Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryItems Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che
Cas:455-24-3
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inquiryhigh quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
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inquiryProduct Description Product website: http://www.finerchem.com Product Name 4-(Trifluoromethyl)benzoic acid CAS No. 455-24-3
Cas:455-24-3
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:455-24-3
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inquiryName: Alpha,Alpha,Alpha-Trifluoro-p-toluic acid CAS No.: 455-24-3 Molecular Formula: C8H5F3O2 Molecular Weight: 190.12 EINEC No.: 207-242-8 Appearance:White Powder Storage:Store
Cas:455-24-3
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:455-24-3
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:455-24-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:455-24-3
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:455-24-3
Min.Order:10 Gram
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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Cas:455-24-3
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:455-24-3
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:455-24-3
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:455-24-3
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Cas:455-24-3
Min.Order:100 Gram
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:455-24-3
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inquirySuperior quality Appearance:White to light yellow crystal powde Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediat
Cas:455-24-3
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:455-24-3
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inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
Cas:455-24-3
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inquiry4-(Trifluoromethyl)benzoic acid Chemical Properties Melting point 219-220 °C(lit.) Boiling point 247°C 753mm density 1.3173 (estimate) Fp 247°C/753mm storage temp. Store below +30°C. pka 3.69±0.10(Predic
Cas:455-24-3
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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Type:Trading Company
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Cas:455-24-3
Min.Order:1 Kilogram
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Cas:455-24-3
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:455-24-3
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Type:Trading Company
inquiryConditions | Yield |
---|---|
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry; | 99% |
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h; | 99% |
With oxygen; copper(II) acetate monohydrate; cobalt(II) diacetate tetrahydrate In water at 70℃; under 760.051 Torr; for 1h; | 99% |
1-(4-(trifluoromethyl)phenyl)ethane-1,2-diol
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With oxygen; sodium methylate; silver trifluoromethanesulfonate In tetrahydrofuran; methanol at 37℃; under 760.051 Torr; Sealed tube; | 99% |
Conditions | Yield |
---|---|
With manganese(II) bromide; silver carbonate; potassium hydroxide In 1,3,5-trimethyl-benzene at 50 - 165℃; for 2h; Schlenk technique; Inert atmosphere; | 98% |
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 72h; | 97% |
With 3,5-Lutidine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; sodium persulfate; tris(2,2'‐bipyridine)ruthenium(II) hexafluorophosphate In water; acetonitrile at 20℃; for 48h; Sealed tube; Irradiation; | 95% |
Conditions | Yield |
---|---|
With formic acid; 1,10-ethyliden-3-octyl-7-trifluoromethylalloxazinium chloride; oxygen In acetonitrile at 40℃; for 24h; Irradiation; | 98% |
With cerium(III) chloride; 1,1,1-trichloroethanol; oxygen In acetonitrile at 60℃; Irradiation; | 90% |
With oxygen; Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Green chemistry; | 87% |
With pyridine; dipotassium peroxodisulfate; oxygen In acetonitrile at 80℃; under 760.051 Torr; for 16h; Green chemistry; | 72% |
Conditions | Yield |
---|---|
With iodine; aluminium In acetonitrile at 80℃; for 18h; | 98% |
With lithium hydroxide monohydrate; water In ethanol at 25℃; for 12h; | 94.8% |
With methanol; water; sodium hydroxide at 20℃; for 2h; | 68.4% |
