Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
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inquiryUnique advantages of Pitavastatin calcium Cas 147526-32-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to pale yellowish powder Storage:Cool dry place Package:100g
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inquiryService we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to your requirem
high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
The atorvastatin calcium. English Name: Calcium Pitavastatin Molecular weight: 880.98 147526-32-7 CAS: Uses: applicable to hyperlipidemia and high cholesterol. Quality standard: enterprise standard project standard Properties whit
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryProduct Name: Pitavastatin calcium Synonyms: 147526-32-7 Pitavastatin Calcium;Pitavastatin Calcuim;Pitavastatin calcium, >=98.5%;Pitavastatin (calcium salt);monocalciumbis[(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl)-3,5-Dihydroxy
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry147526-32-7 Pharmaceutical Powder Pitavastatin Calcium Treatment Coronary Heart Disease Physical and Chemical Properties Common Name Pitavastatin Calcium Chemical Name Mo
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryProduct Name: Pitavastatin calcium CAS: 147526-32-7 MF: C25H26CaFNO4 MW: 463.56 EINECS: 807-641-2 Mol File: 147526-32-7.mol Pitavastatin calcium Structure Pitavastatin calcium Chemical Properties alpha D20 +23.1° (c = 1.00
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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inquirymethyl (3R,5S,6E)-7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoate
pitavastatin
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 0.5h; | 100% |
With water; sodium hydroxide In methanol at 20℃; for 2h; Product distribution / selectivity; |
pitavastatin calcium salt
pitavastatin
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate at 25 - 35℃; | 95.9% |
With hydrogenchloride In dichloromethane; water at 0 - 25℃; for 0.833333h; pH=3; | |
With hydrogenchloride In water; ethyl acetate pH=4; | 3.7 g |
With hydrogenchloride In dichloromethane; water |
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester
pitavastatin
Conditions | Yield |
---|---|
Stage #1: (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester With trifluoroacetic acid In acetonitrile at 30 - 35℃; Stage #2: With caesium carbonate In acetonitrile at 35 - 40℃; | 94% |
Multi-step reaction with 3 steps 1.1: water; oxalic acid / methanol / 6 h / 35 °C 1.2: 2.75 h / 10 - 30 °C / pH 7 2.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 2.2: 0.67 h / 25 °C 3.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 4 steps 1.1: water; oxalic acid / methanol / 6 h / 35 °C 1.2: 2.75 h / 10 - 30 °C / pH 7 2.1: sodium hydroxide; water / acetonitrile / 1.5 h / 30 °C 2.2: 0.25 h / 0 °C / pH 4 2.3: 0.5 h / 0 °C 3.1: sodium hydroxide / water / 0.75 h / 30 °C 3.2: 0.75 h / 35 °C 4.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / acetonitrile; water / 2 h / 13 °C 2: sodium hydroxide / water / 2 h / 10 °C / Large scale View Scheme |
(E)-(3R,5S)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester
pitavastatin
Conditions | Yield |
---|---|
With ethanol; sodium hydroxide In water at 20℃; for 3h; | 87.4% |
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester
pitavastatin
Conditions | Yield |
---|---|
With sodium hydroxide In water at 10℃; for 2h; Large scale; | 83.9% |
Stage #1: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester With hydrogenchloride; water In methanol at 25℃; for 2.16667h; Stage #2: With hydrogenchloride In dichloromethane at 0 - 25℃; for 0.916667h; pH=3; | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 1.2: 0.67 h / 25 °C 2.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / acetonitrile / 1.5 h / 30 °C 1.2: 0.25 h / 0 °C / pH 4 1.3: 0.5 h / 0 °C 2.1: sodium hydroxide / water / 0.75 h / 30 °C 2.2: 0.75 h / 35 °C 3.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 12h; Ambient temperature; |
pitavastatin
Conditions | Yield |
---|---|
