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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Boceprevir

Cas:394730-60-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

TRIMETHYLHYDRAZINE

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

We are very compeitive on Boceprevir.Our mfr is GMP certified for this item with DMF document. Product Name: Boceprevir Synonyms: Boceprevir (1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobu

factory supply Boceprevir 394730-60-0

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:

Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Boceprevir manufacturer with low price

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Boceprevir 394730-60-0 ISO Manufacturer

Cas:394730-60-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Boceprevir

Cas:394730-60-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 394730-60-0 with best quality

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

BoceprevirCAS NO.: 394730-60-0

Cas:394730-60-0

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Boceprevir 394730-60-0

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

good quality ,competitive price. Storage:keep from moisture,store in tight container Application: Anti - hepatitis c Transportation:by air or by courier

Boceprevir

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Qingdao Beluga Import and Export Co., LTD

Boceprevir CAS:394730-60-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Boceprevir CAS:394730-60-0

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

high quality & Good price powder Boceprevir

Cas:394730-60-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Boceprevir CAS: 394730-60-0 Specification Item Standard Identification A.H-NMR:Comply with the structure B.LC-MS:Comply with the structure C.The IR spectrum of sa

Factory supply Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Boceprevir 394730-60-0

Cas:394730-60-0

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Boceprevir

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Boceprevir

Cas:394730-60-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Boceprevir

Cas:394730-60-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

BoceprevirAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates, OLED&Battery Ingre

Boceprevir

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

Additive Chinese name to allow Chinese name using the additive of food additive function maximum permissible usage (g/kg) maximum allowable residue (g/kg) Butyl acetate food food prepared with spices used to flavor various spices composition shall

boceprevir

Cas:394730-60-0

Min.Order:10 Metric Ton

FOB Price: $850.0 / 1100.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Boceprevir Synonyms: Boceprevir (1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2

TIANFUCHEM-- Boceprevir

Cas:394730-60-0

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Boceprevir CAS No.:394730-60-0 Molecule Formula:C27H45N5O5 Molecule Weight:519.68 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE

Best Quality Boceprevir with good supplier

Cas:394730-60-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Boceprevir USP/EP/BP

Cas:394730-60-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity Boceprevir

Cas:394730-60-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Boceprevir

Cas:394730-60-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM-- Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Boceprevir

Cas:394730-60-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-(tert-butyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicylo[3.1.0]-hexane-2-carboxamide
394735-28-5

(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-(tert-butyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicylo[3.1.0]-hexane-2-carboxamide

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Stage #1: (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-(tert-butyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicylo[3.1.0]-hexane-2-carboxamide With sodium hypochlorite solution; sodium acetate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In tert-butyl methyl ether at 10 - 20℃;
Stage #2: With water; acetic acid In tert-butyl methyl ether for 2.25h;
Stage #3: With sodium hypochlorite solution; ascorbic acid Product distribution / selectivity; more than 3 stages;
94%
With sodium permanganate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid In tert-butyl methyl ether; water at 12℃;91%
With Dess-Martin periodane In ethyl acetate at 5 - 18℃; for 5.25h; Reagent/catalyst;40%
C27H46N5O8S(1-)*Na(1+)
817170-37-9

C27H46N5O8S(1-)*Na(1+)

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
With Oxone In tert-butyl methyl ether; water at 25℃; for 1h; Purification / work up;94%
With dipotassium peroxodisulfate In tert-butyl methyl ether; water at 25℃; for 0.75h; Purification / work up;88%
With sodium chloride In tert-butyl methyl ether; water at 30℃; for 0.5h; Purification / work up;84%
With Glyoxilic acid In water at 8 - 25℃; for 4h; Purification / work up;65%
With sodium glyoxylate In water at 8 - 25℃; for 4.33333h; Purification / work up;52%
(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
816444-90-3

(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

C8H14N2O2*ClH
817169-86-1

C8H14N2O2*ClH

A

boceprevir
394730-60-0

boceprevir

B

N-methylmorpholine hydrochloride
3651-67-0

N-methylmorpholine hydrochloride

Conditions
ConditionsYield
With 4-methyl-morpholine; isobutyl chloroformate In ethyl acetate at 0 - 10℃; for 1h;A 90%
B n/a
(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
816444-90-3

(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

C8H14N2O2*ClH
817169-86-1

C8H14N2O2*ClH

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 15 - 20℃; for 1h;85%
(2-cyclobutyl-1-formylethyl)carbamic acid tert-butyl ester
394735-19-4

