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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Nitro-5-(trifluoromethyl)pyridin-2-ol

Cas:33252-64-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 33252-64-1 with fast shipping

Cas:33252-64-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE CAS:33252-64-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE CAS:33252-64-1

Cas:33252-64-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(1H)-Pyridinone,3-nitro-5-(trifluoromethyl)-

Cas:33252-64-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:33252-64-1

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

3-Nitro-5-(trifluoromethyl)pyridin-2-ol 33252-64-1

Cas:33252-64-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2(1H)-Pyridinone,3-nitro-5-(trifluoromethyl)-

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine manufacturer

Cas:33252-64-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-HYDROXY-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Methylcyclohexanol cas no. 33252-64-1 98%

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

2-hydroxy-3-nitro-5-(trifluoromethyl)pyridineAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

3-Nitro-5-(trifluoromethyl)pyridin-2-ol CAS 33252-64-1

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Nitro-5-(trifluoromethyl)pyridin-2(1H)-one

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2(1H)-Pyridinone,3-nitro-5-(trifluoromethyl)-

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1 Application:C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

3-nitro-5-(trifluoromethyl)pyridin-2-ol

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-Nitro-5-(trifluoromethyl)pyridin-2-ol cas 33252-64-1Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-Nitro-5-(trifluoromethyl)pyridin-2-ol cas 33252-64-1

Cas:33252-64-1

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

5-(Trifluoromethyl)-3-nitro-2-aminopyridine
53359-69-6

5-(Trifluoromethyl)-3-nitro-2-aminopyridine

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite In water at 0 - 20℃; Inert atmosphere;73%
2-hydroxy-5-(trifluoromethyl)pyridine
33252-63-0

2-hydroxy-5-(trifluoromethyl)pyridine

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

Conditions
ConditionsYield
Stage #1: 2-hydroxy-5-(trifluoromethyl)pyridine With sulfuric acid; nitric acid at 0 - 65℃; for 25h;
Stage #2: With sodium hydroxide In water at 20℃;
58%
With sulfuric acid; nitric acid at 80 - 85℃;28%
With sulfuric acid; potassium nitrate at 0 - 65℃; for 4h;
With sulfuric acid; nitric acid In water at 80℃; for 1h;
With sulfuric acid; nitric acid In water at 60℃; for 18h;
2-amino-5-trifluoromethylpyridine
74784-70-6

2-amino-5-trifluoromethylpyridine

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / 0 - 20 °C / Inert atmosphere
2: sulfuric acid; sodium nitrite / water / 0 - 20 °C / Inert atmosphere
View Scheme
benzyltrimethylammonium chloride
56-93-9

benzyltrimethylammonium chloride

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-chloro-3-nitro-5-(trifluoromethyl)pyridine
72587-15-6

2-chloro-3-nitro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With trichlorophosphate In acetonitrile for 3h; Heating;92%
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-chloro-3-nitro-5-(trifluoromethyl)pyridine
72587-15-6

2-chloro-3-nitro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With quinoline; trichlorophosphate at 50 - 120℃; for 1.5h; Inert atmosphere;88%
With quinoline; trichlorophosphate for 18h; Heating / reflux;87%
With trichlorophosphate In DMF (N,N-dimethyl-formamide) at 110℃; for 0.5h;86%
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

methyl iodide
74-88-4

methyl iodide

1-methyl-3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one
1573056-08-2

1-methyl-3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 3h;70%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1.5h;
phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-chloro-3-nitro-5-(trifluoromethyl)pyridine
72587-15-6

2-chloro-3-nitro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With trichlorophosphate52%
With trichlorophosphate52%
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

6-Trifluoromethyl-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one

6-Trifluoromethyl-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 66 percent / PCl5, POCl3 / 80 °C
2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h
3: 73 percent / Fe, glacial AcOH / 2 h / Heating
4: 43 percent / H2 / 10percent Pd/C / acetic acid / 3 h / 2280 Torr
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-benzyloxycarbonyl-6-trifluoromethyl-4-azaoxindole
136888-31-8

3-benzyloxycarbonyl-6-trifluoromethyl-4-azaoxindole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 66 percent / PCl5, POCl3 / 80 °C
2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h
3: 73 percent / Fe, glacial AcOH / 2 h / Heating
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-bis(benzyloxycarbonyl)methyl-3-nitro-5-trifluoromethylpyridine
136888-30-7

2-bis(benzyloxycarbonyl)methyl-3-nitro-5-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 66 percent / PCl5, POCl3 / 80 °C
2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h
View Scheme
p-methyloxycarbonylbenzyl chloride
34040-64-7

p-methyloxycarbonylbenzyl chloride

3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

methyl 4-(3-nitro-5-trifluoromethylpyridine-2-yloxymethyl)benzoate
209687-69-4

methyl 4-(3-nitro-5-trifluoromethylpyridine-2-yloxymethyl)benzoate

Conditions
ConditionsYield
In argon; toluene
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-hydroxy-3-amino-5-trifluoromethylpyridine
90778-25-9

2-hydroxy-3-amino-5-trifluoromethylpyridine

Conditions
ConditionsYield
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 20℃; under 760.051 Torr; for 2h;
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 20℃; under 760.051 Torr; for 2h;
With hydrogen; 5%-palladium/activated carbon In methanol at 20℃; under 760.051 Torr; for 2h;
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide
1192021-84-3

N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-chloro-N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide
1192021-85-4

3-chloro-N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr
2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 50 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C
2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: triethylamine / N,N-dimethyl-formamide / 50 °C / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]-3-(methoxymethyl)isonicotinamide
1192021-96-7