Stage #1: (±)-E-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-6-heptenoic acid ethyl ester With sodium hydroxide Hydrolysis; Stage #2: With (+)-1-phenylethylamine resolution; |
pitavastatin
Conditions | Yield |
---|---|
Stage #1: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-[(1S)-1-phenylethyl]hept-6-enamide With sodium hydroxide In ethanol at 50 - 55℃; for 26h; Stage #2: With hydrogenchloride In ethyl acetate Further stages.; |
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: DMSO; P2O5; Et3N 2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O 3.1: DIBAH 4.1: NaH; n-BuLi 5.1: NaBH4; Et2BOMe / -78 °C 6.1: aq. NaOH 6.2: (+)-α-methylbenzylamine View Scheme | |
Multi-step reaction with 4 steps 1.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 1.2: 1 h / 75 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 4.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 1.2: 1 h / 75 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 4.2: 0.67 h / 25 °C 5.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 6 steps 1.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 1.2: 1 h / 75 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: sodium hydroxide; water / acetonitrile / 1.5 h / 30 °C 4.2: 0.25 h / 0 °C / pH 4 4.3: 0.5 h / 0 °C 5.1: sodium hydroxide / water / 0.75 h / 30 °C 5.2: 0.75 h / 35 °C 6.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 5 steps 1: thionyl chloride / toluene; dichloromethane / 15 °C 2: toluene / 12 h / Reflux; Large scale 3: potassium carbonate / dimethyl sulfoxide / 3 h / 30 - 50 °C / Large scale 4: hydrogenchloride / acetonitrile; water / 2 h / 13 °C 5: sodium hydroxide / water / 2 h / 10 °C / Large scale View Scheme |
2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: NaOH; (n-octyl)3MeNCl / toluene; H2O 2.1: DIBAH 3.1: NaH; n-BuLi 4.1: NaBH4; Et2BOMe / -78 °C 5.1: aq. NaOH 5.2: (+)-α-methylbenzylamine View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium t-butanolate / 1-methyl-pyrrolidin-2-one; 2-methyltetrahydrofuran; tetrahydrofuran / -60 - 22 °C 2.1: hydrogenchloride / acetonitrile; water / 1.5 h / 45 °C 2.2: 1.5 h 3.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium t-butanolate / 1-methyl-pyrrolidin-2-one; 2-methyltetrahydrofuran; tetrahydrofuran / -60 - 22 °C 2.1: hydrogenchloride / acetonitrile; water / 2.5 h / 45 °C 2.2: 1.5 h / 10 °C 3.1: sodium hydroxide / water / pH 12.3 3.2: 1.25 h / pH 9.7 4.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme |
(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH; n-BuLi 2.1: NaBH4; Et2BOMe / -78 °C 3.1: aq. NaOH 3.2: (+)-α-methylbenzylamine View Scheme |
(E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: DIBAH 2.1: NaH; n-BuLi 3.1: NaBH4; Et2BOMe / -78 °C 4.1: aq. NaOH 4.2: (+)-α-methylbenzylamine View Scheme |
(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxohept-6-enic acid ethyl ester
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaBH4; Et2BOMe / -78 °C 2.1: aq. NaOH 2.2: (+)-α-methylbenzylamine View Scheme | |
With Candida rugosa IFO0591 In dimethyl sulfoxide at 30℃; for 20h; pH=7; Product distribution / selectivity; Aerobic conditions; potassium phosphate buffer (pH 7.0); | n/a |
With Candida molischiana IFO10296 In dimethyl sulfoxide at 30℃; for 20h; pH=7; Product distribution / selectivity; Aerobic conditions; potassium phosphate buffer (pH 7.0); | n/a |
(E)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dioxo-hept-6-enoic acid ethyl ester
pitavastatin
Conditions | Yield |
---|---|
With Candida famata RIFY7455 In dimethyl sulfoxide at 30℃; for 20h; pH=7; Product distribution / selectivity; Aerobic conditions; potassium phosphate buffer (pH 7.0); | n/a |
With Candida albicans IFO1594 In dimethyl sulfoxide at 30℃; for 20h; pH=7; Product distribution / selectivity; Aerobic conditions; potassium phosphate buffer (pH 7.0); | n/a |
With Candida parapsilosis CBS604 In dimethyl sulfoxide at 30℃; for 20h; pH=7; Product distribution / selectivity; Aerobic conditions; potassium phosphate buffer (pH 7.0); | n/a |
(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere 2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere 3.1: hydrogenchloride / water; methanol / 0 - 20 °C 4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C 4.2: 1 h / 50 °C 5.1: sodium hydroxide; water / methanol / 2 h / 20 °C View Scheme |
