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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Gestadene

Cas:14340-01-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Gestadienol supplier in China

Cas:14340-01-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Gestadienol

Cas:14340-01-3

Min.Order:1

Negotiable

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Gestadene CAS NO.14340-01-3

Cas:14340-01-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Gestadienol CAS 14340-01-3

Cas:14340-01-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Professional CAS 14340-01-3 with best quality

Cas:14340-01-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Gestadene 14340-01-3

Cas:14340-01-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Gestadienol CAS:14340-01-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Gestadienol CAS:14340-01-3

Cas:14340-01-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Gestadene

Cas:14340-01-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Gestadene

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Gestadene CAS NO.14340-01-3

Cas:14340-01-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

GESTADIENOL;17Α-HYDROXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE

Cas:14340-01-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Gestadienol

Cas:14340-01-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

14340-01-3 Gestadienol

Cas:14340-01-3

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Gestadienol

Cas:14340-01-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best PriceGestadienol

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Gestadene CAS NO.14340-01-3

Cas:14340-01-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Gestadienol

Cas:14340-01-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Gestadienol

Cas:14340-01-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Gestadene CAS NO.14340-01-3

Cas:14340-01-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Gestadienol

Cas:14340-01-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Gestadene

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Gestadienol

Cas:14340-01-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.14340-01-3 98% Gestadienol

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Gestadene CAS NO.14340-01-3

Cas:14340-01-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

Gestadene

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

Gestadienol

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Gestadienol

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:to formulate preparations Transportation:by courier, air or sea Port:At any port fro

Gestadienol 14340-01-3 API

Cas:14340-01-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Gestadienol

Cas:14340-01-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3,20-bis-ethylendioxy-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,20-bis-ethylendioxy-17α-hydroxy-19-norpregna-5(10),9(11)-diene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With water; trifluoroacetic acid In tetrahydrofuran at 20℃; for 2h;77%
C25H35NO4

C25H35NO4

methyllithium
917-54-4

methyllithium

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: C25H35NO4; methyllithium In diethyl ether at 0 - 10℃; for 4h; Cooling with ice;
Stage #2: With hydrogenchloride; water In acetone at 25℃; for 8h; Solvent;
72%
17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

methyllithium
917-54-4

methyllithium

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: 17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene; methyllithium In diethyl ether at 0 - 10℃; for 4h;
Stage #2: With hydrogenchloride In acetone at 25℃; for 8h;
72%
3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene
290825-36-4

3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With di-t-butyl biphenyl; lithium In tetrahydrofuran at -70℃; for 2.25h; Title compound not separated from byproducts;
3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / DMAP; TEA / tetrahydrofuran / 20 °C
2: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
2.1: diethyl ether / 4 h / 0 - 10 °C / Cooling with ice
2.2: 8 h / 25 °C
View Scheme
17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)
54201-84-2

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

ethylene deltenone
5571-36-8

ethylene deltenone

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / methanol / 20 °C / Large scale
2.1: ethyl vinyl ether; toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling with ice; Large scale
2.2: 8 h / 0 - 10 °C / Large scale
2.3: 4 h / 25 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid / methanol / 20 °C / Large scale
2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
3.1: 2 h / 0 - 10 °C / Cooling with ice
3.2: 0.5 h
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid / methanol / 20 °C / Large scale
2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
3.1: tetrahydrofuran; 2-methyltetrahydrofuran / 4 h / 0 - 10 °C / Cooling with ice
3.2: 2 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / methanol / 20 °C
2: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale
3: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
View Scheme
ethylene deltenone
5571-36-8

ethylene deltenone

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid / methanol / 20 °C / Large scale
2.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
3.1: diethyl ether / 4 h / 0 - 10 °C / Cooling with ice
3.2: 8 h / 25 °C
View Scheme
C25H35NO4

C25H35NO4

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: C25H35NO4; methyllithium In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; for 4h; Cooling with ice;
Stage #2: With hydrogenchloride; water In methanol at 25℃; for 2h; Solvent; Overall yield = 73%; Overall yield = 6.6 g;
In tetrahydrofuran; diethyl ether at 0 - 20℃; for 8h; Cooling; Large scale; Overall yield = 1036 g;
C25H35NO4

