CAS No.2952-00-3,(trans-4-Aminocyclohexyl)acetic acid Suppliers

Dayang Chem (Hangzhou) Co.,Ltd.

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2-(TRANS-4-AMINOCYCLOHEXYL)ACETIC ACID

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

(Trans-4-Aminocyclohexyl)Acetic Acid

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Shanghai Upbio Tech Co.,Ltd

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(trans-4-Aminocyclohexyl)acetic acid

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(trans-4-Aminocyclohexyl)acetic acid

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

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Antimex Chemical Limied

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(trans-4-Aminocyclohexyl)acetic acid

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ZHEJIANG JIUZHOU CHEM CO.,LTD

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(trans-4-Aminocyclohexyl)acetic acid

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ENAO Chemical Co, Limited

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2-(Trans-4-aminocyclohexyl)aceticacid

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Synthetic route

: (trans-4-benzamino-cyclohexyl)-acetic acid ethyl ester

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
With methanol; barium dihydroxide

: 2901-44-2
trans-2-(4-acetamidocyclohexyl)acetic acid

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
With sulfuric acid
With sodium hydroxide In butan-1-ol at 25 - 120℃; for 16.25h;

: 76308-28-6
ethyl 2‐[(1r,4r)‐4‐aminocyclohexyl]acetate

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
With water for 12h; Heating;	1.46 g

: 343775-23-5
trans-(4-Amino-cyclohexyl)-acetic acid ethyl ester

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chloroform; aq. NaOH solution 2: barium hydroxide; aqueous methanol View Scheme

: 18699-02-0
4-acetamidophenylacetic acid

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / PtO2 / acetic acid 2: aq. H2SO4 View Scheme

: 104-03-0
4-nitrobenzeneacetic acid

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; nickel In water at 125 - 130℃; under 86258.6 - 97509.8 Torr; for 168h;
With palladium 10% on activated carbon; hydrogen In water at 20℃; under 3102.97 Torr; for 72h;
With palladium 10% on activated carbon; hydrogen at 20℃; under 3102.97 Torr; for 72h;
With 5%-palladium/activated carbon; hydrogen In 2-methyl-propan-1-ol at 25 - 55℃; under 3750.38 Torr; for 6.25h; Autoclave;	2.5 g

: C12H19NO3

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 25 - 30 °C / 1500.15 - 2250.23 Torr 2: sodium hydroxide / water / 5 h / 25 - 30 °C 3: sodium hydroxide / butan-1-ol / 16.25 h / 25 - 120 °C View Scheme

: ethyl 2-(trans/cis)-(4-acetamidocyclohexyl)acetate

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 5 h / 25 - 30 °C 2: sodium hydroxide / butan-1-ol / 16.25 h / 25 - 120 °C View Scheme

: 27514-08-5
N-(4-oxocyclohexyl)acetamide

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / methanol / 1 h / 0 - 5 °C 1.2: 1 h / 0 - 5 °C 2.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 25 - 30 °C / 1500.15 - 2250.23 Torr 3.1: sodium hydroxide / water / 5 h / 25 - 30 °C 4.1: sodium hydroxide / butan-1-ol / 16.25 h / 25 - 120 °C View Scheme

: 1470-91-3
but-3-enoyl chloride

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 189504-66-3
(4-But-3-enoylamino-cyclohexyl)-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In water 1.) 0 deg C to 5 deg C, 2.) room temp., 20 min;	72%

: 1943-83-5
2-chloroethyl isothiocyanate

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 61367-24-6
{4-[3-(2-Chloro-ethyl)-ureido]-cyclohexyl}-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: {4-[3-Chloro-4-(2-chloro-ethylsulfanyl)-butyrylamino]-cyclohexyl}-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 72 percent / NaOH / H2O / 1.) 0 deg C to 5 deg C, 2.) room temp., 20 min 2: CCl4 / -30 - -20 °C 3: nitromethane / 24 h / 60 - 70 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: {4-[4-Chloro-3-(2-chloro-ethylsulfanyl)-butyrylamino]-cyclohexyl}-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / NaOH / H2O / 1.) 0 deg C to 5 deg C, 2.) room temp., 20 min 2: CCl4 / -30 - -20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 52320-89-5
C11H18ClN3O4