(R)-5-(tert-butyldimethylsilyloxy)-7-methoxy-3,7-dioxoheptanoic acid
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere 2.1: hydrogenchloride / water; methanol / 0 - 20 °C 3.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C 3.2: 1 h / 50 °C 4.1: sodium hydroxide; water / methanol / 2 h / 20 °C View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water; methanol / 0 - 20 °C 2.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C 2.2: 1 h / 50 °C 3.1: sodium hydroxide; water / methanol / 2 h / 20 °C View Scheme |
Cyclopropyl methyl ketone
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: toluene / 5 h / 25 °C / Inert atmosphere 3.2: 3 h 3.3: 2 h / 40 °C 4.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 5.1: water; oxalic acid / methanol / 6 h / 35 °C 5.2: 2.75 h / 10 - 30 °C / pH 7 6.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 6.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: toluene / 5 h / 25 °C / Inert atmosphere 3.2: 3 h 3.3: 2 h / 40 °C 4.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 5.1: water; oxalic acid / methanol / 6 h / 35 °C 5.2: 2.75 h / 10 - 30 °C / pH 7 6.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 6.2: 0.67 h / 25 °C 7.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 25 °C 3.2: 0.25 h / 10 °C 4.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 4.2: 1 h / 75 °C 5.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 6.1: water; oxalic acid / methanol / 6 h / 35 °C 6.2: 2.75 h / 10 - 30 °C / pH 7 7.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 7.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme |
methyl 3-cyclopropyl-3-oxopropanoate
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: toluene / 5 h / 25 °C / Inert atmosphere 2.2: 3 h 2.3: 2 h / 40 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 4.1: water; oxalic acid / methanol / 6 h / 35 °C 4.2: 2.75 h / 10 - 30 °C / pH 7 5.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 5.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: toluene / 5 h / 25 °C / Inert atmosphere 2.2: 3 h 2.3: 2 h / 40 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 4.1: water; oxalic acid / methanol / 6 h / 35 °C 4.2: 2.75 h / 10 - 30 °C / pH 7 5.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 5.2: 0.67 h / 25 °C 6.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 25 °C 2.2: 0.25 h / 10 °C 3.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 3.2: 1 h / 75 °C 4.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 5.1: water; oxalic acid / methanol / 6 h / 35 °C 5.2: 2.75 h / 10 - 30 °C / pH 7 6.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 6.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme |
methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene / 5 h / 25 °C / Inert atmosphere 1.2: 3 h 1.3: 2 h / 40 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 4.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene / 5 h / 25 °C / Inert atmosphere 1.2: 3 h 1.3: 2 h / 40 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 4.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 4.2: 0.67 h / 25 °C 5.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 25 °C 1.2: 0.25 h / 10 °C 2.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 2.2: 1 h / 75 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 4.1: water; oxalic acid / methanol / 6 h / 35 °C 4.2: 2.75 h / 10 - 30 °C / pH 7 5.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 5.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water / 0.75 h / 30 °C 1.2: 0.75 h / 35 °C 2.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 2.1: water; oxalic acid / methanol / 6 h / 35 °C 2.2: 2.75 h / 10 - 30 °C / pH 7 3.1: hydrogenchloride; water / methanol / 2.17 h / 25 °C 3.2: 0.92 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 2.1: water; oxalic acid / methanol / 6 h / 35 °C 2.2: 2.75 h / 10 - 30 °C / pH 7 3.1: sodium hydroxide; water / methanol / 1.67 h / 0 °C 3.2: 0.67 h / 25 °C 4.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 2.1: water; oxalic acid / methanol / 6 h / 35 °C 2.2: 2.75 h / 10 - 30 °C / pH 7 3.1: sodium hydroxide; water / acetonitrile / 1.5 h / 30 °C 3.2: 0.25 h / 0 °C / pH 4 3.3: 0.5 h / 0 °C 4.1: sodium hydroxide / water / 0.75 h / 30 °C 4.2: 0.75 h / 35 °C 5.1: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme |
