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Greenutra Resource Inc

Product Name: Tabersonine Chemical Name: Aspidospermidine-3-carboxylic Acid, 2, 3, 6, 7-tetradehydro-, Methyl Seter Part Used: Seed Active Ingredients: Tabersonine CAS No. : 4429-63-4 [EINECS NO.]: 224-615-0 Molecular Formula: C21H24N2O2

Tabersonine/voacanga seed extract powder

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $15.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tabersonine

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Tabersonine CAS NO.4429-63-4

Cas:4429-63-4

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Tabersonine HACCP manufacturer

Cas:4429-63-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality TABERSONINE

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tabersonine

Cas:4429-63-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Tabersonine C21H24N2O2 cas 4429-63-4

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TABERSONINE Cas no.4429-63-4

Cas:4429-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 4429-63-4 with best quality

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Aspidospermidine-3-carboxylicacid, 2,3,6,7-tetradehydro-, methyl ester, (5a,12R,19a)- 4429-63-4

Cas:4429-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

100% Natural Tabersonine powder/Voacanga Seed Extract TABERSONINE/CAS:4429-63-4

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $510.0 / 560.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

TABERSONINE CAS: 4429-63-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

TABERSONINE CAS: 4429-63-4

Cas:4429-63-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tabersonine

Cas:4429-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail

Tabersonine, 98%, from Voacanga africana Staph. CAS:4429-63-4

Cas:4429-63-4

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Hot sale high quality voacanga extract powder Tabersonine

Cas:4429-63-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Aspidospermidine-3-carboxylicacid, 2,3,6,7-tetradehydro-, methyl ester, (5a,12R,19a)-

Cas:4429-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Tabersonine

Cas:4429-63-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. (-)-Tabersonine is one of the terpenoid indole alkaloids (TIAs) from Catharanthus roseus. (-)-Tabersonine shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity. Kind Pharma has

Tabersonine

Cas:4429-63-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TABERSONINE

Cas:4429-63-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

tabersonine

Cas:4429-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tabersonine

Cas:4429-63-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Tabersonine CAS 4429-63-4

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

High Quality Tabersonine

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Tabersonine HCl

Cas:4429-63-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Tabersonine

Cas:4429-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity TABERSONINE

Cas:4429-63-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tabersonine

Cas:4429-63-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Luyunjia Chemistry Xiamen Limited

HK Luyunjia Chemical Industry Co.,Ltd is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and

Hydrochloric acid it Boning

Cas:4429-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

TABERSONINE

Cas:4429-63-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Tabersonine, 98%, from Voacanga africana Staph. CAS:4429-63-4 CAS NO.4429-63-4

Cas:4429-63-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Synthetic route

19-Iodo-tabersonine
55856-70-7

19-Iodo-tabersonine

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With sodium hydroxide; hydrogen; nickel In methanol at 0℃; for 0.0833333h;90%
methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate
62414-79-3

methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With triphenylphosphine In tetrachloromethane; acetonitrile at 70℃; for 0.5h;73%
With triphenylphosphine In tetrachloromethane; acetonitrile at 70℃; for 0.5h;71%
With triphenylphosphine In tetrachloromethane; acetonitrile at 70℃; for 0.5h; Inert atmosphere;64%
methyl cyanoformate
17640-15-2

methyl cyanoformate

(-)-1,2,14,15-tetradehydroaspidospermidine
32975-46-5

(-)-1,2,14,15-tetradehydroaspidospermidine

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Stage #1: (-)-1,2,14,15-tetradehydroaspidospermidine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 1h; Inert atmosphere;
Stage #2: methyl cyanoformate In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
73%
With lithium diisopropyl amide In tetrahydrofuran at -78℃;73%
C21H24N2O2
91201-53-5

C21H24N2O2

A

tabersonine
4429-63-4

tabersonine

B

1,2-seco-1,21-cyclotabersonine

1,2-seco-1,21-cyclotabersonine

Conditions
ConditionsYield
In acetonitrile at 30℃; Irradiation; Title compound not separated from byproducts;A n/a
B 10%
(S)-3a-Ethyl-2-hydroxy-2,3,3a,4,6,11,12,12b-octahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
62414-79-3, 63490-95-9, 74165-08-5, 80695-59-6, 80695-62-1, 95042-67-4