carbon dioxide
5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃; | 97% |
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h; | 92% |
With (1,3-bis(2,6-diisopropyl-4-(morpholinomethyl)phenyl)imidazolidin-2-ylidene)copper(I) bromide; potassium tert-butylate In tetrahydrofuran under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry; | 90% |
With 1,3-bis-(diphenylphosphino)propane; cesium fluoride; [Rh(OH)(cod)]2 In 1,4-dioxane at 60℃; | 76% |
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 74% |
methyl 3-oxo-3-(4-(trifluoromethyl)phenyl) propanedithioate
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; for 9h; Reflux; chemoselective reaction; | 97% |
Conditions | Yield |
---|---|
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation; | 96% |
With water; potassium carbonate In acetonitrile; tert-butyl alcohol at 100℃; under 3750.38 Torr; for 0.0161111h; | 96% |
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 7h; | 82% |
With water; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; under 11251.1 Torr; Flow reactor; | 78% |
With water; sodium carbonate; palladium diacetate at 20 - 165℃; under 10501.1 - 22502.3 Torr; for 0.333333h; microwave irradiation; | 59% |
Conditions | Yield |
---|---|
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 24h; | 96% |
Conditions | Yield |
---|---|
With water at 20℃; Temperature; Reflux; | 95.4% |
1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethanone
A
4-trifluoromethylbenzoic acid
B
4-methoxybenzoic acid
Conditions | Yield |
---|---|
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction; | A 90% B 93% |
Conditions | Yield |
---|---|
With 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; water; palladium diacetate; potassium carbonate In dimethyl sulfoxide at 100℃; under 760.051 Torr; for 15h; | 92% |
With potassium hydroxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride In water for 48h; Heating; | 500 % Turnov. |
carbon dioxide
p-trifluoromethylphenyl bromide
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 2-(diphenylphosphino)-2’(3-(dimethylamino)-3-oxopropyl)-6’-(3-(icosyloxy)-3-oxopropyl)biphenyl; water; palladium diacetate; N-ethyl-N,N-diisopropylamine In toluene under 760.051 Torr; for 16h; Inert atmosphere; Schlenk technique; Irradiation; | 92% |
Stage #1: p-trifluoromethylphenyl bromide With bromobenzene; trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; zinc In acetonitrile Inert atmosphere; Stage #2: carbon dioxide With palladium diacetate; tricyclohexylphosphine In tetrahydrofuran; acetonitrile at 0℃; under 760.051 Torr; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate; acetonitrile | 90% |
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 4h; Electrolysis; | 78% |
4-Trifluoromethylbenzaldehyde
diethoxyphosphoryl-acetic acid ethyl ester
A
4-trifluoromethylbenzoic acid
B
ethyl (E)-4-trifluoromethylcinnamate
Conditions | Yield |
---|---|
Stage #1: 4-Trifluoromethylbenzaldehyde; diethoxyphosphoryl-acetic acid ethyl ester With potassium carbonate for 6h; Horner-Wadsworth-Emmons olefination; Neat (no solvent); high-speed ball milling; Stage #2: With Oxone for 12h; Neat (no solvent); high-speed ball milling; optical yield given as %de; diastereoselective reaction; | A n/a B 91% |
Conditions | Yield |
---|---|
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 20h; Schlenk technique; Inert atmosphere; Glovebox; | 91% |
Conditions | Yield |
---|---|
With water; potassium hydroxide at 115℃; for 1h; | 90% |
(±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
Stage #1: (±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 760.051 Torr; for 3.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=1; chemoselective reaction; | 89% |
Stage #1: (±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol With 2,3,4,5,6-pentamethyliodobenzene; oxygen; isobutyraldehyde In 1,2-dichloro-ethane under 760.051 Torr; for 24h; Stage #2: With sodium chlorite; 2-methyl-but-2-ene In aq. phosphate buffer; 1,2-dichloro-ethane; tert-butyl alcohol at 25℃; for 14h; | 79% |
With oxygen In dichloromethane at 20℃; under 760.051 Torr; for 12h; Irradiation; | 78% |
Conditions | Yield |
---|---|
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h; | 88% |
Conditions | Yield |
---|---|
