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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Cyano-5-fluorobenzyl bromide Manufacturer/High quality/Best price/In stock

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product Name 2-Cyano-5-fluorobenzyl bromide CAS No. 421552-12-7 Appearance White powder Assay ≥99% Capacity 50mt/year Min.packing 1gra

2-Cyano-5-fluorobenzyl bromide

Cas:421552-12-7

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Wuhan Fortuna Chemical Co.,Ltd

Top grade 2-cyano-5-fluorine benzyl bromide CAS 421552-12-7 with large quantity Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates,

Top grade 2-cyano-5-fluorine benzyl bromide CAS 421552-12-7 with large quantity

Cas:421552-12-7

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

2-Cyano-5-fluorobenzyl bromide CAS No.:421552-12-7 Name: 2-Cyano-5-fluorobenzyl bromide Synonyms: 2-

High purity 2-Cyano-5-fluorobenzyl bromide CAS No.:421552-12-7

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience 2. Free samples will be provided,ensure specifications and quality are right for customer 3. Customers will receive the most professional techn

Large Stock 99.0% 2-CYANO-5-FLUOROBENZYL BROMIDE 421552-12-7 Producer

Cas:421552-12-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

2-CYANOBENZO-5-FLUOROBENZYL BROMIDE

Cas:421552-12-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-Cyano-5-fluorobenzyl bromide

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

2-Cyano-5-flurobenzyl broMide

Cas:421552-12-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Cyano-5-fluorobenzyl bromide

Cas:421552-12-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-cyano-5-fluorobenzylbroMide In stock

Cas:421552-12-7

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-CYANO-5-FLUOROBENZYL BROMIDE 421552-12-7

Cas:421552-12-7

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 421552-12-7 with competitive price

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

2-Cyano-5-flurobenzyl broMide

Cas:421552-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

2-Cyano-5-fluorobenzyl bromide CAS No.: 421552-12-7 Formula: C8H5BrFN Molecular weight: 214.04 Appearance: white powder Appearance:White

2-Cyano-5-flurobenzyl bromide CAS: 421552-12-7

Cas:421552-12-7

Min.Order:5 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

2-CYANO-5-FLUOROBENZYL BROMIDE CAS NO 421552-12-7

Cas:421552-12-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzonitrile,2-(bromomethyl)-4-fluoro- 421552-12-7

Cas:421552-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 2-CYANO-5-FLUOROBENZYL BROMIDE CAS:421552-12-7

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $672.0 / 680.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-CYANO-5-FLUOROBENZYL BROMIDE CAS: 421552-12-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

2-CYANO-5-FLUOROBENZYL BROMIDE CAS: 421552-12-7

Cas:421552-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Large Stock 99% 2-cyano-5-fluorobenzylbroMide CAS 421552-12-7 AKS

Cas:421552-12-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:421552-12-7

Cas:421552-12-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

2-Cyano-5-Fluorobenzyl Bromide

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 30.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2-(bromomethyl)-4-fluorobenzonitrile

Cas:421552-12-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Cyano-5-Fluorobenzyl Bromide

Cas:421552-12-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-CYANO-5-FLUOROBENZYL BROMIDE

Cas:421552-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzonitrile,2-(bromomethyl)-4-fluoro-

Cas:421552-12-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Cyano-5-fluorobenzyl bromide/Manufacturer/High quality/Best price

Cas:421552-12-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-CYANO-5-FLUOROBENZYL BROMIDE

Cas:421552-12-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD

Company Profile SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD is a high-tech enterprise dedicated to the fields of fine chemical products.The scope of products covers pharmaceutical intermediates, plant extracts, chemical reagent, animal p

Factory Fast Delivery 2-Cyano-5-fluorobenzyl bromide CAS 421552-12-7

Cas:421552-12-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 24.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 2-CYANO-5-FLUOROBENZYL BROMIDE

Cas:421552-12-7

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

4-fluoro-2-methylbenzonitrile
147754-12-9

4-fluoro-2-methylbenzonitrile

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With N-Bromosuccinimide; toluene-4-sulfonic acid In tetrachloromethane for 4h; Heating;86%
With N-Bromosuccinimide; toluene-4-sulfonic acid In tetrachloromethane Reflux;86%
With N-Bromosuccinimide; dibenzoyl peroxide In chloroform at 85℃; for 24h; Inert atmosphere;58%
2-Bromo-5-fluorotoluene
452-63-1

2-Bromo-5-fluorotoluene

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 2 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Reflux; Inert atmosphere
View Scheme
3-methyl-6-chlorouracil
4318-56-3

3-methyl-6-chlorouracil

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-[(6-chloro-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]-4-fluorobenzonitrile
865759-24-6

