Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:133099-04-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:133099-04-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiry
Cas:133099-04-4
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
Cas:133099-04-4
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:133099-04-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:133099-04-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Darifenacin CAS: 133099-04-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:133099-04-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:133099-04-4
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:133099-04-4
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o
Cas:133099-04-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: Darifenacin CAS No.:133099-04-4 Molecule Formula:C28H30N2O2 Molecule Weight:426.55 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:133099-04-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:133099-04-4
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:133099-04-4
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:133099-04-4
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiryISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING
Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:133099-04-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWhy is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t
Cas:133099-04-4
Min.Order:0
Negotiable
Type:Trading Company
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
darifenacin
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium hydroxide In iso-butanol for 48h; Reflux; | 80% |
(2,3-dihydrobenzo[b]furan-5-yl)methyl chloride
darifenacin
Conditions | Yield |
---|---|
Stage #1: (2,3-dihydrobenzo[b]furan-5-yl)methyl chloride; potassium (S)-((3-(cyanodiphenylmethyl)pyrrolidin-1-yl)-methyl)trifluoroborate With potassium tert-butylate In tert-Amyl alcohol; water at 110℃; for 20h; Inert atmosphere; Stage #2: With tetrabutylammomium bromide; potassium hydroxide In tert-Amyl alcohol at 110℃; for 24h; Inert atmosphere; | 46% |
2,3-dihydro-5-(2-bromoethyl)benzofuran
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
darifenacin
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 2h; Heating / reflux; | 9% |
With potassium phosphate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium carbonate In water; toluene at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium phosphate In cyclohexane; water at 20 - 90℃; for 3.5h; Product distribution / selectivity; | |
With potassium hydroxide In acetonitrile at 40 - 50℃; for 18h; Product distribution / selectivity; |
(S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide
darifenacin
Conditions | Yield |
---|---|
Stage #1: (S)-2-{1-[2-(benzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide With hydrogen; acetic acid; palladium 10% on activated carbon at 40℃; under 760.051 Torr; for 6h; Stage #2: With sodium hydroxide In dichloromethane; water Product distribution / selectivity; |
3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride
darifenacin
Conditions | Yield |
---|---|
Stage #1: 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride With hydrogen; acetic acid; 5%-palladium/activated carbon at 80 - 90℃; for 7 - 8h; Stage #2: With sodium hydroxide; water pH=10; |
2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester
darifenacin
Conditions | Yield |
---|---|
With ammonia In methanol at 28 - 45℃; for 5 - 7h; Product distribution / selectivity; |
2,3-dihydro-5-(2-bromoethyl)benzofuran
darifenacin
Conditions | Yield |
---|---|
Stage #1: (S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetamide L-tartrate With potassium carbonate In water at 25 - 30℃; for 0.5h; Stage #2: 2,3-dihydro-5-(2-bromoethyl)benzofuran In water at 25 - 75℃; for 12h; | |
With potassium hydroxide In acetonitrile at 25 - 45℃; Product distribution / selectivity; |
(S)-darifenacin hydrobromide
darifenacin
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20 - 25℃; pH=12; |
(S)-2,2-diphenyl-2-[1-(tert-butyloxycarbonyl)-3-pyrrolidinyl]acetonitrile
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / methanol / 7 h / 20 - 30 °C 2.1: sulfuric acid / 12 h / 85 - 90 °C 3.1: ethanol / 1 h 4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 4.2: 12 h / 25 - 75 °C View Scheme |
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)-acetonitrile
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / 12 h / 85 - 90 °C 2.1: ethanol / 1 h 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / 10 h / 95 - 100 °C 1.2: 25 - 30 °C 2.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 16 h / 80 °C 1.2: 0.5 h 2.1: potassium tert-butylate / tert-Amyl alcohol; water / 20 h / 110 °C / Inert atmosphere 2.2: 24 h / 110 °C / Inert atmosphere View Scheme |
