Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryGood quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/973.html Product Name 4-Fluoro-5-hydroxy-2-methylindole CAS No. 288
Cas:288385-88-6
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:288385-88-6
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inquiryroducts: 4-fluoro-2-methyl-1H-indol-5-ol Cas No.: 288385-88-6 Molecular Formula: C9H8FNO Molecular Weight: 165.16 Assay: 98% HPLC Molecular Structure: Appearance:Whi
Cas:288385-88-6
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry4-Fluoro-5-hydroxy-2-methylindole CAS:288385-88-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:288385-88-6
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:288385-88-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:288385-88-6
Min.Order:10 Gram
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inquiry4-fluoro-2-methyl-1H-indol-5-olAppearance:Detailed see specifications Storage:Store in dry, dark and ventilated Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:288385-88-6
Min.Order:1 Kilogram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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Min.Order:1 Milligram
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inquiry4-Fluoro-5-hydroxy-2-methylindole Basic information Product Name: 4-Fluoro-5-hydroxy-2-methylindole Synonyms: 4-FLUORO-5-HYDROXY-2-METHYLINDOLE;4-FLUORO-2-METHYL-1H-INDOL-5-OL;2-Methyl-4-fluoro-5-hydroxyindole;4-Fluoro-5-hydroxy-2-methyl-1H-ind
Cas:288385-88-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
Cas:288385-88-6
Min.Order:100 Gram
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Type:Manufacturers
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:288385-88-6
Min.Order:1 Kilogram
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Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:288385-88-6
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Negotiable
Type:Lab/Research institutions
inquiry4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In methanol at 55 - 60℃; under 1500.15 - 2250.23 Torr; for 4h; Autoclave; | 91.3% |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In methanol at 45 - 50℃; under 2250.23 - 3000.3 Torr; for 6h; Autoclave; | 91% |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With hydrogen In acetonitrile at 50 - 55℃; under 2250.23 - 3000.3 Torr; for 5h; Autoclave; | 89.7% |
1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With sodium dithionite In water at 0 - 30℃; for 1h; | 81% |
With sodium dithionite In methanol; water at 20 - 25℃; for 5h; Reissert Indole Synthesis; Large scale; | 69% |
With sodium dithionite; potassium carbonate In water at 25℃; for 2h; Product distribution / selectivity; Industry scale; | 68% |
2-methyl-4-fluoro-5-methoxy-1H-indole
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With boron tribromide In dichloromethane | 70% |
With boron tribromide In dichloromethane | 70% |
With boron tribromide In dichloromethane | 70% |
1-(3-benzyloxy-2-fluoro-6-nitro-phenyl)-propan-2-one
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; | 61% |
With acetic acid; palladium on charcoal In ethanol; ethyl acetate | 30% |
With acetic acid; palladium on charcoal In ethanol; ethyl acetate | 30% |
2,3,4-trifluoronitrobenzene
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium tert-butylate / tetrahydrofuran / 7.75 h / 10 °C / Large scale 1.2: 5.5 h / 10 - 22 °C / Large scale 2.1: sulfuric acid / acetic acid / 6.42 h / 70 °C / Large scale 3.1: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale 4.1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale 5.1: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydride / tetrahydrofuran / 12 h / 5 - 20 °C 2: hydrogenchloride; acetic acid / 12 h / Reflux 3: N,N-dimethyl-formamide / 10 h / 100 °C 4: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C 5: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C View Scheme |
2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoic acid ethyl ester
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / acetic acid / 6.42 h / 70 °C / Large scale 2: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale 3: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale 4: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride; acetic acid / 12 h / Reflux 2: N,N-dimethyl-formamide / 10 h / 100 °C 3: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C 4: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C View Scheme |
1-(2,3-difluoro-6-nitrophenyl)propan-2-one
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale 2: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale 3: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 10 h / 100 °C 2: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C 3: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C View Scheme |
1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale 2: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale View Scheme |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C 2: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C View Scheme |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With water; sodium hydrogencarbonate In methanol at 20℃; for 10h; |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper(l) chloride / tetrahydrofuran / 5 h / 65 - 70 °C 2: hydrogen / acetonitrile / 5 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Autoclave View Scheme |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 - 105 °C 2: copper(l) chloride / tetrahydrofuran / 5 h / 65 - 70 °C 3: hydrogen / acetonitrile / 5 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C 2: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C 3: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C 2: zinc(II) chloride / tetrahydrofuran / 5 h / 75 - 80 °C 3: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave View Scheme |
2-fluoro-3-benzyloxy-6-nitrotoluene
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C 2: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave View Scheme |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 - 95 °C 2: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C 3: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 - 95 °C 2: zinc(II) chloride / tetrahydrofuran / 5 h / 75 - 80 °C 3: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave View Scheme |