2-[(6-chloro-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]-4-fluorobenzonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 20 - 55℃; for 4h; Time; Temperature;98.9%
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 107℃; for 2h; Solvent; Temperature; Reagent/catalyst;96.6%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 65 - 75℃; for 6h; Temperature; Solvent; Large scale;96.3%
p-toluidine
106-49-0

p-toluidine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-(p-methylphenylamino)methyl-4-fluorobenzonitrile

2-(p-methylphenylamino)methyl-4-fluorobenzonitrile

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran at 60℃; for 8h; Reflux;95%
With potassium carbonate In dimethyl sulfoxide
2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-(bromomethyl)-4-fluorobenzaldehyde

2-(bromomethyl)-4-fluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 2-(bromomethyl)-4-fluorobenzonitrile With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In hexane; dichloromethane at 0℃; for 1h; Inert atmosphere;
94%
With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;94%
4-(piperazin-1-ylmethyl)benzonitrile
89292-70-6

4-(piperazin-1-ylmethyl)benzonitrile

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((4-(4-cyanobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

2-((4-(4-cyanobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;89%
1-(4-trifluoromethylbenzyl)piperazine
107890-32-4

1-(4-trifluoromethylbenzyl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((4-(4-trifluoromethylbenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

2-((4-(4-trifluoromethylbenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;88%
2-chloro-3H,4H-thieno[3,2-d]pyrimidin-4-one
1245811-20-4

2-chloro-3H,4H-thieno[3,2-d]pyrimidin-4-one

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C14H7ClFN3OS

C14H7ClFN3OS

Conditions
ConditionsYield
Stage #1: 2-chloro-3H,4H-thieno[3,2-d]pyrimidin-4-one With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide for 0.333333h; Cooling with ice;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide at 65℃; for 14h;
85.3%
Stage #1: 2-chloro-3H,4H-thieno[3,2-d]pyrimidin-4-one With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 65℃; for 6h;
1-phenylethyl piperazine
69628-75-7

1-phenylethyl piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-((4-(1-phenylethyl)piperazin-1-yl)methyl)benzonitrile

4-fluoro-2-((4-(1-phenylethyl)piperazin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;85%
1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

tert-butyl 4-(2-cyano-5-fluorobenzyl)piperazine-1-carboxylate

tert-butyl 4-(2-cyano-5-fluorobenzyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;85%
With potassium carbonate In acetone at 20℃;85%
With potassium carbonate at 20℃;
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-((2-methoxyethoxy)methyl)benzonitrile
1569066-21-2

4-fluoro-2-((2-methoxyethoxy)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran at -60 - 20℃; for 0.5h;
Stage #2: 2-(bromomethyl)-4-fluorobenzonitrile In tetrahydrofuran at -60℃; for 1.5h;
84%
Stage #1: 2-methoxy-ethanol With sodium hydride In tetrahydrofuran at -60 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2-(bromomethyl)-4-fluorobenzonitrile In tetrahydrofuran at -60 - 20℃; for 3.5h; Inert atmosphere;
84%
1-(1,2,3,4-tetrahydronaphthalen-2-yl)piperazine
1900-04-5

1-(1,2,3,4-tetrahydronaphthalen-2-yl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-((4-(1,2,3,4-tetrahydronaphthalen-2-yl)piperazin-1-yl)methyl)benzonitrile

4-fluoro-2-((4-(1,2,3,4-tetrahydronaphthalen-2-yl)piperazin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;84%
1-(2-chloro-benzyl)-piperazine
17532-19-3

1-(2-chloro-benzyl)-piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((4-(2-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

2-((4-(2-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;83%
2-chloro-7-methylthieno[3,2-d]pyrimidin-4(3H)-one
1265593-71-2

2-chloro-7-methylthieno[3,2-d]pyrimidin-4(3H)-one

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C15H9ClFN3OS

C15H9ClFN3OS

Conditions
ConditionsYield
Stage #1: 2-chloro-7-methylthieno[3,2-d]pyrimidin-4(3H)-one With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 65℃; for 6h;
83%
C4(14)CH5ClN2O2

C4(14)CH5ClN2O2

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C12(14)CH9ClFN3O2

C12(14)CH9ClFN3O2

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine In ethyl acetate at 65℃; for 2.5h;82%
1-[(4-chlorophenyl)methyl]piperazine
23145-88-2

1-[(4-chlorophenyl)methyl]piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((4-(4-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

2-((4-(4-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;80%
With potassium carbonate at 20℃;
1-(4-fluorophenylmethyl)piperazine
70931-28-1

