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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hangzhou Think Chemical Co. Ltd

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one CAS:224789-21-3 Name 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one Molecular Structure

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazol[5,1-f][1,2,4]-triazin-4-one

Cas:224789-21-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one

Cas:224789-21-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

CAS No.224789-21-3 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S

CAS No.224789-21-3 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 224789-21-3 with best quality

Cas:224789-21-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-(2-ethoxyphenyl)-5-methyl-7-propyl- 224789-21-3

Cas:224789-21-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Vardenafil intermediate,2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE CAS:224789-21-3

Cas:224789-21-3

Min.Order:1 Kilogram

FOB Price: $21.0 / 24.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-(2-ethoxyphenyl)-5-methyl-7-propyl-

Cas:224789-21-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:224789-21-3

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Cas:224789-21-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-(2-ethoxyphenyl)-5-methyl-7-propyl-

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazol[5,1-F][1,2,4]-Triazin-4-One

Cas:224789-21-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

224789-21-3 C17H20N4O2 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONEAppearance:white powder Storage:Normal temperature Package:according to customers' requirements Application:Heterocyclic Compou

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-(2-ethoxyphenyl)-5-methyl-7-propyl-

Cas:224789-21-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-f][1,2,4]Triazin-4(3H)-One CAS No.:224789-21-3 Molecule Formula:C17H20N4O2 Molecule Weight:312.36 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Sta

High Quality 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-f][1,2,4]Triazin-4(3H)-One in stock

Cas:224789-21-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-(2-Ethoxyphenyl)-5-Methyl-7-propyl-3H-iMidazo[5,1-f][1,2,4]triazin-4-one

Cas:224789-21-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CAS No.224789-21-3 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

CAS No.224789-21-3 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

CAS No.224789-21-3 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-(2-ethoxyphenyl)-5-methyl-7-propyl-

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazol[5,1-f][1,2,4]-triazin-4-one

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazol[5,1-F][1,2,4]-Triazin-4-One

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Cas:224789-21-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide
927690-90-2

N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With trichlorophosphate In toluene for 2h; Reflux;78%
With trichlorophosphate
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux;
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux;
3-(2-ethoxy-benzoylamino)-5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-90-2

3-(2-ethoxy-benzoylamino)-5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h;72%
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h; Sealed tube;72%
5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-88-8

5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C
1.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C
2.1: 52 percent / pyridine / 2 h / 60 °C
3.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
3-amino-5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-89-9

3-amino-5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 52 percent / pyridine / 2 h / 60 °C
2: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate
146650-89-7

ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 53 percent / ammonium hydroxide / 24 h / 130 °C
2.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C
2.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C
3.1: 52 percent / pyridine / 2 h / 60 °C
4.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
2-butyrylaminopropionic acid
59875-04-6

2-butyrylaminopropionic acid

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py; DMAP
2: POCl3
View Scheme
Multi-step reaction with 3 steps
1.1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: 3.25 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux
2: ethanol / 3 h / Reflux
3: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: AlMeClNH2
2: N2H4
3: POCl3
View Scheme
Multi-step reaction with 3 steps
1.1: trimethylaluminum; ammonium chloride / toluene / 7 h / 0 - 80 °C
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: 3.25 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: amino(methyl)aluminum chloride / toluene / 6 h / 80 °C
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: Reflux
3.1: ethanol / 3 h / Reflux
4.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxy-benzamidine hydrochloride
18637-00-8

2-ethoxy-benzamidine hydrochloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N2H4
2: POCl3
View Scheme
ethyl 3-butyramido-2-oxobutyrate
68282-26-8

ethyl 3-butyramido-2-oxobutyrate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3
View Scheme
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: 3.25 h / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 3 h / Reflux
2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxybenzimidohydrazide
889943-46-8

2-ethoxybenzimidohydrazide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 3 h / Reflux
2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
C9H13N3O*ClH

C9H13N3O*ClH

ethyl 3-butyramido-2-oxobutyrate
68282-26-8

ethyl 3-butyramido-2-oxobutyrate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Stage #1: C9H13N3O*ClH; ethyl 3-butyramido-2-oxobutyrate In ethanol at 70℃; for 4h;
Stage #2: With trichlorophosphate In 1,2-dichloro-ethane for 2h; Heating / reflux;
2-butyrylaminopropionic acid
59875-04-6

