Taizhou FremChem Co. Ltd. is a high-tech enterprise located in China Medical City specializing in R&D, manufacturing, sales of new APIS, pharmaceutical intermediates and fine chemicals. All of our company is committed to provide high quality chemical
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:272-49-1
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryCAS 272-49-1 4-Azaindole Product Description Product Name 4-Azaindole CAS No.
Cas:272-49-1
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inquiryHigh quality 4-Azaindole CAS 272-49-1 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, F
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:According to the demand o
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla
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inquiry4-Azaindole CAS:272-49-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
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Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:272-49-1
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:272-49-1
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inquiryProduct Name: 4-Azaindole Synonyms: 4-AZAINDOLE;1H-PYRROLO[3.2-B]PYRIDINE;1,4-DIAZAINDENE;4-AZAINDOLE, 98+%;4-Aza-1H-indole;4-Azaindole,1H-pyrrolo[3,2-b]pyridine;4-Azindole;Pyrrolo Pyridine derivative CAS: 272-49-1 MF: C7H6N2 MW: 118.1
Cas:272-49-1
Min.Order:1 Gram
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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1-(1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With potassium carbonate In methanol | 100% |
2-((trimethylsilyl)ethynyl)pyridin-3-amine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran; acetonitrile at 20℃; for 2h; | 97% |
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20℃; for 5h; | 70% |
2-(3-nitro-2-pyridinyl)-N,N-dimethyletheneamine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal | 95% |
With formic acid; palladium 10% on activated carbon In methanol for 4h; Inert atmosphere; | 71% |
With hydrogenchloride; iron In 1,4-dioxane; methanol at 80℃; for 3h; | |
With palladium 10% on activated carbon; hydrogen In ethanol | 15 mg |
2-(3-nitropyridin-2-yl)acetonitrile
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; | 89% |
With palladium 10% on activated carbon; hydrogen at 20℃; for 24h; | 85% |
With hydrogen; sodium hydrogencarbonate; palladium In ethanol; water; acetic acid | 68% |
With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol at 20℃; under 2844.39 Torr; for 24h; | 68% |
(E)-3-amino-2-(2-ethoxyethenyl)pyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 2h; Heating; | 88% |
(2-trimethylsilanylethynylpyridin-3-yl) carbamic acid tert-butyl ester
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 8h; Heating / reflux; | 79% |
(E)-N,N-dimethyl-2-(3-nitropyridin-2-yl)ethenamine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With formic acid; palladium 10% on activated carbon In methanol for 4h; Inert atmosphere; | 71% |
With hydrogen; palladium on activated charcoal | 37% |
With formic acid; palladium on activated charcoal In methanol for 4h; | 0.31 g |
With formic acid; palladium 10% on activated carbon In methanol for 4h; Inert atmosphere; | |
With iron(III) chloride; hydrazine hydrate In methanol; water at 25 - 70℃; |
2-ethenyl-3-nitropyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 1,10-Phenanthroline; carbon monoxide In acetonitrile at 120℃; under 4560.31 Torr; for 42h; | 65% |
(2-Trimethylsilanylethynyl-pyridin-3-yl)carbamic acid ethyl ester
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 1h; Heating / reflux; | 63.5% |
With sodium ethanolate In ethanol for 1h; Heating / reflux; | 63.5% |
With sodium ethanolate In ethanol Heating; Yield given; |
3-amino-2-(2,2-diethoxyethyl)pyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 1h; Heating; | 56% |
tert-butyl N-(2-methylpyridin-3-yl)carbamate
N,N-dimethyl-formamide
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: tert-butyl N-(2-methylpyridin-3-yl)carbamate With n-butyllithium In tetrahydrofuran; hexane at -15 - 0℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at 0 - 20℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane at 45℃; Cooling; | 40% |
N-(2-methyl-[3]pyridyl)-formamide
potassium ethoxide
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
at 350℃; |
N-(2-methyl-[3]pyridyl)-formamide
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With potassium ethoxide at 350℃; |
Conditions | Yield |
---|---|
With potassium tert-butylate 1.) Et2O, NH3 liquid, -33 deg C, 2.) Et2O, NH3 liquid, irrad., -33 deg C, 100 min.; Yield given. Multistep reaction; |
2-(2,2-diethoxyethyl)-3-nitropyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium on activated charcoal | |