C25H35NO4

methyl Grignard reagent

methyl Grignard reagent

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: C25H35NO4; methyl Grignard reagent at 0 - 10℃; for 2h; Cooling with ice;
Stage #2: With hydrogenchloride; water for 0.5h; Solvent; Overall yield = 68%; Overall yield = 2.1g;
17α-[(±)1-(1-n-propyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-n-propyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: 17α-[(±)1-(1-n-propyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene; methyllithium In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; for 4h; Cooling with ice;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; 2-methyltetrahydrofuran for 0.5h; Solvent; Overall yield = 70%; Overall yield = 4g;
In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; Overall yield = 70 %; Overall yield = 4.0 g;
17α-[(±)1-(1-isobutyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-isobutyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: 17α-[(±)1-(1-isobutyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene; methyllithium In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; for 4h; Cooling with ice;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; 2-methyltetrahydrofuran for 0.5h; Solvent; Overall yield = 67%; Overall yield = 4.7g;
In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; Overall yield = 67 %; Overall yield = 4.7 g;
C26H35NO4

C26H35NO4

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: C26H35NO4; methyllithium In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; for 4h; Cooling with ice;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; 2-methyltetrahydrofuran for 0.5h; Solvent; Overall yield = 72%; Overall yield = 11.2 g;
methyllithium
917-54-4

methyllithium

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Stage #1: 3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene With toluene-4-sulfonic acid; ethyl vinyl ether In tetrahydrofuran at 20℃; for 3h; Cooling with ice; Large scale;
Stage #2: methyllithium In tetrahydrofuran; diethyl ether at 0 - 10℃; for 8h; Large scale;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; diethyl ether at 25℃; for 4h; Large scale; Overall yield = 75%; Overall yield = 1036 g;
A n/a
B n/a
3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
2.1: 2 h / 0 - 10 °C / Cooling with ice
2.2: 0.5 h
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Cooling with ice; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 4 h / 0 - 10 °C / Cooling with ice
2.2: 2 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale
2: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
View Scheme
17α-[(±)1-(1-tetrahydropyran)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-tetrahydropyran)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; Overall yield = 72 %; Overall yield = 11.2 g;
17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

methyllithium
917-54-4

methyllithium

A

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

B

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 10℃; Reagent/catalyst; Solvent; Overall yield = 73 %; Overall yield = 6.6 g;
3,3-dimethoxy-estra-5(10),9(11)-diene-17-one
10109-76-9

3,3-dimethoxy-estra-5(10),9(11)-diene-17-one

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / tetrahydrofuran; acetone / 2 h / 5 - 40 °C / Inert atmosphere
1.2: 1 h / 35 - 40 °C
2.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
3.1: sodium methylate; methanol / 3 h / 60 - 65 °C
3.2: 1 h / Heating
4.1: acetic acid; perchloric acid / 0.17 h / 20 - 30 °C
View Scheme
3,3-dimethoxy-21-(phenylsulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene

3,3-dimethoxy-21-(phenylsulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate; methanol / 3 h / 60 - 65 °C
1.2: 1 h / Heating
2.1: acetic acid; perchloric acid / 0.17 h / 20 - 30 °C
View Scheme
3,3-(2,2-dimethyltrimethylene-1,3-dioxy)-5(10),9(11)-estradien-17-one
91175-92-7

3,3-(2,2-dimethyltrimethylene-1,3-dioxy)-5(10),9(11)-estradien-17-one

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / tetrahydrofuran; acetone / 2 h / 5 - 40 °C / Inert atmosphere
1.2: 1 h / 35 - 40 °C
2.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
3.1: sodium methylate; methanol / 3 h / 60 - 65 °C
3.2: 1 h
4.1: acetic acid; perchloric acid / 0.17 h / 20 - 30 °C
View Scheme
3,3-dimethoxy-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene

3,3-dimethoxy-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With perchloric acid; acetic acid at 20 - 30℃; for 0.166667h;59 g
3,3-(2,2-dimethylpropylenedioxy)-17α-ethynyl-17β-hydroxyestra-5(10),9(11)-diene

3,3-(2,2-dimethylpropylenedioxy)-17α-ethynyl-17β-hydroxyestra-5(10),9(11)-diene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
2.1: sodium methylate; methanol / 3 h / 60 - 65 °C
2.2: 1 h
3.1: acetic acid; perchloric acid / 0.17 h / 20 - 30 °C
View Scheme
3,3-(propylenedioxy)estra-5(10),9(11)-diene-17-one

