Products

Refine

Country

Business Type

Certificate

Display

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : (3R,3aS,6aR)-hexahydrofuro[2,3-b]

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Specifications CAS No.: 156928-09-5 Other Names: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol MF: C6H10O3 EINECS No.: - Place of Origin:

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol CAS:156928-09-5

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $300.0 / 400.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL

Cas:156928-09-5

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

According to customer request Appearance:Pale Yellow Oil Storage:2-8°C Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai

Cas no.156928-09-5 98% (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 156928-09-5 with competitive price

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)- 156928-09-5

Cas:156928-09-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol CAS:156928-09-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in h

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol CAS:156928-09-5

Cas:156928-09-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(3R,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Ol

Cas:156928-09-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:Organic Chemistry Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/C

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

In stock (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol 156928-09-5Appearance:off-white powder Storage:room temperature Package:according to customers' requirements Application:Organic intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect..

In stock (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol 156928-09-5

Cas:156928-09-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

Furo[2,3-b]furan-3-ol,hexahydro-, (3R,3aS,6aR)-

Cas:156928-09-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol CAS No.:156928-09-5 Molecule Formula:C6H10O3 Molecule Weight:130.14 Purity: 96.0% Package: 200kg/drum Description:Colorless to light yellow liquid Manufacture Standards:Enterpr

Best Quality (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Offer(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol CAS:156928-09-5

Cas:156928-09-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Cas:156928-09-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran
162119-35-9

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃; Product distribution / selectivity;100%
With potassium carbonate In methanol at 20℃;30%
With methyllithium In tetrahydrofuran
(2R,3S)-3-dimethoxymethyl-5-benzyloxy-1,2-pentanediol

(2R,3S)-3-dimethoxymethyl-5-benzyloxy-1,2-pentanediol

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (2R,3S)-3-dimethoxymethyl-5-benzyloxy-1,2-pentanediol With sulfuric acid In toluene at 0 - 35℃; for 15.5h;
Stage #2: With palladium 10% on activated carbon; hydrogen at 25℃; for 6h;
Stage #3: at 72 - 197℃; for 4.5h;
99%
(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one
809286-93-9

(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one

A

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

B

(3S,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan
252873-50-0

(3S,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan

Conditions
ConditionsYield
Stage #1: (3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one With sodium tetrahydroborate In methanol; isopropyl alcohol at 0℃; for 1.5h;
Stage #2: With ammonium chloride In methanol; isopropyl alcohol Product distribution / selectivity;
A 97.2%
B n/a
Stage #1: (3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one With sodium tetrahydroborate In ethanol at -15℃; for 2h;
Stage #2: With hydrogenchloride In ethanol; water Product distribution / selectivity;
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl benzoate
725264-69-7

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl benzoate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With methanol; water; sodium hydroxide In tetrahydrofuran at 20℃; for 0.5h;95%
With sodium hydroxide In water at 27 - 30℃; for 4h;93%
C6H10O4

C6H10O4

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With hydrogenchloride; diisobutylaluminium hydride In water; toluene at -50 - 60℃; for 16h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;95%
With diisobutylaluminium hydride In toluene at -50 - 40℃; Inert atmosphere;56.4 g
C16H22O4

C16H22O4

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol under 760.051 Torr; for 1h; Solvent;91%
C9H18O5

C9H18O5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With hydrogenchloride In water at -2 - 5℃; Temperature;90.4%
(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

B

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran
162119-35-9

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran

C

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester
162020-29-3

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Conditions
ConditionsYield
With acetic anhydride In tert-butyl methyl ether at 20℃; for 110h; Reagent/catalyst; Enzymatic reaction;A 90%
B n/a
C n/a
With acetic anhydride In 1,2-dimethoxyethane at 23℃; for 3h; Yield given. Yields of byproduct given;
exo-2,7-dioxabicyclo[3.2.0]hept-3-en-6-ylmethyl benzyl carbonate

exo-2,7-dioxabicyclo[3.2.0]hept-3-en-6-ylmethyl benzyl carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 24h; Reagent/catalyst;90%
With lipase Enzymatic reaction;
(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan
156928-10-8

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan

B

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

C

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran
162119-35-9

3-acetoxy-(3R,3αS,6αR)-bis-tetrahydrofuran

D

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester
162020-29-3

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Conditions
ConditionsYield
With acetic anhydride In tert-butyl methyl ether at 20℃; for 110h; Reagent/catalyst; Enzymatic reaction;A n/a
B 90%
C n/a
D n/a
(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan
156928-10-8

