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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:Clear colorless liquid Storage:Refer to COA / M

DB BIOTECH CO., LTD

Q1:Can you give me a discount price Surely,It depend on your qty Q2:How can i get a sample free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. Q3: How

VK2 mk7 MENAQUINONE-7

Cas:2124-57-4

Min.Order:25 Gram

FOB Price: $400.0

Type:Trading Company

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply with Best Price High Quality 99% Vitamin K2 Menaquinone-7

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $25.0 / 125.0

Type:Trading Company

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Kono Chem Co.,Ltd

Type: Vitamin K2(35),MK-7,CAS: 2124-57-4 Form: Powder Part: Seed Extraction Type: Solvent Extraction Packaging: Drum, Vacuum Packed, Other Place of Origin: S

Vitamin K2(35),MK-7 CAS 2124-57-4

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $2800.0 / 3000.0

Type:Other

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Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

High quality Vitamin K2 Mk7 Menaquinone-7 Powder

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $120.0 / 133.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

2124-57-4 Vitamin K2(35)

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Vitamin K2(35) 2124-57-4 GMP Manufacturer

Cas:2124-57-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

Product Name:Vitamin K2 MK7 Appearance:Light yellow powder Assay: 0.5%-2% Shipping method: Fedex, DHL, TNT, Sea, Air or as you wish Type: natural and synthetic Package: Aluminum Foil Bag Hot Market: Europe, America, Asia Usage: Food,Cosmetics,

Eastling Supply Natural and Synthetic Vitamin K2 MK7

Cas:2124-57-4

Min.Order:100 Gram

FOB Price: $21.9 / 183.0

Type:Trading Company

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Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

MK7/ Menaquinone-7/ Vitamin K2/ Menatetrenone CAS 2124-57-4

Cas:2124-57-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Vitamin K2

Cas:2124-57-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Menaquinone 7

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Menaquinone 7

Cas:2124-57-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of

Vitamin K2(35) Manufacturer

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

CAS: 2124-57-4 Chemical formula: C46H64O2 Molecular weight: 649 Density: 0.961 Melting point: 54 ° C Boiling point: bp0.0002 200 ° (some dec) Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) Storage conditions:

Menlaquinone 7 2124-57-4

Cas:2124-57-4

Min.Order:5 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top qualityCAS 2124-57-4 with best price

Cas:2124-57-4

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Light yellow powder Storage:ln stock Package:25kg/Barrel Application:Very important fat-soluble vitamin Transportation:Express/Sea/Air Port:Any port of China

Vitamin K2(35), MK-7, Menatetrenone

Cas:2124-57-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: High quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply Wholesale Price Menlaquinone 7 98% Purity Vitamin MK 7 Powder With CAS 2124-57-4

Cas:2124-57-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Vitamin K2(35) Basic information Product Name: Vitamin K2(35) Synonyms: MENAQUINONE-7;(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione;Menaquinone K7;Vitamin K2(35);Vitamin MK 7;Menl

Methyl carbamat

Cas:2124-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Vitamin K2(35)

Cas:2124-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Vitamins, Vitamin K2(35) CAS:2124-57-4

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $400.0 / 420.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Vitamin K2(35) CAS:2124-57-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Vitamin K2(35) CAS:2124-57-4

Cas:2124-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Vitamin K2(35)

Cas:2124-57-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out

Vitamin K2(35)CAS: 2124-57-4

Cas:2124-57-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

VITAMIN MK 7

Cas:2124-57-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

MK-7

Cas:2124-57-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Vitamin K2(35)

Cas:2124-57-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Vitamin K2 MK7

Cas:2124-57-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

high quality of Vitamin K2 MK-7 2124-57-4

Cas:2124-57-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Vitamin K2(35)

Cas:2124-57-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-1,4-dimethoxy-3-methylnaphthalene
1218784-62-3

2-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-1,4-dimethoxy-3-methylnaphthalene

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate In water; acetonitrile at 20℃; for 4.08333h;80%
With ammonium cerium (IV) nitrate In acetonitrile at 20℃; for 4.08333h;80%
With ammonium cerium (IV) nitrate In water; acetonitrile at 0℃; for 0.75h;72%
With ammonium cerium (IV) nitrate In dichloromethane; water; acetonitrile at 0℃; for 0.75h;0.753 g
C50H74O2
1597486-88-8

