-methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
85%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
123371-45-9

ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

C21H30N3O9P
1442461-31-5

C21H30N3O9P

Conditions
ConditionsYield
Stage #1: ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
83%
With potassium carbonate In acetonitrile at 20 - 85℃;
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate
914915-59-6

ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

C21H30N3O8PS

C21H30N3O8PS

Conditions
ConditionsYield
Stage #1: ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
83%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

O,O‐diethyl 2-iodoethoxymethylphosphonate

O,O‐diethyl 2-iodoethoxymethylphosphonate

Conditions
ConditionsYield
With sodium iodide In acetone for 24h; Finkelstein Reaction; Reflux; Green chemistry;83%
With potassium iodide In tetrahydrofuran at 45℃; for 1h;
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
5937-24-6

ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

C21H30FN2O7P

C21H30FN2O7P

Conditions
ConditionsYield
Stage #1: ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
82%
ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
5948-68-5

ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

C21H31N2O8P
1442461-33-7

C21H31N2O8P

Conditions
ConditionsYield
Stage #1: ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
80%
With potassium carbonate In acetonitrile at 20 - 85℃;
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

ethyl 1,2,3,4-tetrahydro-4-(2-hydroxyphenyl)-6-methyl-2-thioxopyrimidine-5-carboxylate
5948-74-3

ethyl 1,2,3,4-tetrahydro-4-(2-hydroxyphenyl)-6-methyl-2-thioxopyrimidine-5-carboxylate

C21H31N2O7PS

C21H31N2O7PS

Conditions
ConditionsYield
Stage #1: ethyl 1,2,3,4-tetrahydro-4-(2-hydroxyphenyl)-6-methyl-2-thioxopyrimidine-5-carboxylate With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
80%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
74936-72-4

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

C23H31N2O10P

C23H31N2O10P

Conditions
ConditionsYield
Stage #1: 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
78%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
201287-93-6

4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

ethyl 3-(2-((diethoxyphosphoryl)methoxy)ethyl)-4-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 3-(2-((diethoxyphosphoryl)methoxy)ethyl)-4-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester With potassium carbonate In acetonitrile at 20℃; Inert atmosphere;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In acetonitrile at 20 - 85℃; Inert atmosphere;
77%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

diethyl <(2-azidoethoxy)methyl>phosphonate
160713-48-4

diethyl <(2-azidoethoxy)methyl>phosphonate

Conditions
ConditionsYield
With sodium azide; tetrabutylammomium bromide In toluene at 90℃; for 4h;73%
With sodium azide; tetrabutylammomium bromide In toluene at 90℃; for 4h;68%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

potassium phtalimide
1074-82-4

potassium phtalimide

[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-phosphonic acid diethyl ester
212894-83-2

[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 7h;73%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

6-methylthiopurine
50-66-8

6-methylthiopurine

[2-(6-Methylsulfanyl-purin-9-yl)-ethoxymethyl]-phosphonic acid diethyl ester
126354-37-8

[2-(6-Methylsulfanyl-purin-9-yl)-ethoxymethyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide 1)At 50 deg C for 1 h 2) addition of IIb,50 deg C for 22 h;71%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

A

2-amino-6-chloro-9-[2-(phosphonomethoxy)ethyl]purine bisethyl ester
126354-43-6

2-amino-6-chloro-9-[2-(phosphonomethoxy)ethyl]purine bisethyl ester

B

7-(2-Diethoxyphosphonylmethoxyethyl)-2-amino-6-chloropurine
126354-44-7

7-(2-Diethoxyphosphonylmethoxyethyl)-2-amino-6-chloropurine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;A 64%
B 12%
2-benzyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide
72357-88-1

2-benzyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

C21H27N2O7PS

C21H27N2O7PS

Conditions
ConditionsYield
With sodium hydride; potassium iodide In N,N-dimethyl-formamide at 80℃; Cooling with ice;60%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

2,6-diaminopurine
1904-98-9

2,6-diaminopurine

[2-(2,6-Diamino-purin-9-yl)-ethoxymethyl]-phosphonic acid diethyl ester
119742-08-4

[2-(2,6-Diamino-purin-9-yl)-ethoxymethyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide 1) 80 deg C for 1 h 2) After addition IIb 80 deg C for 24 h;58%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide
359-85-3

4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide

C14H21N2O6PS

C14H21N2O6PS

Conditions
ConditionsYield
Stage #1: 4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Cooling with ice;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester With potassium iodide In N,N-dimethyl-formamide; mineral oil at 50℃;
49%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
116384-53-3

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 80℃; for 15h;46%
Stage #1: adenine With potassium carbonate In N,N-dimethyl-formamide at 25 - 85℃; for 1h;
Stage #2: 2-chloroethoxymethyl phosphonic acid diethyl ester In N,N-dimethyl-formamide for 20h;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80℃; for 5h;
4-methoxy-5-methyl-pyrimidin-2(1H)-one
25902-89-0

4-methoxy-5-methyl-pyrimidin-2(1H)-one

2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

[2-(4-Methoxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester
126354-57-2

[2-(4-Methoxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide 1) 80 deg C for 1 h b) addition of IIb,100 deg C for 15 h;45%
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

O,O-diethyl (2-aminoethoxy)methylphosphonate
160713-49-5

O,O-diethyl (2-aminoethoxy)methylphosphonate

Conditions
ConditionsYield
Stage #1: 2-chloroethoxymethyl phosphonic acid diethyl ester With sodium azide; tetramethylammonium bromide In toluene at 70℃;
Stage #2: With triphenylphosphine In toluene at 20℃;
Multi-step reaction with 2 steps
1: 73 percent / dimethylformamide / 7 h / 120 °C
2: hydrazine / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 68 percent / tetrabutylammonium bromide, sodium azide / toluene / 4 h / 90 °C
2: 75 percent / triphenylphosphine / toluene / 1 h / Ambient temperature
View Scheme
2-chloroethoxymethyl phosphonic acid diethyl ester
116384-56-6

2-chloroethoxymethyl phosphonic acid diethyl ester

6-ethyl>amino>-2(1H)-amino-5-nitropyrimidin-4(3H)-one
160713-50-8

6-ethyl>amino>-2(1H)-amino-5-nitropyrimidin-4(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaN3; N(CH3)4Br / toluene / 70 °C
1.2: Ph3P / toluene / 20 °C
2.1: 65 percent / acetone; methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 68 percent / tetrabutylammonium bromide, sodium azide / toluene / 4 h / 90 °C
2: 75 percent / triphenylphosphine / toluene / 1 h / Ambient temperature
3: 50.2 percent / acetone / 12 h / Ambient temperature
View Scheme

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