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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dr

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)- 30356-07-1

Cas:30356-07-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline CAS:30356-07-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates,

(S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline CAS:30356-07-1

Cas:30356-07-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application: pharm and interme

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: (S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-Octahydroisoquinoline CAS No.: 30356-07-1 Molecule Formula:C17H23NO Molecule Weight:257.37 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standa

Lower Price (S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-Octahydroisoquinoline on stock

Cas:30356-07-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

(S)-1-(4-methoxybenzyl)1,2,3,4,5,6,7,8-octahydroisoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd

Independent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi

Dextromethorphan Impurity 1 HCl

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice in stock Application:R&D

30356-07-1

Cas:30356-07-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

30356-07-1

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HuBei Ipure Biotech CO.,ltd

HuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of pl

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

Cas:30356-07-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Wising Chem Co., Ltd

Henan Wising Chem specialize in sourcing the chemicals in China. We are associated with many trusted manufacturers each having different area of expertise required for meeting the needs of our local as well as overseas buyers . We have access to cu

(S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline

Cas:30356-07-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai AngewChem Co., Ltd.

Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Complete

Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-

Cas:30356-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-amine
100466-49-7

((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-amine

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With acetic acid; hydrazine In ethanol at 50℃; for 12h;81%
C26H40N2O2

C26H40N2O2

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere;81%
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere;81%
(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
51072-36-7

(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With ammonia borane; oxygen In aq. phosphate buffer at 35℃; under 760.051 Torr; for 72h; pH=7.5; Reagent/catalyst; Enzymatic reaction; stereoselective reaction;80%
With (S)-Mandelic acid In water; toluene at 75 - 80℃; for 1h;
1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline hydrochloride

1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline hydrochloride

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With D-glucose; NADP In dimethyl sulfoxide at 25℃; for 18h; pH=9; Kinetics; Reagent/catalyst; Temperature; pH-value; Solvent; Inert atmosphere; Enzymatic reaction; enantioselective reaction;74%
(+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide
93477-35-1

(+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Stage #1: (+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide With sodium hydroxide In water; toluene
Stage #2: With acetic acid In toluene at 20℃; for 0.166667h;
Stage #3: With (S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline acetate In toluene at 10℃; for 2h; Temperature;
30.3%
2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
63477-91-8

2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline

A

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
30356-08-2

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

B

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 10h; Yields of byproduct given. Title compound not separated from byproducts;
4-((S)-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol
74570-02-8, 94006-09-4, 109866-75-3, 125158-41-0

4-((S)-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol

reagent from trimethyl-phenyl-ammonium chloride and KOH-solution

reagent from trimethyl-phenyl-ammonium chloride and KOH-solution

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With methanol; toluene
1,2,3,4,5,6,7,8-octahydroisoquinoline
2721-62-2

1,2,3,4,5,6,7,8-octahydroisoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene / 48 h / 85 °C
2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: Cu2O / toluene / 16 h / Heating
2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(I) oxide / toluene / 16 h / Reflux
2: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere
3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: copper(I) oxide / toluene / 16 h / Reflux
2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
3,4,5,6,7,8-Hexahydro-1H-isoquinoline-2-carboxylic acid methyl ester

3,4,5,6,7,8-Hexahydro-1H-isoquinoline-2-carboxylic acid methyl ester

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
2: toluene / 48 h / 85 °C
3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
2: Cu2O / toluene / 16 h / Heating
3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
3,4,5,6,7,8-Hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester

3,4,5,6,7,8-Hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
2: toluene / 48 h / 85 °C
3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
2: Cu2O / toluene / 16 h / Heating
3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-amine
100466-48-6

((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-amine

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
2: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
N-benzyl-5,6,7,8-tetrahydroisoquinolinium bromide
100466-46-4

N-benzyl-5,6,7,8-tetrahydroisoquinolinium bromide

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating
2: CH2Cl2 / 2 h
3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
4: toluene / 48 h / 85 °C
5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating
2: CH2Cl2 / 2 h
3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
4: Cu2O / toluene / 16 h / Heating
5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating
2: CH2Cl2 / 2 h
3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
4: toluene / 48 h / 85 °C
5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating
2: CH2Cl2 / 2 h
3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
4: Cu2O / toluene / 16 h / Heating
5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux
2: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
3: copper(I) oxide / toluene / 16 h / Reflux
4: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere
5: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
N-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
100466-47-5