C50H74O2

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate In dichloromethane; water; acetonitrile at 0℃; for 0.25h;72%
2-(chloromethyl)-3-methylnaphthalene-1,4-dione
31599-79-8

2-(chloromethyl)-3-methylnaphthalene-1,4-dione

C33H52

C33H52

trimethylaluminum
75-24-1

trimethylaluminum

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Stage #1: C33H52; trimethylaluminum With zirconocene dichloride In toluene at 0℃; for 1h;
Stage #2: 2-(chloromethyl)-3-methylnaphthalene-1,4-dione With bis(triphenylphosphine)nickel(II) chloride; n-butyllithium In tetrahydrofuran; hexane at -20℃; for 1h;
65%
(2E,6E)-farnesyl acetate
4128-17-0

(2E,6E)-farnesyl acetate

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: salicylic acid; selenium(IV) oxide; tert.-butylhydroperoxide / water; dichloromethane / 24 h / 0 - 20 °C
2.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
3.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
5.2: -78 - 20 °C
6.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
7.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
8.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
9.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
9.2: 4.5 h / 0 °C / Inert atmosphere
10.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 11 steps
1.1: salicylic acid; selenium(IV) oxide; tert.-butylhydroperoxide / water; dichloromethane / 24 h / 0 - 20 °C
2.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
3.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
5.2: -78 - 20 °C
6.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
7.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
8.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
9.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
10.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
10.2: 5 h / 0 °C / Inert atmosphere
11.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 11 steps
1.1: selenium(IV) oxide; salicylic acid; tert.-butylhydroperoxide / dichloromethane / 14 h / 0 °C
1.2: 2 h
2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.75 h / -45 - -40 °C
2.2: 2 h / 0 °C
3.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: sodium methylate / methanol / 4 h / 0 °C
5.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
6.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
7.1: triphenylphosphine; bromine / dichloromethane / 0 °C
8.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
8.2: 12 h / Inert atmosphere
9.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
10.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
11.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
E,E,E-12-hydroxyfarnesyl acetate
93787-91-8

E,E,E-12-hydroxyfarnesyl acetate

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
3.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
5.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
7.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
7.2: 4.5 h / 0 °C / Inert atmosphere
8.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 9 steps
1.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
3.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
5.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
6.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
7.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
8.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
8.2: 5 h / 0 °C / Inert atmosphere
9.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 10 steps
1.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.75 h / -45 - -40 °C
1.2: 2 h / 0 °C
2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: sodium methylate / methanol / 4 h / 0 °C
4.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
5.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
6.1: triphenylphosphine; bromine / dichloromethane / 0 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 12 h / Inert atmosphere
8.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
9.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
10.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
(2E,6E,10E)-3,7,11-trimethyl-12-(phenylsulfonyl)-dodeca-2,6,10-trien-1-yl acetate
1597486-72-0

(2E,6E,10E)-3,7,11-trimethyl-12-(phenylsulfonyl)-dodeca-2,6,10-trien-1-yl acetate

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
5.2: 4.5 h / 0 °C / Inert atmosphere
6.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
3.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
4.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
6.2: 5 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide / methanol; water / 1 h / 20 °C / pH 12
3.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
6.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide / methanol / 1 h / 20 °C / pH 12
3.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
6.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
5.2: 4.5 h / 0 °C / Inert atmosphere
6.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
3.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
4.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
6.2: 5 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
2.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 1.5 h / -78 °C
2.2: -78 - 0 °C
3.1: sodium methylate / methanol / 2 h / 20 °C / pH 12
4.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
6.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
7.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
8.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium hydroxide / methanol / 1 h / 20 °C / pH 12
3.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
6.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 8 steps
1.1: pyridine / N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
2.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 1.5 h / -78 °C
2.2: 5 h / -78 °C
3.1: sodium methylate; methanol / 2 h / 20 °C
4.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
5.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
6.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
7.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
8.1: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
C38H56O4S
1597487-01-8