With acetic acid; isopentyl nitrite at 80℃; for 24h; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 750.075 Torr; for 12h; chemoselective reaction; | 86% |
carbon monoxide
p-trifluoromethylphenyl bromide
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With water; potassium carbonate In acetonitrile; tert-butyl alcohol at 120℃; under 30003 Torr; for 7h; | 85% |
carbon dioxide
p-trifluoromethylphenyl bromide
A
α,α,α-trifluorotoluene
B
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 10h; Ambient temperature; electrochemically; | A 2.4 mmol B 84% |
Conditions | Yield |
---|---|
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube; | 84% |
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Temperature; Inert atmosphere; | 80% |
4-(trifluoromethyl)mandelic acid
A
4-Trifluoromethylbenzaldehyde
B
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; oxygen; CoCl2 In water; dimethyl sulfoxide at 125℃; under 760.051 Torr; for 24h; Title compound not separated from byproducts.; | A 17% B 83% |
Conditions | Yield |
---|---|
With copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate In dimethyl sulfoxide at 140℃; under 750.075 Torr; for 3h; Schlenk technique; Sealed tube; | 83% |
carbon dioxide
Sodium; 4-trifluoromethyl-benzenesulfonate
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; Sodium; 4-trifluoromethyl-benzenesulfonate With copper(l) iodide; potassium tert-butylate; o-phenanthroline In dimethyl sulfoxide at 140℃; under 760.051 Torr; for 12h; Schlenk technique; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Schlenk technique; | 81% |
Conditions | Yield |
---|---|
With 2.9-dimethyl-1,10-phenanthroline; neocuproine; zinc In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 16h; | 81% |
1-(4-(trifluoromethyl)phenyl)cyclohexanol
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With iron(III) chloride; cerium(III) chloride; tetrabutyl-ammonium chloride; oxygen In acetonitrile at 20℃; under 760.051 Torr; for 24h; Schlenk technique; Irradiation; | 81% |
carbon dioxide
4-chlorobenzotrifluoride
A
α,α,α-trifluorotoluene
B
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 5℃; electrolysis (I=0.4 A); | A 3 % Chromat. B 80% |
Conditions | Yield |
---|---|
With thionyl chloride Reflux; | 100% |
With thionyl chloride for 2h; Reflux; | 100% |
Stage #1: 4-trifluoromethylbenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h; | 100% |
4-trifluoromethylbenzoic acid
N,O-dimethylhydroxylamine*hydrochloride
N-methoxy-N-methyl-4-trifluoromethylbenzamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h; | 100% |
Stage #1: 4-trifluoromethylbenzoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 23℃; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0℃; for 2h; | 95% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; | 95% |
n-heptan1ol
4-trifluoromethylbenzoic acid
heptyl 4-(trifluoromethyl)benzoate
Conditions | Yield |
---|---|
With Candida antarctica lipase B immobilised in a macroporous DVB crosslinked polymer (Novozym 435) In cyclohexane at 80℃; for 24h; Enzymatic reaction; | 100% |
4-trifluoromethylbenzoic acid
C21H33N3O
N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)nicotinamide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With water In ethanol at 0 - 20℃; for 0.0833333h; | 100% |
Conditions | Yield |
---|---|
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere; | 99% |
Stage #1: 4-trifluoromethylbenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667h; Stage #2: With sodium tetrahydroborate In water; ethyl acetate at 0℃; for 0.466667h; | 90% |
With cobalt(II) tetrafluoroborate hexahydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 100℃; under 60006 Torr; for 22h; | 82% |
Conditions | Yield |
---|---|
With sulfuric acid In toluene | 99% |
With sulfuric acid In toluene | 99% |
With sulfuric acid In toluene | 99% |
4-trifluoromethylbenzoic acid
phenylboronic acid
phenyl[4-(trifluoromethyl)phenyl]methanone
Conditions | Yield |
---|---|
With dimethyl dicarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 6h; | 99% |
Stage #1: 4-trifluoromethylbenzoic acid With di(succinimido) carbonate; sodium carbonate; tricyclohexylphosphine; palladium(II) hexafluoroacetylacetonate In tetrahydrofuran at 60℃; Stage #2: phenylboronic acid In tetrahydrofuran at 60℃; for 20h; Further stages.; | 89% |