1-(2,3-dihydrobenzofuran-5-yl)ethanone
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C / Inert atmosphere 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C View Scheme |
2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 1.2: 4 h / 45 - 50 °C / Inert atmosphere 2.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 2.2: 12 h / 25 - 75 °C View Scheme |
2,3-Dihydrobenzofuran
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere 1.2: 0.5 h / 0 - 5 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 0 - 5 °C 2.2: 6 h / 0 - 5 °C 3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 5 - 10 °C / Inert atmosphere 3.2: 4 h / 45 - 50 °C / Inert atmosphere 4.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 4.2: 12 h / 25 - 75 °C View Scheme |
2-(2,3-dihydrobenzofuran-5-yl)ethylchloride
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium bromide / acetone / 48 h / Heating / reflux 2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium bromide / acetone / 48 h / Heating / reflux 2: potassium carbonate / acetonitrile 3: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
2,3-dihydro-5-(2-bromoethyl)benzofuran
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile 2: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 0.33 h / 25 - 60 °C / pH 12 - 14 2: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme |
(S)-diphenyl-[1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-acetonitrile
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux 2.1: sulfuric acid / 10 h / 95 - 100 °C 2.2: 25 - 30 °C 3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme |
2,2-diphenyl-2-((S)-pyrrolidin-3-yl)-acetic acid methyl ester
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile 2: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
methyl 2,2-diphenyl-2-((S)-1-tosyl-pyrrolidin-3-yl)-acetate
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen bromide; acetic acid 2: potassium carbonate / acetonitrile 3: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
Diphenylacetonitrile
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h 1.2: 5 h / 95 - 100 °C 2.1: hydrogen bromide / water; phenol / 4 h / Heating / reflux 3.1: sulfuric acid / 10 h / 95 - 100 °C 3.2: 25 - 30 °C 4.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme |
methyl 2,2-diphenylacetate
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydride / toluene / 1 h / 55 - 60 °C 1.2: 3 h / 25 - 30 °C / Heating / reflux 2.1: hydrogen bromide; acetic acid 3.1: potassium carbonate / acetonitrile 4.1: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C 2: sodium bromide / acetone / 48 h / Heating / reflux 3: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C 2: sodium bromide / acetone / 48 h / Heating / reflux 3: potassium carbonate / acetonitrile 4: ammonia / methanol / 5 - 7 h / 28 - 45 °C View Scheme |
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / 0.25 h / 50 - 60 °C / pH 12 2.1: sulfuric acid / 10 h / 95 - 100 °C 2.2: 25 - 30 °C 3.1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C View Scheme |
(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-ol
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triphenylphosphine; benzoic acid; diethylazodicarboxylate / toluene / 0 - 20 °C 1.2: 5 h / 20 °C 2.1: triethylamine / dichloromethane / -10 - 20 °C 3.1: sodium hydride / toluene / 2 h / Reflux 3.2: 9 h / Reflux 4.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux View Scheme |
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-hydroxypyrrolidine
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / -10 - 20 °C 2.1: sodium hydride / toluene / 2 h / Reflux 2.2: 9 h / Reflux 3.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux View Scheme |
(S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-p-toluenesulfonylpyrrolidine
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / toluene / 2 h / Reflux 1.2: 9 h / Reflux 2.1: tetrabutylammomium bromide; potassium hydroxide / iso-butanol / 48 h / Reflux View Scheme |
2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide
darifenacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water / 50 - 60 °C 2: potassium hydroxide / acetonitrile / 25 - 45 °C View Scheme |
darifenacin
(S)-darifenacin hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide In water; acetone at 0 - 20℃; for 7h; | 75% |
With hydrogen bromide In water; acetone | 65% |
With hydrogen bromide In water; acetone for 1.25 - 2.33333h; Product distribution / selectivity; |
darifenacin
darifenacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 0 - 30℃; for 12h; Product distribution / selectivity; | |
With hydrogenchloride In water; acetone at 0 - 30℃; for 12h; |
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