C38H56O4S

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
2.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
4.2: 4.5 h / 0 °C / Inert atmosphere
5.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
2.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
5.2: 5 h / 0 °C / Inert atmosphere
6.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium hydroxide / methanol; water / 1 h / 20 °C / pH 12
2: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
5: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
6: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium hydroxide / methanol / 1 h / 20 °C / pH 12
2: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
5: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
6: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyl-12-(phenylsulfonyl)tetracosa-2,6,10,14,18,22-hexaen-1-ol
1597486-78-6

(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyl-12-(phenylsulfonyl)tetracosa-2,6,10,14,18,22-hexaen-1-ol

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
3.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
3.2: 4.5 h / 0 °C / Inert atmosphere
4.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
2.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
4.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
4.2: 5 h / 0 °C / Inert atmosphere
5.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
4: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
4: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
5: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
(2E,6E,10E)-12-bromo-3,7,11-trimethyl-2,6,10-dodecatrienyl acetate
104423-44-1

(2E,6E,10E)-12-bromo-3,7,11-trimethyl-2,6,10-dodecatrienyl acetate

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
2.2: -78 - 20 °C
3.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
4.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
6.2: 4.5 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
2.2: -78 - 20 °C
3.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
4.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
5.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
7.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
7.2: 5 h / 0 °C / Inert atmosphere
8.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: sodium methylate / methanol / 4 h / 0 °C
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: triphenylphosphine; bromine / dichloromethane / 0 °C
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 12 h / Inert atmosphere
7.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
8.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-ol
68778-93-8

(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-ol

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
3.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
3.2: 5 h / 0 °C / Inert atmosphere
4.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine; bromine / dichloromethane / 0 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 12 h / Inert atmosphere
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine; bromine / dichloromethane / 0 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 12 h / Inert atmosphere
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
3: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
3: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
4: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
1-bromo-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
74610-00-7

1-bromo-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
2.2: 5 h / 0 °C / Inert atmosphere
3.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
2: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
2: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
3: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
phenylsulfonyl hexaprenyl bromide
1597486-86-6

phenylsulfonyl hexaprenyl bromide

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
2.2: 4.5 h / 0 °C / Inert atmosphere
3.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
C62H82O6S2
1597486-87-7

C62H82O6S2

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
1.2: 4.5 h / 0 °C / Inert atmosphere
2.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
C56H78O4S
1597486-91-3

C56H78O4S

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
1.2: 5 h / 0 °C / Inert atmosphere
2.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
(2E,6E,10E)-3,7,11-trimethyl-12-oxododeca-2,6,10-trien-1-yl acetate
40266-21-5

(2E,6E,10E)-3,7,11-trimethyl-12-oxododeca-2,6,10-trien-1-yl acetate

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
2.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
4.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
4.2: -78 - 20 °C
5.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
6.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
7.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
8.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
9.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
9.2: 5 h / 0 °C / Inert atmosphere
10.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 9 steps
1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
2.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
4.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
4.2: -78 - 20 °C
5.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
6.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
7.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
8.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
8.2: 4.5 h / 0 °C / Inert atmosphere
9.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 10 steps
1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.5 h / -10 °C
2.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
4.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.5 h / -78 °C
4.2: -78 - 20 °C
5.1: sodium hydroxide / methanol; water / 1 h / 20 °C / pH 12
6.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
7.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
8.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
9.1: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
10.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
1,4-diethoxy-2-methyl-3-[(2E)-3-methyl-4-(phenylsulfonyl)-2-buten-1-yl]naphtalene
1597486-65-1

1,4-diethoxy-2-methyl-3-[(2E)-3-methyl-4-(phenylsulfonyl)-2-buten-1-yl]naphtalene

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
2.2: 4.5 h / 0 °C / Inert atmosphere
3.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
2.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
2.2: 5 h / 0 °C / Inert atmosphere
3.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Farnesol
106-28-5

