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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-(3-ISOPROPYL-5-METHYL-4H-1,2,4-TRIAZOL-4-YL)-8-AZABICYCLO[3.2.1]OCTANE 4-METHYLBENZENESULFONATE

Cas:423165-08-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate CAS NO.: 423165-08-6

Cas:423165-08-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 423165-08-6 ,3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-(3-ISOPROPYL-5-METHYL-4H-1,2,4-TRIAZOL-4-YL)-8-AZABICYCLO[3.2.1]OCTANE 4-METHYLBENZENESULFONATE

Cas:423165-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane p-toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-(3-Isopropyl-5-Methyl-4H-1,2,4-Triazol-4-Yl)-8-Azabicyclo[3.2.1]Octane 4-Methylbenzenesulfonate

Cas:423165-08-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]]octane P-Toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

423165-08-6

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-p-toluenesulfonate

Cas:423165-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

exo-8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
423165-13-3

exo-8-benzyl-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol at 50℃; under 2250.23 Torr; Solvent; Time; Inert atmosphere; Large scale;92%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 2585.81 Torr; Inert atmosphere;86%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 6723.1 Torr; for 17h;80%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃;80%
8-Benzyl-1αH,5αH-nortropan-3-one Oxime
76272-34-9

8-Benzyl-1αH,5αH-nortropan-3-one Oxime

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium; propan-1-ol / toluene / 12 h / Reflux; Inert atmosphere
2: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
3: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
4: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere
5: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
7: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
8: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: sodium / pentan-1-ol / 4 h / Reflux
2.1: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
3.1: phosphorus pentachloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice
3.2: 17.5 h / 0 - 20 °C / Inert atmosphere
3.3: 2 h / Inert atmosphere; Reflux
4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
8-benzyl-8-azabicyclo[3.2.1]octan-3-amine

8-benzyl-8-azabicyclo[3.2.1]octan-3-amine

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
3: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere
4: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
5: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
6: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
7: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
2.1: phosphorus pentachloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 17.5 h / 0 - 20 °C / Inert atmosphere
2.3: 2 h / Inert atmosphere; Reflux
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester
132259-54-2

exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
2: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere
3: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
5: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
N-((1R,3S,5S)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-2-methyl-propionimidoyl chloride

N-((1R,3S,5S)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-2-methyl-propionimidoyl chloride

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
2: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl-amine
76272-36-1

8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl-amine

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere
2: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
4: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
exo-N-(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)-2-methylpropanamide
376348-67-3

exo-N-(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)-2-methylpropanamide

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
3: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: phosphorus pentachloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice
1.2: 17.5 h / 0 - 20 °C / Inert atmosphere
1.3: 2 h / Inert atmosphere; Reflux
2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
N-benzylnortropinone
28957-72-4

N-benzylnortropinone

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 20 h / Inert atmosphere; Reflux
2: sodium; propan-1-ol / toluene / 12 h / Reflux; Inert atmosphere
3: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
4: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere
5: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere
6: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
7: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere
8: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere
9: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; ethanol / 2 h / Inert atmosphere
2.1: sodium / pentan-1-ol / 4 h / Reflux
3.1: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
4.1: phosphorus pentachloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice
4.2: 17.5 h / 0 - 20 °C / Inert atmosphere
4.3: 2 h / Inert atmosphere; Reflux
5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
(-)-(3S)-3-benzyloxycarbonylamino-3-phenylpropanal

(-)-(3S)-3-benzyloxycarbonylamino-3-phenylpropanal

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

benzyl (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropylcarbamate
376348-80-0

benzyl (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropylcarbamate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Inert atmosphere;93%
4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide
376348-78-6

4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

maraviroc
376348-65-1

maraviroc

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In ethyl acetate at 0 - 15℃; for 2h; Inert atmosphere; Large scale;91%
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Inert atmosphere; optical yield given as %ee;78%
exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

tert-butyl (1S)-3-oxo-1-phenylpropylcarbamate
135865-78-0

tert-butyl (1S)-3-oxo-1-phenylpropylcarbamate

tert-butyl (1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylcarbamate
376348-70-8

tert-butyl (1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylcarbamate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 0 - 20℃; for 3h; Inert atmosphere;89%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 0 - 20℃; for 3h;60%
(S)-benzyl 1-(naphthalen-2-yl)-3-oxopropylcarbamate
1255215-24-7

(S)-benzyl 1-(naphthalen-2-yl)-3-oxopropylcarbamate

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

benzyl (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-(naphthalen-2-yl)propylcarbamate
1255215-30-5

benzyl (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-(naphthalen-2-yl)propylcarbamate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Inert atmosphere;71%
(S)-N-(3-oxo-1-phenylpropyl)cyclohexanecarboxamide
1255215-14-5

(S)-N-(3-oxo-1-phenylpropyl)cyclohexanecarboxamide

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

N-((S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
1255215-28-1

N-((S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexanecarboxamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; Inert atmosphere;63%
exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

C30H46N8O4
1519003-85-0

C30H46N8O4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
View Scheme
exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

C55H81N9O8
1519003-78-1

C55H81N9O8

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
4: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol; copper(II) sulfate; sodium L-ascorbate / tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere
View Scheme
exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

(S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropan-1-amine
376348-71-9

(S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropan-1-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C
2: hydrogenchloride / water; methanol; 1,4-dioxane / 3 h / 20 °C
View Scheme
exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate
423165-08-6

exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane p-toluenesulfonate

maraviroc
376348-65-1

maraviroc

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C
2: hydrogenchloride / water; methanol; 1,4-dioxane / 3 h / 20 °C
3: sodium carbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme

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