(S)-3a-Ethyl-2-hydroxy-2,3,3a,4,6,11,12,12b-octahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With tetrachloromethane; triphenylphosphine In acetonitrile
tabersonine N4-oxide
67249-34-7

tabersonine N4-oxide

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With iron(II) sulfate for 0.25h; Heating;0.5 mg
16-epi-19-S-vindolinine
41787-54-6

16-epi-19-S-vindolinine

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / 10percent Na2CO3, I2 / tetrahydrofuran; H2O / 1 h / Ambient temperature
2: 90 percent / H2, NaOH / Raney Nickel / methanol / 0.08 h / 0 °C
View Scheme
5-chloro-2-ethyl-(4S)-hydroxypentanal lactol
80642-07-5

5-chloro-2-ethyl-(4S)-hydroxypentanal lactol

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) boric acid, 2.) triethylamine / 1.) methanol, reflux, 24 h, 2.) methanol, reflux, 12 h
2: 71 percent / triphenylphosphine / acetonitrile; CCl4 / 0.5 h / 70 °C
View Scheme
methyl 1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5-carboxylate
66859-22-1

methyl 1,2,3,4,5,6-hexahydroazepino<4,5-b>indole-5-carboxylate

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) boric acid, 2.) triethylamine / 1.) methanol, reflux, 24 h, 2.) methanol, reflux, 12 h
2: 71 percent / triphenylphosphine / acetonitrile; CCl4 / 0.5 h / 70 °C
View Scheme
1-(benzenesulfonyl)-2-methyl-1H-indole-3-carbaldehyde
124293-81-8

1-(benzenesulfonyl)-2-methyl-1H-indole-3-carbaldehyde

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 0.67 h / -15 °C / Inert atmosphere
3.2: 2 h / -15 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
6.2: 2 h / -78 - 20 °C / Inert atmosphere
7.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
8.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
9.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
10.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
11.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
11.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C20H22N2O3S2

C20H22N2O3S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 0.67 h / -15 °C / Inert atmosphere
2.2: 2 h / -15 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
5.2: 2 h / -78 - 20 °C / Inert atmosphere
6.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
7.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
8.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
9.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
10.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
10.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C26H32N2O5S2
1451192-91-8

C26H32N2O5S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 0.67 h / -15 °C / Inert atmosphere
1.2: 2 h / -15 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
4.2: 2 h / -78 - 20 °C / Inert atmosphere
5.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
7.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
8.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
9.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
9.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C29H36N2O5S2
1451192-86-1

C29H36N2O5S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: diisobutylaluminium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
4.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
6.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
7.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
8.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
8.2: 1 h / -78 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / dichloromethane / -78 °C
1.2: 0 - 20 °C
2.1: Methylenetriphenylphosphorane / -78 - 20 °C
2.2: 20 °C
3.1: hydrogenchloride / water
3.2: Reflux
4.1: potassium tert-butylate / tetrahydrofuran / 0 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C28H36N2O4S2
1451192-92-9

C28H36N2O4S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C / Inert atmosphere
3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
5.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
6.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
7.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
7.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C28H34N2O4S2
1451192-88-3

C28H34N2O4S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 0 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C / Inert atmosphere
2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
4.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
6.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
6.2: 1 h / -78 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: Methylenetriphenylphosphorane / -78 - 20 °C
1.2: 20 °C
2.1: hydrogenchloride / water
2.2: Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 0 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C29H36N2O3S2
1451192-93-0

C29H36N2O3S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 48 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
3.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
5.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C27H32N2O3S2
1451192-89-4

C27H32N2O3S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / methanol; water / 0 °C / Inert atmosphere
2.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
4.2: 1 h / -78 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water
1.2: Reflux
2.1: potassium tert-butylate / tetrahydrofuran / 0 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C23H24N2O2S
1451192-94-1

C23H24N2O2S

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium carbonate / ethanol / 24 h / 85 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
View Scheme
C25H28N2O3S
1451192-90-7

C25H28N2O3S

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 0 °C
2: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
(R,E)-2-methyl-N-((2-methyl-1H-indol-3-yl)methylene)propane-2-sulfinamide