4-fluoro-2-methyl-1H-indol-5-ol
7-benzyloxy-4-chloro-6-methoxyquinazoline
7-(benzyloxy)-4-[(4-fluoro-2-methyl-1H-indol-5-yl)-oxy]-6-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 85℃; Inert atmosphere; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; | 75% |
With caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 16h; Inert atmosphere; | 53% |
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydroxide In water; acetonitrile at 0℃; for 0.25h; Industry scale; Stage #2: 7-benzyloxy-4-chloro-6-methoxyquinazoline In 1-methyl-pyrrolidin-2-one; water; acetonitrile at 80℃; for 4.75h; Industry scale; | |
With potassium carbonate In N,N-dimethyl acetamide at 90℃; for 2h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere; |
4-fluoro-2-methyl-1H-indol-5-ol
4,6-dichloro-5-cyanopyrimidine
Conditions | Yield |
---|---|
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With potassium carbonate In N,N-dimethyl-formamide; acetonitrile at 20℃; for 1h; Inert atmosphere; Stage #2: 4,6-dichloro-5-cyanopyrimidine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 1h; Inert atmosphere; | 99% |
4-fluoro-2-methyl-1H-indol-5-ol
4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yl pivalate
Conditions | Yield |
---|---|
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20 - 29℃; for 1.16667h; Large scale; Stage #2: 4-chloro-5-methylpyrrolo[1,2-f ][1,2,4]triazin-6-yl pivalate In acetonitrile at 26 - 28℃; for 3h; Large scale; | 96.2% |
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20 - 50℃; for 1.67 - 19h; Product distribution / selectivity; |
4-fluoro-2-methyl-1H-indol-5-ol
6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine
Conditions | Yield |
---|---|
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydride In DMF (N,N-dimethyl-formamide) at -20 - 0℃; for 0.5h; Stage #2: 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h; | 95% |
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydride In N,N-dimethyl-formamide at -78 - 20℃; Stage #2: 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine In N,N-dimethyl-formamide at 20℃; for 1h; |
4-amino-6-chloro-pyrimidine-5-carbaldehyde
4-amino-6-(4-fluoro-2-methyl-1H-indol-5-yloxy)-pyrimidine-5-carbaldehyde
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 20℃; for 2h; | 94% |
With caesium carbonate In dimethyl sulfoxide |
4-fluoro-2-methyl-1H-indol-5-ol
6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine
6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidin-4-amine
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 50℃; | 85% |
4-fluoro-2-methyl-1H-indol-5-ol
C9(13)C3H14ClN(15)N2O2
C18(13)C3H21FN2(15)N2O3
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 48℃; for 1.5h; Inert atmosphere; | 82% |
4-fluoro-2-methyl-1H-indol-5-ol
4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 70 - 75℃; for 5.5h; Inert atmosphere; | 80% |
With potassium carbonate In N,N-dimethyl-formamide Heating; | 55.2 g |
With potassium carbonate In N,N-dimethyl-formamide Heating; | 30.09 g |
4-fluoro-2-methyl-1H-indol-5-ol
4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
Conditions | Yield |
---|---|
With caesium carbonate In methanol; dichloromethane; N,N-dimethyl-formamide | 79% |
4-fluoro-2-methyl-1H-indol-5-ol
4,6-dichloro-2-(methylsulfonyl)pyrimidine
5-((4,6-dichloropyrimidin-2-yl)oxy)-4-fluoro-2-methyl-1H-indole
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at -70 - 20℃; | 79% |
4-fluoro-2-methyl-1H-indol-5-ol
6,7-dimethoxy-4-chloroquinazoline
4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6,7-dimethoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; | 78% |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 100℃; | 76% |
4-fluoro-2-methyl-1H-indol-5-ol
Ethyl 6-(7-(benzyloxy)-4-chloroquinazolin-6-yloxy)hexanoate
Ethyl 6-(7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)quinazolin-6-yloxy)-hexanoate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; | 71% |
4-fluoro-2-methyl-1H-indol-5-ol
trifluoromethylsulfonic anhydride
trifluoro-methanesulfonic acid 4-fluoro-2-methyl-1H-indol-5-yl ester
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine In dichloromethane at 20℃; | 70% |
4-fluoro-2-methyl-1H-indol-5-ol
6-chloro-N-(5-propenyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine
(E)-6-chloro-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-N-(5-(prop-1-en-1-yl)-1H-pyrazol-3-yl)pyrimidin-4-amine
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 55℃; for 16h; | 64% |
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In acetonitrile at 60℃; for 24h; | 64% |
4-fluoro-2-methyl-1H-indol-5-ol
methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 95℃; for 0.75h; | 45% |
4-fluoro-2-methyl-1H-indol-5-ol
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 70℃; for 1h; Inert atmosphere; | 45% |
4-fluoro-2-methyl-1H-indol-5-ol
1-chloro-4-(pyridin-4-yl-methyl)-phthalazine
1-(4-fluoro-2-methylindol-5-yloxy)-4-(pyridin-4-ylmethyl)phthalazine
Conditions | Yield |
---|---|
With caesium carbonate In dichloromethane; ethyl acetate; N,N-dimethyl-formamide | 41% |
4-fluoro-2-methyl-1H-indol-5-ol
7-(benzyloxy)-4-chloro-6-methoxycinnoline
7-benzyloxy-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxycinnoline
Conditions | Yield |
---|---|
With caesium carbonate In dichloromethane; ethyl acetate; N,N-dimethyl-formamide | 39% |
4-fluoro-2-methyl-1H-indol-5-ol
4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline
4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline
Conditions | Yield |
---|---|
With caesium carbonate In methanol; 2,4-dichlorophenoxyacetic acid dimethylamine; pentane | 38% |
4-fluoro-2-methyl-1H-indol-5-ol
7-methoxy-6-cyano-4-chloro-quinoline
6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-methoxyquinoline
Conditions | Yield |
---|---|
With caesium carbonate In methanol; ethyl acetate; N,N-dimethyl-formamide | 35% |
4-fluoro-2-methyl-1H-indol-5-ol
7-(benzyloxy)-4-chloro-6-methoxyquinoline
7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 16h; Inert atmosphere; | 27% |
With dmap In 1,4-dioxane for 72h; Reflux; |
4-fluoro-2-methyl-1H-indol-5-ol
4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine
Conditions | Yield |
---|---|
7% |
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