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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Bekanamycin Manufacturer/High quality/Best price/In stock

Cas:4696-76-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Bekanamycin 4696-76-8 GMP Manufacturer

Cas:4696-76-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 4696-76-8 with competitive price

Cas:4696-76-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Leader Biochemical Group

PRODUCT DETAILS

China Biggest Factory manufacturer supply Kanamycin B

Cas:4696-76-8

Min.Order:50 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

CAS RN.: 4696-76-8 EINECS: 225-170-5 Molecular Weight:

KanamycinB (7CI,8CI) 4696-76-8

Cas:4696-76-8

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Changchun Artel lmport and Export trade company

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable &amp

4696-76-8 Kanamycin B Xi'an Leader Biochemicals Corp. CAS NO.4696-76-8

Cas:4696-76-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Kanamycin B

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Hangzhou Lingrui Chemical Co.,Ltd.

bekanamycinAppearance:white powder Storage:sealed, keep in the ventilated, dry Package:according to customers' requirements Application:health care Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or accordi

bekanamycin

Cas:4696-76-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Bekanamycin

Cas:4696-76-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

4696-76-8

Cas:4696-76-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Bekanamycin

Cas:4696-76-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Bekanamycin

Cas:4696-76-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

≥85.0% HPLC Appearance:white powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Bekanamycin B Pharmaceutical Antibiotics Intermediate arbekacin sulfate made in china

Cas:4696-76-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Kanamycin B

Cas:4696-76-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Kanamycin B

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

Bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Kanamycin B base

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Kanamycin B

Cas:4696-76-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Bekanamycin 4696-76-8

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Kanamycin B

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

Hangzhou Fandachem Co.,Ltd

BekanamycinAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Bekanamycin

Cas:4696-76-8

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

kananmycin B
4696-76-8

kananmycin B

1,3,2',6',3''-penta-N-tert-butoxycarbonyl kanamycin B

1,3,2',6',3''-penta-N-tert-butoxycarbonyl kanamycin B

Conditions
ConditionsYield
With sodium carbonate In water; isopropyl alcohol at 30℃; for 6h; Temperature;94%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

kananmycin B
4696-76-8

kananmycin B

1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B
60929-91-1, 119818-17-6

1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B

Conditions
ConditionsYield
With sodium carbonate In ethanol; dichloromethane; water at 25℃; for 16h; Reagent/catalyst; Solvent; Temperature;92.3%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

kananmycin B
4696-76-8

kananmycin B

1,3,2',6',3''-penta-N-BOC-kanamycin B
64271-30-3

1,3,2',6',3''-penta-N-BOC-kanamycin B

Conditions
ConditionsYield
In water; dimethyl sulfoxide at 60℃; for 6h;90%
acetone O-<(vinyloxy)carbonyl>oxime
139705-38-7

acetone O-<(vinyloxy)carbonyl>oxime

kananmycin B
4696-76-8

kananmycin B

C33H47N5O20

C33H47N5O20

Conditions
ConditionsYield
In phosphate buffer at 0℃; for 5h; pH=8.0;84%
kananmycin B
4696-76-8

kananmycin B

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

guanidinoboc10-kanamycin B

guanidinoboc10-kanamycin B

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃;80%
kananmycin B
4696-76-8

kananmycin B

pentaazidokanamycin B
1268528-26-2

pentaazidokanamycin B

Conditions
ConditionsYield
With triflic azide; triethylamine; zinc(II) chloride In methanol; water at 20℃; Inert atmosphere;76%
Stage #1: kananmycin B With copper(II) sulfate In water for 0.25h;
Stage #2: With triethylamine In water for 0.333333h; Cooling with ice; Further stages;
1.66 g
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

kananmycin B
4696-76-8

kananmycin B

3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B
132260-09-4

3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Stage #1: kananmycin B With zinc(II) acetate dihydrate In dimethyl sulfoxide at 21℃;
Stage #2: di-tert-butyl dicarbonate In dimethyl sulfoxide at 21℃; for 5h;
66%
With zinc diacetate 1.) DMSO, RT, overnight, 2.) 5 h; Yield given. Multistep reaction;
kananmycin B
4696-76-8

kananmycin B

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

C73H127N15O30
320616-55-5

C73H127N15O30

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;65%
acetic anhydride
108-24-7