2-butyrylaminopropionic acid

2-ethoxy-benzamidine hydrochloride
18637-00-8

2-ethoxy-benzamidine hydrochloride

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With pyridine; sodium hydrogencarbonate; hydrazine hydrate; trichlorophosphate In tetrahydrofuran; ethanol; ethyl acetate; 1,2-dichloro-ethane4.00 g (28%)
3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one
1417529-52-2

3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / Reflux; Inert atmosphere
2.1: ammonia / tetrahydrofuran / 20 °C
3.1: tertiary amine / dichloromethane / 0.08 h / Cooling
3.2: 1.17 h / 0 - 20 °C
4.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one
1417529-54-4

6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonia / tetrahydrofuran / 20 °C
2.1: tertiary amine / dichloromethane / 0.08 h / Cooling
2.2: 1.17 h / 0 - 20 °C
3.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
C13H16N4O2
1417529-56-6

C13H16N4O2

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tertiary amine / dichloromethane / 0.08 h / Cooling
1.2: 1.17 h / 0 - 20 °C
2.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
2-Ethoxybenzamidine
53623-81-7

2-Ethoxybenzamidine

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: 3.25 h / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: Reflux
2.1: ethanol / 3 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride
224789-26-8

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

Conditions
ConditionsYield
With chlorosulfonic acid at 0 - 20℃;91%
With chlorosulfonic acid for 12h; Cooling with ice;76%
With chlorosulphuric acid for 12h; Cooling with ice;76%
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-(2-ethoxy-5-iodo-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one

2-(2-ethoxy-5-iodo-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one

Conditions
ConditionsYield
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;79%
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;79%
With N-iodo-succinimide In trifluoroacetic acid at 0 - 20℃;71%
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-(2-ethoxy)-phenyl-5-methyl-7-n-propyl-3H-imidazolo[5,1-f][1,2,4]triazine-4-thione

2-(2-ethoxy)-phenyl-5-methyl-7-n-propyl-3H-imidazolo[5,1-f][1,2,4]triazine-4-thione

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With pyridine; diphosphorus pentasulfide In toluene for 6h; Reflux;
Stage #2: With ammonia; water In ethanol for 0.5h; Reflux;
72%
With pyridine; tetraphosphorus decasulfide for 6h; Reflux;72%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil
224785-90-4

vardenafil

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h;
Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity;
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

citric acid
77-92-9

citric acid

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil citrate
1193386-64-9

vardenafil citrate

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at -5 - 20℃;
Stage #2: 4-ethylpiperazine With sodium hydroxide In tetrahydrofuran; water at 15℃; pH=9 - 9.5;
Stage #3: citric acid In tetrahydrofuran at 50 - 70℃;
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil
224785-90-4

vardenafil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: chlorosulfonic acid / -5 - 20 °C
1.2: 15 °C / pH 9 - 9.5
1.3: 50 - 70 °C
2.1: sodium hydroxide / water / pH 9 - 10
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride

2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chlorosulfonic acid / -5 - 20 °C
1.2: 15 °C / pH 9 - 9.5
1.3: 50 - 70 °C
2.1: sodium hydroxide / water / pH 9 - 10
3.1: hydrogenchloride / water; acetone
View Scheme
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
3: hydrogenchloride; water / acetone
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]
1255919-03-9

2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

N-{[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl) phenyl]sulfonyl}glycene
448184-54-1

N-{[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl) phenyl]sulfonyl}glycene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: chlorosulfonic acid / 0 - 5 °C
2.1: sodium hydroxide / water / 0.5 h / 25 - 30 °C
2.2: 2.5 h / 2 - 20 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

C19H26N6O4S
448184-52-9

C19H26N6O4S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

{[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid
448184-56-3

{[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
3: triethylamine / 0.25 h / 25 - 30 °C
4: water; sodium hydroxide / methanol / 0.25 h / 25 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

C23H30N6O7S

C23H30N6O7S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
3: triethylamine / 0.25 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide
448184-48-3

2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
3: peracetic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-{2-ethoxy-5-[(3-oxo-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f]-1,2,4-triazin-4(3H)-one
448184-58-5

2-{2-ethoxy-5-[(3-oxo-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f]-1,2,4-triazin-4(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 0.5 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil hydrochloride

vardenafil hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C
2: dichloromethane
3: hydrogenchloride / water; acetone / 50 °C
View Scheme

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