(E)-3(R)-5(S)-dihydroxy-7-[4'-(4-fluorophenyl)-2'-cyclopropylquinoline-3'-yl]hept-6-eneacidD(+)phenylethylamine salt
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide; calcium chloride / water 2: hydrogenchloride / dichloromethane; water / 0.83 h / 0 - 25 °C / pH 3 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / acetonitrile; water / 1.5 h / 45 °C 1.2: 1.5 h 2.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / acetonitrile; water / 2.5 h / 45 °C 1.2: 1.5 h / 10 °C 2.1: sodium hydroxide / water / pH 12.3 2.2: 1.25 h / pH 9.7 3.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme |
2-((4R,6S)-6-((benzo[d]thiazol-2-ylsulfonyl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid methyl ester
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium t-butanolate / 1-methyl-pyrrolidin-2-one; 2-methyltetrahydrofuran; tetrahydrofuran / -60 - 22 °C 2.1: hydrogenchloride / acetonitrile; water / 1.5 h / 45 °C 2.2: 1.5 h 3.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium t-butanolate / 1-methyl-pyrrolidin-2-one; 2-methyltetrahydrofuran; tetrahydrofuran / -60 - 22 °C 2.1: hydrogenchloride / acetonitrile; water / 2.5 h / 45 °C 2.2: 1.5 h / 10 °C 3.1: sodium hydroxide / water / pH 12.3 3.2: 1.25 h / pH 9.7 4.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water / pH 12.3 1.2: 1.25 h / pH 9.7 2.1: hydrogenchloride / water; ethyl acetate / pH 4 View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / acetonitrile / 19 h / 0 - 20 °C 4.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 1.33 h / -78 °C 4.2: 3 h / 20 °C 5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / dimethyl sulfoxide / 4 h / 70 °C / Inert atmosphere 6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / dimethyl sulfoxide / 9 h / 90 °C / Inert atmosphere 7.1: sodium hydroxide / methanol / 0.5 h / 20 °C View Scheme |
anthranilic acid nitrile
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: tin(IV) chloride / toluene / 3 h / 15 °C / Inert atmosphere; Reflux 2.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2.5 h / 15 - 40 °C / Inert atmosphere 3.1: diisobutylaluminium hydride / toluene; hexane / 1 h / 0 - 20 °C / Inert atmosphere 4.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere 5.2: 0 - 20 °C / Inert atmosphere 6.1: hydrogenchloride / acetonitrile / 19 h / 0 - 20 °C 7.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 1.33 h / -78 °C 7.2: 3 h / 20 °C 8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / dimethyl sulfoxide / 4 h / 70 °C / Inert atmosphere 9.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / dimethyl sulfoxide / 9 h / 90 °C / Inert atmosphere 10.1: sodium hydroxide / methanol / 0.5 h / 20 °C View Scheme |
pitavastatin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2.5 h / 15 - 40 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / 0 - 20 °C / Inert atmosphere 3.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere 4.2: 0 - 20 °C / Inert atmosphere 5.1: hydrogenchloride / acetonitrile / 19 h / 0 - 20 °C 6.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 1.33 h / -78 °C 6.2: 3 h / 20 °C 7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / dimethyl sulfoxide / 4 h / 70 °C / Inert atmosphere 8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / dimethyl sulfoxide / 9 h / 90 °C / Inert atmosphere 9.1: sodium hydroxide / methanol / 0.5 h / 20 °C View Scheme |
pitavastatin
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 5 - 20℃; Inert atmosphere; | 82% |
pitavastatin
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 0 - 30℃; for 3h; | 81% |
In toluene for 1h; Heating; |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 60 - 70℃; pH=7 - 8; | 81% |
pitavastatin
Conditions | Yield |
---|---|
In toluene for 12h; Heating; Yield given; |
(R)-1-(1-Naphthyl)ethylamine
pitavastatin
(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt
Conditions | Yield |
---|---|
In hexane; acetone at 20℃; for 16h; |
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