Multi-step reaction with 2 steps 1: 80 percent / H2 / 5 percent Pd-C / ethanol / Ambient temperature 2: 56 percent / conc. HCl / ethanol / 1 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 50 percent / triethylamine; CuI / Pd(PPh3)4 / acetonitrile / 4 h / 20 °C 2: 60 percent / tin(II) chloride dihydrate; NH4Cl / ethanol / 4 h / 60 °C 3: 70 percent / potassium tert-butoxide / 1-methyl-pyrrolidin-2-one / 5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide 1.2: 50 percent / dimethylformamide / 1 h 2.1: 86 percent / aq. HCl / 8 h / Heating 3.1: dimethylformamide / 4.25 h / 90 °C 4.1: 0.31 g / HCOOH / Pd/C / methanol / 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 43 percent / K2CO3 / (PPh3)4Pd / dioxane / 48 h / Heating 2: dimethylformamide / 4.25 h / 90 °C 3: 0.31 g / HCOOH / Pd/C / methanol / 4 h View Scheme |
3-nitro-2-[2-(trimethylsilyl)ethynyl]pyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 60 percent / tin(II) chloride dihydrate; NH4Cl / ethanol / 4 h / 60 °C 2: 70 percent / potassium tert-butoxide / 1-methyl-pyrrolidin-2-one / 5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaOEt / ethanol 2: 1.) H2; 2.) HCl / 1.) Pd/C View Scheme | |
Multi-step reaction with 3 steps 1: ethanol / 3 h / Heating 2: 80 percent / H2 / 5 percent Pd-C / ethanol / Ambient temperature 3: 56 percent / conc. HCl / ethanol / 1 h / Heating View Scheme |
2-methyl-3-nitropyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylformamide / 4.25 h / 90 °C 2: 0.31 g / HCOOH / Pd/C / methanol / 4 h View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent 2: 95 percent / H2 / Pd/C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere 2: formic acid / palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere View Scheme |
diethyl 2-(3-nitropyridin-2-yl)malonate
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / aq. HCl / 8 h / Heating 2: dimethylformamide / 4.25 h / 90 °C 3: 0.31 g / HCOOH / Pd/C / methanol / 4 h View Scheme |
(E)-2-(2-ethoxyetenyl)-3-nitropyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / H2 / W-2 Raney Ni / methanol 2: 88 percent / conc. HCl / methanol / 2 h / Heating View Scheme |
3-amino-2-bromopyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 58 percent / pyridine / 3 h / 0-10 deg C 2: CuI, Et3N / Pd(PPh3)2Cl2 / 100 - 110 °C 3: NaOEt / ethanol / Heating View Scheme | |
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / tetrahydrofuran / 6 h / 60 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme |
2-bromo-3-nitropyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: CuI, Et3N / Pd(PPh3)2Cl2 / 100 - 110 °C 2: NaOEt / ethanol 3: 1.) H2; 2.) HCl / 1.) Pd/C View Scheme |
ethyl 2-bromo-3-pyridinecarbamate
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CuI, Et3N / Pd(PPh3)2Cl2 / 100 - 110 °C 2: NaOEt / ethanol / Heating View Scheme |
3-nitro-2,6-lutidine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 62 percent / ZnCl2, N,N-dimethylformamide / 24 h / 100 °C 2: 1.) ozonized oxygen, 2.) hydrogen peroxide 3: 100 percent 4: 95 percent / H2 / Pd/C View Scheme |
2-methyl-3-nitro-6-styrylpyridine
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) ozonized oxygen, 2.) hydrogen peroxide 2: 100 percent 3: 95 percent / H2 / Pd/C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethyl ether; acetic acid anhydride 2: potassium ethylate / 350 °C View Scheme |
2-methyl-3-nitropyridine
N,N-dimethyl-formamide dimethyl acetal
A
2-methyl-3-pyridinamine
B
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitropyridine; N,N-dimethyl-formamide dimethyl acetal In N,N-dimethyl-formamide at 120℃; for 17h; Stage #2: With palladium 10% on activated carbon; hydrogen In methanol; formic acid for 23h; |
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 8 h / Reflux 2: N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere 3: formic acid / palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 8 h / Reflux 2: N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere 3: palladium 10% on activated carbon; formic acid / methanol / 4 h / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 8 h / Reflux 2: N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere 3: palladium 10% on activated carbon; formic acid / methanol / 4 h / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 1h; | 100% |
1H-pyrrolo[3,2-b]pyridine
di-tert-butyl dicarbonate
1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; for 3h; Inert atmosphere; | 100% |
In tetrahydrofuran at 20℃; for 48h; | 99% |
With dmap; triethylamine In dichloromethane at 20℃; | 95% |
1H-pyrrolo[3,2-b]pyridine
1-(2-(triethylsilyloxy)ethyl)-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 1h; | 100% |
1H-pyrrolo[3,2-b]pyridine
1H-pyrrolo[3,2-b]pyridine 4-oxide
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 72h; | 100% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; | 88% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; | 70% |
1H-pyrrolo[3,2-b]pyridine
3-iodo-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With N-iodo-succinimide In tetrahydrofuran at 20℃; | 100% |
With iodine; potassium iodide In ethanol; water at 20℃; for 4h; | 98% |
With N-iodo-succinimide In tetrahydrofuran at 20℃; | 93.5% |
1H-pyrrolo[3,2-b]pyridine
formaldehyd
N,N-dimethylammonium chloride
N,N-dimethyl-1-(1H-pyrrolo[3,2-b]pyridin-3-yl)methanamine
Conditions | Yield |
---|---|
