Factory direct sales, accept customization. Alfacalcidol is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical
Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k
Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Assay 98%min -----------------------------------------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryReason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa
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inquiryAlphacalcidol CAS 41294-56-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributin
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryAlfacalcidol Basic information Product Name: Alfacalcidol Synonyms: VITAMIN D3, 1ALPHA-HYDROXY-;HYDROXYVITAMIN D3;ALFACALCIDOL;ALPHACALCIDOL;1-HYDROXYCHOLECALCIFEROL;1ALP
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryProduct name Alfacalcidol Other names 1α-Hydroxyvitamin D3 CAS41294-56-8MFC27H44O2Appearance White powderPurity 99%MINStructure ApplicationAlfacalcidol is a non-selective VDR activator medication. Appearance:White powder Storage:Stor
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: Alfacalcidol CAS: 41294-56-8 MF: C27H44O2 MW: 400.64 EINECS: 255-297-1 Mol File: 41294-56-8.mol Alfacalcidol Structure Alfacalcidol Chemical Properties Melting point 134-136°C Boiling point 531.5±5
About Product Details Items Specifications Test Results Appearance White to white crystalline powde
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Alfacalcidol CAS:41294-56-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Detail Minimum Order Qty. 10 Gram
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inquiryAlfacalcidol CAS: 41294-56-8 Specification proname: alfacalcidol casno: 41294-56-8 molecular formula: c27h44o2 appearance: white to off-white crystalline powder application: a synthetic analog of calcitiol (the h... deliverytime: 3-5 days af
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry1α,3β-bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-triene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h; Heating; | 98% |
With tetrabutyl ammonium fluoride In tetrahydrofuran at 55℃; | 70% |
With tetrabutyl ammonium fluoride In tetrahydrofuran for 4h; Yield given; |
(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1h; | 94% |
1α-di<(2-methoxyethoxy)methoxy>vitamin D3
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With zinc dibromide In dichloromethane | 91% |
(1R,3aS,7aR)-4-[2-[(3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran for 40h; Ambient temperature; | 79% |
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature; | 79% |
1α-hydroxy-5,6-trans-vitamin D3
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With anthracene In methanol at 20℃; for 4h; Inert atmosphere; UV-irradiation; | 75% |
With anthracene; triethylamine In toluene Kinetics; Concentration; Time; UV-irradiation; |
1α-hydroxyprecalciferol3
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 80℃; for 24h; | 64% |
In benzene for 8h; Heating; Yield given; | |
In ethanol-d6 at 80℃; Rate constant; Equilibrium constant; |
(1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Stage #1: (1S,6R)-3-deoxy-1-hydroxy-6-methoxy-3,5-cyclo-5,6-dihydrovitamin D3 With acetic acid In dimethyl sulfoxide at 20 - 50℃; for 1h; Inert atmosphere; Stage #2: With 4-Phenylurazole In ethyl acetate at 10℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere; | 45% |
Multi-step reaction with 3 steps 1: Hunig base / 5 h / Ambient temperature 2: pTsOH / dioxane; H2O / 0.08 h / 55 °C 3: 39 percent / conc. HCl / methanol / 3.5 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: 83 percent / N-ethyl diisopropylamine (Huenig's base) / CH2Cl2 / 1.) 0 deg C, 2.) room temperature, 5 h 2: 51 percent / water / toluene-p-sulphonic acid (PTSA) / dioxane / 0.08 h / 55 °C 3: 39 percent / conc. hydrochloric acid / methanol / 3.5 h / 60 °C View Scheme |
(1S)-1-methoxymethoxyvitamin D3
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 60℃; for 3.5h; | 39% |
With hydrogenchloride In methanol at 60℃; for 3.5h; | 39% |
1α,3β-dihydroxycholesta-5,7-diene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Stage #1: 1α,3β-dihydroxycholesta-5,7-diene In 1,4-dioxane Irradiation; Stage #2: at 100℃; | 13% |
In benzene Irradiation; | |
(i) EtOH, (UV-irradiation), (ii) (heating); Multistep reaction; |
1α,3β-diacetoxycholesta-5,7-diene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
(i) pentane, (UV-irradiation), (ii) (isomerization), (iii) (saponification); Multistep reaction; | |
Multi-step reaction with 2 steps 1: aq. KOH / methanol 2: (i) EtOH, (UV-irradiation), (ii) (heating) View Scheme |
Grundmann's ketone
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 50 percent / tetrahydrofuran 2.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 2.2: ZnBr2 / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - -10 °C 2.3: 75 percent / Et3N / (Ph3P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C 3.1: 94 percent / n-Bu4NF / tetrahydrofuran / 1 h View Scheme | |
