HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:Refrigerator
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryName Dorzolomide hydrochloride Synonyms (2S,4S)-2-Ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide hydrochloride
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:A white or almost white powder Storage:Store in sealed conta
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiryDorzolamide Hydrochloride CAS: 130693-82-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryProduct Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
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inquiryProduct quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: Dorzolamide CAS No.:130693-82-2 Molecule Formula:C10H17ClN2O4S3 Molecule Weight:360.90 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiry(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide di-p-toluyl-L-tartate salt
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide di-p-toluyl-L-tartate salt With sodium hydrogencarbonate In water; ethyl acetate at 25 - 30℃; for 0.25h; Stage #2: With hydrogenchloride In ethyl acetate; isopropyl alcohol at 25 - 85℃; for 12.5h; Product distribution / selectivity; | 100% |
With hydrogenchloride In isopropyl alcohol at 80℃; for 0.0833333 - 0.166667h; pH=3 - 4; Product distribution / selectivity; Heating / reflux; | |
Stage #1: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide di-p-toluyl-L-tartate salt With sodium hydrogencarbonate In ethyl acetate at 20℃; Stage #2: With hydrogenchloride In methanol; isopropyl alcohol for 0.666667h; |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno<2,3-b>thiopyran-2-sulfonamide 7,7-dioxide maleate salt With hydrogenchloride; sodium hydroxide In water at 52℃; pH=7.7; Inert atmosphere; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20 - 75℃; | 99.2% |
Stage #1: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno<2,3-b>thiopyran-2-sulfonamide 7,7-dioxide maleate salt With sodium hydroxide In water at 52℃; Inert atmosphere; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 75℃; | 8.1 g |
dorzolamide
dorzolamide hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate pH=1; | 95% |
With hydrogenchloride In water; dimethyl sulfoxide at 5 - 10℃; for 3h; pH=1.0; |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: 5,6-dihydro-4-(S)-ethylamino-6-(S)-methyl-4H-thieno[2,3-b]thiopyran-7,7-dioxide hydrochloride With sulfuric acid; sulfur trioxide at 20℃; for 2 - 3h; Stage #2: With thionyl chloride for 3 - 6h; Heating / reflux; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | 70% |
Stage #1: 5,6-dihydro-4-(S)-ethylamino-6-(S)-methyl-4H-thieno[2,3-b]thiopyran-7,7-dioxide hydrochloride With sulfuric acid; sulfur trioxide at -7 - 20℃; for 22h; Stage #2: With thionyl chloride at 20 - 65℃; for 24h; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
With (-)-di-p-toluoyl-L-tartaric acid | 22.48% |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: trans-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide; Di-p-toluoyl-L-tartaric acid In propan-1-ol Heating / reflux; Stage #2: With sodium hydrogencarbonate In water Stage #3: With hydrogenchloride In ethanol | 22.48% |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2C10H16N2O4S3*C11H10O7 With sodium carbonate In water; ethyl acetate Stage #2: With hydrogenchloride In ethyl acetate; isopropyl alcohol pH=1 - 2; |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: dihydrogen peroxide / sodium tungstate (VI) dihydrate / ethyl acetate; water / -20 °C 2.1: water; sodium tetrahydroborate; methanol / ethyl acetate / 10 - 20 °C 3.1: sulfuric acid / 0 - 30 °C 3.2: 10 °C / pH 7 - 8 4.1: sodium tetrahydroborate / tetrahydrofuran / -5 - 5 °C 4.2: 5 - 20 °C 5.1: sodium hydroxide / 20 °C / pH 7.5 - 8 6.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 7.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 7.2: 0.67 h View Scheme |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sulfuric acid / 0 - 30 °C 1.2: 10 °C / pH 7 - 8 2.1: sodium tetrahydroborate / tetrahydrofuran / -5 - 5 °C 2.2: 5 - 20 °C 3.1: sodium hydroxide / 20 °C / pH 7.5 - 8 4.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 5.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 5.2: 0.67 h View Scheme |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 2.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 2.2: 0.67 h View Scheme |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / 20 °C / pH 7.5 - 8 2.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 3.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 3.2: 0.67 h View Scheme |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / tetrahydrofuran / -5 - 5 °C 1.2: 5 - 20 °C 2.1: sodium hydroxide / 20 °C / pH 7.5 - 8 3.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 4.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 4.2: 0.67 h View Scheme |