Farnesol

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere
2.1: salicylic acid; selenium(IV) oxide; tert.-butylhydroperoxide / water; dichloromethane / 24 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
4.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
6.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
6.2: -78 - 20 °C
7.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
8.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
9.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
10.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
10.2: 4.5 h / 0 °C / Inert atmosphere
11.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 12 steps
1.1: pyridine / 12 h / 0 - 20 °C / Inert atmosphere
2.1: salicylic acid; selenium(IV) oxide; tert.-butylhydroperoxide / water; dichloromethane / 24 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 0.75 h / -10 °C
4.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 18 h / 20 °C / Darkness
6.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
6.2: -78 - 20 °C
7.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
8.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere
9.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
10.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.83 h / -20 °C / Inert atmosphere; Cooling with acetone-dry ice
11.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with acetone-dry ice
11.2: 5 h / 0 °C / Inert atmosphere
12.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 °C
2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2.67 h / -78 °C
2.2: -78 - 20 °C
3.1: sodium hydroxide; water / methanol / 1 h / 20 °C / pH 12
4.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -20 - 0 °C / Inert atmosphere; Cooling with acetone-dry ice
6.1: (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with acetone-dry ice; Inert atmosphere
6.2: 4.5 h / 0 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / water; dichloromethane; acetonitrile / 0.25 h / 0 °C
View Scheme
1,4-dimethoxy-2-methylnaphthalene
53772-19-3

1,4-dimethoxy-2-methylnaphthalene

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: titanium tetrachloride / dichloromethane / 2.17 h / -45 - 0 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
2.2: 2.25 h / 0 °C
2.3: 0.67 h / Reflux
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 14 h / Inert atmosphere
4.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
5.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
6.1: iodine / chloroform / 6 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 12 h / Inert atmosphere
8.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
9.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
10.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1.1: titanium tetrachloride / dichloromethane / 2.17 h / -45 - 0 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
2.2: 2.25 h / 0 °C
2.3: 0.67 h / Reflux
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 14 h / Inert atmosphere
4.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
5.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
6.1: iodine / chloroform / 6 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 12 h / Inert atmosphere
8.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
9.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
10.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: tin(IV) chloride / 1,2-dichloro-ethane / 20 - 80 °C
2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
3: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: tin(IV) chloride / 1,2-dichloro-ethane / 5 h / 80 °C
2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
3: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
4: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
1,4-dimethoxynaphthalene-3-methyl-2-carboxaldehyde
17827-40-6

1,4-dimethoxynaphthalene-3-methyl-2-carboxaldehyde

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
1.2: 2.25 h / 0 °C
1.3: 0.67 h / Reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 14 h / Inert atmosphere
3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
4.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
5.1: iodine / chloroform / 6 h / 20 °C
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 12 h / Inert atmosphere
7.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
8.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
1.2: 2.25 h / 0 °C
1.3: 0.67 h / Reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 14 h / Inert atmosphere
3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
4.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
5.1: iodine / chloroform / 6 h / 20 °C
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 12 h / Inert atmosphere
7.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
8.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
9.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
(1,4-dimethoxy-3-methylnaphthalen-2-yl)acetaldehyde
51794-08-2

(1,4-dimethoxy-3-methylnaphthalen-2-yl)acetaldehyde

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 14 h / Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
3.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4.1: iodine / chloroform / 6 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 12 h / Inert atmosphere
6.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
7.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
8.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 14 h / Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
3.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4.1: iodine / chloroform / 6 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 12 h / Inert atmosphere
6.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
7.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
8.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-enoic acid ethyl ester

4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-enoic acid ethyl ester

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: iodine / chloroform / 6 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: 12 h / Inert atmosphere
5.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
6.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
7.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: iodine / chloroform / 6 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: 12 h / Inert atmosphere
5.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
6.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
7.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
2-[3-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-1-methylpropenyl][1,3]dithiane

2-[3-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-1-methylpropenyl][1,3]dithiane

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
(E)-4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-en-1-ol
94828-29-2

(E)-4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-en-1-ol

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: iodine / chloroform / 6 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 12 h / Inert atmosphere
4.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
5.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: iodine / chloroform / 6 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 12 h / Inert atmosphere
4.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
5.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
6.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-enal
99306-85-1

4-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylbut-2-enal

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iodine / chloroform / 6 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 12 h / Inert atmosphere
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: iodine / chloroform / 6 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 12 h / Inert atmosphere
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
2-(2,6,10-trimethylundeca-1,5,9-trienyl)[1,3]dithiane