(2-cyclobutyl-1-formylethyl)carbamic acid tert-butyl ester

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 12 h / 20 °C
2: H2O2; LiOH / methanol / 3 h / 0 °C
3: HCl / dioxane / 2 h / 20 °C
4: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
5: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: Et3N / CH2Cl2 / 12 h / 20 °C
2: HCl / 24 h / Heating
3: Et3N / CH2Cl2 / 20 °C
4: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
5: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
6: HCl / dioxane / 2 h / 20 °C
7: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
8: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(2-cyano-1-cyclobutylmethyl-2-hydroxyethyl)carbamic acid tert-butyl ester
394735-20-7

(2-cyano-1-cyclobutylmethyl-2-hydroxyethyl)carbamic acid tert-butyl ester

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2O2; LiOH / methanol / 3 h / 0 °C
2: HCl / dioxane / 2 h / 20 °C
3: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
4: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: HCl / 24 h / Heating
2: Et3N / CH2Cl2 / 20 °C
3: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
4: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
5: HCl / dioxane / 2 h / 20 °C
6: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
7: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoic acid
565456-75-9

2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoic acid

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
2: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: Et3N / CH2Cl2 / 12 h / 20 °C
4: H2O2; LiOH / methanol / 3 h / 0 °C
5: HCl / dioxane / 2 h / 20 °C
6: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
7: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
2: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: Et3N / CH2Cl2 / 12 h / 20 °C
4: HCl / 24 h / Heating
5: Et3N / CH2Cl2 / 20 °C
6: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
7: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
8: HCl / dioxane / 2 h / 20 °C
9: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
10: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
tert-butyl 3-cyclobutyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
394735-18-3

tert-butyl 3-cyclobutyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: Et3N / CH2Cl2 / 12 h / 20 °C
3: H2O2; LiOH / methanol / 3 h / 0 °C
4: HCl / dioxane / 2 h / 20 °C
5: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
6: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: Et3N / CH2Cl2 / 12 h / 20 °C
3: HCl / 24 h / Heating
4: Et3N / CH2Cl2 / 20 °C
5: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
6: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
7: HCl / dioxane / 2 h / 20 °C
8: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
9: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
methyl 3-tert-butoxycarbonylamino-4-cyclobutyl-2-hydroxybutyrate
394735-21-8

methyl 3-tert-butoxycarbonylamino-4-cyclobutyl-2-hydroxybutyrate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
2: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
3: HCl / dioxane / 2 h / 20 °C
4: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
5: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
3-(tert-butoxycarbonylamino)-4-cyclobutyl-2-hydroxybutanoic acid
864765-28-6

3-(tert-butoxycarbonylamino)-4-cyclobutyl-2-hydroxybutanoic acid

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
2: HCl / dioxane / 2 h / 20 °C
3: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
4: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
ethyl 2-amino-3-cyclobutylpropanoate
394735-17-2

ethyl 2-amino-3-cyclobutylpropanoate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: CH2Cl2 / 12 h / 20 °C
2: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
3: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
4: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5: Et3N / CH2Cl2 / 12 h / 20 °C
6: H2O2; LiOH / methanol / 3 h / 0 °C
7: HCl / dioxane / 2 h / 20 °C
8: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
9: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1: CH2Cl2 / 12 h / 20 °C
2: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
3: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
4: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5: Et3N / CH2Cl2 / 12 h / 20 °C
6: HCl / 24 h / Heating
7: Et3N / CH2Cl2 / 20 °C
8: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
9: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
10: HCl / dioxane / 2 h / 20 °C
11: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
12: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
3-(tert-butyl) 2-methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,3-dicarboxylate
569679-06-7

3-(tert-butyl) 2-methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,3-dicarboxylate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: HCl / dioxane
2: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
3: HCl / dioxane / 3 h / 20 °C
4: CH2Cl2 / 20 °C
5: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
6: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
7: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate
816430-02-1

ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
2: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
3: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4: Et3N / CH2Cl2 / 12 h / 20 °C
5: H2O2; LiOH / methanol / 3 h / 0 °C
6: HCl / dioxane / 2 h / 20 °C
7: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
8: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
2: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
3: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4: Et3N / CH2Cl2 / 12 h / 20 °C
5: HCl / 24 h / Heating
6: Et3N / CH2Cl2 / 20 °C
7: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
8: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
9: HCl / dioxane / 2 h / 20 °C
10: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
11: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
tert-butyl 4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-ylcarbamate
394735-22-9

tert-butyl 4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-ylcarbamate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCl / dioxane / 2 h / 20 °C
2: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
3: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / isopropyl alcohol / 4 h / 50 °C / Large scale
2: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; ethyl acetate; 1-methyl-pyrrolidin-2-one / 16 h / 20 - 24 °C
3: acetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium permanganate / tert-butyl methyl ether; water / 12 °C
View Scheme
2-(benzhydrylidene-amino)-3-cyclobutyl-propionic acid ethyl ester
1025799-39-6

