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Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Alfacalcidol is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical

Alfacalcidol 99%

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Luhan Pharmachem Co., Ltd

Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod

Alfacalcidol

Cas:41294-56-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Alfacalcidol Manufacturer/High quality/Best price/In stock

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min -----------------------------------------------------------------------------------------------

High purity Various Specifications alphacalcidol CAS:41294-56-8

Cas:41294-56-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Α-Calcidol supplier in China

Cas:41294-56-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Alfacalcidol CAS NO.41294-56-8

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Alphacalcidol CAS 41294-56-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributin

Alphacalcidol CAS 41294-56-8

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Α-Calcidol

Cas:41294-56-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Alfacalcidol 41294-56-8 GMP Manufacturer

Cas:41294-56-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1α-Hydroxycholecalciferol

Cas:41294-56-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Alfacalcidol Basic information Product Name: Alfacalcidol Synonyms: VITAMIN D3, 1ALPHA-HYDROXY-;HYDROXYVITAMIN D3;ALFACALCIDOL;ALPHACALCIDOL;1-HYDROXYCHOLECALCIFEROL;1ALP

TIANFU-CHEM CAS:41294-56-8 Alfacalcidol

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 41294-56-8 with competitive price

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Good quality Alfacalcidol CAS 41294-56-8

Cas:41294-56-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name Alfacalcidol Other names 1α-Hydroxyvitamin D3 CAS41294-56-8MFC27H44O2Appearance White powderPurity 99%MINStructure ApplicationAlfacalcidol is a non-selective VDR activator medication. Appearance:White powder Storage:Stor

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Alfacalcidol CAS 41294-56-8 White Powder for A synthetic analog

Cas:41294-56-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Alfacalcidol 41294-56-8

Cas:41294-56-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Alfacalcidol CAS: 41294-56-8 MF: C27H44O2 MW: 400.64 EINECS: 255-297-1 Mol File: 41294-56-8.mol Alfacalcidol Structure Alfacalcidol Chemical Properties Melting point 134-136°C Boiling point 531.5±5

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Alfacalcidol CAS 41294-56-8 For research Use only

Cas:41294-56-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Alfacalcidol manufacturer with low price

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Gram

FOB Price: $400.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Alfacalcidol CAS:41294-56-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Alfacalcidol CAS:41294-56-8

Cas:41294-56-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Alfacalcidol/ LIDE PHARMA- Factory supply / Best price

Cas:41294-56-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Hot Sales Alfacalcidol CAS NO.41294-56-8 CAS NO.41294-56-8

Cas:41294-56-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Alfacalcidol CAS: 41294-56-8 Specification proname: alfacalcidol casno: 41294-56-8 molecular formula: c27h44o2 appearance: white to off-white crystalline powder application: a synthetic analog of calcitiol (the h... deliverytime: 3-5 days af

Factory supply Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Alfacalcidol

Cas:41294-56-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Alfacalcidol

Cas:41294-56-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Synthetic route

1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene
108887-35-0

1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h; Heating;98%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 55℃;70%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 4h; Yield given;
(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene
873567-11-4

(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1h;94%
1α-di<(2-methoxyethoxy)methoxy>vitamin D3
162889-26-1

1α-di<(2-methoxyethoxy)methoxy>vitamin D3

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With zinc dibromide In dichloromethane91%
(1R,3aS,7aR)-4-[2-[(3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene
138924-22-8

(1R,3aS,7aR)-4-[2-[(3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 40h; Ambient temperature;79%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;79%
Conditions
ConditionsYield
With anthracene In methanol at 20℃; for 4h; Inert atmosphere; UV-irradiation;75%
With anthracene; triethylamine In toluene Kinetics; Concentration; Time; UV-irradiation;
1α-hydroxyprecalciferol3
41461-13-6

1α-hydroxyprecalciferol3

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With potassium hydroxide In methanol at 80℃; for 24h;64%
In benzene for 8h; Heating; Yield given;
In ethanol-d6 at 80℃; Rate constant; Equilibrium constant;
(1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3
67657-73-2

(1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Stage #1: (1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3 With acetic acid In dimethyl sulfoxide at 20 - 50℃; for 1h; Inert atmosphere;
Stage #2: With 4-Phenylurazole In ethyl acetate at 10℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;
45%
Multi-step reaction with 3 steps
1: Hunig base / 5 h / Ambient temperature
2: pTsOH / dioxane; H2O / 0.08 h / 55 °C
3: 39 percent / conc. HCl / methanol / 3.5 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 83 percent / N-ethyl diisopropylamine (Huenig's base) / CH2Cl2 / 1.) 0 deg C, 2.) room temperature, 5 h
2: 51 percent / water / toluene-p-sulphonic acid (PTSA) / dioxane / 0.08 h / 55 °C
3: 39 percent / conc. hydrochloric acid / methanol / 3.5 h / 60 °C
View Scheme
(1S)-1-methoxymethoxyvitamin D3
101046-92-8