3,3-(propylenedioxy)estra-5(10),9(11)-diene-17-one

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / tetrahydrofuran; acetone / 2 h / 5 - 40 °C / Inert atmosphere
1.2: 1 h / 35 - 40 °C
2.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
3.1: sodium methylate; methanol / 3 h / 60 - 65 °C
3.2: 1 h
4.1: hydrogenchloride / methanol; water / 0.17 h / 20 - 30 °C
View Scheme
3,3-(propylenedioxy)-21-(phenylsulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene

3,3-(propylenedioxy)-21-(phenylsulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate; methanol / 3 h / 60 - 65 °C
1.2: 1 h
2.1: hydrogenchloride / methanol; water / 0.17 h / 20 - 30 °C
View Scheme
3,3-(propylenedioxy)-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene.

3,3-(propylenedioxy)-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene.

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20 - 30℃; for 0.166667h;52 g
17α-hydroxy-20-methoxy-19-norpregna-4(5),9(10),20-trien-3-one

17α-hydroxy-20-methoxy-19-norpregna-4(5),9(10),20-trien-3-one

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20 - 30℃; for 1h;46 g
21-(phenylsulfinyl)-19-norpregna-4(5), 9(10),17(20),20-tetraene-3-one

21-(phenylsulfinyl)-19-norpregna-4(5), 9(10),17(20),20-tetraene-3-one

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate; methanol / methanol / 2 h / 60 - 65 °C
1.2: 1 h / Heating
2.1: hydrogenchloride / methanol; water / 1 h / 20 - 30 °C
View Scheme
RU 3097
14531-92-1

RU 3097

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
2.1: sodium methylate; methanol / methanol / 2 h / 60 - 65 °C
2.2: 1 h / Heating
3.1: hydrogenchloride / methanol; water / 1 h / 20 - 30 °C
View Scheme
3,3-(2,2-dimethylpropylenedioxy)-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene

3,3-(2,2-dimethylpropylenedioxy)-17α-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
With perchloric acid; acetic acid at 20 - 30℃; for 0.166667h;51 g
3,3-(propylenedioxy)-17α-ethynyl-17β-hydroxyestra-5(10),9(11)-diene

3,3-(propylenedioxy)-17α-ethynyl-17β-hydroxyestra-5(10),9(11)-diene

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; acetic acid / methanol; water; dichloromethane / 0.5 h / -10 - 0 °C
2.1: sodium methylate; methanol / 3 h / 60 - 65 °C
2.2: 1 h
3.1: hydrogenchloride / methanol; water / 0.17 h / 20 - 30 °C
View Scheme
ethylene glycol
107-21-1

ethylene glycol

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)
54201-84-2

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)

Conditions
ConditionsYield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester In dichloromethane at 20℃; Inert atmosphere;77%
With toluene-4-sulfonic acid; orthoformic acid triethyl ester In dichloromethane at 18 - 25℃; for 17h;4.2 g
acetic acid
64-19-7

acetic acid

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; trifluoroacetic anhydride In dichloromethane at 0℃; for 0.25h;62.3%
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

3,20-bis-ethylenedioxy-5α,17α-dihydroxy-11β-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-19-norpregn-9-ene

3,20-bis-ethylenedioxy-5α,17α-dihydroxy-11β-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-19-norpregn-9-ene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 20 °C / Inert atmosphere
2.1: dihydrogen peroxide; Hexafluoroacetone; disodium hydrogenphosphate / dichloromethane / 0 - 5 °C
3.1: magnesium; iodine; ethylene dibromide / tetrahydrofuran / 2 h / Inert atmosphere; Heating
3.2: 1.25 h / 20 °C
View Scheme
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)
54201-83-1

5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / dichloromethane / 20 °C / Inert atmosphere
2: dihydrogen peroxide; Hexafluoroacetone; disodium hydrogenphosphate / dichloromethane / 0 - 5 °C
View Scheme
17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

trimethyl orthoformate
149-73-5

trimethyl orthoformate

3,3,20,20-bis(ethylenedioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3,20,20-bis(ethylenedioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 20 - 25℃; for 3h;62 g

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