(R,E)-2-methyl-N-((2-methyl-1H-indol-3-yl)methylene)propane-2-sulfinamide

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydride; 1H-imidazole / tetrahydrofuran
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
3.1: N,N-dimethyl-formamide / -78 - 20 °C
4.1: Methylenetriphenylphosphorane / -78 - 20 °C
4.2: 20 °C
5.1: hydrogenchloride / water
5.2: Reflux
6.1: potassium tert-butylate / tetrahydrofuran / 0 °C
7.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydride; 1H-imidazole / tetrahydrofuran
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / -78 - 20 °C
4.1: diisobutylaluminium hydride / dichloromethane / -78 °C
4.2: 0 - 20 °C
5.1: Methylenetriphenylphosphorane / -78 - 20 °C
5.2: 20 °C
6.1: hydrogenchloride / water
6.2: Reflux
7.1: potassium tert-butylate / tetrahydrofuran / 0 °C
8.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
2-methyl-1H-indole-3-carbaldehyde
5416-80-8

2-methyl-1H-indole-3-carbaldehyde

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 70 °C
2.1: sodium hydride; 1H-imidazole / tetrahydrofuran
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
4.1: N,N-dimethyl-formamide / -78 - 20 °C
5.1: Methylenetriphenylphosphorane / -78 - 20 °C
5.2: 20 °C
6.1: hydrogenchloride / water
6.2: Reflux
7.1: potassium tert-butylate / tetrahydrofuran / 0 °C
8.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
Multi-step reaction with 9 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 70 °C
2.1: sodium hydride; 1H-imidazole / tetrahydrofuran
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
4.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / -78 - 20 °C
5.1: diisobutylaluminium hydride / dichloromethane / -78 °C
5.2: 0 - 20 °C
6.1: Methylenetriphenylphosphorane / -78 - 20 °C
6.2: 20 °C
7.1: hydrogenchloride / water
7.2: Reflux
8.1: potassium tert-butylate / tetrahydrofuran / 0 °C
9.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C20H22N2O3S2

C20H22N2O3S2

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
2.1: N,N-dimethyl-formamide / -78 - 20 °C
3.1: Methylenetriphenylphosphorane / -78 - 20 °C
3.2: 20 °C
4.1: hydrogenchloride / water
4.2: Reflux
5.1: potassium tert-butylate / tetrahydrofuran / 0 °C
6.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / -78 - 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / -78 °C
3.2: 0 - 20 °C
4.1: Methylenetriphenylphosphorane / -78 - 20 °C
4.2: 20 °C
5.1: hydrogenchloride / water
5.2: Reflux
6.1: potassium tert-butylate / tetrahydrofuran / 0 °C
7.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C26H31N2O5S2(1-)*Li(1+)

C26H31N2O5S2(1-)*Li(1+)

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / -78 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / -78 °C
2.2: 0 - 20 °C
3.1: Methylenetriphenylphosphorane / -78 - 20 °C
3.2: 20 °C
4.1: hydrogenchloride / water
4.2: Reflux
5.1: potassium tert-butylate / tetrahydrofuran / 0 °C
6.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
C25H29N2O4S2(1-)*Li(1+)

C25H29N2O4S2(1-)*Li(1+)

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / -78 - 20 °C
2.1: Methylenetriphenylphosphorane / -78 - 20 °C
2.2: 20 °C
3.1: hydrogenchloride / water
3.2: Reflux
4.1: potassium tert-butylate / tetrahydrofuran / 0 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
View Scheme
methyl (2S,3aR,3a1S,10bR)-2-((tert-butyldimethylsilyl)oxy)-3a-ethyl-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate

methyl (2S,3aR,3a1S,10bR)-2-((tert-butyldimethylsilyl)oxy)-3a-ethyl-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere
2: triphenylphosphine / acetonitrile; tetrachloromethane / 0.5 h / 70 °C / Inert atmosphere
View Scheme
stemmadenine acetate

stemmadenine acetate

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: T. iboga precondylocarpine acetate synthase 1; FAD / aq. buffer / 2 h / 37 °C / pH 9.5 / Enzymatic reaction
2: NADPH / aq. buffer / 1 h / 37 °C / pH 9.5 / Enzymatic reaction
3: NADPH / aq. buffer / pH 9.5 / Enzymatic reaction
View Scheme
C23H27N2O4(1+)

C23H27N2O4(1+)