N-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: CH2Cl2 / 2 h
2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
3: toluene / 48 h / 85 °C
4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1: CH2Cl2 / 2 h
2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
3: Cu2O / toluene / 16 h / Heating
4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1: CH2Cl2 / 2 h
2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating
3: toluene / 48 h / 85 °C
4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C
View Scheme
C18H32N2O

C18H32N2O

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere
2: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
2: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
isoquinoline
119-65-3

isoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: trifluoroacetic acid; 5%-palladium/activated carbon; hydrogen / 48 h / 50 °C / 2585.81 Torr
2: acetone / 1 h / Reflux
3: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux
4: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
5: copper(I) oxide / toluene / 16 h / Reflux
6: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere
7: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid; 5%-palladium/activated carbon; hydrogen / 48 h / 50 °C / 2585.81 Torr
2.1: acetone / 1 h / Reflux
3.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux
4.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
4.2: 48 h / Inert atmosphere; Reflux
5.1: copper(I) oxide / toluene / 16 h / Reflux
6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
7.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
5,6,7,8-tetrahydroisoquinoline
36556-06-6

5,6,7,8-tetrahydroisoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: acetone / 1 h / Reflux
2: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux
3: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
4: copper(I) oxide / toluene / 16 h / Reflux
5: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere
6: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
5,6,7,8-tetrahydroisoquinoline

5,6,7,8-tetrahydroisoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetone / 1 h / Reflux
2.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux
3.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
3.2: 48 h / Inert atmosphere; Reflux
4.1: copper(I) oxide / toluene / 16 h / Reflux
5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
6.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
C16H20N(1+)*Br(1-)

C16H20N(1+)*Br(1-)

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux
2.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C
2.2: 48 h / Inert atmosphere; Reflux
3.1: copper(I) oxide / toluene / 16 h / Reflux
4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
5.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere
View Scheme
4-Methoxyphenylacetic acid
104-01-8

4-Methoxyphenylacetic acid

2-(1-cyclohexenyl)ethylamine
3399-73-3

2-(1-cyclohexenyl)ethylamine

A

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
30356-08-2

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

B

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Stage #1: 4-Methoxyphenylacetic acid; 2-(1-cyclohexenyl)ethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 70 - 80℃; Dean-Stark;
Stage #2: With trichlorophosphate In 5,5-dimethyl-1,3-cyclohexadiene at 50 - 110℃; for 3.16667h;
Stage #3: With (S)-Mandelic acid
2-(1-cyclohexenyl)ethylamine
3399-73-3

2-(1-cyclohexenyl)ethylamine

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 70 - 80 °C / Dean-Stark
1.2: 3.17 h / 50 - 110 °C
1.3: 25 - 30 °C / pH 5 - 5.5
2.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 70 - 80 °C / Dean-Stark
1.2: 3.17 h / 50 - 110 °C
2.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C
2.2: 2 h / 5 - 25 °C
2.3: 2 h / 5 - 25 °C
3.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere
2.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C
2.2: 20 °C
3.1: sodium tetrahydroborate / methanol / 4 h / 20 °C
4.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction
View Scheme
(R)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate

(R)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / 0.5 h / 25 - 30 °C / pH 12 - 13.5
2.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C
2.2: 2 h / 5 - 25 °C
2.3: 2 h / 5 - 25 °C
3.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C
View Scheme
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
30356-08-2

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C
1.2: 2 h / 5 - 25 °C
1.3: 2 h / 5 - 25 °C
2.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C
View Scheme
1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-isoquinoline
51072-35-6

1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-isoquinoline

A

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
30356-08-2

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

B

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With (R)-N-(5-fluoro-2-hydroxybenzyl)-2-methylpropane-2-sulfinamide; trichlorosilane In dichloromethane at -20 - -15℃; for 12.5h; Inert atmosphere;A n/a
B n/a
1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline hydrochloride

1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline hydrochloride

A

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
30356-08-2

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

B

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
With D-glucose; NADP In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=7.5; Kinetics; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction;A n/a
B n/a
With D-glucose; NADP In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=7.5; Kinetics; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction;A n/a
B n/a
N-(2-cyclohex-1-enylethyl)-2-(4-methoxyphenyl)-acetamide
51072-34-5