2-(2,6,10-trimethylundeca-1,5,9-trienyl)[1,3]dithiane

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: sodium methylate / methanol / 4 h / 0 °C
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: triphenylphosphine; bromine / dichloromethane / 0 °C
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 12 h / Inert atmosphere
7.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
8.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
2.1: sodium methylate / methanol / 4 h / 0 °C
3.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
4.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
5.1: triphenylphosphine; bromine / dichloromethane / 0 °C
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 12 h / Inert atmosphere
7.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
8.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
9.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
menadione
58-27-5

menadione

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: water; sodium dithionite / ethyl acetate; water / Inert atmosphere
2.1: potassium carbonate / acetone / 6 h / Reflux
3.1: titanium tetrachloride / dichloromethane / 2.17 h / -45 - 0 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
4.2: 2.25 h / 0 °C
4.3: 0.67 h / Reflux
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
5.2: 14 h / Inert atmosphere
6.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
7.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
8.1: iodine / chloroform / 6 h / 20 °C
9.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
9.2: 12 h / Inert atmosphere
10.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
11.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
12.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: water; sodium dithionite / ethyl acetate / Inert atmosphere
2.1: potassium carbonate / acetone / 6 h / Reflux
3.1: titanium tetrachloride / dichloromethane / 2.17 h / -45 - 0 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
4.2: 2.25 h / 0 °C
4.3: 0.67 h / Reflux
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
5.2: 14 h / Inert atmosphere
6.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / Inert atmosphere
7.1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
8.1: iodine / chloroform / 6 h / 20 °C
9.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
9.2: 12 h / Inert atmosphere
10.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
11.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
12.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium dithionite / ethyl acetate; water / 0.33 h / 20 °C / Inert atmosphere
2: potassium carbonate / acetone / 6 h / Reflux
3: tin(IV) chloride / 1,2-dichloro-ethane / 20 - 80 °C
4: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / -20 °C
5: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
6: ammonium cerium (IV) nitrate / water; acetonitrile / 0.75 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium dithionite / ethyl acetate; water / 0.33 h / 20 °C / Inert atmosphere
2: potassium carbonate / acetone / 6 h / Reflux
3: tin(IV) chloride / 1,2-dichloro-ethane / 5 h / 80 °C
4: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C
5: (1,2-bis(diphenylphosphanyl)ethane)dichloridopalladium(II); lithium triethylborohydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
6: ammonium cerium (IV) nitrate / water; acetonitrile; dichloromethane / 0.75 h / 0 °C
View Scheme
Farnesal
502-67-0

Farnesal

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: iodine / chloroform / 6 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: sodium methylate / methanol / 4 h / 0 °C
4.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
5.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
6.1: triphenylphosphine; bromine / dichloromethane / 0 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 12 h / Inert atmosphere
8.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
9.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
10.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1.1: iodine / chloroform / 6 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
3.1: sodium methylate / methanol / 4 h / 0 °C
4.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
5.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
6.1: triphenylphosphine; bromine / dichloromethane / 0 °C
7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 12 h / Inert atmosphere
8.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
9.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
10.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
acetic acid 3,7,11-trimethyl-12-[2-(2,6,10-trimethylundeca-1,5,9-trienyl)[1,3]dithian-2-yl]-dodeca-2,6,10-trienyl ester

acetic acid 3,7,11-trimethyl-12-[2-(2,6,10-trimethylundeca-1,5,9-trienyl)[1,3]dithian-2-yl]-dodeca-2,6,10-trienyl ester

menaquinone-7
2124-57-4

menaquinone-7

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium methylate / methanol / 4 h / 0 °C
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: triphenylphosphine; bromine / dichloromethane / 0 °C
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 12 h / Inert atmosphere
6.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
7.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
8.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium methylate / methanol / 4 h / 0 °C
2.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
3.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
4.1: triphenylphosphine; bromine / dichloromethane / 0 °C
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 12 h / Inert atmosphere
6.1: Dess-Martin periodane; water / dichloromethane; acetonitrile / 20 °C
7.1: hydrazine; potassium hydroxide / diethylene glycol / 4 h / 60 - 215 °C / Inert atmosphere; Reflux
8.1: ammonium cerium (IV) nitrate / acetonitrile / 4.08 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

propionic acid anhydride
123-62-6

propionic acid anhydride

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl dipropionate
1453189-07-5

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl dipropionate

Conditions
ConditionsYield
With sodium acetate; zinc at 130℃; for 0.5h;66%
With sodium acetate; zinc at 130℃; for 0.5h;66%
menaquinone-7
2124-57-4

menaquinone-7

benzoic acid anhydride
93-97-0

benzoic acid anhydride

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-octacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl dibenzoate
1453189-00-8