(1S)-1-methoxymethoxyvitamin D3

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
With hydrogenchloride In methanol at 60℃; for 3.5h;39%
With hydrogenchloride In methanol at 60℃; for 3.5h;39%
1α,3β-dihydroxycholesta-5,7-diene
43217-89-6

1α,3β-dihydroxycholesta-5,7-diene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Stage #1: 1α,3β-dihydroxycholesta-5,7-diene In 1,4-dioxane Irradiation;
Stage #2: at 100℃;
13%
In benzene Irradiation;
(i) EtOH, (UV-irradiation), (ii) (heating); Multistep reaction;
1α,3β-diacetoxycholesta-5,7-diene
41461-10-3

1α,3β-diacetoxycholesta-5,7-diene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
(i) pentane, (UV-irradiation), (ii) (isomerization), (iii) (saponification); Multistep reaction;
Multi-step reaction with 2 steps
1: aq. KOH / methanol
2: (i) EtOH, (UV-irradiation), (ii) (heating)
View Scheme
Grundmann's ketone
66251-18-1

Grundmann's ketone

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 50 percent / tetrahydrofuran
2.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C
2.2: ZnBr2 / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - -10 °C
2.3: 75 percent / Et3N / (Ph3P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C
3.1: 94 percent / n-Bu4NF / tetrahydrofuran / 1 h
View Scheme
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
1.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
2.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 1.) sodium hexamethyldisilazide / 1.) THF, -60 deg C, 1 h, 2.) THF, RT, 1 h
2: 163.5 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating
3: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 1.) sodium hexamethyldisilazide / 1.) THF, -60 deg C, 1 h, 2.) THF, RT, 1 h
2: 33 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating
3: 17.5 mg / toluene / 1 h / 80 °C
4: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature
View Scheme
(8E)-8-bromomethylene-de-A,B-cholestane
93490-17-6

(8E)-8-bromomethylene-de-A,B-cholestane

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C
1.2: ZnBr2 / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - -10 °C
1.3: 75 percent / Et3N / (Ph3P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C
2.1: 94 percent / n-Bu4NF / tetrahydrofuran / 1 h
View Scheme
Multi-step reaction with 2 steps
1: 163.5 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating
2: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 33 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating
2: 17.5 mg / toluene / 1 h / 80 °C
3: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature
View Scheme
(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal
104651-47-0

(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 96 percent / PPh3 / CH2Cl2 / 0.05 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C
2.2: 100 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C
3.1: pyridine / CH2Cl2 / 2 h / 20 °C
4.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating
5.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating
6.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
7.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
8.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
8.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
9.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
(8β)-De-A,B-22-cholestyne-8-one
263712-15-8

(8β)-De-A,B-22-cholestyne-8-one

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
2.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
2.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
3.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
(8β)-De-A,B-22-cholestyne-8-ol
263712-14-7

(8β)-De-A,B-22-cholestyne-8-ol

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
2.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
3.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
4.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
(8β)-De-A,B-23,23-dibromo-8-(tert-butyldimethylsilyloxy)-24-norchol-22-ene
214777-06-7

(8β)-De-A,B-23,23-dibromo-8-(tert-butyldimethylsilyloxy)-24-norchol-22-ene

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C
1.2: 100 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C
2.1: pyridine / CH2Cl2 / 2 h / 20 °C
3.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating
4.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating
5.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
6.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
7.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
7.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
8.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne
263712-13-6

(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating
2.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
3.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
4.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
4.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
5.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne-24-ol
263712-12-5

(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne-24-ol

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridine / CH2Cl2 / 2 h / 20 °C
2.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating
3.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating
4.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
5.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
6.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
6.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
7.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
thiocarbonic acid O-{4-[4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-isopropyl-pent-2-ynyl} ester O-phenyl ester

thiocarbonic acid O-{4-[4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-isopropyl-pent-2-ynyl} ester O-phenyl ester

