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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 32846-66-5 with best quality

Cas:32846-66-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,4-CUBANEDICARBOXYLIC ACID 32846-66-5

Cas:32846-66-5

Min.Order:1 Kilogram

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Qingdao Beluga Import and Export Co., LTD

1,4-CUBANEDICARBOXYLIC ACID CAS:32846-66-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

1,4-CUBANEDICARBOXYLIC ACID CAS:32846-66-5

Cas:32846-66-5

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM_ 1,4-CUBANEDICARBOXYLIC ACID,32846-66-5

Cas:32846-66-5

Min.Order:1 Kilogram

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Hangzhou ZeErRui Chemical Co., Ltd.

CAS No. 32846-66-5 Molecular formula: C10H8O4 Molecular weight: 192.17 Melting point 224 °C Flash point 244.6 °C Morphology Powder Appearance:Detailed see specifications Storage:keep sealed and keep from dire

1,4-CUBANEDICARBOXYLIC ACID supplier

Cas:32846-66-5

Min.Order:1 Gram

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

32846-66-5

Cas:32846-66-5

Min.Order:0

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Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:1 Gram

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1,4-Cubanedicarboxylic Acid

Cas:32846-66-5

Min.Order:0

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Type:Manufacturers

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Antimex Chemical Limied

1,4-CUBANEDICARBOXYLIC ACIDAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:Used in Synthesis, Pharmaceuticals and other fields Transportation:Sea/air/courier

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

Pentacyclo[4.2.0.02,5.03,8.04,7]octane-1,4-dicarboxylic acid

Cas:32846-66-5

Min.Order:0

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Hangzhou Fandachem Co.,Ltd

1,4-CUBANEDICARBOXYLIC ACID cas 32846-66-5Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

1,4-CUBANEDICARBOXYLIC ACID cas 32846-66-5

Cas:32846-66-5

Min.Order:0

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

32846-66-5

Cas:32846-66-5

Min.Order:0

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

1,4-Cubanedicarboxylic acid

Cas:32846-66-5

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

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Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

1,4-CUBANEDICARBOXYLIC ACID CAS NO.32846-66-5

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai AngewChem Co., Ltd.

98%, in stock Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale pr

1,4-CUBANEDICARBOXYLIC ACID manufacturer high quality

Cas:32846-66-5

Min.Order:1 Gram

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Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

1,4-Cubanedicarboxylic acid

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Nanjing Norris Pharm Technology Co., Ltd.

R & D enterprises have their own stock in stock Appearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Port:Shanghai;Guangzhou

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Type:Lab/Research institutions

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Nanjing Raymon Biotech Co., Ltd.

1,4-CUBANEDICARBOXYLIC ACIDAppearance:yellow to white solid Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fed

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Trading Company

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Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

32846-66-5

Cas:32846-66-5

Min.Order:0

Negotiable

Type:Trading Company

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coolpharm Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

1,4-CUBANEDICARBOXYLIC ACID

Cas:32846-66-5

Min.Order:0

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Type:Other

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Synthetic route

cubane-1,4-dicarboxylic acid dimethyl ester
29412-62-2

cubane-1,4-dicarboxylic acid dimethyl ester

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 4h; Heating;99%
Stage #1: cubane-1,4-dicarboxylic acid dimethyl ester With water; sodium hydroxide In methanol for 4.5h; Reflux;
Stage #2: With hydrogenchloride In water pH=Ca. 1;
99%
With sodium hydroxide In methanol; water for 8h; Heating;96.16%
cubane-1,4-dicarboxylic acid dimethyl ester
29412-62-2

cubane-1,4-dicarboxylic acid dimethyl ester

A

4-(methoxycarbonyl)-1-cubanecarboxylic acid
24539-28-4

4-(methoxycarbonyl)-1-cubanecarboxylic acid

B

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol Ambient temperature;A 95%
B 3%
With barium dihydroxide In methanol; water for 18h; Ambient temperature;
4-(methoxycarbonyl)-1-cubanecarboxylic acid
24539-28-4

4-(methoxycarbonyl)-1-cubanecarboxylic acid

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 4.5h; Reflux;91%
4-methoxycarbonylcubane-1-carbonyl chloride
60462-18-2

4-methoxycarbonylcubane-1-carbonyl chloride

A

cubane-1-carboxylic acid
53578-15-7

cubane-1-carboxylic acid

B

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With dmap; 2-mercaptopyridine-1-oxide sodium salt; 2-methylpropan-2-thiol In benzene Heating; Irradiation;A 57%
B 10.8%
5,9-dibromopentacyclo<5.3.0.02,5.03,9.04,8>decane-6,10-dione
25867-85-0