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NADPH / aq. buffer / 1 h / 37 °C / pH 9.5 / Enzymatic reaction
2: NADPH / aq. buffer / pH 9.5 / Enzymatic reaction
View Scheme
dehydrosecodine

dehydrosecodine

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With NADPH In aq. buffer pH=9.5; Reagent/catalyst; Enzymatic reaction;
stemmadenine

stemmadenine

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridine / 20 °C
1.2: 4 h / 20 °C
2.1: flavin adenine dinucleotide; precondylocarpine acetate synthase; dehydroprecondyiocarpine acetate synthase; tabersonine synthase / methanol / pH 8.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / 20 °C
1.2: 4 h / 20 °C
2.1: platinum; oxygen / ethyl acetate / 20 °C
3.1: NADPH; dehydroprecondyiocarpine acetate synthase; tabersonine synthase / methanol / 1 h / 37 °C / pH 7.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / 20 °C
1.2: 4 h / 20 °C
2.1: flavin adenine dinucleotide; precondylocarpine acetate synthase; dehydroprecondyiocarpine acetate synthase / methanol / pH 8.5 / Enzymatic reaction
3.1: NADPH; dehydroprecondyiocarpine acetate synthase; tabersonine synthase / methanol / 1 h / 37 °C / pH 7.5 / Enzymatic reaction
View Scheme
stemmadenine acetate

stemmadenine acetate

tabersonine
4429-63-4

tabersonine

Conditions
ConditionsYield
With dehydroprecondyiocarpine acetate synthase; precondylocarpine acetate synthase; tabersonine synthase; flavin adenine dinucleotide In methanol pH=8.5; Enzymatic reaction;
Multi-step reaction with 2 steps
1: platinum; oxygen / ethyl acetate / 20 °C
2: NADPH; dehydroprecondyiocarpine acetate synthase; tabersonine synthase / methanol / 1 h / 37 °C / pH 7.5 / Enzymatic reaction
View Scheme
tabersonine
4429-63-4

tabersonine

dihydro-2β,16β tabersonine
110456-33-2

dihydro-2β,16β tabersonine

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol; water at 20℃; for 20h; Inert atmosphere;100%
With hydrogenchloride; zinc In methanol for 3h; Heating;76%
With sodium cyanoborohydride In propionic acid for 0.166667h; Ambient temperature;
tabersonine
4429-63-4

tabersonine

10-iodo-tabersonin

10-iodo-tabersonin

Conditions
ConditionsYield
With N-iodo-succinimide; trifluoroacetic acid at 20℃; for 3h;98%
With N-iodo-succinimide
tabersonine
4429-63-4

tabersonine

(-)-vincadifformine
3247-10-7

(-)-vincadifformine

Conditions
ConditionsYield
Stage #1: tabersonine With ammonium hydroxide In Petroleum ether at 20℃; for 0.5h;
Stage #2: With palladium on activated charcoal; hydrogen In methanol at 20℃; under 760.051 Torr; for 7h; Solvent; Temperature;
95.4%
With platinum(IV) oxide; hydrogen In ethyl acetate for 16h; Inert atmosphere;81%
With platinum(IV) oxide; hydrogen In ethyl acetate81%
With hydrogen; palladium
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 35 - 45℃; under 3000.3 - 3750.38 Torr;
tabersonine
4429-63-4

tabersonine

decarbomethoxytabersonine
100044-35-7

decarbomethoxytabersonine

Conditions
ConditionsYield
With hydrogenchloride at 110℃;94%
tabersonine
4429-63-4

tabersonine

(-)-17-hydroxytabersonine
93771-99-4

(-)-17-hydroxytabersonine

Conditions
ConditionsYield
With triphenylphosphine In tetrachloromethane; acetonitrile at 70℃; for 0.5h;93%
With benzeneseleninic anhydride In benzene at 60℃; for 0.5h;93%
tabersonine
4429-63-4

tabersonine

A

2βH,3αH-tubersonine
50868-35-4

2βH,3αH-tubersonine

B

dihydro-2β,16β tabersonine
110456-33-2

dihydro-2β,16β tabersonine

Conditions
ConditionsYield
With sodium methylate In methanol at 50℃; for 24h;A 3%
B 92%
tabersonine
4429-63-4

tabersonine

2,2,2-Trichloroethyl chloroformate
17341-93-4

2,2,2-Trichloroethyl chloroformate

C24H25Cl3N2O4

C24H25Cl3N2O4

Conditions
ConditionsYield
Stage #1: tabersonine With dmap; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: 2,2,2-Trichloroethyl chloroformate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 3h;
92%
tabersonine
4429-63-4

tabersonine

methyl 15-bromo-2,3,6,7-tetrahydro-(5α,12β,19α)-aspidospermidine-3-carboxylate
73749-08-3