6-methyl-4-oxo-5,6-dihydro-4H-thieno[2.3-b]thiopyran-2-sulfonamide-7,7-dioxide
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: water; sodium tetrahydroborate; methanol / ethyl acetate / 10 - 20 °C 2.1: sulfuric acid / 0 - 30 °C 2.2: 10 °C / pH 7 - 8 3.1: sodium tetrahydroborate / tetrahydrofuran / -5 - 5 °C 3.2: 5 - 20 °C 4.1: sodium hydroxide / 20 °C / pH 7.5 - 8 5.1: isopropyl alcohol; acetonitrile / 1 h / 70 °C / Reflux 6.1: sodium hydrogencarbonate / ethyl acetate / 20 °C 6.2: 0.67 h View Scheme |
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one-2-sulfonamide
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium tungstate (VI) dihydrate; oxygen / methanol; water / 6 h / 10 - 50 °C / Inert atmosphere 2.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / Inert atmosphere 3.1: methanesulfonic acid / 18 h / 10 - 87 °C / Inert atmosphere 3.2: 4.5 h / 7 - 40 °C / pH 7.3 4.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 4.2: 40 °C 5.1: sodium hydroxide / water / 52 °C / Inert atmosphere 5.2: 75 °C View Scheme |
(6S)-4-oxo-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / Inert atmosphere 2.1: methanesulfonic acid / 18 h / 10 - 87 °C / Inert atmosphere 2.2: 4.5 h / 7 - 40 °C / pH 7.3 3.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 3.2: 40 °C 4.1: sodium hydroxide / water / 52 °C / Inert atmosphere 4.2: 75 °C View Scheme |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: methanesulfonic acid / 18 h / 10 - 87 °C / Inert atmosphere 1.2: 4.5 h / 7 - 40 °C / pH 7.3 2.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 2.2: 40 °C 3.1: sodium hydroxide / water / 52 °C / Inert atmosphere 3.2: 75 °C View Scheme |
(4S,6S)‑4‑acetamido‑5,6‑dihydro‑6‑methyl‑4H‑thieno[2,3‑b]thiopyran‑2‑sulfonamide‑7,7‑dioxide
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 1.2: 40 °C 2.1: sodium hydroxide / water / 52 °C / Inert atmosphere 2.2: 75 °C View Scheme |
(S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: thionyl chloride; chlorosulfonic acid / 10 h / -3 - 28 °C / Inert atmosphere 2.1: ammonia / methanol; acetone / -10 °C / Inert atmosphere 3.1: sodium tungstate (VI) dihydrate; oxygen / methanol; water / 6 h / 10 - 50 °C / Inert atmosphere 4.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / Inert atmosphere 5.1: methanesulfonic acid / 18 h / 10 - 87 °C / Inert atmosphere 5.2: 4.5 h / 7 - 40 °C / pH 7.3 6.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 6.2: 40 °C 7.1: sodium hydroxide / water / 52 °C / Inert atmosphere 7.2: 75 °C View Scheme |
(S)-6-methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonyl chloride
dorzolamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: ammonia / methanol; acetone / -10 °C / Inert atmosphere 2.1: sodium tungstate (VI) dihydrate; oxygen / methanol; water / 6 h / 10 - 50 °C / Inert atmosphere 3.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / Inert atmosphere 4.1: methanesulfonic acid / 18 h / 10 - 87 °C / Inert atmosphere 4.2: 4.5 h / 7 - 40 °C / pH 7.3 5.1: borane-THF / tetrahydrofuran / 17 h / 38 °C / Inert atmosphere 5.2: 40 °C 6.1: sodium hydroxide / water / 52 °C / Inert atmosphere 6.2: 75 °C View Scheme |
A
4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
B
dorzolamide hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In acetone at 0 - 5℃; for 2h; pH=1 - 2; | A n/a B n/a |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
In methanol; water for 2h; Solvent; Reflux; | 3.2 g |
N,N-dimethyl-formamide dimethyl acetal
dorzolamide hydrochloride
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 80% |
dorzolamide hydrochloride
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; | 56% |
dorzolamide hydrochloride
N,N-dimethylformamide diethyl diacetal
N'-[(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7λ6-thieno[2,3-b]thiopyran-2-sulfonyl]-N,N-dimethylmethanimidamide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; |
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