5,9-dibromopentacyclo<5.3.0.02,5.03,9.04,8>decane-6,10-dione

A

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

B

C10H8O4

C10H8O4

Conditions
ConditionsYield
With potassium hydroxide for 3.5h; Heating; Yields of byproduct given. Title compound not separated from byproducts;
1-bromo-9-oxopentacyclo<4.3.0.02,5.03,8.04,7>nonane-4-carboxylic acid
25867-88-3

1-bromo-9-oxopentacyclo<4.3.0.02,5.03,8.04,7>nonane-4-carboxylic acid

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide Heating;
5,9-dibromopentacyclo<5.3.0.02,5.03,9.04,8>decane-6,10-dione
25867-85-0

5,9-dibromopentacyclo<5.3.0.02,5.03,9.04,8>decane-6,10-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide 1.) reflux, 4 h, H2O; Yield given. Multistep reaction;
(4R,7R)-2,4-Dibromo-3a,4,7,7a-tetrahydro-4,7-methano-indene-1,8-dione

(4R,7R)-2,4-Dibromo-3a,4,7,7a-tetrahydro-4,7-methano-indene-1,8-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) conc. HCl / 1.) methanol, RT, irradiation, 2.) reflux, water
2: 1.) NaOH, 2.) aq. HCl / 1.) reflux, 4 h, H2O
View Scheme
endo-2,4-dibromodicyclopentadiene-1,8-dione bisethylene ketal

endo-2,4-dibromodicyclopentadiene-1,8-dione bisethylene ketal

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 98percent H2SO4 / 30 h / 20 - 25 °C
2: 1.) conc. HCl / 1.) methanol, RT, irradiation, 2.) reflux, water
3: 1.) NaOH, 2.) aq. HCl / 1.) reflux, 4 h, H2O
View Scheme
endo-2,4-dibromodicyclopentadiene-1,8-dione

endo-2,4-dibromodicyclopentadiene-1,8-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: endo-2,4-dibromodicyclopentadiene-1,8-dione With sulfuric acid; water In methanol UV-irradiation; Large scale reaction;
Stage #2: With water; sodium hydroxide for 3h; Reflux;
Stage #1: endo-2,4-dibromodicyclopentadiene-1,8-dione With hydrogenchloride In methanol; water Irradiation;
Stage #2: With sodium hydroxide In water Heating;
endo-2,4-dibromodicyclopentadiene-1,8-dione

endo-2,4-dibromodicyclopentadiene-1,8-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: endo-2,4-dibromodicyclopentadiene-1,8-dione With sulfuric acid In methanol; water at 25℃; UV-irradiation; Large scale reaction;
Stage #2: With sodium hydroxide In water for 3h; Favorskii rearrangement; Reflux;
C10H8Br2O

C10H8Br2O

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: C10H8Br2O With sodium hydroxide In water at 20℃; for 3h; Inert atmosphere; Reflux; Large scale;
Stage #2: With hydrogenchloride In water at 0 - 20℃; pH=1 - 2; Large scale;
1,4-dioxaspiro[4.4]nonane
176-32-9

1,4-dioxaspiro[4.4]nonane

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 3 h / Reflux
3.1: sulfuric acid / 25 h / 20 - 25 °C
4.1: hydrogenchloride / methanol; water / 40 h / Inert atmosphere; Irradiation
4.2: 1.5 h / Reflux; Inert atmosphere
4.3: 4.5 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: bromine / 1,4-dioxane
2.1: sulfuric acid / 20 °C
3.1: hydrogenchloride / methanol; water / Irradiation
3.2: Heating
View Scheme
Multi-step reaction with 4 steps
1.1: bromine / 1,4-dioxane / 22 h / 5 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 24 h / 5 - 110 °C
3.1: sulfuric acid / 30 h / 20 °C
4.1: sulfuric acid; methanol / water / Inert atmosphere; UV-irradiation; Flow reactor
4.2: 3.5 h / Reflux
4.3: 15 h / Reflux
View Scheme
2,2,5-tribromocyclopentanone ethylene acetal
25834-49-5