acetic anhydride

kananmycin B
4696-76-8

kananmycin B

penta-N-hexa-O-acetylkanamycin B
144727-28-6

penta-N-hexa-O-acetylkanamycin B

Conditions
ConditionsYield
With pyridine
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

kananmycin B
4696-76-8

kananmycin B

1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B
60929-91-1, 119818-17-6

1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 2h; Ambient temperature;
benzyl chloroformate
501-53-1

benzyl chloroformate

kananmycin B
4696-76-8

kananmycin B

N,N'-bis-benzyloxycarbonyl-O4-(3-benzyloxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O6-(2,6-bis-benzyloxycarbonylamino-α-D-2,6-dideoxy-glucopyranosyl)-1L-2-deoxy-streptamine
65269-36-5

N,N'-bis-benzyloxycarbonyl-O4-(3-benzyloxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O6-(2,6-bis-benzyloxycarbonylamino-α-D-2,6-dideoxy-glucopyranosyl)-1L-2-deoxy-streptamine

Conditions
ConditionsYield
With sodium carbonate In water Yield given;
kananmycin B
4696-76-8

kananmycin B

C28H49N10O16P

C28H49N10O16P

Conditions
ConditionsYield
at 37℃; aminoglycoside-4'-nucleotidyltransferaze of Bacillus brevis, MgCl2, potassium phosphate buffer (pH 6.0);
kananmycin B
4696-76-8

kananmycin B

A

2-deoxystreptamine
2037-48-1

2-deoxystreptamine

B

kanosamine
60183-25-7

kanosamine

C

2,6-dideoxy-2,6-diamino-D-glucose
59433-00-0

2,6-dideoxy-2,6-diamino-D-glucose

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; Product distribution; Heating; other aminoglycosides and their carbenicillin products;
kananmycin B
4696-76-8

kananmycin B

4'',6''-O-cyclohexylidenekanamycin B
64879-71-6

4'',6''-O-cyclohexylidenekanamycin B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide / 2 h / Ambient temperature
2: dimethylformamide / Ambient temperature
View Scheme
kananmycin B
4696-76-8

kananmycin B

C61H97N5O22S
132260-19-6

C61H97N5O22S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
View Scheme
Multi-step reaction with 6 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-6''-deoxy-6''-chlorokanamycin B
132260-28-7

1-C-(hydroxymethyl)-6''-deoxy-6''-chlorokanamycin B

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 88.5 percent / lithium chloride / dimethylformamide / 7 h / 90 °C
10: CF3COOH / Ambient temperature
View Scheme
Multi-step reaction with 12 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 88.5 percent / lithium chloride / dimethylformamide / 7 h / 90 °C
12: CF3COOH / Ambient temperature
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-6''-deoxy-6''-acetamidokanamycin B
132297-01-9

1-C-(hydroxymethyl)-6''-deoxy-6''-acetamidokanamycin B

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
10: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
11: 73 percent / ethanol / 1.5 h / Ambient temperature
12: CF3COOH / Ambient temperature
View Scheme
Multi-step reaction with 14 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
12: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
13: 73 percent / ethanol / 1.5 h / Ambient temperature
14: CF3COOH / Ambient temperature
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-6''-deoxy-6''-azidokanamycin B
132297-00-8

1-C-(hydroxymethyl)-6''-deoxy-6''-azidokanamycin B

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
10: CF3COOH / Ambient temperature
View Scheme
Multi-step reaction with 12 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
12: CF3COOH / Ambient temperature
View Scheme
kananmycin B
4696-76-8

kananmycin B

3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B
132260-14-1

3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
View Scheme
Multi-step reaction with 6 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
View Scheme
kananmycin B
4696-76-8

kananmycin B

3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B
132260-10-7

3,2',6'-tris-N-(tert-butoxycarbonyl)-3''-N-(trifluoroacetyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1.1: zinc(II) acetate dihydrate / dimethyl sulfoxide / 21 °C
1.2: 5 h / 21 °C
2.1: dimethyl sulfoxide / 5 h / 21 °C
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B
132260-17-4