N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]-3-(methoxymethyl)isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr
2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C
2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-amino-5-trifluoromethyl-2-mercaptopyridine
89571-66-4

3-amino-5-trifluoromethyl-2-mercaptopyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-(3-fluoropyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-41-5

2-(3-fluoropyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-(3-ethoxypyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-43-7

2-(3-ethoxypyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
5.1: potassium carbonate / 8 h / Reflux
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-45-9

2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C
5.2: 1 h / 20 °C / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-[3-(methylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-46-0

2-[3-(methylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
5.1: N,N-dimethyl-formamide / 2 h / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-[3-(ethylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-47-1

2-[3-(ethylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
5.1: N,N-dimethyl-formamide / 1 h / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

A

2-[3-(ethanesulfinyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-49-3

2-[3-(ethanesulfinyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

B

2-[3-(ethanesulfonyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
1286196-48-2

2-[3-(ethanesulfonyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
4.1: dimethyl sulfoxide / 2 h / 170 °C
5.1: N,N-dimethyl-formamide / 1 h / Cooling with ice
6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 0 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

5-trifluoromethyl-2-mercapto-3-nitropyridine
89571-67-5

5-trifluoromethyl-2-mercapto-3-nitropyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trichlorophosphate; quinoline / 5.5 h / Reflux
1.2: Cooling with ice
2.1: thiourea / ethanol / 5.5 h / 50 °C
2.2: 1.5 h / 20 °C
2.3: Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-[2-(2,2,2-trifluoroethoxy)-phenyl]-6-trifluoromethyl-oxazolo[5,4-b]pyridine
1282532-89-1

2-[2-(2,2,2-trifluoroethoxy)-phenyl]-6-trifluoromethyl-oxazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h
3.1: trichlorophosphate / 4 h / 120 °C
3.2: pH 7 / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h / 20 °C
3.1: trichlorophosphate / 4 h / 120 °C
3.2: pH 7 / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h
3.1: trichlorophosphate / 4 h / 120 °C
3.2: pH ~ 7 / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h
3.1: trichlorophosphate / 4 h / 120 °C
3.2: pH ~ 7 / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

N-(2-hydroxy-5-trifluoromethylpyridin-3-yl)-3-(2,2,2-trifluoroethoxy)-isonicotinamide
1282541-13-2

N-(2-hydroxy-5-trifluoromethylpyridin-3-yl)-3-(2,2,2-trifluoroethoxy)-isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice
2.2: 4.5 h
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: tetrahydrofuran / 20 °C / Cooling with ice
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

N-[2-hydroxy-6-(trifluoromethyl)pyridin-3-yl]-isonicotinamide
1192021-97-8

N-[2-hydroxy-6-(trifluoromethyl)pyridin-3-yl]-isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr
2: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 50 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

2-[2-(2,2,2-trifluoroethoxy)phenyl]-6-trifluoromethyloxazolo[5,4-b]pyridine

2-[2-(2,2,2-trifluoroethoxy)phenyl]-6-trifluoromethyloxazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr
2: tetrahydrofuran / 20 °C / Cooling with ice
3: trichlorophosphate / 4 h / 120 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile
866775-16-8

3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2: tetrabutylammomium bromide / toluene / 10 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2: tetrabutylammomium bromide / toluene / 9 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: phosphorus(V) oxybromide / 20 °C / Reflux
2: tetrabutylammomium bromide / toluene / 9 h / Reflux
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
866775-17-9

3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere
4.1: hydrogenchloride; water / 24 h / Reflux
5.1: sulfuric acid / 48 h / Reflux
5.2: 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux
3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h
3.2: 24 h / Reflux
3.3: 84 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: phosphorus(V) oxybromide / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h
3.2: 24 h / Reflux
3.3: 84 h / Reflux
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
866775-18-0

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere
4.1: hydrogenchloride; water / 24 h / Reflux
5.1: sulfuric acid / 48 h / Reflux
5.2: 20 °C
6.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux
3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h
3.2: 24 h / Reflux
3.3: 84 h / Reflux
4.1: bromine; acetic acid; sulfuric acid / water / 19.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: phosphorus(V) oxybromide / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h
3.2: 24 h / Reflux
3.3: 84 h / Reflux
4.1: bromine; acetic acid; sulfuric acid / water / 19.5 h / 20 °C
View Scheme
3-nitro-5-trifluoromethylpyridin-2-ol
33252-64-1

3-nitro-5-trifluoromethylpyridin-2-ol

3-amino-6-methoxy-5-trifluoromethylpyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide
1334546-75-6

3-amino-6-methoxy-5-trifluoromethylpyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere
4.1: hydrogenchloride; water / 24 h / Reflux
5.1: sulfuric acid / 48 h / Reflux
5.2: 20 °C
6.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C
7.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux
8.1: sodium hydroxide; water / 1 h / 20 °C
8.2: pH 1
9.1: hydroxylamine hydrochloride; triethylamine; ethanol / 5 h / Reflux
10.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 2 h
View Scheme
Multi-step reaction with 8 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C
2.1: tetrabutylammomium bromide; copper(l) cyanide / toluene / 10 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h
3.2: 24 h / Reflux
3.3: 48 h / Reflux
4.1: sulfuric acid / water / 0.5 h
4.2: 18 h / 20 °C
5.1: toluene-4-sulfonic acid / toluene / 20 °C / Reflux; Dean-Stark
6.1: sodium hydroxide; methanol / 1 h / 20 °C
7.1: triethylamine; hydroxylamine hydrochloride / water; ethanol / 5 h / Reflux
8.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h
View Scheme

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