2,2,5-tribromocyclopentanone ethylene acetal

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / methanol / 3 h / Reflux
2.1: sulfuric acid / 25 h / 20 - 25 °C
3.1: hydrogenchloride / methanol; water / 40 h / Inert atmosphere; Irradiation
3.2: 1.5 h / Reflux; Inert atmosphere
3.3: 4.5 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / methanol / 24 h / 5 - 110 °C
2.1: sulfuric acid / 30 h / 20 °C
3.1: sulfuric acid; methanol / water / Inert atmosphere; UV-irradiation; Flow reactor
3.2: 3.5 h / Reflux
3.3: 15 h / Reflux
View Scheme
(3aα,4β,7α,7aα)-2,4-dibromo-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione bisethylene ketal

(3aα,4β,7α,7aα)-2,4-dibromo-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione bisethylene ketal

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / 25 h / 20 - 25 °C
2.1: hydrogenchloride / methanol; water / 40 h / Inert atmosphere; Irradiation
2.2: 1.5 h / Reflux; Inert atmosphere
2.3: 4.5 h / Reflux; Inert atmosphere
View Scheme
(3aα,4β,7α,7aα)-2,4-dibromo-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione
32846-64-3, 65656-68-0

(3aα,4β,7α,7aα)-2,4-dibromo-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: (3aα,4β,7α,7aα)-2,4-dibromo-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione With hydrogenchloride In methanol; water for 40h; Inert atmosphere; Irradiation;
Stage #2: In water for 1.5h; Reflux; Inert atmosphere;
Stage #3: With sodium hydroxide In water for 4.5h; Reflux; Inert atmosphere;
cyclopentanone
120-92-3

cyclopentanone

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Dowex 50W-X8 resin / toluene / 30 h / Dean-Stark; Heating
2.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 3 h / Reflux
4.1: sulfuric acid / 25 h / 20 - 25 °C
5.1: hydrogenchloride / methanol; water / 40 h / Inert atmosphere; Irradiation
5.2: 1.5 h / Reflux; Inert atmosphere
5.3: 4.5 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: Dowex / benzene
2.1: bromine / 1,4-dioxane
3.1: sulfuric acid / 20 °C
4.1: hydrogenchloride / methanol; water / Irradiation
4.2: Heating
View Scheme
Multi-step reaction with 5 steps
1.1: Dowex 50WX8 (H) / benzene / 30 h / Dean-Stark; Reflux
2.1: bromine / 1,4-dioxane / 22 h / 5 - 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 24 h / 5 - 110 °C
4.1: sulfuric acid / 30 h / 20 °C
5.1: sulfuric acid; methanol / water / Inert atmosphere; UV-irradiation; Flow reactor
5.2: 3.5 h / Reflux
5.3: 15 h / Reflux
View Scheme
endo-2,4-dibromodicyclopentadiene-1,8-dione bisethylene ketal

endo-2,4-dibromodicyclopentadiene-1,8-dione bisethylene ketal

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / 20 °C
2.1: hydrogenchloride / methanol; water / Irradiation
2.2: Heating
View Scheme
endo-2,4-dibromodicyclopentadiene-1,8-dione 1,8-bis(ethylene acetal)

endo-2,4-dibromodicyclopentadiene-1,8-dione 1,8-bis(ethylene acetal)

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / 30 h / 20 °C
2.1: sulfuric acid; methanol / water / Inert atmosphere; UV-irradiation; Flow reactor
2.2: 3.5 h / Reflux
2.3: 15 h / Reflux
View Scheme
endo-2,4-dibromocyclopentadiene-1,8-dione

endo-2,4-dibromocyclopentadiene-1,8-dione

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

Conditions
ConditionsYield
Stage #1: endo-2,4-dibromocyclopentadiene-1,8-dione With methanol; sulfuric acid In water Inert atmosphere; UV-irradiation; Flow reactor;
Stage #2: With water for 3.5h; Reflux;
Stage #3: With sodium hydroxide In water for 15h; Favorskii Rearrangement; Reflux;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

1,4-Bis<(tert-butoxycarbonyl)amino>cubane
87830-27-1

1,4-Bis<(tert-butoxycarbonyl)amino>cubane

Conditions
ConditionsYield
With diphenylphosphoranyl azide; triethylamine for 12h; Heating;94%
With diphenyl phosphoryl azide; triethylamine for 12h; Heating;75.11%
With diphenyl phosphoryl azide; triethylamine for 16h; Reflux;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

1,4-diiodocubane
97229-08-8

1,4-diiodocubane

Conditions
ConditionsYield
With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione In 1,2-dichloro-ethane for 2h; Product distribution / selectivity; Reflux; Irradiation;93%
With [bis(acetoxy)iodo]benzene; iodine In benzene for 6h; Heating;85%
With [bis(acetoxy)iodo]benzene; iodine In benzene for 6h; Moriarty reaction; Inert atmosphere; Reflux;84%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