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH 2: NaNO2, HCO2H / formic acid View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 76325-96-7
trans-4-aminocyclohexylacetic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water pH=5;

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 946598-34-1
trans 2-{1-[4-(N-(tert-butoxycarbonyl))amino]cyclohexyl}ethyl acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C 3: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: dichloromethane / 18 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: dichloromethane / 14 h / 5 - 30 °C 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 4 h / 25 - 30 °C / Inert atmosphere 3: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 1.75 h / -20 - 30 °C View Scheme
Multi-step reaction with 4 steps 1.1: dichloromethane / 14 h / 5 - 30 °C 2.1: 1,1'-carbonyldiimidazole / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 2 h / 25 - 30 °C / Inert atmosphere 2.2: 4 h / 25 - 30 °C / Inert atmosphere 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 2 h / 0 - 5 °C / Inert atmosphere 4.1: sodium tris(acetoxy)borohydride / 20 h / 25 - 30 °C View Scheme
Multi-step reaction with 6 steps 1.1: sodium hydroxide / 1,4-dioxane / 0.17 h / 0 - 5 °C 1.2: 3.16 h / 0 - 30 °C 2.1: 4-methyl-morpholine / dichloromethane / 4 h / -20 - -15 °C 3.1: hydrogenchloride / ethyl acetate / 12 h / 25 - 30 °C 4.1: triethylamine / dichloromethane / 0.17 h / 25 - 30 °C 4.2: 12 h / 25 - 30 °C 5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 2 h / 0 - 5 °C / Inert atmosphere 6.1: sodium tris(acetoxy)borohydride / 20 h / 25 - 30 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: tert-butyl (trans-4-(2-(7-nitro-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 215790-43-5
trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C 3: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: tert-butyl (trans-4-(2-(4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]ethyl}-cyclohexylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C 3: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C 4: sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexanamine dihydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C 3: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 5: trifluoroacetic acid / 1,2-dichloro-ethane / 16 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 2-(2-(trans-4-aminocyclohexyl)ethyl)-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile dihydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: N-(trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: N-(trans-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: ethyl (trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: triethylamine / dichloromethane / 14 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: isopropyl (trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: hydrogenchloride / water / 2 h / Reflux 2.1: triethylamine / dichloromethane / 20 °C 3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5.1: trifluoroacetic acid / dichloromethane / 20 °C 6.1: 1,1'-carbonyldiimidazole / acetonitrile; dichloromethane / 16 h / 20 °C / Inert atmosphere 6.2: Inert atmosphere; Reflux View Scheme

Yield

Multi-step reaction with 6 steps
1.1: hydrogenchloride / water / 2 h / Reflux
2.1: triethylamine / dichloromethane / 20 °C
3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere
4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 20 °C
6.1: 1,1'-carbonyldiimidazole / acetonitrile; dichloromethane / 16 h / 20 °C / Inert atmosphere
6.2: Inert atmosphere; Reflux
View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: isobutyl (trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: tert-butyl (trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 2 h / 20 °C 3: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: phenyl (trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / water / 2 h / Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / 20 °C View Scheme

: 2952-00-3
trans-2-(4-aminocyclohexyl)acetic acid

: 3-(trans-4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1,1-dimethylurea

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: hydrogenchloride / water / 2 h / Reflux 2.1: triethylamine / dichloromethane / 20 °C 3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5.1: trifluoroacetic acid / dichloromethane / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 6.2: 16 h / 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1.1: hydrogenchloride / water / 2 h / Reflux
2.1: triethylamine / dichloromethane / 20 °C
3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere
4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
6.2: 16 h / 20 °C / Inert atmosphere
View Scheme

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