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-octacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl dibenzoate

Conditions
ConditionsYield
With sodium acetate; zinc at 140℃; for 1h;50%
Stage #1: menaquinone-7; benzoic acid anhydride With sodium acetate; zinc at 140℃; for 1h;
Stage #2: With diethylamine In tetrahydrofuran at 20℃; for 1h;
50%
menaquinone-7
2124-57-4

menaquinone-7

4-(trifluoromethyl)benzoic anhydride
25753-16-6

4-(trifluoromethyl)benzoic anhydride

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl bis(4-(trifluoromethyl)benzoate)
1453189-14-4

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-diyl bis(4-(trifluoromethyl)benzoate)

Conditions
ConditionsYield
With sodium acetate; zinc at 170℃; for 23h;11%
Stage #1: menaquinone-7; 4-(trifluoromethyl)benzoic anhydride With sodium acetate; zinc at 170℃; for 23h;
Stage #2: With diethylamine In tetrahydrofuran at 20℃; for 1h;
11%
menaquinone-7
2124-57-4

menaquinone-7

acetic anhydride
108-24-7

acetic anhydride

1,4-diacetoxy-2-methyl-3-(3,7,11,15,19,23,27-heptamethyl-octacosaheptaen-(2t,6t,10t,14t,18t,22t,26)-yl)-naphthalene
122726-03-8

1,4-diacetoxy-2-methyl-3-(3,7,11,15,19,23,27-heptamethyl-octacosaheptaen-(2t,6t,10t,14t,18t,22t,26)-yl)-naphthalene

Conditions
ConditionsYield
With sodium acetate; zinc
With sodium acetate; zinc
menaquinone-7
2124-57-4

menaquinone-7

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-2-methylnaphthalen-1-yl benzoate
1453189-02-0

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-2-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-((diethoxyphosphoryl)oxy)-2-((2E,6E, 10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate
1453189-03-1

4-((diethoxyphosphoryl)oxy)-2-((2E,6E, 10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-((diethoxyphosphoryl)oxy)-3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methylnaphthalen-1-yl benzoate
1453189-04-2

4-((diethoxyphosphoryl)oxy)-3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-(((tert-butoxycarbonyl)glycyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate
1453189-05-3

4-(((tert-butoxycarbonyl)glycyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-(((tert-butoxycarbonyl)-L-valyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate
1453189-06-4

4-(((tert-butoxycarbonyl)-L-valyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-3-methylnaphthalen-1-yl propionate
1453189-08-6

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-3-methylnaphthalen-1-yl propionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-((diethoxyphosphoryl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl propionate
1453189-10-0

4-((diethoxyphosphoryl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl propionate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3: triethylamine / dichloromethane / 20 h / 0 - 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl (tert-butoxycarbonyl)-L-valinate

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl (tert-butoxycarbonyl)-L-valinate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-(((tert-butoxycarbonyl)glycyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl propionate
1453189-12-2

4-(((tert-butoxycarbonyl)glycyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl propionate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl 3-((tert-butoxycarbonyl)amino)propanoate
1453189-13-3

3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl 3-((tert-butoxycarbonyl)amino)propanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

4-((3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl)oxy)-4-oxobutanoic acid
1453189-15-5

4-((3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methyl-4-(propionyloxy)naphthalen-1-yl)oxy)-4-oxobutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
3: dmap / dichloromethane / 3.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium acetate; zinc / 0.5 h / 130 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
3: dmap / dichloromethane / 3.5 h / 20 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-3-methylnaphthalen-1-yl benzoate
1453189-01-9

2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-3-methylnaphthalen-1-yl benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; zinc / 1 h / 140 °C
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium acetate; zinc / 1 h / 140 °C
1.2: 1 h / 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 h / 50 °C
View Scheme
menaquinone-7
2124-57-4

menaquinone-7

acetic anhydride
108-24-7

acetic anhydride

acetic acid 3-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-4-hydroxy-2-methyl-naphthalen-1-yl ester

acetic acid 3-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-4-hydroxy-2-methyl-naphthalen-1-yl ester

Conditions
ConditionsYield
With sodium acetate; zinc for 0.5h; Inert atmosphere; Reflux;

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