1,4-bis(hydroxymethyl)cubane
60462-27-3

1,4-bis(hydroxymethyl)cubane

Conditions
ConditionsYield
With aluminium hydride In tetrahydrofuran at 16 - 18℃; for 6h; further reagent: LiAlH4;84%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 4h; Reflux;74%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;
Multi-step reaction with 2 steps
1: Dowex / Heating
2: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N1,N4-dimethoxy-N1,N4-dimethylcubane-1,4-dicarboxamide

N1,N4-dimethoxy-N1,N4-dimethylcubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With thionyl chloride for 3h; Inert atmosphere; Reflux;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 17h;
76%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

1,4-Dibromocubane
59346-70-2

1,4-Dibromocubane

Conditions
ConditionsYield
With bromine; mercury(II) oxide In various solvent(s) Heating;72%
(i) HgO, (ii) Br2; Multistep reaction;
With bromine; mercury(II) oxide In various solvent(s) at 80 - 90℃; for 2.5h; Yield given;
zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

[Zn4O(cubane-1,4-dicarboxylate)3]

[Zn4O(cubane-1,4-dicarboxylate)3]

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 24h;72%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

cubane-1,4-dicarboxylic acid dimethyl ester
29412-62-2

cubane-1,4-dicarboxylic acid dimethyl ester

Conditions
ConditionsYield
With Dowex 50W-X8 resin In methanol for 24h; Reflux;71%
2-fluoro-2,2-dinitroethylsulfuric acid
53510-13-7

2-fluoro-2,2-dinitroethylsulfuric acid

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

bis(2-fluoro-2,2-dinitroethyl) pentacyclo<4.2.0.02,5.03,8.04,7>octane-1,4-dicarboxylate

bis(2-fluoro-2,2-dinitroethyl) pentacyclo<4.2.0.02,5.03,8.04,7>octane-1,4-dicarboxylate

Conditions
ConditionsYield
at 30℃; for 0.5h;68.5%
4-Ethynylaniline
14235-81-5

4-Ethynylaniline

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

N1,N4-bis(4’-ethynylphenyl)cubane-1,4-dicarboxamide

N1,N4-bis(4’-ethynylphenyl)cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 4-Ethynylaniline In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
67%
4-nitro-phenol
100-02-7

4-nitro-phenol

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

1,4-Bis(4-nitrophenoxycarbonyl)cubane

1,4-Bis(4-nitrophenoxycarbonyl)cubane

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h; Esterification;60%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

5-(4-aminophenyl)-10,15,20-triphenylporphyrin
67605-64-5

5-(4-aminophenyl)-10,15,20-triphenylporphyrin

N1,N4-bis[4’-{(10’’,15’’,20’’-triphenylporphyrin)-5’’-yl}phenyl]cubane-1,4-dicarboxamide

N1,N4-bis[4’-{(10’’,15’’,20’’-triphenylporphyrin)-5’’-yl}phenyl]cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 5-(4-aminophenyl)-10,15,20-triphenylporphyrin In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
56%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

[5-(2'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II)

[5-(2'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II)

N1,N4-bis[2’-{(10’’,20’’-bis(4’-methylphenyl)-15’’-phenylporphyrinato)zinc(II)-5’’-yl}phenylacetylene]cubane-1,4-dicarboxamide

N1,N4-bis[2’-{(10’’,20’’-bis(4’-methylphenyl)-15’’-phenylporphyrinato)zinc(II)-5’’-yl}phenylacetylene]cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: [5-(2'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II) In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
50%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

N1,N4-bis(3’-ethynylphenyl)cubane-1,4-dicarboxamide

N1,N4-bis(3’-ethynylphenyl)cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 3-acetylenephenylamine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
50%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

A

1,3,4-Triiodo-cubane
129380-05-8

1,3,4-Triiodo-cubane

B

1,4-diiodocubane
97229-08-8

1,4-diiodocubane

Conditions
ConditionsYield
With tert-Butyl hypoiodite In 1,1,2-Trichloro-1,2,2-trifluoroethane for 24h; Irradiation;A 45%
B 35%
With tert-Butyl hypoiodite In 1,1,2-Trichloro-1,2,2-trifluoroethane for 24h; Irradiation;A 45%
B 35%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

N1,N4-bis(4’-iodophenyl)cubane-1,4-dicarboxamide

N1,N4-bis(4’-iodophenyl)cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: p-aminoiodobenzene In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
39%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

[5-(3'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II)

[5-(3'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II)

