The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dr
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry(S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline CAS:30356-07-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates,
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application: pharm and interme
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inquiryProduct name: (S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-Octahydroisoquinoline CAS No.: 30356-07-1 Molecule Formula:C17H23NO Molecule Weight:257.37 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standa
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
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inquiryKONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
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inquiryIndependent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirylow price high quality high purity good sevice in stock Application:R&D
Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (1S)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryHuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of pl
Cas:30356-07-1
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inquiryHenan Wising Chem specialize in sourcing the chemicals in China. We are associated with many trusted manufacturers each having different area of expertise required for meeting the needs of our local as well as overseas buyers . We have access to cu
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inquiryJoyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom
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inquiryShanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Complete
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inquiry((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-amine
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With acetic acid; hydrazine In ethanol at 50℃; for 12h; | 81% |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere; | 81% |
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere; | 81% |
(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With ammonia borane; oxygen In aq. phosphate buffer at 35℃; under 760.051 Torr; for 72h; pH=7.5; Reagent/catalyst; Enzymatic reaction; stereoselective reaction; | 80% |
With (S)-Mandelic acid In water; toluene at 75 - 80℃; for 1h; |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With D-glucose; NADP In dimethyl sulfoxide at 25℃; for 18h; pH=9; Kinetics; Reagent/catalyst; Temperature; pH-value; Solvent; Inert atmosphere; Enzymatic reaction; enantioselective reaction; | 74% |
(+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: (+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide With sodium hydroxide In water; toluene Stage #2: With acetic acid In toluene at 20℃; for 0.166667h; Stage #3: With (S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline acetate In toluene at 10℃; for 2h; Temperature; | 30.3% |
2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
A
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
B
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 80℃; for 10h; Yields of byproduct given. Title compound not separated from byproducts; |
4-((S)-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With methanol; toluene |
1,2,3,4,5,6,7,8-octahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 48 h / 85 °C 2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: Cu2O / toluene / 16 h / Heating 2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper(I) oxide / toluene / 16 h / Reflux 2: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: copper(I) oxide / toluene / 16 h / Reflux 2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: toluene / 48 h / 85 °C 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: Cu2O / toluene / 16 h / Heating 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: toluene / 48 h / 85 °C 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: Cu2O / toluene / 16 h / Heating 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-amine
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 2: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |
N-benzyl-5,6,7,8-tetrahydroisoquinolinium bromide
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating 2: CH2Cl2 / 2 h 3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 4: toluene / 48 h / 85 °C 5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating 2: CH2Cl2 / 2 h 3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 4: Cu2O / toluene / 16 h / Heating 5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating 2: CH2Cl2 / 2 h 3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 4: toluene / 48 h / 85 °C 5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1: 93 percent / NaBH4 / methanol; H2O / 1 h / Heating 2: CH2Cl2 / 2 h 3: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 4: Cu2O / toluene / 16 h / Heating 5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 6: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux 2: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 3: copper(I) oxide / toluene / 16 h / Reflux 4: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 5: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
N-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: CH2Cl2 / 2 h 2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 3: toluene / 48 h / 85 °C 4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: CH2Cl2 / 2 h 2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 3: Cu2O / toluene / 16 h / Heating 4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: CH2Cl2 / 2 h 2: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 3: toluene / 48 h / 85 °C 4: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 5: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 2: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 2: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
isoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: trifluoroacetic acid; 5%-palladium/activated carbon; hydrogen / 48 h / 50 °C / 2585.81 Torr 2: acetone / 1 h / Reflux 3: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux 4: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 5: copper(I) oxide / toluene / 16 h / Reflux 6: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 7: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: trifluoroacetic acid; 5%-palladium/activated carbon; hydrogen / 48 h / 50 °C / 2585.81 Torr 2.1: acetone / 1 h / Reflux 3.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux 4.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 4.2: 48 h / Inert atmosphere; Reflux 5.1: copper(I) oxide / toluene / 16 h / Reflux 6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 7.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
