CAS No.2647-50-9,Flubromazepam Suppliers

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Synthetic route

: 1647-74-1
5-bromo-2-bromoacetamido-2'-fluorobenzophenone

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
With ammonia In methanol for 16h; Heating / reflux;	56.8%
With ammonia for 5h; Heating;	4.5 g
With ammonia In methanol for 18h;	98.6 mg
With ammonia In methanol at 0 - 20℃;	68 mg

: 1479-58-9
5-bromo-2'-fluoro-2-aminobenzophenone

: 598-21-0
2-Bromoacetyl bromide

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Stage #1: 5-bromo-2'-fluoro-2-aminobenzophenone; 2-Bromoacetyl bromide With sodium hydrogencarbonate In dichloromethane Stage #2: With ammonia In methanol Heating / reflux;
Stage #1: 5-bromo-2'-fluoro-2-aminobenzophenone; 2-Bromoacetyl bromide With sodium hydrogencarbonate In dichloromethane Stage #2: With ammonia In methanol Heating / reflux;

: 2824-08-0
N(1)-[4-bromo-2-[(2-fluorophenyl)carbonyl]phenyl]glycinamide

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
With acetic acid In ethanol for 0.25h; Heating / reflux;

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 2: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 3: ammonia / methanol / 18 h View Scheme

: 1479-58-9
5-bromo-2'-fluoro-2-aminobenzophenone

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2: ammonia / methanol / 18 h View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / dichloromethane; water / 2 h / 0 °C 2: ammonia / methanol / 0 - 20 °C View Scheme

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 50 °C 1.2: pH Ca. 4 2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 4.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 5.1: ammonia / methanol / 18 h View Scheme

Yield

Multi-step reaction with 5 steps
1.1: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 50 °C
1.2: pH Ca. 4
2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere
4.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
5.1: ammonia / methanol / 18 h
View Scheme

: 74189-16-5
2-amino-5-bromobenzoic acid hydrochloride

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 3: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 4: ammonia / methanol / 18 h View Scheme

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 10329-38-1
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide

Conditions

Conditions	Yield
With peracetic acid In dichloromethane for 4.5h; Ambient temperature;	80.9%

: 123-38-6
propionaldehyde

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 7-bromo-5-(2-fluorophenyl)-4-propyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 4h; Stage #2: propionaldehyde In methanol at 20℃;	62%

: 2999-46-4
Ethyl isocyanoacetate

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 612526-24-6
ethyl 8-bromo-6-(2'-fluorophenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With diethyl chlorophosphate In tetrahydrofuran at 0℃; for 0.5h; Stage #3: Ethyl isocyanoacetate In tetrahydrofuran at 0℃; for 1h;	58%
Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: With diethyl chlorophosphate In tetrahydrofuran at 0℃; for 0.5h; Stage #3: Ethyl isocyanoacetate With sodium hydride; acetic acid more than 3 stages;

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 1066-54-2
trimethylsilylacetylene

: 5-(2-fluoro-phenyl)-7-trimethylsilylacetyleno-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Conditions

Conditions	Yield
With triethylamine; bis(triphenylphosphine) palladium (Il) acetate In acetonitrile for 3h; Heating / reflux;	47%
With triethylamine In acetonitrile for 3h; Heck Reaction; Heating / reflux;	47%

: 1068-57-1
acetic acid hydrazide

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 612526-40-6
flubromazolam

Conditions

Conditions	Yield
Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: With di-morpholin-4-yl-phosphinic acid chloride In tetrahydrofuran at 0 - 20℃; for 2h; Stage #3: acetic acid hydrazide In tetrahydrofuran; butan-1-ol at 20℃; for 2.25h; Heating / reflux;	40%

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: Acetic acid 7-bromo-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80.9 percent / 40percent peroxyacetic acid / CH2Cl2 / 4.5 h / Ambient temperature 2: 6.5 g / 3 h / 0 °C View Scheme

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 62659-65-8
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80.9 percent / 40percent peroxyacetic acid / CH2Cl2 / 4.5 h / Ambient temperature 2: 6.5 g / 3 h / 0 °C 3: 3.3 g / 1 N NaOH / methanol / 0.5 h / 25 °C View Scheme

: 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 885124-07-2
7-bromo-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;

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