Multi-step reaction with 2 steps 1.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 1.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 2.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 1.) sodium hexamethyldisilazide / 1.) THF, -60 deg C, 1 h, 2.) THF, RT, 1 h 2: 163.5 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating 3: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 1.) sodium hexamethyldisilazide / 1.) THF, -60 deg C, 1 h, 2.) THF, RT, 1 h 2: 33 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating 3: 17.5 mg / toluene / 1 h / 80 °C 4: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature View Scheme |
(8E)-8-bromomethylene-de-A,B-cholestane
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C 1.2: ZnBr2 / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - -10 °C 1.3: 75 percent / Et3N / (Ph3P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C 2.1: 94 percent / n-Bu4NF / tetrahydrofuran / 1 h View Scheme | |
Multi-step reaction with 2 steps 1: 163.5 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating 2: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: 33 mg / (dba)3Pd2*CHCl3, TPP, Et3N / toluene / 1.5 h / Heating 2: 17.5 mg / toluene / 1 h / 80 °C 3: 79 percent / TBAF / tetrahydrofuran / 40 h / Ambient temperature View Scheme |
(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 96 percent / PPh3 / CH2Cl2 / 0.05 h / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C 2.2: 100 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C 3.1: pyridine / CH2Cl2 / 2 h / 20 °C 4.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating 5.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating 6.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 7.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 8.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 8.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 9.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
(8β)-De-A,B-22-cholestyne-8-one
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 2.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 2.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 3.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
(8β)-De-A,B-22-cholestyne-8-ol
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 2.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 3.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 3.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 4.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
(8β)-De-A,B-23,23-dibromo-8-(tert-butyldimethylsilyloxy)-24-norchol-22-ene
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C 1.2: 100 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C 2.1: pyridine / CH2Cl2 / 2 h / 20 °C 3.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating 4.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating 5.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 6.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 7.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 7.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 8.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating 2.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 3.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 4.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 4.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 5.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
(8β)-De-A,B-8-(tert-butyldimethylsilyloxy)-22-cholestyne-24-ol
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: pyridine / CH2Cl2 / 2 h / 20 °C 2.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating 3.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating 4.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 5.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 6.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 6.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 7.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 98 percent / n-Bu3SnH; 2,2-azabisisobutyronitrile / toluene / 3 h / Heating 2.1: 68 percent / 6N HCl / tetrahydrofuran / 7 h / Heating 3.1: 56 percent / PCC; Celite / CH2Cl2 / 1.5 h / 20 °C 4.1: 100 percent / H2 / 5 percent Pd/C / ethyl acetate / 0.5 h / 20 °C 5.1: n-BuLi / tetrahydrofuran / 0.08 h / -75 °C 5.2: 46 percent / tetrahydrofuran / 2 h / -75 - 20 °C 6.1: 98 percent / TBAF / tetrahydrofuran / 2 h / Heating View Scheme |
D-Xylose
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: Br2, K2CO3 / H2O / Ambient temperature 2: acetic acid / 50 °C 3: 97 percent / H2, Et3N / Pd/C / ethyl acetate / Ambient temperature 4: 90 percent / KOH, H2O / ethanol / Ambient temperature 5: 95 percent / imidazole / dimethylformamide / Ambient temperature 6: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 7: 97 percent / DIBAL / CH2Cl2 / -65 °C 8: 65 percent / tBuOK / tetrahydrofuran / 0 °C 9: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature 10: 74 percent / pyridine / -5 °C 11: 95 percent / K2CO3 / ethanol / Ambient temperature 12: 95 percent / dimethylsulfoxide / Ambient temperature 13: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 14: 51 percent / (dba)3Pd2*CHCl3 15: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