1-C-(hydroxymethyl)-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
5: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
6: 81 percent / triethylamine / CHCl3 / 0.5 h / Heating
7: 80.5 percent / hydrogen / Raney nickel W2 catalyst / methanol / 3 h / 3040 Torr
View Scheme
Multi-step reaction with 9 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
7: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
8: 81 percent / triethylamine / CHCl3 / 0.5 h / Heating
9: 80.5 percent / hydrogen / Raney nickel W2 catalyst / methanol / 3 h / 3040 Torr
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-N-<(benzyloxy)carbonyl>-3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B
132260-12-9

1-N-<(benzyloxy)carbonyl>-3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
View Scheme
Multi-step reaction with 4 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-deamino-1-nitro-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B
132260-15-2

1-deamino-1-nitro-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
5: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
View Scheme
Multi-step reaction with 7 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
7: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-1-deamino-1-nitro-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B
132260-16-3

1-C-(hydroxymethyl)-1-deamino-1-nitro-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
5: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
6: 81 percent / triethylamine / CHCl3 / 0.5 h / Heating
View Scheme
Multi-step reaction with 8 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 62 percent / H2 / 10percent Pd/C / methanol; H2O / 3 h / 2280 Torr
7: 45 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.75 h / 90 °C
8: 81 percent / triethylamine / CHCl3 / 0.5 h / Heating
View Scheme
kananmycin B
4696-76-8

kananmycin B

C44H80N6O20
132260-27-6

C44H80N6O20

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
10: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
View Scheme
Multi-step reaction with 12 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
12: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-6''-deoxy-6''-chloro-1,3,2',6',3''-pentakis-N-(tert-butoxycarbonyl)kanamycin B
132260-24-3

1-C-(hydroxymethyl)-6''-deoxy-6''-chloro-1,3,2',6',3''-pentakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 88.5 percent / lithium chloride / dimethylformamide / 7 h / 90 °C
View Scheme
Multi-step reaction with 11 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 88.5 percent / lithium chloride / dimethylformamide / 7 h / 90 °C
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-N-<(benzyloxy)carbonyl>-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B
132260-13-0

1-N-<(benzyloxy)carbonyl>-3,2',6',3''-tetrakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
View Scheme
Multi-step reaction with 5 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
View Scheme
kananmycin B
4696-76-8

kananmycin B

1-C-(hydroxymethyl)-6''-deoxy-6''-acetamido-1,3,2',6',3''-pentakis-N-(tert-butoxycarbonyl)kanamycin B
132260-26-5

1-C-(hydroxymethyl)-6''-deoxy-6''-acetamido-1,3,2',6',3''-pentakis-N-(tert-butoxycarbonyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 73 percent / copper(II) acetate monohydrate / dimethylformamide / 1.5 h
3: dioxane; methanol / 0.5 h / 40 °C
4: 65 percent / pyridine / 64 h
5: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
6: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
7: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
8: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
9: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
10: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
11: 73 percent / ethanol / 1.5 h / Ambient temperature
View Scheme
Multi-step reaction with 13 steps
1: 1.) Zn(OAc)2*2H2O / 1.) DMSO, RT, overnight, 2.) 5 h
2: 98 percent / dimethylsulfoxide / 1.5 h / Ambient temperature
3: 79 percent / dimethylformamide / 15 h / Ambient temperature
4: 33percent aqueous NH3 / tetrahydrofuran / 39 h / Ambient temperature
5: dioxane; methanol / 0.5 h / 40 °C
6: 65 percent / pyridine / 64 h
7: 76 percent / H2 / 10percent Pd/C / methanol / 2280 Torr
8: 40 percent / 3-chloroperbenzoic acid, 3-tert-butyl-5-methyl-4-hydroxyphenyl sulfide / 1,2-dichloro-ethane / 0.5 h / Heating
9: 72 percent / triethylamine / CHCl3 / 1.5 h / Heating
10: 1.) H2, (BOC)2O / 1.) Raney nickel W2 / 1.) methanol, 4 atm, 4 h, 2.) 20 h
11: 95 percent / LiN3 / dimethylformamide / 23 h / 65 °C
12: 1.) triphenylphosphine, 2.) 33percent aqueous NH3 / 1.) pyridine, RT, 2 h, 2.) 24 h
13: 73 percent / ethanol / 1.5 h / Ambient temperature
View Scheme

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