N-(2-cyclohex-1-enylethyl)-2-(4-methoxyphenyl)-acetamide

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / toluene / 8 h / Reflux
2: D-glucose; NADP / dimethyl sulfoxide / 18 h / 25 °C / pH 9 / Inert atmosphere; Enzymatic reaction
View Scheme
Multi-step reaction with 3 steps
1.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C
1.2: 20 °C
2.1: sodium tetrahydroborate / methanol / 4 h / 20 °C
3.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction
View Scheme
4-Methoxyphenylacetic acid
104-01-8

4-Methoxyphenylacetic acid

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere
2.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C
2.2: 20 °C
3.1: sodium tetrahydroborate / methanol / 4 h / 20 °C
4.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction
View Scheme
1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-isoquinoline hydrogen sulphate

1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-isoquinoline hydrogen sulphate

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 4 h / 20 °C
2: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(S)-1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

(S)-1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 30℃; for 2h;99%
formic acid
64-18-6

formic acid

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
29144-31-8

(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline

Conditions
ConditionsYield
In toluene Reflux;95%
naphthalene-1-carbonic acid chloride
879-18-5

naphthalene-1-carbonic acid chloride

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

[(S)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-naphthalen-1-yl-methanone
90133-19-0

[(S)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-naphthalen-1-yl-methanone

Conditions
ConditionsYield
With triethylamine In dichloromethane Ambient temperature;
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

formic acid ethyl ester
109-94-4

formic acid ethyl ester

(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
29144-31-8

(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline

Conditions
ConditionsYield
at 40℃; for 15h;
at 40℃; for 15h;
formaldehyd
50-00-0

formaldehyd

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

Toluene-4-sulfonate(S)-1-(4-methoxy-benzyl)-2-methylene-1,2,3,4,5,6,7,8-octahydro-isoquinolinium;

Toluene-4-sulfonate(S)-1-(4-methoxy-benzyl)-2-methylene-1,2,3,4,5,6,7,8-octahydro-isoquinolinium;

Conditions
ConditionsYield
In dichloromethane for 3h;
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-hydroxylamine

O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-hydroxylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: CH2Cl2 / 3 h
2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C
2.2: CuBr / dimethylformamide / 12 h / 50 °C
2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(Z)-(3S)-7-dimethyl-oct-6-enal O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-oxime

(Z)-(3S)-7-dimethyl-oct-6-enal O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-oxime

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: CH2Cl2 / 3 h
2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C
2.2: CuBr / dimethylformamide / 12 h / 50 °C
2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h
3.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / microwave irradiation
3.2: PL-MIA resin / CH2Cl2 / 4 h / 20 °C
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(E)-(3S)-7-dimethyl-oct-6-enal O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-oxime

(E)-(3S)-7-dimethyl-oct-6-enal O-{4-[(1R)-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-(1S)-methyl-but-2-ynyl}-oxime

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: CH2Cl2 / 3 h
2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C
2.2: CuBr / dimethylformamide / 12 h / 50 °C
2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h
3.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / microwave irradiation
3.2: PL-MIA resin / CH2Cl2 / 4 h / 20 °C
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(+)-dextrorphan
125-73-5

(+)-dextrorphan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 15 h / 40 °C
2: LiAlH4 / diethyl ether / 2 h / Ambient temperature
3: 45 percent / H3PO4 / 65 h / 135 - 140 °C
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(S)-(+)-N-methyl-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
89614-56-2

(S)-(+)-N-methyl-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 15 h / 40 °C
2: LiAlH4 / diethyl ether / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: toluene / Reflux
2: potassium borohydride / water; methanol / 1 h
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

dextrorphan

dextrorphan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 15 h / 40 °C
2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C
3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 15 h / 40 °C
2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C
3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere
View Scheme
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

C37H51NO2

C37H51NO2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 15 h / 40 °C
2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C
3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

(+)-N-phenylacetyl octabase

(+)-N-phenylacetyl octabase

Conditions
ConditionsYield
With sodium hydroxide for 0.166667h;
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
30356-07-1

(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline

C37H51NO2

C37H51NO2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 15 h / 40 °C
2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C
3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 20 °C
View Scheme
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