methyl 15-bromo-2,3,6,7-tetrahydro-(5α,12β,19α)-aspidospermidine-3-carboxylate

Conditions
ConditionsYield
With N-Bromosuccinimide; acetic acid at 20℃; for 4h;91%
With N-Bromosuccinimide In tetrahydrofuran
tabersonine
4429-63-4

tabersonine

14,15-didehydro-16-hydroxy-<3H>indole
79820-33-0

14,15-didehydro-16-hydroxy-<3H>indole

Conditions
ConditionsYield
With oxygen; rose bengal; triethyl phosphite In methanol for 0.333333h; Irradiation;88%
With acetic buffer; ozone at 25℃;78%
Multi-step reaction with 2 steps
1: 38 percent / m-chloroperbenzoic acid / benzene / 24 h / Ambient temperature
2: 73 percent / Raney Ni / acetone
View Scheme
acetic anhydride
108-24-7

acetic anhydride

tabersonine
4429-63-4

tabersonine

C23H26N2O3

C23H26N2O3

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 20℃; for 24h;85%
tabersonine
4429-63-4

tabersonine

C21H23BrN2O2

C21H23BrN2O2

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 5h; Reflux; Inert atmosphere;81%
tabersonine
4429-63-4

tabersonine

A

methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate
62414-79-3

methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate

B

7-hydroxy-2,3-didehydro-aspidospermidine-3-carboxylic acid methyl ester
63490-95-9

7-hydroxy-2,3-didehydro-aspidospermidine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
Hydroboration, Oxidation;A 20%
B 80%
tabersonine
4429-63-4

tabersonine

A

C21H25N3O4
112794-44-2

C21H25N3O4

B

C21H25N3O3
112924-07-9

C21H25N3O3

Conditions
ConditionsYield
With potassiuim nitrosodisulfonate; acetic acid In N,N-dimethyl-formamide for 96h; Ambient temperature;A 8%
B 78%
tabersonine
4429-63-4

tabersonine

A

C21H23ClN2O2

C21H23ClN2O2

B

C21H22Cl2N2O2

C21H22Cl2N2O2

Conditions
ConditionsYield
With N-chloro-succinimide; trifluoroacetic acid at 20℃; for 4h;A 68%
B 7%
tabersonine
4429-63-4

tabersonine

A

(3aR,10bR,12bS)-3a-Ethyl-3a,4,5,11,12,12b-hexahydro-1H,6H-6,12a-diaza-indeno[7,1-cd]fluoren-5a-ol
78346-69-7

(3aR,10bR,12bS)-3a-Ethyl-3a,4,5,11,12,12b-hexahydro-1H,6H-6,12a-diaza-indeno[7,1-cd]fluoren-5a-ol

B

(-)-1,2,14,15-tetradehydroaspidospermidine
32975-46-5

(-)-1,2,14,15-tetradehydroaspidospermidine

Conditions
ConditionsYield
With hydrogenchloride at 105℃; for 0.166667h;A 65%
B 28%
With hydrogenchloride at 105℃; for 0.166667h;A 49%
B 41%
methanol
67-56-1

methanol

tabersonine
4429-63-4

tabersonine

dichloro-10,12 dihydro-2,16 hydroxy-16 methoxy-2 tabersonine
73232-83-4

dichloro-10,12 dihydro-2,16 hydroxy-16 methoxy-2 tabersonine

Conditions
ConditionsYield
With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid for 24h; Ambient temperature;60%
With hydrogenchloride; MCPB
tabersonine
4429-63-4

tabersonine

A

Δ14-vincamine
32790-09-3

Δ14-vincamine

B

14-epi-Δ17-vincamine
32790-10-6

14-epi-Δ17-vincamine

Conditions
ConditionsYield
With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid In methanol for 24h; Ambient temperature;A 30%
B 60%
In methanol for 24h; Product distribution; Ambient temperature; diferent amount of hydrochloric acid and m-chloroperbenzoic acid, other derivative of tabersonine;A 30%
B 60%
With 3,3-dimethyldioxirane; trifluoroacetic anhydride In dichloromethane; acetone at 0℃; for 10h;A 29%
B 27%
ethanol
64-17-5

ethanol

tabersonine
4429-63-4

tabersonine

(3aR,5R,5aS,10bR,12bS)-7,9-Dichloro-5a-ethoxy-3a-ethyl-5-hydroxy-3a,4,5,5a,6,11,12,12b-octahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
77250-38-5

