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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Resatorvid manufacturer/supplier

Cas:243984-11-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

RESATORVID

Cas:243984-11-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 243984-11-4 with competitive price

Cas:243984-11-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

Cas:243984-11-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

TAK-242 Resatorvid cas 243984-11-4

Cas:243984-11-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

High Quality Resatorvid(TAK-242) 243984-11-4 in stock fast delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:according to customers' requirements Application:APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Resatorvid

Cas:243984-11-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

243984-11-4 CAS NO.243984-11-4

Cas:243984-11-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Resatorvid

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

High Quality Resatorvid(TAK-242) 243984-11-4 in stock fast delivery good supplier

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec TAK-242 100mg

Cas:243984-11-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

TAK-242(Resatorvid)

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Resatorvid CAS No.243984-11-4

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

TAK-242(Resatorvid)  

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

243984-11-4

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

243984-11-4 (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylateAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by ex

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

RESATORVID

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

TAK-242

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

RESATORVID

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

Resatorvid

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Qingdao little fox Biological &Technology Co.,Ltd

High Quality Resatorvid(TAK-242) 243984-11-4 in stock fast delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:25kg/drum Application:APIs Transportation:APIs

High Quality Resatorvid(TAK-242) 243984-11-4 in stock fast delivery good supplier

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

TAK-242 (Resatorvid)

Cas:243984-11-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Luspharm Trading Co.,Ltd

Our strength We have clients throughout the world: Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire. Our Laboratoy We have our own independent lab test center: This ma

RESATORVID

Cas:243984-11-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

RESATORVID Basic information Pr

RESATORVID

Cas:243984-11-4

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

Resatorvid

Cas:243984-11-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Mingqi Chemical Co., Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Our advantages:1, High quality with competitive price:1) Standard:BP/USP/EP/Enterprise standard2) All Purity≥99%3) We are manufacturer a

Factory Direct Sales Low Price Resatorvid(TAK-242)

Cas:243984-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

wolcase-chem

Shenzhen WOLCASE Pharmaceutical Co. Ltd. is committed to the field of medical science to provide quality products and services. The product mainly includes the medicine industry raw material medicine, the intermediate, the deuterium material, impu

Tak-242(resatorvid) CAS NO.243984-11-4

Cas:243984-11-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid
890155-18-7

(6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid

ethanol
64-17-5

ethanol

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 19h; Heating;72%
ethyl (6R)-6-{[[(2S)-2-(acetyloxy)-2-phenylacetyl]-(2-chloro-4-fluorophenyl)amino]sulfonyl}cyclohex-1-ene-1-carboxylate
415679-88-8

ethyl (6R)-6-{[[(2S)-2-(acetyloxy)-2-phenylacetyl]-(2-chloro-4-fluorophenyl)amino]sulfonyl}cyclohex-1-ene-1-carboxylate

A

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

B

acetic acid (2-chloro-4-fluoro-phenylcarbamoyl)-phenyl-methyl ester

acetic acid (2-chloro-4-fluoro-phenylcarbamoyl)-phenyl-methyl ester

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 0℃; for 2h;A 68%
B n/a
acetoxymethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
890155-23-4

acetoxymethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethanol
64-17-5

ethanol

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 25h; Heating;65%
(1'S)-1'phenylethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
890155-19-8

(1'S)-1'phenylethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethanol
64-17-5

ethanol

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 26h; Heating;37%
ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
243983-70-2

ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

A

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

B

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
HPLC-CHIRALPAK AD;A 634 mg
B 681 mg
ethyl (6R)-6-({(2-chloro-4-fluoro-phenyl)-[(2R)-4-methoxy-2-methyl-4-oxobutanoyl]amino}sulfonyl)cyclohex-1-ene-1-carboxylate

ethyl (6R)-6-({(2-chloro-4-fluoro-phenyl)-[(2R)-4-methoxy-2-methyl-4-oxobutanoyl]amino}sulfonyl)cyclohex-1-ene-1-carboxylate

A

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

B

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 0℃; for 2h; Title compound not separated from byproducts.;
ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate
243984-26-1

ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / Et3N / ethyl acetate
2: 634 mg / HPLC-CHIRALPAK AD
View Scheme
2-(ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid
243984-25-0

2-(ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2 / 14 h / Heating
2: 78 percent / Et3N / ethyl acetate
3: 634 mg / HPLC-CHIRALPAK AD
View Scheme
(6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid
340722-43-2

(6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / Cs2CO3; tetrabutylammonium iodide / acetonitrile / 2.5 h / 52 - 55 °C
2: Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
3: 72 percent / H2SO4 / 19 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 72 percent / Cs2CO3; tetrabutylammonium iodide / acetonitrile / 2.5 h / 52 - 55 °C
2: 48 percent / Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
3: 65 percent / H2SO4 / 25 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 32 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 7 h
2: 84 percent / H2; AcOH / Pd/C / 2 h / atmospheric pressure
3: 72 percent / H2SO4 / 19 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 32 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 6 h
2: 37 percent / H2SO4 / 26 h / Heating
View Scheme
ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
243983-70-2

ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 74 percent / Ba(OH)2*8H2O / acetonitrile / 1 h / 60 °C
2: 72 percent / Cs2CO3; tetrabutylammonium iodide / acetonitrile / 2.5 h / 52 - 55 °C
3: Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
4: 72 percent / H2SO4 / 19 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 74 percent / Ba(OH)2*8H2O / acetonitrile / 1 h / 60 °C
2: 72 percent / Cs2CO3; tetrabutylammonium iodide / acetonitrile / 2.5 h / 52 - 55 °C
3: 48 percent / Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
4: 65 percent / H2SO4 / 25 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 74 percent / Ba(OH)2*8H2O / acetonitrile / 1 h / 60 °C
2: 32 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 7 h
3: 84 percent / H2; AcOH / Pd/C / 2 h / atmospheric pressure
4: 72 percent / H2SO4 / 19 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 74 percent / Ba(OH)2*8H2O / acetonitrile / 1 h / 60 °C
2: 32 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 6 h
3: 37 percent / H2SO4 / 26 h / Heating
View Scheme
acetoxymethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
340722-42-1

acetoxymethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
2: 72 percent / H2SO4 / 19 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 48 percent / Lipase PS-D / acetone; H2O / 17.5 h / 28 °C
2: 65 percent / H2SO4 / 25 h / Heating
View Scheme
(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
890155-20-1

(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / H2; AcOH / Pd/C / 2 h / atmospheric pressure
2: 72 percent / H2SO4 / 19 h / Heating
View Scheme
ethyl 2-mercaptocyclohex-1-ene-1-carboxylate
54928-91-5

ethyl 2-mercaptocyclohex-1-ene-1-carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / Cl2(gas); aq. AcOH / 0.83 h / 15 °C
2: 78 percent / Et3N / ethyl acetate
3: 634 mg / HPLC-CHIRALPAK AD
View Scheme
Multi-step reaction with 4 steps
1: sodium trioxoboran tetrahydrate; AcOH / 12 h / 50 - 85 °C
2: SOCl2 / 14 h / Heating
3: 78 percent / Et3N / ethyl acetate
4: 634 mg / HPLC-CHIRALPAK AD
View Scheme
ethyl 2-oxocyclohexane carboxylate
1655-07-8

ethyl 2-oxocyclohexane carboxylate

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: H2S(gas) / ethanol / 2 h / -50 °C
1.2: HCl(gas) / ethanol / 2 h / -20 °C
1.3: 73 percent / H2S(gas) / ethanol / 16 h / -20 °C
2.1: 74 percent / Cl2(gas); aq. AcOH / 0.83 h / 15 °C
3.1: 78 percent / Et3N / ethyl acetate
4.1: 634 mg / HPLC-CHIRALPAK AD
View Scheme
Multi-step reaction with 5 steps
1.1: H2S(gas) / ethanol / 2 h / -50 °C
1.2: HCl(gas) / ethanol / 2 h / -20 °C
1.3: 73 percent / H2S(gas) / ethanol / 16 h / -20 °C
2.1: sodium trioxoboran tetrahydrate; AcOH / 12 h / 50 - 85 °C
3.1: SOCl2 / 14 h / Heating
4.1: 78 percent / Et3N / ethyl acetate
5.1: 634 mg / HPLC-CHIRALPAK AD
View Scheme
ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate
243984-26-1

ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate

2-chloro-4-fluoroaniline
2106-02-7

2-chloro-4-fluoroaniline

A

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

B

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

ethyl (6S)-6-[N-(2-chloro-4-fluoro-phenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0℃; for 14.5h;
C29H34ClFN4O8S2

C29H34ClFN4O8S2

A

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

B

C20H22ClFN4O4S

C20H22ClFN4O4S

Conditions
ConditionsYield
With water at 37℃; pH=7.4;
ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-(phenylsulfonyl)-7-azido-2-heptanol
1346434-25-0

1-(phenylsulfonyl)-7-azido-2-heptanol

C29H34ClFN4O8S2

C29H34ClFN4O8S2

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 1-(phenylsulfonyl)-7-azido-2-heptanol With pyridine In tetrahydrofuran
Stage #2: ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate With triethylamine In tetrahydrofuran
26%
ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

1-(phenylsulfonyl)-7-azido-2-heptyl chloroformate
1346434-36-3

1-(phenylsulfonyl)-7-azido-2-heptyl chloroformate

ethyl 6-((N-((7-azido-1-(phenylsulfonyl)heptan-2-yl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

ethyl 6-((N-((7-azido-1-(phenylsulfonyl)heptan-2-yl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 2h;26%
ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

1-(phenylsulfonyl)-7-azido-2-heptyl chloroformate
1346434-36-3

1-(phenylsulfonyl)-7-azido-2-heptyl chloroformate

C29H34ClFN4O8S2

C29H34ClFN4O8S2

Conditions
ConditionsYield
With trimethylamine In tetrahydrofuran at 20℃; for 2h;
ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate
243984-11-4

ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate

C7H12ClN3O2
1346453-80-2

C7H12ClN3O2

A

(S)-ethyl 6-(N-(((6-azidohexyl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

(S)-ethyl 6-(N-(((6-azidohexyl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

B

(R)-ethyl 6-(N-(((6-azidohexyl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

(R)-ethyl 6-(N-(((6-azidohexyl)oxy)carbonyl)-N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 3h; Reagent/catalyst;

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