Stage #1: 4-trifluoromethylbenzoic acid With potassium phosphate In 1,4-dioxane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With 2-chloro-1,3-dimethylimidazolinium chloride In 1,4-dioxane at 20℃; for 2h; Inert atmosphere; Stage #3: phenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 90℃; for 16h; Inert atmosphere; Sealed tube; | 62% |
With 2,2-dimethylpropanoic anhydride; tricyclohexylphosphine In tetrahydrofuran; water at 60℃; for 16h; | 40% |
Conditions | Yield |
---|---|
With [Cl(C6F13C2H4)2SnOSn(C2H4C6F13)2Cl]2 In various solvent(s) at 150℃; for 10h; | 99% |
With 2-butyl-1,3-diphenyl-1,3,2-diazaphospholidine; 1,1'-azodicarbonyl-dipiperidine In 1,2-dichloro-ethane at 40℃; under 760.051 Torr; Mitsunobu Displacement; | 89% |
Conditions | Yield |
---|---|
With 14C2H2F3O(1-)*6C4H8O*La2Na8(14+) at 80℃; for 6h; Inert atmosphere; | 99% |
With borane-ammonia complex In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Reflux; | 99% |
With tetrachloromethane; Bis(p-nitrophenyl) phosphate; 3-Methyl-1-phenyl-2-phospholene 1-oxide In toluene at 110℃; for 20h; Green chemistry; | 98% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h; | 99% |
With 2,4,6-trimethyl-pyridine; dmap; carbon tetrabromide In N,N-dimethyl-formamide for 0.5h; UV-irradiation; | 94 %Spectr. |
Conditions | Yield |
---|---|
With C30H54N6Ru(2+)*2BF4(1-); potassium perfluoro-tert-butoxide; potassium carbonate at 140℃; for 24h; Glovebox; Inert atmosphere; | 99% |
4-trifluoromethylbenzoic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 15h; | 99% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 15h; | 99% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 99% |
4-trifluoromethylbenzoic acid
potassium 4-(trifluoromethyl)benzoate
Conditions | Yield |
---|---|
With potassium tert-butylate In ethanol at 20℃; Inert atmosphere; | 98% |
With potassium tert-butylate In ethanol at 20℃; for 3h; | 98% |
Conditions | Yield |
---|---|
With phenylsilane; triphenylphosphine In toluene at 20 - 60℃; for 21h; Reagent/catalyst; Staudinger Azide Reduction; Inert atmosphere; chemoselective reaction; | 98% |
With 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; triethylamine In chlorobenzene at 20 - 130℃; for 14h; | 85% |
Conditions | Yield |
---|---|
Stage #1: 4-trifluoromethylbenzoic acid With dichlorotriphenylphosphorane In chloroform at 20℃; for 0.25h; Inert atmosphere; Stage #2: p-aminoethylbenzoate In chloroform at 100℃; Inert atmosphere; Irradiation; | 98% |
4-trifluoromethylbenzoic acid
phenylmagnesium bromide
phenyl[4-(trifluoromethyl)phenyl]methanone
Conditions | Yield |
---|---|
Stage #1: 4-trifluoromethylbenzoic acid With tert-butylmagnesium chloride In tetrahydrofuran; toluene at 0℃; for 0.25h; Inert atmosphere; Stage #2: phenylmagnesium bromide With diisopropylaminomagnesium chloride lithium chloride In tetrahydrofuran; toluene at 0 - 20℃; for 3.25h; Inert atmosphere; Sonication; | 98% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; | 97% |
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 3h; Inert atmosphere; | 67% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 25℃; for 2h; |
4-trifluoromethylbenzoic acid
1-t-Butoxycarbonylpiperazine
tert-butyl 4-(4-(trifluoromethyl)benzoyl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; | 97% |
Stage #1: 4-trifluoromethylbenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 1-t-Butoxycarbonylpiperazine In N,N-dimethyl-formamide at 20℃; for 16h; |
4-trifluoromethylbenzoic acid
Propargylamine
4-(trifluoromethyl)-N-(prop-2-yn-1-yl)benzamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane | 97% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Concentration; Inert atmosphere; | 93.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 70.5% |
4-trifluoromethylbenzoic acid
bis(pinacol)diborane
4-trifluoromethylphenylboronic acid pinacol ester
Conditions | Yield |
---|---|
With palladium diacetate; 2,2-dimethylpropanoic anhydride; triethylamine; 1,4-di(diphenylphosphino)-butane In 1,4-dioxane at 160℃; for 15h; | 97% |
With biphenyl; naphthalene-1,4-dicarbonitrile In water; acetonitrile at 30℃; for 6h; Inert atmosphere; UV-irradiation; | 34% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique; | 97% |
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