1-(4-fluorophenylmethyl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-((4-(4-fluorobenzyl)piperazin-1-yl)methyl)benzonitrile

4-fluoro-2-((4-(4-fluorobenzyl)piperazin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;79%
C6H2BrClN2OS

C6H2BrClN2OS

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C14H6BrClFN3OS

C14H6BrClFN3OS

Conditions
ConditionsYield
Stage #1: C6H2BrClN2OS With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 65℃; for 6h;
78%
1-(3-chlorobenzyl)piperazine
23145-91-7

1-(3-chlorobenzyl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((4-(3-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

2-((4-(3-chlorobenzyl)piperazin-1-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;76%
tert-butyl 2-chloro-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate
1377432-80-8

tert-butyl 2-chloro-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((2-chloro-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-3-yl)methyl)-4-fluorobenzonitrile

2-((2-chloro-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-3-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
Stage #1: tert-butyl 2-chloro-4-oxo-3H,4H,5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0 - 20℃;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 65℃;
75.2%
Stage #1: tert-butyl 2-chloro-4-oxo-3H,4H,5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 60℃; for 12h;
66.2%
1-(3,4-chlorobenzyl)piperazine
55513-17-2

1-(3,4-chlorobenzyl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C19H18Cl2FN3

C19H18Cl2FN3

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 3h;75%
1-(4-methoxyphenyl)piperazine
38212-30-5

1-(4-methoxyphenyl)piperazine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)benzonitrile

4-fluoro-2-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran Reflux;73%
With potassium carbonate at 20℃;
Trelagliptin

Trelagliptin

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C26H24F2N6O2

C26H24F2N6O2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h;73%
dimethyl amine
124-40-3

dimethyl amine

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((dimethylamino)methyl)-4-fluorobenzonitrile
1023649-68-4

2-((dimethylamino)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
at 20℃; for 0.216667h;68%
ethyl 2-(dimethyl(oxo)- λ6-sulfaneylidene)-2-phenylacetate

ethyl 2-(dimethyl(oxo)- λ6-sulfaneylidene)-2-phenylacetate

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

ethyl 3-(2-cyano-5-fluorophenyl)-2-phenylacrylate

ethyl 3-(2-cyano-5-fluorophenyl)-2-phenylacrylate

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; palladium diacetate; triethylamine; lithium tert-butoxide In toluene at 80℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;42%
5-bromo-2-chloro-pyrimidin-4(3H)-one
844843-37-4

5-bromo-2-chloro-pyrimidin-4(3H)-one

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

2-((5-bromo-2-chloro-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile

2-((5-bromo-2-chloro-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-pyrimidin-4(3H)-one With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere;
Stage #3: 2-(bromomethyl)-4-fluorobenzonitrile In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 65℃; Inert atmosphere;
35%
sodium methylate
124-41-4

sodium methylate

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

4-fluoro-2-(methoxymethyl)benzonitrile
934012-90-5

4-fluoro-2-(methoxymethyl)benzonitrile

Conditions
ConditionsYield
In methanol at 20 - 55℃; for 3h;28%
In methanol at 20 - 55℃; for 3h;28%
2-bromo-5-methyl-1,5-dihydro-9H-imidazo[1,2-a]purine-6,9(7H)-dione TFA salt

2-bromo-5-methyl-1,5-dihydro-9H-imidazo[1,2-a]purine-6,9(7H)-dione TFA salt

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

A

2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile
1417715-74-2

2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

B

2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-3-yl)methyl-4-fluorobenzonitrile
1417715-75-3

2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-3-yl)methyl-4-fluorobenzonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;A 24%
B 22%
homophthalic anhydride
703-59-3

homophthalic anhydride

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

5,6-dihydro-5-oxo-9-fluoro-indeno[1,2-c]isoquinoline

5,6-dihydro-5-oxo-9-fluoro-indeno[1,2-c]isoquinoline

Conditions
ConditionsYield
With triethylamine In acetonitrile for 2h; Heating;2.180 g
2-amino-5-chloropyridine-3-carboxamide
58483-97-9

2-amino-5-chloropyridine-3-carboxamide

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

5-chloro-1-(2-cyano-5-fluorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride
1021873-77-7

5-chloro-1-(2-cyano-5-fluorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-amino-5-chloropyridine-3-carboxamide; 2-(bromomethyl)-4-fluorobenzonitrile In N,N-dimethyl-formamide at 100℃; for 14h;
Stage #2: With water; sodium hydrogencarbonate
Stage #3: With hydrogenchloride In methanol
C25H39N5O6
1261999-60-3

C25H39N5O6

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

C33H43FN6O6

C33H43FN6O6

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;

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