Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
17-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
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inquirysuperior quality Appearance:Pale Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Precursor of many aporphine and morphine-type alkalo
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:Herbal extr
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inquiryHangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your re
Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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inquiryADVANTAGE:1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day2. The products are provided with COA, HPLC, NMR, quality assurance, pac
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiry7-Isoquinolinol,1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-,(1S)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transporta
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inquiryCas:485-19-8
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inquiry*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:1kg/tin 5kg/tin 25kg/carton Application:Use in healthcare products. Use in food products. Use in Cosmetic p
good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port
home-produced Application:medicine
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:485-19-8
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Basic information Product Name: (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-m
Cas:485-19-8
Min.Order:100 Kilogram
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inquiryCompound sourcing ServicesAgency of testing serviceFactory audit serviceFounded in Dec. 1999, Nanjing Chemlin Chemical Industrial Co.,Ltd(CHEMLIN) has been covering the business scope from trading of chemicals to custom-synthesis & Manufacturing. Co
United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat
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inquiryShaanxi Cuicheng Biomedical Technology Co., Ltd. is located in Chuangzhi Industrial Park, Economic and Technological Development Zone, Hanzhong City, Shaanxi Province, China. It is a company specializing in natural medicines and high-throughput scree
Hangzhou Haiqiang Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quali
1.We have rich experience in the development and production 2.Our factory is in Shanghai of China,We have convenient traffic conditions.3.We have advanced testing equipment and shipping line. Package:5g, 10g, 50g, 100g, 1kg Application:Pharmaceutical
High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate
In Stock,Offering NMR, HPLC/TLC and COA Reports Application:For pharmaceutical, cosmetics, agrochemical and food industries research / Activity Screening / Standard / Reference compounds
Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en
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inquiryreticuline
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With borane-ammonia complex; recombinant monoamine oxidase D11 from Aspergillus niger; oxygen In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 48h; pH=7.7; Time; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | 80% |
1-(3'-benzyloxy-4'-methoxybenzyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol; acetic acid under 2585.7 Torr; for 6h; | 0.026 g |
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 75 percent / KOH / H2O / 5 h / Heating 2: 93 percent / NaBH4 / ethanol / 1.) room temperature, 18 h, 2.) reflux, 1 h 3: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C 4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 5: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 6: K2CO3 / acetone / 14 h / Heating 7: lithium aluminum hydride / tetrahydrofuran / Heating 8: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 73 percent / ammonium acetate / 1.5 h / Heating 2: 55 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 1.) reflux, 2 h, 2.) room temperature, overnight 3: formic acid / 48 h / 50 °C 4: 88 percent / ammonium sulfate / toluene / 48 h / Heating 5: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 6: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 7: K2CO3 / acetone / 14 h / Heating 8: lithium aluminum hydride / tetrahydrofuran / Heating 9: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: formic acid / 48 h / 50 °C 2: 88 percent / ammonium sulfate / toluene / 48 h / Heating 3: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 4: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 5: K2CO3 / acetone / 14 h / Heating 6: lithium aluminum hydride / tetrahydrofuran / Heating 7: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C 2: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 3: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 4: K2CO3 / acetone / 14 h / Heating 5: lithium aluminum hydride / tetrahydrofuran / Heating 6: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
3-methoxy-4-benzyloxy-ω-nitrostyrolene
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 55 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 1.) reflux, 2 h, 2.) room temperature, overnight 2: formic acid / 48 h / 50 °C 3: 88 percent / ammonium sulfate / toluene / 48 h / Heating 4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 5: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 6: K2CO3 / acetone / 14 h / Heating 7: lithium aluminum hydride / tetrahydrofuran / Heating 8: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
4-methoxy-3-(benzyloxy)benzyl bromide