(2S,4S)-5-(t-butyldiphenylsiloxy)-2-hydroxypentan-4-olide
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 2: 97 percent / DIBAL / CH2Cl2 / -65 °C 3: 65 percent / tBuOK / tetrahydrofuran / 0 °C 4: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature 5: 74 percent / pyridine / -5 °C 6: 95 percent / K2CO3 / ethanol / Ambient temperature 7: 95 percent / dimethylsulfoxide / Ambient temperature 8: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 9: 51 percent / (dba)3Pd2*CHCl3 10: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
3β-acetoxy-5β-acetoxymethyltetrahydrofuran-2-one
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 90 percent / KOH, H2O / ethanol / Ambient temperature 2: 95 percent / imidazole / dimethylformamide / Ambient temperature 3: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 4: 97 percent / DIBAL / CH2Cl2 / -65 °C 5: 65 percent / tBuOK / tetrahydrofuran / 0 °C 6: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature 7: 74 percent / pyridine / -5 °C 8: 95 percent / K2CO3 / ethanol / Ambient temperature 9: 95 percent / dimethylsulfoxide / Ambient temperature 10: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 11: 51 percent / (dba)3Pd2*CHCl3 12: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
D-xylono-1,5-lactone
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1: acetic acid / 50 °C 2: 97 percent / H2, Et3N / Pd/C / ethyl acetate / Ambient temperature 3: 90 percent / KOH, H2O / ethanol / Ambient temperature 4: 95 percent / imidazole / dimethylformamide / Ambient temperature 5: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 6: 97 percent / DIBAL / CH2Cl2 / -65 °C 7: 65 percent / tBuOK / tetrahydrofuran / 0 °C 8: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature 9: 74 percent / pyridine / -5 °C 10: 95 percent / K2CO3 / ethanol / Ambient temperature 11: 95 percent / dimethylsulfoxide / Ambient temperature 12: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 13: 51 percent / (dba)3Pd2*CHCl3 14: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 74 percent / pyridine / -5 °C 2: 95 percent / K2CO3 / ethanol / Ambient temperature 3: 95 percent / dimethylsulfoxide / Ambient temperature 4: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 5: 51 percent / (dba)3Pd2*CHCl3 6: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / dimethylsulfoxide / Ambient temperature 2: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 3: 51 percent / (dba)3Pd2*CHCl3 4: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
(4R,6S)-6-(2-Methoxy-ethoxymethoxy)-oct-7-en-1-yn-4-ol
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 2: 51 percent / (dba)3Pd2*CHCl3 3: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
(4R,6S)-4,6-bis[(2-methoxyethoxyethyl)oxy]-7-octen-1-yne
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / (dba)3Pd2*CHCl3 2: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / K2CO3 / ethanol / Ambient temperature 2: 95 percent / dimethylsulfoxide / Ambient temperature 3: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 4: 51 percent / (dba)3Pd2*CHCl3 5: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 97 percent / (nBu)4NF / tetrahydrofuran / Ambient temperature 2: 74 percent / pyridine / -5 °C 3: 95 percent / K2CO3 / ethanol / Ambient temperature 4: 95 percent / dimethylsulfoxide / Ambient temperature 5: 97 percent / (iPr)2NEt / CH2Cl2 / Ambient temperature 6: 51 percent / (dba)3Pd2*CHCl3 7: 91 percent / ZnBr2 / CH2Cl2 View Scheme |
1α-hydroxyvitamin D3
(4S,6R)-1-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophene-4,6-diol
Conditions | Yield |
---|---|
With sulfur dioxide for 1h; Heating; | 91% |
Conditions | Yield |
---|---|
With triethylamine In toluene at 20℃; for 48h; | 67% |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With potassium permanganate In ethanol; water at -15℃; for 2h; | 64% |
4-(ferrocenylmethyl)-1,2,4-triazoline-3,5-dione
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1h; | 57% |
4-ferrocenyl-1,2,4-triazoline-3,5-dione
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1h; | 57% |
butanoic acid anhydride
1α-hydroxyvitamin D3
A
1α-Hydroxyvitamin-D3 1-butyrate
Conditions | Yield |
---|---|
With pyridine for 24h; Yield given. Yields of byproduct given; |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
With oxygen; rose bengal In ethanol Irradiation; Yield given; |
1α-hydroxyvitamin D3
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
Conditions | Yield |
---|---|
With Silber-4-hydroxy-valerat In diethyl ether for 20h; Yield given; |
1α-hydroxyvitamin D3
1α-hydroxyprecalciferol3
Conditions | Yield |
---|---|
In ethanol-d6 at 80℃; Rate constant; Equilibrium constant; Thermodynamic data; Ea, logA, ΔG(excit.), ΔH(excit.), ΔS(excit.); |
1α-hydroxyvitamin D3
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / liq. SO2 / 1 h / Heating 2: CD3OD, MeONa / 3 h / 0 °C 3: NaHCO3 / dimethylformamide / 0.67 h / 120 °C View Scheme |
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