2-(benzhydrylidene-amino)-3-cyclobutyl-propionic acid ethyl ester

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 18 g / aq. HCl / diethyl ether / 5 h / 20 °C
2: CH2Cl2 / 12 h / 20 °C
3: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
4: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
5: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
6: Et3N / CH2Cl2 / 12 h / 20 °C
7: H2O2; LiOH / methanol / 3 h / 0 °C
8: HCl / dioxane / 2 h / 20 °C
9: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
10: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 13 steps
1: 18 g / aq. HCl / diethyl ether / 5 h / 20 °C
2: CH2Cl2 / 12 h / 20 °C
3: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
4: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
5: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
6: Et3N / CH2Cl2 / 12 h / 20 °C
7: HCl / 24 h / Heating
8: Et3N / CH2Cl2 / 20 °C
9: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
10: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
11: HCl / dioxane / 2 h / 20 °C
12: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
13: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(1R,2S,5S)-3-((S)-2-tert-Butoxycarbonylamino-3,3-dimethyl-butyryl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid methyl ester
394735-26-3

(1R,2S,5S)-3-((S)-2-tert-Butoxycarbonylamino-3,3-dimethyl-butyryl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid methyl ester

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: HCl / dioxane / 3 h / 20 °C
2: CH2Cl2 / 20 °C
3: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
4: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
5: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
2: HCl / dioxane / 3 h / 20 °C
3: CH2Cl2 / 20 °C
4: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
5: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
6: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.17 h / 0 - 5 °C
1.2: 6 h / 25 - 30 °C
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 6 h / 25 - 30 °C
3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 0 - 30 °C
4.1: Dess-Martin periodane / dichloromethane / 0 - 30 °C
View Scheme
methyl (1R,2S,5S)-3-((S)-2-(3-(tert-butyl)-ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
394735-27-4

methyl (1R,2S,5S)-3-((S)-2-(3-(tert-butyl)-ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
2: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
3: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: water; lithium hydroxide monohydrate / tetrahydrofuran / 6 h / 25 - 30 °C
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 0 - 30 °C
3: Dess-Martin periodane / dichloromethane / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: water; sodium hydroxide / toluene; methanol / 0 - 30 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide; ethyl acetate / 0 - 10 °C
3: Dess-Martin periodane / ethyl acetate / 5.25 h / 5 - 18 °C
View Scheme
methyl 3-amino-4-cyclobutyl-2-hydroxybutyrate hydrochloride

methyl 3-amino-4-cyclobutyl-2-hydroxybutyrate hydrochloride

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Et3N / CH2Cl2 / 20 °C
2: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
3: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
4: HCl / dioxane / 2 h / 20 °C
5: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
6: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride

3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
2: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; ethyl acetate; 1-methyl-pyrrolidin-2-one / 16 h / 20 - 24 °C
2: acetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium permanganate / tert-butyl methyl ether; water / 12 °C
View Scheme
(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
816444-90-3

(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
2: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 0 - 30 °C
2: Dess-Martin periodane / dichloromethane / 0 - 30 °C
View Scheme
(1R,2S,5S)-methyl 3-((S)-2-amino-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

(1R,2S,5S)-methyl 3-((S)-2-amino-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: CH2Cl2 / 20 °C
2: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
3: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
4: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(Bromomethyl)cyclobutane
17247-58-4