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 2: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 3: K2CO3 / acetone / 14 h / Heating 4: lithium aluminum hydride / tetrahydrofuran / Heating 5: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 88 percent / K2CO3 / ethanol 2: 73 percent / ammonium acetate / 1.5 h / Heating 3: 55 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 1.) reflux, 2 h, 2.) room temperature, overnight 4: formic acid / 48 h / 50 °C 5: 88 percent / ammonium sulfate / toluene / 48 h / Heating 6: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 7: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 8: K2CO3 / acetone / 14 h / Heating 9: lithium aluminum hydride / tetrahydrofuran / Heating 10: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
(S)-valinol-tert-butyl ether formamidine of 7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 2: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 3: K2CO3 / acetone / 14 h / Heating 4: lithium aluminum hydride / tetrahydrofuran / Heating 5: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
1-(3'-benzyloxy-4'-methoxybenzyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3 / acetone / 14 h / Heating 2: lithium aluminum hydride / tetrahydrofuran / Heating 3: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
(S)-7-Benzyloxy-1-(3-benzyloxy-4-methoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminum hydride / tetrahydrofuran / Heating 2: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 88 percent / ammonium sulfate / toluene / 48 h / Heating 2: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 3: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 4: K2CO3 / acetone / 14 h / Heating 5: lithium aluminum hydride / tetrahydrofuran / Heating 6: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 2: K2CO3 / acetone / 14 h / Heating 3: lithium aluminum hydride / tetrahydrofuran / Heating 4: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 93 percent / NaBH4 / ethanol / 1.) room temperature, 18 h, 2.) reflux, 1 h 2: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C 3: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 4: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 5: K2CO3 / acetone / 14 h / Heating 6: lithium aluminum hydride / tetrahydrofuran / Heating 7: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme |
(-)-Norreticuline
S-Adenosyl-L-methionine
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With ipecac alkaloid O-methyltransferase 3 Enzymatic reaction; |
reticuline
A
(R)-reticuline
B
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With Escherichia coli monoamine oxidase MAO-N D11 Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With recombinant monoamine oxidase D11 from Aspergillus niger In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 24h; pH=7.7; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
formaldehyd
N-benzoyl-norreticuline
A
(R)-reticuline
B
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With sodium cyanoborohydride; zinc(II) chloride In methanol at 20℃; for 24h; Overall yield = 96 %; Overall yield = 32.5 mg; |
Conditions | Yield |
---|---|
With 4-morpholineethanesulfonic acid; ascorbate; isopropyl β-D-thiogalactopyranoside at 37℃; Enzymatic reaction; |
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 2.5h; | 66% |
5-Chloro-1-phenyltetrazole
(+)-(S)-reticuline
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 24h; Reflux; | 63% |
(+)-(S)-reticuline
A
isoboldine
B
(S)-(-)-pallidine
C
S-(-)-coreximine
D
(S)-scoulerine
Conditions | Yield |
---|---|
With phosphate buffer; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; NADPH; magnesium chloride at 37℃; for 2h; rat liver microsomes; | A 7.5% B 5.2% C 21.1% D 7.9% |
(+)-(S)-reticuline
(S)-(+)-<2',6',8-3H3>reticuline
Conditions | Yield |
---|---|
With tritium oxide; potassium tert-butylate at 100℃; for 110h; sealed tube; | |
With tritium oxide; potassium tert-butylate at 100℃; for 110h; |
(+)-(S)-reticuline
(S)-scoulerine
Conditions | Yield |
---|---|
enzymatic reaction with berberine bridge enzyme; | |
berberine bridge enzyme Mechanism; stereochemistry of enzymatic berberine bridge formation; | |
With glycine-NaOH buffer; berberine bridge-forming enzyme In water at 30℃; for 1h; Mechanism; further benzylisoquinolines; tritium labelling (-N-CT3) experiments; | |
With berberine bridge enzyme; tris hydrochloride at 37℃; for 2h; pH=8.8; Enzymatic reaction; | |
With berberine bridge enzyme Enzymatic reaction; |
Conditions | Yield |
---|---|
With pyridine at 20℃; |
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 20 °C 2: m-CPBA / CH2Cl2 3: 1.6 mg / aq. NH4OH / methanol / 20 °C View Scheme |
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 20 °C 2: m-CPBA / CH2Cl2 View Scheme |
(+)-(S)-reticuline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 20 °C 2: m-CPBA / CH2Cl2 3: 1.3 mg / aq. NH4OH / methanol / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: enzymatic reaction with berberine bridge enzyme 2: S-adenosyl-L-methionine / enzymatic reaction with (S)-scoulerine-9-O-methyltransferase 3: enzymatic reaction with (S)-tetrahydroprotoberberine oxidase View Scheme |
(+)-(S)-reticuline
(-)-isocorypalmine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: enzymatic reaction with berberine bridge enzyme 2: S-adenosyl-L-methionine / enzymatic reaction with (S)-scoulerine-9-O-methyltransferase View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: recombinant berberine bridge enzyme; recombinant CYP719A13 enzyme from Argemone mexicana; recombinant CYP719A14 enzyme from Argemone mexicana; recombinant cytochrome P450 reductase from Eschscholzia californica; NADPH / 1 h / 30 °C / pH 8 / Enzymatic reaction 2: recombinant CYP719A13 enzyme from Argemone mexicana; NADPH / 0.17 h / 30 °C / pH 8 / Enzymatic reaction View Scheme |
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