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan

B

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With acetic anhydride In tert-butyl methyl ether at 20℃; for 110h; Reagent/catalyst; Enzymatic reaction;A 90%
B n/a
vinyl acetate
108-05-4

vinyl acetate

(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

A

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

B

(3S,3aS,6aR)-perhydrofuro[2,3-b]furan-3-yl acetate

(3S,3aS,6aR)-perhydrofuro[2,3-b]furan-3-yl acetate

Conditions
ConditionsYield
With Chirazyme L-2 In tert-butyl methyl ether at 25℃; for 40h; Enzymatic reaction;A 90%
B n/a
((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester
362634-60-4

((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;86%
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate
186488-54-0

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With sodium methylate In methanol Mitsunobu Displacement; Inert atmosphere; stereoselective reaction;82%
With lithium hydroxide; triethylamine In methanol; water at 23℃; for 2h;326 mg
(3S,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan
252873-50-0

(3S,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (3S,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan With di-isopropyl azodicarboxylate; triphenylphosphine; 4-nitro-benzoic acid In benzene at 23℃; for 1.5h; Mitsunobu reaction;
Stage #2: With lithium hydroxide; triethylamine In methanol; water at 20℃; for 2h;
82%
Multi-step reaction with 2 steps
1: triphenylphosphine; diisopropyl azodicarboxylate / benzene / 1.5 h / 23 °C
2: 326 mg / LiOH; Et3N / methanol; H2O / 2 h / 23 °C
View Scheme
Multi-step reaction with 2 steps
1: 94 percent / 4-methylmorpholino-N-oxide; tetrapropylammonium perruthenate / CH2Cl2 / 0.17 h / 23 °C
2: 70 percent / NaBH4 / ethanol / 2.5 h / -18 °C
View Scheme
(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one
809286-93-9

(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at -15 - 20℃; for 3h;81%
With sodium tetrahydroborate; ethanol at 0℃; for 0.5h;80%
With sodium tetrahydroborate In ethanol at -18℃; for 2.5h;70%
With sodium tetrahydroborate In ethanol at -18℃; for 2.5h;70%
(2R,3R)-1,2-O-isopropylidene-3-vinyl-1,2,5-pentanetriol
115482-97-8

(2R,3R)-1,2-O-isopropylidene-3-vinyl-1,2,5-pentanetriol

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (2R,3R)-1,2-O-isopropylidene-3-vinyl-1,2,5-pentanetriol With ozone
Stage #2: With toluene-4-sulfonic acid
80%
Stage #1: (2R,3R)-1,2-O-isopropylidene-3-vinyl-1,2,5-pentanetriol With dimethylsulfide; ozone In methanol; dichloromethane at -78 - 20℃; for 3h; Inert atmosphere;
Stage #2: toluene-4-sulfonic acid In methanol; chloroform for 1h; Reflux;
80%
C11H20O5

C11H20O5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 50℃; for 6h; Solvent;77%
(3aS,4S,6aR)-4-methoxy-tetrahydro-furo[3.4-b]furan-2(3H)-one
866594-60-7

(3aS,4S,6aR)-4-methoxy-tetrahydro-furo[3.4-b]furan-2(3H)-one

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (3aS,4S,6aR)-4-methoxy-tetrahydro-furo[3.4-b]furan-2(3H)-one With lithium borohydride In tetrahydrofuran at 50℃; for 2.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran at -10℃; for 2h;
76%
ethyl (2R,3S)-3-(methyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate

ethyl (2R,3S)-3-(methyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: ethyl (2R,3S)-3-(methyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran
Stage #2: With sulfuric acid In dichloromethane; water; ethyl acetate; toluene at -10 - 80℃; for 68.15h;
75%
Stage #1: ethyl (2R,3S)-3-(methyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at -10 - 20℃; for 17.25h;
Stage #2: With sulfuric acid In tetrahydrofuran at -8 - 5℃; for 2h;
n/a
C13H16O5

C13H16O5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With sodium hydroxide In methanol at -15 - -5℃;73.77%
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / 22 - 26 °C
2: sodium carbonate; methanol / 22 - 26 °C
3: hydrogenchloride / water / -2 - 5 °C
View Scheme
C14H24O5

C14H24O5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 60℃; for 6h; Solvent; Temperature;72%
(3aS,6aR)-4-methoxytetrahydrofuro[3,4-b]furan-2(3H)-one