5,6,7,8-tetrahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: acetone / 1 h / Reflux 2: sodium tetrahydroborate / methanol; water / 2 h / 0 °C / Reflux 3: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 4: copper(I) oxide / toluene / 16 h / Reflux 5: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 6: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetone / 1 h / Reflux 2.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux 3.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 3.2: 48 h / Inert atmosphere; Reflux 4.1: copper(I) oxide / toluene / 16 h / Reflux 5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 6.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate / water; ethanol / 1 h / 0 °C / Reflux 2.1: methyl chloroformate / dichloromethane / 2 h / 0 - 20 °C 2.2: 48 h / Inert atmosphere; Reflux 3.1: copper(I) oxide / toluene / 16 h / Reflux 4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 5.1: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
4-Methoxyphenylacetic acid
2-(1-cyclohexenyl)ethylamine
A
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
B
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: 4-Methoxyphenylacetic acid; 2-(1-cyclohexenyl)ethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 70 - 80℃; Dean-Stark; Stage #2: With trichlorophosphate In 5,5-dimethyl-1,3-cyclohexadiene at 50 - 110℃; for 3.16667h; Stage #3: With (S)-Mandelic acid |
2-(1-cyclohexenyl)ethylamine
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 5,5-dimethyl-1,3-cyclohexadiene / 70 - 80 °C / Dean-Stark 1.2: 3.17 h / 50 - 110 °C 1.3: 25 - 30 °C / pH 5 - 5.5 2.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 5,5-dimethyl-1,3-cyclohexadiene / 70 - 80 °C / Dean-Stark 1.2: 3.17 h / 50 - 110 °C 2.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C 2.2: 2 h / 5 - 25 °C 2.3: 2 h / 5 - 25 °C 3.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere 2.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C 2.2: 20 °C 3.1: sodium tetrahydroborate / methanol / 4 h / 20 °C 4.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / 0.5 h / 25 - 30 °C / pH 12 - 13.5 2.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C 2.2: 2 h / 5 - 25 °C 2.3: 2 h / 5 - 25 °C 3.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C View Scheme |
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hypochlorite / tert-butyl methyl ether / 4 h / -10 - 25 °C 1.2: 2 h / 5 - 25 °C 1.3: 2 h / 5 - 25 °C 2.1: (S)-Mandelic acid / toluene; water / 1 h / 75 - 80 °C View Scheme |
1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydro-isoquinoline
A
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
B
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With (R)-N-(5-fluoro-2-hydroxybenzyl)-2-methylpropane-2-sulfinamide; trichlorosilane In dichloromethane at -20 - -15℃; for 12.5h; Inert atmosphere; | A n/a B n/a |
A
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
B
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With D-glucose; NADP In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=7.5; Kinetics; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With D-glucose; NADP In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=7.5; Kinetics; Reagent/catalyst; Inert atmosphere; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
N-(2-cyclohex-1-enylethyl)-2-(4-methoxyphenyl)-acetamide
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / toluene / 8 h / Reflux 2: D-glucose; NADP / dimethyl sulfoxide / 18 h / 25 °C / pH 9 / Inert atmosphere; Enzymatic reaction View Scheme | |
Multi-step reaction with 3 steps 1.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C 1.2: 20 °C 2.1: sodium tetrahydroborate / methanol / 4 h / 20 °C 3.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction View Scheme |
4-Methoxyphenylacetic acid
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere 2.1: trichlorophosphate / toluene / 4 h / 85 - 105 °C 2.2: 20 °C 3.1: sodium tetrahydroborate / methanol / 4 h / 20 °C 4.1: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 4 h / 20 °C 2: ammonia borane; oxygen / aq. phosphate buffer / 72 h / 35 °C / 760.05 Torr / pH 7.5 / Enzymatic reaction View Scheme |
di-tert-butyl dicarbonate
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 30℃; for 2h; | 99% |
formic acid
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
Conditions | Yield |
---|---|
In toluene Reflux; | 95% |
naphthalene-1-carbonic acid chloride
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
[(S)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-naphthalen-1-yl-methanone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane Ambient temperature; |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
formic acid ethyl ester
(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
Conditions | Yield |
---|---|
at 40℃; for 15h; | |
at 40℃; for 15h; |
formaldehyd
toluene-4-sulfonic acid
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
In dichloromethane for 3h; |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: CH2Cl2 / 3 h 2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C 2.2: CuBr / dimethylformamide / 12 h / 50 °C 2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: CH2Cl2 / 3 h 2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C 2.2: CuBr / dimethylformamide / 12 h / 50 °C 2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h 3.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / microwave irradiation 3.2: PL-MIA resin / CH2Cl2 / 4 h / 20 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: CH2Cl2 / 3 h 2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH2Cl2; tetrahydrofuran / 6 h / 20 °C 2.2: CuBr / dimethylformamide / 12 h / 50 °C 2.3: 95 percent / NH2NH2 / CH2Cl2 / 1 h 3.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / microwave irradiation 3.2: PL-MIA resin / CH2Cl2 / 4 h / 20 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
(+)-dextrorphan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 15 h / 40 °C 2: LiAlH4 / diethyl ether / 2 h / Ambient temperature 3: 45 percent / H3PO4 / 65 h / 135 - 140 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
(S)-(+)-N-methyl-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 15 h / 40 °C 2: LiAlH4 / diethyl ether / 2 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: toluene / Reflux 2: potassium borohydride / water; methanol / 1 h View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 15 h / 40 °C 2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C 3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: 15 h / 40 °C 2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C 3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 15 h / 40 °C 2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C 3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C View Scheme |
phenylacetyl chloride
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With sodium hydroxide for 0.166667h; |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 15 h / 40 °C 2: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C 3: phosphoric acid / 65 h / 135 - 140 °C / Inert atmosphere 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 20 °C View Scheme |
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