As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:15574-96-6
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:15574-96-6
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:15574-96-6
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:15574-96-6
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inquiryName: Pizotifen Synonyms: Sandomigran CAS:15574-96-6 MF: C19H21NS Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:APIs Transportation:By sea or by air Port:Qingdao port
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or light pink crystalline powder Storage:Store in sea
Cas:15574-96-6
Min.Order:100 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:15574-96-6
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:15574-96-6
Min.Order:1 Gram
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:15574-96-6
Min.Order:1 Kilogram
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inquiryPizotifen CAS:15574-96-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:15574-96-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:15574-96-6
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Our company focuses on the future and the world, and will continue to devote itself to technological progress and the development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad to create a bett
Cas:15574-96-6
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:15574-96-6
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:15574-96-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:15574-96-6
Min.Order:10 Gram
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Type:Lab/Research institutions
inquirysupplier in China Appearance:White to Off-White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Serotonin antagonist structurally relat
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Product name: Pizotifen(CAS:15574-96-6) CAS No.:15574-96-6 Molecule Formula:C19H21NS Molecule Weight:295.44 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard
Cas:15574-96-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
pizotifen
4-(2-bromo-9,10-dihydro-1-thiabenzo[f]-azulen-4-ylidene)-1-methylpiperidine
Conditions | Yield |
---|---|
With bromine In chloroform at 0 - 20℃; for 2h; | 91% |
With bromine In chloroform at 0 - 20℃; for 2h; | 91% |
pizotifen
Conditions | Yield |
---|---|
With water-d2; silver In dimethyl sulfoxide at 40℃; for 12h; | 75% |
chloroformic acid ethyl ester
pizotifen
4-(9,10-dihydro-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-piperidine-1-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In toluene at 60℃; Reflux; | 9% |
pizotifen
Ethyl 4-(2-bromo-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / toluene / 60 °C / Reflux 2: bromine / chloroform / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux View Scheme |
pizotifen
3-[4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl]-propionic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C View Scheme |
pizotifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl)acrylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: piperidine; hydrogenchloride / pyridine / Reflux 4.1: potassium hydroxide / isopropyl alcohol / 24 h / Reflux 4.2: pH 7 / Cooling View Scheme |
pizotifen
ethyl 4-[2-(2-ethoxycarbonylvinyl)-9,10-dihydro-1-thiabenzo[f]azulen-4-ylidene]piperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 60 °C / Reflux 2: bromine / chloroform / 2 h / 20 °C 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux 3: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme |
pizotifen
ethyl 3-[4-(1-tert-butoxy-carbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]-propionate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 6 h / Reflux 5.1: acetonitrile / 20 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / toluene / 60 °C / Reflux 2: bromine / chloroform / 2 h / 20 °C 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux 5: acetonitrile / 20 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux 5: acetonitrile / 20 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C View Scheme |
pizotifen
3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]propionic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 6 h / Reflux 5.1: acetonitrile / 20 h / 20 °C 6.1: sodium hydroxide; water / ethanol / 20 h View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: piperidine; hydrogenchloride / pyridine / Reflux 4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux 4.2: 4 h / 60 °C 5.1: hydrogen bromide / acetic acid / 2 h / 20 - 100 °C 6.1: sodium hydroxide / isopropyl alcohol; water / 20 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: triethylamine / toluene / 60 °C / Reflux 2: bromine / chloroform / 2 h / 20 °C 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux 5: acetonitrile / 20 h / 20 °C 6: sodium hydroxide; water / ethanol / 20 h View Scheme | |
Multi-step reaction with 6 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux 5: acetonitrile / 20 h / 20 °C 6: sodium hydroxide; water / ethanol / 20 h View Scheme |
pizotifen
3-[4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: piperidine; hydrogenchloride / pyridine / Reflux View Scheme |
pizotifen
3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: piperidine; hydrogenchloride / pyridine / Reflux 4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux 4.2: 4 h / 60 °C View Scheme |
pizotifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 6 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / toluene / 60 °C / Reflux 2: bromine / chloroform / 2 h / 20 °C 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: toluene / 6 h / Reflux 3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4: hydrogen bromide / acetic acid / 6 h / Reflux View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 40 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 40 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 40 h / 20 °C View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid nitrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: nitric acid / water / 1 h / Cooling View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: nitric acid / water / 1 h / Cooling View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: nitric acid / water / 1 h / Cooling View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-4H-1-thiabenzon[f]azulen-2-yl)propionic propionic acid hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: water / 0.5 h / 80 - 90 °C 5.2: 0.5 h / 10 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: water / 0.5 h / 80 - 90 °C 5.2: 0.5 h / 10 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: water / 0.5 h / 80 - 90 °C 5.2: 0.5 h / 10 - 90 °C View Scheme |
pizotifen
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: piperidine; hydrogenchloride / pyridine / Reflux 4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux 4.2: 4 h / 60 °C 5.1: hydrogen bromide / acetic acid / 2 h / 20 - 100 °C View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid p-toluene sulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 1 h / 20 °C View Scheme |
pizotifen
3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid benzenesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 15 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 15 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: acetone / 15 h / 20 °C View Scheme |
pizotifen
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C 2.2: 37 h / 50 °C 2.3: 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling 3.2: 2 h / 20 °C 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: sulfuric acid / formic acid / 1 h / Cooling View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 60 °C / Reflux 2.1: bromine / chloroform / 2 h / 20 °C 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: sulfuric acid / formic acid / 1 h / Cooling View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: sulfuric acid / formic acid / 1 h / Cooling View Scheme |
pizotifen
Ethyl [4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / Reflux 4: thionyl chloride / 2.5 h / 0 °C / Reflux View Scheme |
pizotifen
Ethyl [4-(piperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / Reflux 4: thionyl chloride / 2.5 h / 0 °C / Reflux 5: 1,2-dichloro-ethane / Reflux 6: hydrogen bromide / acetic acid / 5 h / Reflux View Scheme |
pizotifen
Ethyl 3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)propionate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: toluene / 6 h / Reflux 3.1: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 4 h / 120 °C 4.2: 3 h / 20 °C 5.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C View Scheme |
pizotifen
Ethyl [4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / Reflux 4: thionyl chloride / 2.5 h / 0 °C / Reflux 5: 1,2-dichloro-ethane / Reflux View Scheme |
pizotifen
2-Cyano-4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme |
pizotifen
[4-(1-Methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylic acid hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / Reflux View Scheme |
pizotifen
Ethyl {4-{1-[4-(4-t-butylphenyl)-4-oxobutyl]piperidin-4-ylidene}-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl}carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: bromine / chloroform / 2 h / 0 - 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / Reflux 4: thionyl chloride / 2.5 h / 0 °C / Reflux 5: 1,2-dichloro-ethane / Reflux 6: hydrogen bromide / acetic acid / 5 h / Reflux 7: triethylamine / N,N-dimethyl-formamide / 21 h / 80 °C View Scheme |
pizotifen
1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: bromine / chloroform / 2 h / 0 - 20 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3.1: water; sodium hydroxide / ethanol / Reflux 4.1: triethylamine; potassium iodide / 1,4-dioxane; N,N-dimethyl-formamide / 80 °C 4.2: 1 h View Scheme |
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