(3aS,6aR)-4-methoxytetrahydrofuro[3,4-b]furan-2(3H)-one

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (3aS,6aR)-4-methoxytetrahydrofuro[3,4-b]furan-2(3H)-one With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 23℃; for 1h; Inert atmosphere;
Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1.5h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0 - 23℃; for 1h;
63%
Stage #1: (3aS,6aR)-4-methoxytetrahydrofuro[3,4-b]furan-2(3H)-one With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 25℃; Inert atmosphere; Reflux; Large scale;
Stage #2: With hydrogenchloride In water at 10℃; for 2h; pH=1 - 3; Reagent/catalyst; Solvent; Inert atmosphere; Large scale;
80 kg
(3S,4'R)-3-(2',2'-dimethyl-[1',3']dioxolane-4'-yl)tetrahydrofuran-2-ol
676999-02-3

(3S,4'R)-3-(2',2'-dimethyl-[1',3']dioxolane-4'-yl)tetrahydrofuran-2-ol

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: (3S,4'R)-3-(2',2'-dimethyl-[1',3']dioxolane-4'-yl)tetrahydrofuran-2-ol With hydrogenchloride In tetrahydrofuran; water at 20℃; for 23h;
Stage #2: With potassium carbonate In tetrahydrofuran; water for 0.333333h;
61%
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 16h;
With hydrogenchloride; sodium bicarbonate; sodium chloride In tetrahydrofuran; water
ethyl (2R,3S)-3-(ethyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate

ethyl (2R,3S)-3-(ethyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: ethyl (2R,3S)-3-(ethyl(phenyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h;
Stage #2: With sulfuric acid In tetrahydrofuran at 20℃; for 3h;
54%
vinyl acetate
108-05-4

vinyl acetate

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

B

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester
162020-29-3

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Conditions
ConditionsYield
With Lipase PS at 50℃; for 24h; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;A 37%
B 53%
vinyl acetate
108-05-4

vinyl acetate

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan
156928-10-8

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan

B

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

C

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester
162020-29-3

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Conditions
ConditionsYield
With lipase AS at 50℃; for 24h; Enzymatic reaction; enantioselective reaction;A n/a
B 30%
C 51%
C13H14O5

C13H14O5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
With diisobutylaluminium hydride In tetrahydrofuran at -74℃; for 1h; Temperature; Solvent; Inert atmosphere;50%
ethyl (2R,3S)-3-(methoxy(methyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate
1233923-19-7

ethyl (2R,3S)-3-(methoxy(methyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

Conditions
ConditionsYield
Stage #1: ethyl (2R,3S)-3-(methoxy(methyl)carbamoyl)-5-oxotetrahydrofuran-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h;
Stage #2: With sulfuric acid In tetrahydrofuran at 20℃; for 3h;
50%
acetic anhydride
108-24-7

acetic anhydride

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

(3SR,3aRS,6aSR)-3-hydroxy-4H-hexahydrofuro<2,3-b>furan

A

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

B

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester
162020-29-3

Acetic acid (3S,3aR,6aS)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Conditions
ConditionsYield
In 1,2-dimethoxyethane at 23℃; immobilized Amano lipase;A n/a
B 45%
Amano lipase 30 immobilized on Celite 521 In 1,2-dimethoxyethane at 23℃; Resolution of racemate;A 42%
B 45%
Amano lipase PS-C I In 1,2-dimethoxyethane Purification / work up; Resolution of racemate;A 32%
B n/a
With porcine pancreatic lipase (PPL) In tert-butyl methyl ether at 20℃; for 110h; Reagent/catalyst; Enzymatic reaction;
benzoyl chloride
98-88-4

benzoyl chloride

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl benzoate
725264-69-7

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl benzoate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 7h; enantioselective reaction;97%
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(4-nitrophenyl)carbonic acid
192725-55-6

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(4-nitrophenyl)carbonic acid

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 23℃; for 12h; Inert atmosphere;92%
With pyridine In dichloromethane89%
With pyridine In ethyl acetate at 0℃; for 1h;51.8%
4-aminobenzenesulfonyl chloride
24939-24-0

4-aminobenzenesulfonyl chloride

isobutylamine
78-81-9

isobutylamine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(S)-3-amino-(S)-2-hydroxy-4-phenyl-1-chlorobutane hydrochloride