In butan-1-ol for 3h; Reflux; | 99% |
In water; butan-1-ol for 3h; Reflux; | |
In water; butan-1-ol at 120℃; for 3h; |
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium tert-butylate In N,N-dimethyl-formamide for 5h; Reflux; | 99% |
1H-pyrrolo[3,2-b]pyridine
N-tert-butyloxycarbonylpiperidin-4-one
Conditions | Yield |
---|---|
With potassium hydroxide In methanol Heating / reflux; | 98% |
With potassium hydroxide In methanol Heating; |
1H-pyrrolo[3,2-b]pyridine
2-mesitylenesulphonyl chloride
1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0 - 25℃; for 16h; Inert atmosphere; | 96% |
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 16h; | 96% |
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With water-d2; silver trifluoromethanesulfonate In chloroform-d1 at 90℃; for 18h; regioselective reaction; | 95% |
1H-pyrrolo[3,2-b]pyridine
benzenesulfonyl chloride
1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran Stage #2: benzenesulfonyl chloride In tetrahydrofuran at 20℃; | 94% |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil at 20℃; for 4.25h; | 57.7% |
With triethylamine In tetrahydrofuran |
1H-pyrrolo[3,2-b]pyridine
p-toluenesulfonyl chloride
1-tosyl-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 4h; | 91% |
With dmap; tetra(n-butyl)ammonium hydrogen sulfate; triethylamine In dichloromethane at 20℃; for 26h; | 90% |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 20℃; for 3.5h; | |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.16667h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran for 16h; |
Conditions | Yield |
---|---|
With tetrabutyl phosphonium bromide; potassium carbonate In water at 20℃; for 12h; regioselective reaction; | 91% |
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 27℃; for 2h; | 90% |
1H-pyrrolo[3,2-b]pyridine
3-bromo-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0℃; for 0.5h; | 89% |
With water; sodium bisulfate hydrate; sodium bromide In acetonitrile for 54h; Irradiation; | 81% |
With sodium hydrogensulfate monohydrate; water; sodium bromide In acetonitrile at 20℃; for 54h; Schlenk technique; Irradiation; Green chemistry; | 81% |
1H-pyrrolo[3,2-b]pyridine
hexamethylenetetramine
1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde
Conditions | Yield |
---|---|
With water; acetic acid for 4h; Reflux; | 89% |
With water; acetic acid for 6h; Reflux; | 79% |
With acetic acid In water for 4h; Heating / reflux; | 56% |
With water; acetic acid Duff Aldehyde Synthesis; Inert atmosphere; Reflux; |
1H-pyrrolo[3,2-b]pyridine
3-nitro-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sulfuric acid; nitric acid at 0℃; for 2h; Stage #2: With sodium hydroxide In water pH=7 - 8; | 89% |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sulfuric acid; nitric acid at 0℃; for 2h; Stage #2: With sodium hydroxide In water pH=7 - 8; | 89% |
With sulfuric acid at 0℃; for 4h; | 80% |
Conditions | Yield |
---|---|
With potassium phosphate; copper In dimethyl sulfoxide at 80℃; for 5h; Inert atmosphere; | 89% |
1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine; 1-(1-phenylvinyl)tetrahydro-1H-thiophen-1-ium tetraphenylborate In dimethyl sulfoxide at 21℃; for 0.0333333h; Schlenk technique; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 21℃; for 12h; Schlenk technique; regioselective reaction; | 87% |
1H-pyrrolo[3,2-b]pyridine
dihydro-6,7 thieno<3,2-c>pyridine
Conditions | Yield |
---|---|
In neat (no solvent) at 100℃; for 2h; Temperature; Microwave irradiation; | 85% |
1H-pyrrolo[3,2-b]pyridine
N-(2-(4,5-dihydrooxazol-2-yl)-phenyl)-1-methyl-1H-indole-2-carboxamide
Conditions | Yield |
---|---|
With potassium acetate; copper diacetate at 80℃; for 12h; Schlenk technique; Sealed tube; | 85% |
With copper diacetate; sodium carbonate In dimethyl sulfoxide at 80℃; for 2h; Sealed tube; | 85% |
1H-pyrrolo[3,2-b]pyridine
methyl iodide
1-methyl-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 5℃; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; | 84.5% |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere; | 83% |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: methyl iodide In tetrahydrofuran for 24h; | 31% |
In N,N-dimethyl-formamide | |
Stage #1: 1H-pyrrolo[3,2-b]pyridine With Tris(3,6-dioxaheptyl)amine; potassium tert-butylate In toluene at 20℃; for 5h; Stage #2: methyl iodide In toluene at 20℃; for 24h; |
1H-pyrrolo[3,2-b]pyridine
cyclohexanedione monoethylene ketal
3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-pyrrolo[3,2-b]pyridine
Conditions | Yield |
---|---|
With potassium hydroxide In methanol Reflux; Inert atmosphere; Schlenk technique; | 84% |
With potassium hydroxide In methanol for 4h; Reflux; |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium bromide In acetonitrile at 20℃; for 2h; Electrolysis; Inert atmosphere; Green chemistry; | 84% |
Conditions | Yield |
---|---|
Stage #1: 1H-pyrrolo[3,2-b]pyridine With sodium hydride In dimethyl sulfoxide for 0.25h; Stage #2: benzenesulfonyl chloride for 0.5h; | 83% |
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