N1,N4-bis[3’-{(10’’,20’’-bis(4’-methylphenyl)-15’’-phenylporphyrinato)zinc(II)-5’’-yl}phenylacetylene]cubane-1,4-dicarboxamide

N1,N4-bis[3’-{(10’’,20’’-bis(4’-methylphenyl)-15’’-phenylporphyrinato)zinc(II)-5’’-yl}phenylacetylene]cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: [5-(3'-aminophenylacetylene)-10,20-bis(4'-methylphenyl)-15-phenylporphyrinato]zinc(II) In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
36%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

3-Iodoaniline
626-01-7

3-Iodoaniline

N1,N4-bis(3’-iodophenyl)cubane-1,4-dicarboxamide

N1,N4-bis(3’-iodophenyl)cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 40℃; for 2h; Inert atmosphere;
Stage #2: 3-Iodoaniline With triethylamine In dichloromethane at 0 - 40℃; for 2h; Inert atmosphere;
31%
methanol
67-56-1

methanol

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

cubane-1,4-dicarboxylic acid dimethyl ester
29412-62-2

cubane-1,4-dicarboxylic acid dimethyl ester

Conditions
ConditionsYield
With sulfuric acid for 18h; Inert atmosphere; Reflux;30%
With ion-exchange resin + form> Heating;
With chlorosulfonic acid 1.) 30 deg C, 30 min, 2.) 1 h; Yield given. Multistep reaction;
[5-(4′-aminophenyl)-10,15,20-triphenylporphyrinato]zinc(II)
131956-11-1

[5-(4′-aminophenyl)-10,15,20-triphenylporphyrinato]zinc(II)

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

N1,N4-bis[4’-{(10’’,15’’,20’’-triphenylporphyrinato)zinc(II)-5’’-yl}phenyl]cubane-1,4-dicarboxamide

N1,N4-bis[4’-{(10’’,15’’,20’’-triphenylporphyrinato)zinc(II)-5’’-yl}phenyl]cubane-1,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: [5-(4′-aminophenyl)-10,15,20-triphenylporphyrinato]zinc(II) In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
28%
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

cubane-1,4-diamine dihydrochloride
87830-28-2

cubane-1,4-diamine dihydrochloride

Conditions
ConditionsYield
Stage #1: cubane-1,4-dicarboxylic acid With diphenyl phosphoryl azide; triethylamine In tert-butyl alcohol for 16h; Curtius Rearrangement; Reflux;
Stage #2: With hydrogenchloride In 1,4-dioxane; methanol; water at 20℃; for 4h;
14.5%
2,2,2-trinitroethanol
918-54-7

2,2,2-trinitroethanol

cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

bis(2,2,2-trinitroethyl) pentacyclo<4.2.0.02,5.03,8.04,7>-octane-1,4-dicarboxylate

bis(2,2,2-trinitroethyl) pentacyclo<4.2.0.02,5.03,8.04,7>-octane-1,4-dicarboxylate

Conditions
ConditionsYield
With chlorosulfonic acid 1.) 30 deg C, 30 min, 2.) 1 h; Yield given. Multistep reaction;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

1,4-cubanedicarboxylic acid dichloride
60462-24-0

1,4-cubanedicarboxylic acid dichloride

Conditions
ConditionsYield
With thionyl chloride Heating;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h; Ambient temperature;
With phosphorus pentachloride In chlorobenzene for 2h; Ambient temperature;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

A

1,3,4-Triiodo-cubane
129380-05-8

1,3,4-Triiodo-cubane

B

1,2,4,7-Tetraiodo-cubane
129380-06-9

1,2,4,7-Tetraiodo-cubane

C

1,4-diiodocubane
97229-08-8

1,4-diiodocubane

Conditions
ConditionsYield
With tert-Butyl hypoiodite In tetrachloromethane; 1,1,2-Trichloro-1,2,2-trifluoroethane Irradiation; Further byproducts given;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

C10H9BrO4

C10H9BrO4

Conditions
ConditionsYield
With hydrogen bromide In acetic acid at 70℃; for 0.25h; Yield given;
cubane-1,4-dicarboxylic acid
32846-66-5

cubane-1,4-dicarboxylic acid

(4S,5S)-4,5-Dibromo-tricyclo[4.2.0.03,8]octane-2,7-dicarboxylic acid
125848-35-3

(4S,5S)-4,5-Dibromo-tricyclo[4.2.0.03,8]octane-2,7-dicarboxylic acid

Conditions
ConditionsYield
With hydrogen bromide In acetic acid at 70℃; overnight;

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