(S)-3-amino-(S)-2-hydroxy-4-phenyl-1-chlorobutane hydrochloride

darunavir

darunavir

Conditions
ConditionsYield
Stage #1: 1,1'-carbonyldiimidazole; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol In tetrahydrofuran for 1h;
Stage #2: (S)-3-amino-(S)-2-hydroxy-4-phenyl-1-chlorobutane hydrochloride In tetrahydrofuran at 55 - 60℃;
Stage #3: 4-aminobenzenesulfonyl chloride; isobutylamine
92%
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate
186488-54-0

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate

Conditions
ConditionsYield
With pyridine; triethylamine at 0 - 20℃;92%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

1-[[[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl]oxy]pyrrolidine-2,5-dione
253265-97-3

1-[[[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl]oxy]pyrrolidine-2,5-dione

Conditions
ConditionsYield
With pyridine In tert-butyl methyl ether at 25 - 40℃; for 62h; Solvent;90%
With triethylamine In acetonitrile at 23℃; for 7h;66%
With triethylamine In dichloromethane Solvent; Reagent/catalyst; Inert atmosphere; Reflux; Large scale;62%
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

C6H9IO2
1359057-78-5

C6H9IO2

Conditions
ConditionsYield
With iodine; triphenylphosphine90%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

C7H12O5S

C7H12O5S

Conditions
ConditionsYield
With pyridine; triethylamine at 0 - 20℃; Reagent/catalyst;90%
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3S,3aR,6aR)-3-Iodo-hexahydro-furo[2,3-b]furan
362634-64-8

(3S,3aR,6aR)-3-Iodo-hexahydro-furo[2,3-b]furan

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In benzene at 60℃;87%
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one
809286-93-9

(3aR,6aR)-3a,4,5,6a-tetrahydrofuro[2,3-b]furan-3(2H)-one

Conditions
ConditionsYield
With disodium hydrogenphosphate; Dess-Martin periodane In dichloromethane at 0 - 23℃; Dess-Martin oxidation; Inert atmosphere;87%
With disodium hydrogenphosphate; Dess-Martin periodane In dichloromethane at 0 - 23℃; for 3h; Inert atmosphere;87%
With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide In dichloromethane at 23℃; for 1h; Molecular sieve;
With disodium hydrogenphosphate; Dess-Martin periodane In dichloromethane at 0 - 23℃; Inert atmosphere;
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan
156928-10-8

(3S,3aR,6aS)-3-hydroxyhexahydrofuro<2,3-b>furan

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3R,3aS,6aR) and (3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate
854745-99-6

(3R,3aS,6aR) and (3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate

Conditions
ConditionsYield
With 4-methyl-morpholine In dichloromethane at 0℃; for 16h;86%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride
251105-80-3

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-{(1S,2R)-2-hydroxy-3-[(2-methylpropyl)-4-nitrophenylsulfonylamino]-1-phenylmethylpropyl}carbamate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-{(1S,2R)-2-hydroxy-3-[(2-methylpropyl)-4-nitrophenylsulfonylamino]-1-phenylmethylpropyl}carbamate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol With pyridine In dichloromethane at 55℃; for 3h;
Stage #2: N-hydroxyphthalimide In dichloromethane at 50℃; for 4h;
Stage #3: N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride In toluene at 50℃; for 6h;
85.8%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

C7H9F3O5S

C7H9F3O5S

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃;85%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride
251105-80-3

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-{(1S,2R)-2-hydroxy-3-[(2-methylpropyl)-4-nitrophenylsulfonylamino]-1-phenylmethylpropyl}carbamate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-{(1S,2R)-2-hydroxy-3-[(2-methylpropyl)-4-nitrophenylsulfonylamino]-1-phenylmethylpropyl}carbamate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol With triethylamine In toluene at 90℃; for 3h;
Stage #2: 1-hydroxy-pyrrolidine-2,5-dione In ethyl acetate at 50℃; for 3h;
Stage #3: N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride In toluene at 50℃; for 6h;
84.9%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
156928-09-5

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide
169280-56-2

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

darunavir

darunavir

Conditions
ConditionsYield
With pyridine; triethylamine; methylamine In ethanol; water; acetonitrile Product distribution / selectivity;81%
With triethylamine; methylamine In ethanol; water; ethyl acetate; acetonitrile71%
Stage #1: di(succinimido) carbonate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol With pyridine In acetonitrile at 25 - 30℃; for 1h;
Stage #2: 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide In acetonitrile at 0 - 5℃; for 0.5h;
Stage #3: With triethylamine; methylamine In acetonitrile at 0 - 30℃;

Downstream Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View