(Bromomethyl)cyclobutane

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: t-BuOK / tetrahydrofuran / 1 h / 0 °C
1.2: tetrahydrofuran / 48 h / 20 °C
2.1: 18 g / aq. HCl / diethyl ether / 5 h / 20 °C
3.1: CH2Cl2 / 12 h / 20 °C
4.1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
5.1: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
6.1: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
7.1: Et3N / CH2Cl2 / 12 h / 20 °C
8.1: H2O2; LiOH / methanol / 3 h / 0 °C
9.1: HCl / dioxane / 2 h / 20 °C
10.1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
11.1: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 14 steps
1.1: t-BuOK / tetrahydrofuran / 1 h / 0 °C
1.2: tetrahydrofuran / 48 h / 20 °C
2.1: 18 g / aq. HCl / diethyl ether / 5 h / 20 °C
3.1: CH2Cl2 / 12 h / 20 °C
4.1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
5.1: 15.0 g / BOP; N-methylmorpholine / CH2Cl2 / 16 h / 20 °C
6.1: 14 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
7.1: Et3N / CH2Cl2 / 12 h / 20 °C
8.1: HCl / 24 h / Heating
9.1: Et3N / CH2Cl2 / 20 °C
10.1: LiOH*H2O / tetrahydrofuran; H2O / 2 h / 20 °C
11.1: NH4Cl; EDCI; HOOBt / NMM / CH2Cl2; dimethylformamide / 72 h / 20 °C
12.1: HCl / dioxane / 2 h / 20 °C
13.1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
14.1: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one
134107-65-6

(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: BuLi / tetrahydrofuran
1.2: tetrahydrofuran / -78 - 20 °C
2.1: LiAlH4 / tetrahydrofuran / Heating
3.1: H2 / Pd/C
4.1: acetone / 3 h / -5 °C
5.1: toluene; methanol
6.1: HCl / dioxane
7.1: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
8.1: HCl / dioxane / 3 h / 20 °C
9.1: CH2Cl2 / 20 °C
10.1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
11.1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
12.1: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
103201-79-2

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: KHMDS; PhSeCl / -78 - 20 °C
1.2: H2O2; pyridine
2.1: BuLi / tetrahydrofuran
2.2: tetrahydrofuran / -78 - 20 °C
3.1: LiAlH4 / tetrahydrofuran / Heating
4.1: H2 / Pd/C
5.1: acetone / 3 h / -5 °C
6.1: toluene; methanol
7.1: HCl / dioxane
8.1: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
9.1: HCl / dioxane / 3 h / 20 °C
10.1: CH2Cl2 / 20 °C
11.1: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
12.1: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
13.1: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
((1R,2S,5S)-3-Benzyl-6,6-dimethyl-3-aza-bicyclo[3.1.0]hex-2-yl)-methanol
1026427-11-1

((1R,2S,5S)-3-Benzyl-6,6-dimethyl-3-aza-bicyclo[3.1.0]hex-2-yl)-methanol

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: H2 / Pd/C
2: acetone / 3 h / -5 °C
3: toluene; methanol
4: HCl / dioxane
5: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
6: HCl / dioxane / 3 h / 20 °C
7: CH2Cl2 / 20 °C
8: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
9: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
10: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
tert-butyl (1R,2S,5S)-2-(hydroxymethyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carboxylate
219754-00-4

tert-butyl (1R,2S,5S)-2-(hydroxymethyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carboxylate

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: acetone / 3 h / -5 °C
2: toluene; methanol
3: HCl / dioxane
4: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
5: HCl / dioxane / 3 h / 20 °C
6: CH2Cl2 / 20 °C
7: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
8: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
9: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
(1R,2S,5S)-3-(tert-butoxycarbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
219754-02-6

(1R,2S,5S)-3-(tert-butoxycarbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: toluene; methanol
2: HCl / dioxane
3: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
4: HCl / dioxane / 3 h / 20 °C
5: CH2Cl2 / 20 °C
6: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
7: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
8: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0 - 30 °C
2: hydrogenchloride / isopropyl alcohol / 6 h / 60 - 65 °C
3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 5 h / 25 - 30 °C
4: Dess-Martin periodane / dichloromethane / 0 - 30 °C
View Scheme
(1S,2S,4S,7R)-6-aza-3,3-dimethyl-8-oxa-7-phenyltricyclo<4.3.0.0>nonan-5-one
219753-99-8

(1S,2S,4S,7R)-6-aza-3,3-dimethyl-8-oxa-7-phenyltricyclo<4.3.0.0>nonan-5-one

boceprevir
394730-60-0

boceprevir

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: LiAlH4 / tetrahydrofuran / Heating
2: H2 / Pd/C
3: acetone / 3 h / -5 °C
4: toluene; methanol
5: HCl / dioxane
6: BOP; N-methylmorpholine / CH2Cl2; dimethylformamide / 24 h / 20 °C
7: HCl / dioxane / 3 h / 20 °C
8: CH2Cl2 / 20 °C
9: LiOH*H2O / tetrahydrofuran; H2O / 3 h / 20 °C
10: EDCI; HOOBt; N-methylmorpholine / dimethylformamide; CH2Cl2 / 48 h / -20 °C
11: dichloroacetic acid; EDCI; DMSO / toluene / 4 h / 20 °C
View Scheme

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