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating
2.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating
3.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C
5.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C
5.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C
6.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 15 steps
1: Br2, K2CO3 / H2O / Ambient temperature
2: acetic acid / 50 °C
3: 97 percent / H2, Et3N / Pd/C / ethyl acetate / Ambient temperature
4: 90 percent / KOH, H2O / ethanol / Ambient temperature
5: 95 percent / imidazole / dimethylformamide / Ambient temperature
6: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
7: 97 percent / DIBAL / CH2Cl2 / -65 °C
8: 65 percent / tBuOK / tetrahydrofuran / 0 °C
9: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature
10: 74 percent / pyridine / -5 °C
11: 95 percent / K2CO3 / ethanol / Ambient temperature
12: 95 percent / dimethylsulfoxide / Ambient temperature
13: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
14: 51 percent / (dba)3Pd2*CHCl3
15: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(2S,4S)-5-(t-butyldiphenylsiloxy)-2-hydroxypentan-4-olide
102717-31-7

(2S,4S)-5-(t-butyldiphenylsiloxy)-2-hydroxypentan-4-olide

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
2: 97 percent / DIBAL / CH2Cl2 / -65 °C
3: 65 percent / tBuOK / tetrahydrofuran / 0 °C
4: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature
5: 74 percent / pyridine / -5 °C
6: 95 percent / K2CO3 / ethanol / Ambient temperature
7: 95 percent / dimethylsulfoxide / Ambient temperature
8: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
9: 51 percent / (dba)3Pd2*CHCl3
10: 91 percent / ZnBr2 / CH2Cl2
View Scheme
3β-acetoxy-5β-acetoxymethyltetrahydrofuran-2-one
79580-65-7

3β-acetoxy-5β-acetoxymethyltetrahydrofuran-2-one

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 90 percent / KOH, H2O / ethanol / Ambient temperature
2: 95 percent / imidazole / dimethylformamide / Ambient temperature
3: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
4: 97 percent / DIBAL / CH2Cl2 / -65 °C
5: 65 percent / tBuOK / tetrahydrofuran / 0 °C
6: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature
7: 74 percent / pyridine / -5 °C
8: 95 percent / K2CO3 / ethanol / Ambient temperature
9: 95 percent / dimethylsulfoxide / Ambient temperature
10: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
11: 51 percent / (dba)3Pd2*CHCl3
12: 91 percent / ZnBr2 / CH2Cl2
View Scheme
D-xylono-1,5-lactone
82796-87-0

D-xylono-1,5-lactone

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1: acetic acid / 50 °C
2: 97 percent / H2, Et3N / Pd/C / ethyl acetate / Ambient temperature
3: 90 percent / KOH, H2O / ethanol / Ambient temperature
4: 95 percent / imidazole / dimethylformamide / Ambient temperature
5: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
6: 97 percent / DIBAL / CH2Cl2 / -65 °C
7: 65 percent / tBuOK / tetrahydrofuran / 0 °C
8: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature
9: 74 percent / pyridine / -5 °C
10: 95 percent / K2CO3 / ethanol / Ambient temperature
11: 95 percent / dimethylsulfoxide / Ambient temperature
12: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
13: 51 percent / (dba)3Pd2*CHCl3
14: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(2S,4S)-4-(2-Methoxy-ethoxymethoxy)-hex-5-ene-1,2-diol

(2S,4S)-4-(2-Methoxy-ethoxymethoxy)-hex-5-ene-1,2-diol

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 74 percent / pyridine / -5 °C
2: 95 percent / K2CO3 / ethanol / Ambient temperature
3: 95 percent / dimethylsulfoxide / Ambient temperature
4: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
5: 51 percent / (dba)3Pd2*CHCl3
6: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(S)-2-[(S)-2-(2-Methoxy-ethoxymethoxy)-but-3-enyl]-oxirane

(S)-2-[(S)-2-(2-Methoxy-ethoxymethoxy)-but-3-enyl]-oxirane

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / dimethylsulfoxide / Ambient temperature
2: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
3: 51 percent / (dba)3Pd2*CHCl3
4: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(4R,6S)-6-(2-Methoxy-ethoxymethoxy)-oct-7-en-1-yn-4-ol
166450-63-1

(4R,6S)-6-(2-Methoxy-ethoxymethoxy)-oct-7-en-1-yn-4-ol

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
2: 51 percent / (dba)3Pd2*CHCl3
3: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(4R,6S)-4,6-bis[(2-methoxyethoxyethyl)oxy]-7-octen-1-yne
162889-20-5