(3aR,5R,5aS,10bR,12bS)-7,9-Dichloro-5a-ethoxy-3a-ethyl-5-hydroxy-3a,4,5,5a,6,11,12,12b-octahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid for 24h; Ambient temperature;60%
tabersonine
4429-63-4

tabersonine

A

14,15-dehydro-10-chloro vincamine

14,15-dehydro-10-chloro vincamine

B

16-epi-14,15-dehydro-10-chloro vincamine
69754-29-6

16-epi-14,15-dehydro-10-chloro vincamine

Conditions
ConditionsYield
With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid In methanol for 24h; Ambient temperature;A 25%
B 55%
tabersonine
4429-63-4

tabersonine

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

(3S,3aS,10bR)-3a-Ethyl-3-hydroxy-2,6-bis-(2,2,2-trifluoro-acetyl)-3a,4,6,11,12,12b-hexahydro-3H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
137993-96-5

(3S,3aS,10bR)-3a-Ethyl-3-hydroxy-2,6-bis-(2,2,2-trifluoro-acetyl)-3a,4,6,11,12,12b-hexahydro-3H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester

Conditions
ConditionsYield
With pyridine for 12h; Ambient temperature;47%
tabersonine
4429-63-4

tabersonine

A

(-)-15β-hydroxyvincadifformine

(-)-15β-hydroxyvincadifformine

B

methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate
62414-79-3

methyl (2S,3aR,3a1S,10bR)-3a-ethyl-2-hydroxy-2,3,3a,3a1,4,6,11,12-octahydro-1H-indolizino-[8,1-cd]carbazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: tabersonine With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 0℃; for 2.5h;
Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran at 60℃; for 0.75h; Further stages.;
A 6.6%
B 41.9%
tabersonine
4429-63-4

tabersonine

A

14β-Bromo 15α-fluoro vincadifformine
128773-80-8

14β-Bromo 15α-fluoro vincadifformine

B

14β-Fluoro 15α-bromo vincadifformine
128773-82-0

14β-Fluoro 15α-bromo vincadifformine

Conditions
ConditionsYield
With hydrogen fluoride; bromine; antimony pentafluoride at -35℃; for 0.75h; Mechanism;A 27%
B 41.4%
tabersonine
4429-63-4

tabersonine

16-hydroxy-tabersonine-N-oxide
80249-96-3

16-hydroxy-tabersonine-N-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In benzene40%
With 3,3-dimethyldioxirane In dichloromethane; acetone at 4 - 5℃; for 24h;31%
tabersonine
4429-63-4

tabersonine

(3aR,5R,10bR,12aR,12bS)-3a-Ethyl-5-hydroxy-12a-oxy-3a,4,5,11,12,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
82690-89-9

(3aR,5R,10bR,12aR,12bS)-3a-Ethyl-5-hydroxy-12a-oxy-3a,4,5,11,12,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In benzene for 24h; Ambient temperature;38%
tabersonine
4429-63-4

tabersonine

A

15α-Fluoro 14β-hydroxy vincadifformine
128773-79-5

15α-Fluoro 14β-hydroxy vincadifformine

B

14α-Fluoro 15β-hydroxy vincadifformine
128773-78-4

14α-Fluoro 15β-hydroxy vincadifformine

C

14β-Fluoro 15α-hydroxy vincadifformine
128779-74-8

14β-Fluoro 15α-hydroxy vincadifformine

Conditions
ConditionsYield
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -35℃; for 1h; Mechanism;A 21%
B 22%
C 35%
tabersonine
4429-63-4

tabersonine

A

C21H22N2O5
74947-48-1

C21H22N2O5

B

Δ14-vincamine
32790-09-3

Δ14-vincamine

C

14-epi-Δ17-vincamine
32790-10-6

14-epi-Δ17-vincamine

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In benzene at 20℃; for 24h;A 5%
B 29%
C 31%
tabersonine
4429-63-4

tabersonine

A

(3aR,5R,10bR,12bS)-5-Aminooxy-3a-ethyl-3a,4,5,11,12,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester
112794-42-0

(3aR,5R,10bR,12bS)-5-Aminooxy-3a-ethyl-3a,4,5,11,12,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-5-carboxylic acid methyl ester

B

C21H27N3O7S
112794-43-1

C21H27N3O7S

Conditions
ConditionsYield
With potassiuim nitrosodisulfonate; acetic acid In N,N-dimethyl-formamide for 2h; Ambient temperature;A 27%
B 6%

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