(4R,6S)-4,6-bis[(2-methoxyethoxyethyl)oxy]-7-octen-1-yne

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51 percent / (dba)3Pd2*CHCl3
2: 91 percent / ZnBr2 / CH2Cl2
View Scheme
2,4,6-Trimethyl-benzenesulfonic acid (2S,4S)-2-hydroxy-4-(2-methoxy-ethoxymethoxy)-hex-5-enyl ester

2,4,6-Trimethyl-benzenesulfonic acid (2S,4S)-2-hydroxy-4-(2-methoxy-ethoxymethoxy)-hex-5-enyl ester

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / K2CO3 / ethanol / Ambient temperature
2: 95 percent / dimethylsulfoxide / Ambient temperature
3: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
4: 51 percent / (dba)3Pd2*CHCl3
5: 91 percent / ZnBr2 / CH2Cl2
View Scheme
(2S,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-methoxy-ethoxymethoxy)-hex-5-en-2-ol

(2S,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-methoxy-ethoxymethoxy)-hex-5-en-2-ol

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature
2: 74 percent / pyridine / -5 °C
3: 95 percent / K2CO3 / ethanol / Ambient temperature
4: 95 percent / dimethylsulfoxide / Ambient temperature
5: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature
6: 51 percent / (dba)3Pd2*CHCl3
7: 91 percent / ZnBr2 / CH2Cl2
View Scheme
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

(4S,6R)-1-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophene-4,6-diol
160796-62-3

(4S,6R)-1-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophene-4,6-diol

Conditions
ConditionsYield
With sulfur dioxide for 1h; Heating;91%
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

C31H46N2O3

C31H46N2O3

Conditions
ConditionsYield
With triethylamine In toluene at 20℃; for 48h;67%
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

(5Z,7E)-(1S,3R)-1,3,7,8-tetrahydroxy-9,10-seco-5,7,10(19)-cholestatrien

(5Z,7E)-(1S,3R)-1,3,7,8-tetrahydroxy-9,10-seco-5,7,10(19)-cholestatrien

Conditions
ConditionsYield
With potassium permanganate In ethanol; water at -15℃; for 2h;64%
4-(ferrocenylmethyl)-1,2,4-triazoline-3,5-dione
640297-29-6

4-(ferrocenylmethyl)-1,2,4-triazoline-3,5-dione

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

alfacalcidol/4-(ferrocenylmethyl)-1,2,4-triazioline-3,5-dione adduct

alfacalcidol/4-(ferrocenylmethyl)-1,2,4-triazioline-3,5-dione adduct

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;57%
4-ferrocenyl-1,2,4-triazoline-3,5-dione
640297-32-1

4-ferrocenyl-1,2,4-triazoline-3,5-dione

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

alfacalcidol/4-ferrocenyl-1,2,4-triazoline-3,5-dione adduct

alfacalcidol/4-ferrocenyl-1,2,4-triazoline-3,5-dione adduct

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;57%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

A

1α-Hydroxyvitamin-D3 1-butyrate
109138-05-8

1α-Hydroxyvitamin-D3 1-butyrate

B

1α-Hydroxyvitamin-D3 3-butyrate

1α-Hydroxyvitamin-D3 3-butyrate

Conditions
ConditionsYield
With pyridine for 24h; Yield given. Yields of byproduct given;
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

1α-hydroxy-6,19-dihydro-6,19-epidioxyvitamin D3

1α-hydroxy-6,19-dihydro-6,19-epidioxyvitamin D3

Conditions
ConditionsYield
With oxygen; rose bengal In ethanol Irradiation; Yield given;
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

((5Z,7E,1S,3R)-1-Hydroxy-9,10-seco-5,7-10(19)-cholestatrien-3-yl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosid

((5Z,7E,1S,3R)-1-Hydroxy-9,10-seco-5,7-10(19)-cholestatrien-3-yl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosid

Conditions
ConditionsYield
With Silber-4-hydroxy-valerat In diethyl ether for 20h; Yield given;
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

1α-hydroxyprecalciferol3
41461-13-6

1α-hydroxyprecalciferol3

Conditions
ConditionsYield
In ethanol-d6 at 80℃; Rate constant; Equilibrium constant; Thermodynamic data; Ea, logA, ΔG(excit.), ΔH(excit.), ΔS(excit.);
1α-hydroxyvitamin D3
41294-56-8

1α-hydroxyvitamin D3

C27H43(2)HO2

C27H43(2)HO2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / liq. SO2 / 1 h / Heating
2: CD3OD, MeONa / 3 h / 0 °C
3: NaHCO3 / dimethylformamide / 0.67 h / 120 °C
View Scheme

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